{"id":"https://openalex.org/W3196562841","doi":"https://doi.org/10.1016/j.neuropharm.2021.108766","title":"Covid-19 interface with drug misuse and substance use disorders","display_name":"Covid-19 interface with drug misuse and substance use disorders","publication_year":2021,"publication_date":"2021-08-26","ids":{"openalex":"https://openalex.org/W3196562841","doi":"https://doi.org/10.1016/j.neuropharm.2021.108766","mag":"3196562841","pmid":"https://pubmed.ncbi.nlm.nih.gov/34454912","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8388132"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuropharm.2021.108766","doi":"https://doi.org/10.1016/j.neuropharm.2021.108766","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2021.108766","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuropharm.2021.108766","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024874472","display_name":"Irma E. Cisneros","orcid":"https://orcid.org/0000-0002-8965-0979","observed_orcids":["https://orcid.org/0000-0002-8965-0979"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"I.E. Cisneros","raw_affiliation_strings":["Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: ircisner@utmb.edu","Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA","Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA","Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA","Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA","Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: ircisner@utmb.edu","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031704402","display_name":"Kathryn A. Cunningham","orcid":"https://orcid.org/0000-0002-4257-1739","observed_orcids":["https://orcid.org/0000-0002-4257-1739"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.A. Cunningham","raw_affiliation_strings":["Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA","Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA","Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA","Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024874472"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":0.5743,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.56419753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"198","issue":null,"first_page":"108766","last_page":"108766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10168","display_name":"COVID-19 and Mental Health","score":0.33570000529289246,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10168","display_name":"COVID-19 and Mental Health","score":0.33570000529289246,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.26809999346733093,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9879999756813049},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.9340000152587891},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.953000009059906},{"id":"https://openalex.org/keywords/drug-overdose","display_name":"drug overdose","score":0.7770000100135803},{"id":"https://openalex.org/keywords/syndemic","display_name":"syndemic","score":0.7250000238418579},{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/psychiatric-distress","display_name":"psychiatric distress","score":0.8119999766349792},{"id":"https://openalex.org/keywords/economic-hardship","display_name":"economic hardship","score":0.6990000009536743},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.531000018119812},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.5099999904632568},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuroimmune-signaling","display_name":"neuroimmune signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuropsychiatric-symptoms","display_name":"neuropsychiatric symptoms","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5569667816162109},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5056862831115723},{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.4961431920528412},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.48779112100601196},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.4666588008403778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4346684515476227},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41536426544189453},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3978641629219055},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3927791714668274},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.30058637261390686},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.19700974225997925},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076064","descriptor_name":"Drug Misuse","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012934","descriptor_name":"Social Isolation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D056189","descriptor_name":"Viral Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuropharm.2021.108766","doi":"https://doi.org/10.1016/j.neuropharm.2021.108766","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2021.108766","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8388132","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8388132","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Text"},{"id":"pmid:34454912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34454912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuropharm.2021.108766","doi":"https://doi.org/10.1016/j.neuropharm.2021.108766","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2021.108766","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2429448174","display_name":null,"funder_award_id":"DA050317-S1","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5952069222","display_name":"Targeting the Ghrelin System for Novel Opioid Use Disorder Therapeutics","funder_award_id":"UG3DA050317","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000890040","display_name":"AIM(2)ing at the inflammasome: Impact of MAVS signaling in cocaine-and HIV-1 induced neuroinflammation","funder_award_id":"R01DA052263","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W1650799242","https://openalex.org/W1813031470","https://openalex.org/W1891696008","https://openalex.org/W1926095516","https://openalex.org/W1963646496","https://openalex.org/W1964876778","https://openalex.org/W1969347718","https://openalex.org/W1980890656","https://openalex.org/W1984553370","https://openalex.org/W1986269912","https://openalex.org/W2002167956","https://openalex.org/W2002556051","https://openalex.org/W2003263043","https://openalex.org/W2010883227","https://openalex.org/W2014276753","https://openalex.org/W2017453007","https://openalex.org/W2021338883","https://openalex.org/W2022677793","https://openalex.org/W2023256158","https://openalex.org/W2023536806","https://openalex.org/W2027148405","https://openalex.org/W2028047260","https://openalex.org/W2033283555","https://openalex.org/W2036553842","https://openalex.org/W2045821838","https://openalex.org/W2047437374","https://openalex.org/W2047739268","https://openalex.org/W2053020615","https://openalex.org/W2057471935","https://openalex.org/W2060324739","https://openalex.org/W2060734129","https://openalex.org/W2062550341","https://openalex.org/W2063259953","https://openalex.org/W2064891273","https://openalex.org/W2072016770","https://openalex.org/W2079153927","https://openalex.org/W2080867289","https://openalex.org/W2084236418","https://openalex.org/W2086208662","https://openalex.org/W2091389527","https://openalex.org/W2092210394","https://openalex.org/W2092875932","https://openalex.org/W2095483369","https://openalex.org/W2096736282","https://openalex.org/W2101966742","https://openalex.org/W2103568206","https://openalex.org/W2106139304","https://openalex.org/W2108556733","https://openalex.org/W2110060230","https://openalex.org/W2111451586","https://openalex.org/W2112011558","https://openalex.org/W2118155622","https://openalex.org/W2131301672","https://openalex.org/W2138723442","https://openalex.org/W2150871843","https://openalex.org/W2154698170","https://openalex.org/W2164423986","https://openalex.org/W2165387836","https://openalex.org/W2166133075","https://openalex.org/W2193977448","https://openalex.org/W2195173326","https://openalex.org/W2307186955","https://openalex.org/W2315560217","https://openalex.org/W2462345027","https://openalex.org/W2468729156","https://openalex.org/W2484423289","https://openalex.org/W2491859250","https://openalex.org/W2537274910","https://openalex.org/W2563179195","https://openalex.org/W2594556782","https://openalex.org/W2598111690","https://openalex.org/W2770842062","https://openalex.org/W2788567776","https://openalex.org/W2802435570","https://openalex.org/W2890418886","https://openalex.org/W2892033450","https://openalex.org/W2893772103","https://openalex.org/W2902748282","https://openalex.org/W2909600291","https://openalex.org/W2913977146","https://openalex.org/W2916960866","https://openalex.org/W2920909012","https://openalex.org/W2934808888","https://openalex.org/W2949184225","https://openalex.org/W2964732936","https://openalex.org/W2967866779","https://openalex.org/W2970676275","https://openalex.org/W2973669742","https://openalex.org/W2988570245","https://openalex.org/W2991459881","https://openalex.org/W3001118548","https://openalex.org/W3005496517","https://openalex.org/W3006084884","https://openalex.org/W3008162429","https://openalex.org/W3008526620","https://openalex.org/W3009619005","https://openalex.org/W3009859788","https://openalex.org/W3009878707","https://openalex.org/W3009906937","https://openalex.org/W3011147220","https://openalex.org/W3011293004","https://openalex.org/W3013270768","https://openalex.org/W3013393665","https://openalex.org/W3015109529","https://openalex.org/W3016811145","https://openalex.org/W3023349249","https://openalex.org/W3024126428","https://openalex.org/W3028711203","https://openalex.org/W3032543466","https://openalex.org/W3033175577","https://openalex.org/W3034140243","https://openalex.org/W3035063822","https://openalex.org/W3035385080","https://openalex.org/W3035502447","https://openalex.org/W3036255694","https://openalex.org/W3036500399","https://openalex.org/W3037368719","https://openalex.org/W3037676127","https://openalex.org/W3037768701","https://openalex.org/W3037867966","https://openalex.org/W3043838084","https://openalex.org/W3045973332","https://openalex.org/W3047520497","https://openalex.org/W3048791385","https://openalex.org/W3080882250","https://openalex.org/W3081536095","https://openalex.org/W3082063364","https://openalex.org/W3084199099","https://openalex.org/W3086642606","https://openalex.org/W3087103626","https://openalex.org/W3087124971","https://openalex.org/W3087227941","https://openalex.org/W3090344202","https://openalex.org/W3092068166","https://openalex.org/W3092257185","https://openalex.org/W3093867667","https://openalex.org/W3094237064","https://openalex.org/W3094559063","https://openalex.org/W3095124560","https://openalex.org/W3107596380","https://openalex.org/W3108192182","https://openalex.org/W3110544186","https://openalex.org/W3111792796","https://openalex.org/W3118627743","https://openalex.org/W3118903662","https://openalex.org/W3119815596","https://openalex.org/W3121132522","https://openalex.org/W3128252805","https://openalex.org/W3130518159","https://openalex.org/W3148521097","https://openalex.org/W3154642949","https://openalex.org/W3173443615","https://openalex.org/W3178716999","https://openalex.org/W4239916685","https://openalex.org/W4408286743","https://openalex.org/W6775143445","https://openalex.org/W6779935296","https://openalex.org/W6784111838","https://openalex.org/W6791050744"],"related_works":["https://openalex.org/W3155142208","https://openalex.org/W3015191949","https://openalex.org/W3129452431","https://openalex.org/W3041497815","https://openalex.org/W4401174618","https://openalex.org/W3117788251","https://openalex.org/W3115548046","https://openalex.org/W4389441504","https://openalex.org/W3041809950","https://openalex.org/W3148013456"],"abstract_inverted_index":{"The":[0],"coronavirus":[1],"disease":[2],"2019":[3],"(Covid-19)":[4],"pandemic":[5],"intensified":[6],"the":[7,56,60,66,70,77,85,88,125,129,136,146],"already":[8],"catastrophic":[9],"drug":[10],"overdose":[11],"and":[12,25,29,42,59,82,87,95,101,108,120,134],"substance":[13],"use":[14],"disorder":[15],"(SUD)":[16],"epidemic,":[17],"signaling":[18],"a":[19,111],"syndemic":[20],"as":[21],"social":[22,41],"isolation,":[23],"economic":[24],"mental":[26],"health":[27],"distress,":[28],"disrupted":[30],"treatment":[31],"services":[32],"disproportionally":[33],"impacted":[34],"this":[35],"vulnerable":[36],"population.":[37],"Along":[38],"with":[39,52],"these":[40],"societal":[43],"factors,":[44],"biological":[45],"factors":[46],"triggered":[47],"by":[48],"intense":[49],"stress":[50],"intertwined":[51],"incumbent":[53],"overactivity":[54],"of":[55,69,90,113,131,145],"immune":[57],"system":[58,73],"resulting":[61],"inflammatory":[62],"outcomes":[63],"may":[64,116],"impact":[65],"functional":[67],"status":[68],"central":[71],"nervous":[72],"(CNS).":[74],"We":[75],"review":[76],"literature":[78],"concerning":[79],"SARS-CoV2":[80],"infiltration":[81],"infection":[83],"in":[84,124,135],"CNS":[86],"prospects":[89],"synergy":[91],"between":[92],"stress,":[93],"inflammation,":[94],"kynurenine":[96],"pathway":[97],"function":[98],"during":[99],"illness":[100],"recovery":[102],"from":[103],"Covid-19.":[104],"Taken":[105],"together,":[106],"inflammation":[107],"neuroimmune":[109],"signaling,":[110],"consequence":[112],"Covid-19":[114],"infection,":[115],"dysregulate":[117],"critical":[118],"pathways":[119],"underlie":[121],"maladaptive":[122],"changes":[123],"CNS,":[126],"to":[127,138,151],"exacerbate":[128],"development":[130],"neuropsychiatric":[132],"symptoms":[133],"vulnerability":[137],"develop":[139],"SUD.":[140],"This":[141],"article":[142],"is":[143],"part":[144],"special":[147],"Issue":[148],"on":[149],"'Vulnerabilities":[150],"Substance":[152],"Abuse'.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-09-13T00:00:00"}