{"id":"https://openalex.org/W3196582013","doi":"https://doi.org/10.1021/acsnano.1c03517","title":"Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis","display_name":"Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis","publication_year":2021,"publication_date":"2021-09-10","ids":{"openalex":"https://openalex.org/W3196582013","doi":"https://doi.org/10.1021/acsnano.1c03517","mag":"3196582013","pmid":"https://pubmed.ncbi.nlm.nih.gov/34506129"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.1c03517","doi":"https://doi.org/10.1021/acsnano.1c03517","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsnano.1c03517","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsnano.1c03517","source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsnano.1c03517","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347401","display_name":"Juan Wang","orcid":"https://orcid.org/0000-0001-6321-3562","observed_orcids":["https://orcid.org/0000-0001-6321-3562"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Wang","raw_affiliation_strings":["South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101481619","display_name":"Zeyuan Cao","orcid":"https://orcid.org/0000-0003-3214-1249","observed_orcids":["https://orcid.org/0000-0003-3214-1249"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyuan Cao","raw_affiliation_strings":["South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115595038","display_name":"Panpan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Wang","raw_affiliation_strings":["South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320831","display_name":"Xiao Li Zhang","orcid":"https://orcid.org/0000-0001-5050-2621","observed_orcids":["https://orcid.org/0000-0001-5050-2621"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zhang","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology and National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, China","South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology and National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108086652","display_name":"Jianxia Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxia Tang","raw_affiliation_strings":["Hunan Key Laboratory of Oral Health Research and Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya School of Stomatology, Xiangya Stomatological Hospital, Central South University, Changsha 410000, China","South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Oral Health Research and Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya School of Stomatology, Xiangya Stomatological Hospital, Central South University, Changsha 410000, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101829232","display_name":"Yifan He","orcid":"https://orcid.org/0000-0003-2142-3208","observed_orcids":["https://orcid.org/0000-0003-2142-3208","https://orcid.org/0009-0006-5965-5062"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan He","raw_affiliation_strings":["South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014633542","display_name":"Zhiqing Huang","orcid":"https://orcid.org/0000-0001-5092-9297","observed_orcids":["https://orcid.org/0000-0001-5092-9297"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqing Huang","raw_affiliation_strings":["South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059729939","display_name":"Xueli Mao","orcid":"https://orcid.org/0000-0002-2611-7712","observed_orcids":["https://orcid.org/0000-0002-2611-7712"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueli Mao","raw_affiliation_strings":["South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061100138","display_name":"Songtao Shi","orcid":"https://orcid.org/0000-0002-3642-912X","observed_orcids":["https://orcid.org/0000-0002-3642-912X","https://orcid.org/0000-0003-1516-7500"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Songtao Shi","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania 19104, United States","Key Laboratory of Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China","South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Key Laboratory of Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061846724","display_name":"Xiaoxing Kou","orcid":"https://orcid.org/0000-0001-9680-0077","observed_orcids":["https://orcid.org/0000-0001-9680-0077"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xiaoxing Kou","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania 19104, United States","Key Laboratory of Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China","South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China"],"raw_orcid":"https://orcid.org/0000-0001-9680-0077","affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Key Laboratory of Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061846724"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047","https://openalex.org/I79576946"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":6.7467,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.98496514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"15","issue":"9","first_page":"14360","last_page":"14372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptotic-extracellular-vesicles","display_name":"apoptotic extracellular vesicles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fas-mediated-apoptosis","display_name":"Fas-mediated apoptosis","score":0.800000011920929},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell-derived-extracellular-vesicles","display_name":"mesenchymal stem cell-derived extracellular vesicles","score":0.9350000023841858},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8930000066757202},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/extracellular-vesicle-therapy","display_name":"extracellular vesicle therapy","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8559413552284241},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.8211498260498047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7839527726173401},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5576686263084412},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5510525703430176},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5157709121704102},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4725891053676605},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.45291611552238464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4271519184112549},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.426333487033844},{"id":"https://openalex.org/C56483683","wikidata":"https://www.wikidata.org/wiki/Q7876087","display_name":"UVB-induced apoptosis","level":5,"score":0.4227987825870514},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.41874033212661743},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4155847430229187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4029068648815155},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.15590372681617737},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1533360779285431},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1423054039478302},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsnano.1c03517","doi":"https://doi.org/10.1021/acsnano.1c03517","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsnano.1c03517","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsnano.1c03517","source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:34506129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34506129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsnano.1c03517","doi":"https://doi.org/10.1021/acsnano.1c03517","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsnano.1c03517","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsnano.1c03517","source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G216067543","display_name":null,"funder_award_id":"2017A030310508","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G2725723300","display_name":null,"funder_award_id":"81800969","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3952450304","display_name":null,"funder_award_id":"2019ZT08Y485","funder_id":"https://openalex.org/F4320334009","funder_display_name":"Guangdong Provincial Pearl River Talents Program"},{"id":"https://openalex.org/G4398890807","display_name":null,"funder_award_id":"2019QN01Y138","funder_id":"https://openalex.org/F4320334009","funder_display_name":"Guangdong Provincial Pearl River Talents Program"},{"id":"https://openalex.org/G6334451135","display_name":null,"funder_award_id":"2019JC01Y182","funder_id":"https://openalex.org/F4320334009","funder_display_name":"Guangdong Provincial Pearl River Talents Program"},{"id":"https://openalex.org/G7701305781","display_name":null,"funder_award_id":"2018ZX10302207-001-002","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G8017842227","display_name":null,"funder_award_id":"2016A030313262","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320334009","display_name":"Guangdong Provincial Pearl River Talents Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196582013.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1546871754","https://openalex.org/W1567732942","https://openalex.org/W1871308790","https://openalex.org/W1882370412","https://openalex.org/W1967270924","https://openalex.org/W1978676088","https://openalex.org/W1989364839","https://openalex.org/W1990597414","https://openalex.org/W1992532837","https://openalex.org/W2025371271","https://openalex.org/W2037307064","https://openalex.org/W2052853635","https://openalex.org/W2054728789","https://openalex.org/W2091304198","https://openalex.org/W2092996339","https://openalex.org/W2116268000","https://openalex.org/W2136558879","https://openalex.org/W2139176535","https://openalex.org/W2158954941","https://openalex.org/W2170852633","https://openalex.org/W2252441686","https://openalex.org/W2321917939","https://openalex.org/W2345539556","https://openalex.org/W2463368821","https://openalex.org/W2488088692","https://openalex.org/W2574381144","https://openalex.org/W2588346896","https://openalex.org/W2611802393","https://openalex.org/W2746492067","https://openalex.org/W2766031263","https://openalex.org/W2769675217","https://openalex.org/W2785390423","https://openalex.org/W2786514708","https://openalex.org/W2792733823","https://openalex.org/W2796781998","https://openalex.org/W2800034394","https://openalex.org/W2805892376","https://openalex.org/W2808930783","https://openalex.org/W2810413556","https://openalex.org/W2883760072","https://openalex.org/W2886823104","https://openalex.org/W2900599076","https://openalex.org/W2901476790","https://openalex.org/W2917573388","https://openalex.org/W2933304441","https://openalex.org/W2933470566","https://openalex.org/W2941628463","https://openalex.org/W2942580548","https://openalex.org/W2944911353","https://openalex.org/W2976429808","https://openalex.org/W2988984460","https://openalex.org/W2996061365","https://openalex.org/W2999988704","https://openalex.org/W3090508436","https://openalex.org/W3164832369","https://openalex.org/W3168265815","https://openalex.org/W4211037848"],"related_works":["https://openalex.org/W4379599301","https://openalex.org/W2982299434","https://openalex.org/W4283770244","https://openalex.org/W4200438299","https://openalex.org/W4366173645","https://openalex.org/W4381308699","https://openalex.org/W7202270308","https://openalex.org/W4407842593","https://openalex.org/W4387331025","https://openalex.org/W1989364839"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Apoptosis":[7],"is":[8,49],"critical":[9],"for":[10,157],"maintaining":[11],"bodily":[12],"homeostasis":[13],"and":[14,38,73,115,153],"produces":[15],"a":[16,155],"large":[17],"number":[18],"of":[19,26,32,42,80,90,117,140,147],"apoptotic":[20],"extracellular":[21],"vesicles":[22],"(apoEVs).":[23],"Several":[24],"types":[25],"cancer":[27],"cells":[28,98],"display":[29],"reduced":[30],"expression":[31],"Fas":[33,44,101,126,131],"on":[34],"the":[35,88,104,107,130,138,145],"cell":[36,71,76,83,108],"surface":[37],"are":[39],"thus":[40],"capable":[41],"escaping":[43],"ligand-induced":[45],"apoptosis.":[46,141],"However,":[47],"it":[48],"unknown":[50],"whether":[51],"normal":[52],"cell-derived":[53],"apoEVs":[54,65,85,94,123,148,158],"can":[55,66],"regulate":[56],"tumor":[57],"growth.":[58,77],"In":[59],"this":[60],"study,":[61],"we":[62],"show":[63],"that":[64],"induce":[67],"multiple":[68],"myeloma":[69],"(MM)":[70],"apoptosis":[72,152],"inhibit":[74],"MM":[75,91,97,134,151],"Systemic":[78],"infusion":[79],"mesenchymal":[81],"stem":[82],"(MSC)-derived":[84],"significantly":[86],"prolongs":[87],"lifespan":[89],"mice.":[92],"Mechanistically,":[93],"directly":[95],"contact":[96],"to":[99,106,128,137,159],"facilitate":[100],"trafficking":[102],"from":[103],"cytoplasm":[105],"membrane":[109],"by":[110],"evoking":[111],"Ca":[112,119],"2+":[113,120],"influx":[114],"elevation":[116],"cytosolic":[118],".":[121],"Subsequently,":[122],"use":[124],"their":[125],"ligand":[127],"activate":[129],"pathway":[132],"in":[133,149],"cells,":[135],"leading":[136],"initiation":[139],"This":[142],"study":[143],"identifies":[144],"role":[146],"inducing":[150],"suggests":[154],"potential":[156],"treat":[160],"MM.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":40},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-09-13T00:00:00"}