{"id":"https://openalex.org/W3195977032","doi":"https://doi.org/10.1016/j.ajpc.2021.100245","title":"Cost-effectiveness of cascade genetic testing for familial hypercholesterolemia in the United States: A simulation analysis","display_name":"Cost-effectiveness of cascade genetic testing for familial hypercholesterolemia in the United States: A simulation analysis","publication_year":2021,"publication_date":"2021-08-15","ids":{"openalex":"https://openalex.org/W3195977032","doi":"https://doi.org/10.1016/j.ajpc.2021.100245","mag":"3195977032","pmid":"https://pubmed.ncbi.nlm.nih.gov/34485965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8403726"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpc.2021.100245","doi":"https://doi.org/10.1016/j.ajpc.2021.100245","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpc.2021.100245","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666667721001008/pdf","source":{"id":"https://openalex.org/S4210223033","display_name":"American Journal of Preventive Cardiology","issn_l":"2666-6677","issn":["2666-6677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Preventive Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2666667721001008/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074573252","display_name":"Candace L. Jackson","orcid":"https://orcid.org/0000-0001-6908-8029","observed_orcids":["https://orcid.org/0000-0001-6908-8029"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candace L. Jackson","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020058980","display_name":"Todd R. Huschka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Huschka","raw_affiliation_strings":["Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054059203","display_name":"Bijan J. Borah","orcid":"https://orcid.org/0000-0002-4526-462X","observed_orcids":["https://orcid.org/0000-0002-4526-462X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bijan Borah","raw_affiliation_strings":["Division of Health Care Delivery Research, Mayo Clinic, Rochester, MN, United States","Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Care Delivery Research, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053197482","display_name":"Katherine E. Agre","orcid":"https://orcid.org/0000-0002-6202-2112","observed_orcids":["https://orcid.org/0000-0002-6202-2112"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Agre","raw_affiliation_strings":["Clinical Genomics, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Genomics, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030634769","display_name":"Magdi Zordok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magdi Zordok","raw_affiliation_strings":["Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005621109","display_name":"Medhat Farwati","orcid":"https://orcid.org/0000-0002-9052-9690","observed_orcids":["https://orcid.org/0000-0002-9052-9690"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Medhat Farwati","raw_affiliation_strings":["Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078054821","display_name":"James P. Moriarty","orcid":"https://orcid.org/0000-0002-5139-1932","observed_orcids":["https://orcid.org/0000-0002-5139-1932"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Moriarty","raw_affiliation_strings":["Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065025844","display_name":"Iftikhar J. Kullo","orcid":"https://orcid.org/0000-0002-6524-3471","observed_orcids":["https://orcid.org/0000-0002-6524-3471"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Iftikhar J. Kullo","raw_affiliation_strings":["Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States","Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065025844"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":1600,"currency":"USD","value_usd":1600},"apc_paid":{"value":1600,"currency":"USD","value_usd":1600},"fwci":4.9331,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.96468293,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"100245","last_page":"100245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cascade-testing","display_name":"cascade testing","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.953000009059906},{"id":"https://openalex.org/keywords/screening-age-thresholds","display_name":"screening age thresholds","score":0.7360000014305115},{"id":"https://openalex.org/keywords/relatives-of-probands","display_name":"relatives of probands","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.6050000190734863},{"id":"https://openalex.org/keywords/life-years-gained","display_name":"life-years gained","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.654132604598999},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.5400354266166687},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5225043892860413},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4685198962688446},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4471622705459595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4283842444419861},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32448726892471313},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2840037941932678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24751269817352295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2059866189956665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19641688466072083},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.16019174456596375},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10745081305503845},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ajpc.2021.100245","doi":"https://doi.org/10.1016/j.ajpc.2021.100245","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpc.2021.100245","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666667721001008/pdf","source":{"id":"https://openalex.org/S4210223033","display_name":"American Journal of Preventive Cardiology","issn_l":"2666-6677","issn":["2666-6677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Preventive Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8403726","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8403726","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Prev Cardiol","raw_type":"Text"},{"id":"pmid:34485965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34485965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of preventive cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7e4f6deca497480fbc6c8e59838e5bf8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7e4f6deca497480fbc6c8e59838e5bf8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Preventive Cardiology, Vol 8, Iss , Pp 100245- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ajpc.2021.100245","doi":"https://doi.org/10.1016/j.ajpc.2021.100245","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpc.2021.100245","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666667721001008/pdf","source":{"id":"https://openalex.org/S4210223033","display_name":"American Journal of Preventive Cardiology","issn_l":"2666-6677","issn":["2666-6677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Preventive Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1375804293","display_name":"EHR-based Genomic Discovery and Implementation","funder_award_id":"U01HG006379","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G186267009","display_name":null,"funder_award_id":"HL137010","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3840122606","display_name":"Patient-Oriented Research in Genomic Discovery and Implementation","funder_award_id":"K24HL137010","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195977032.pdf","grobid_xml":"https://content.openalex.org/works/W3195977032.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W189389301","https://openalex.org/W1844854928","https://openalex.org/W1963587614","https://openalex.org/W1976101978","https://openalex.org/W1976130642","https://openalex.org/W2030060743","https://openalex.org/W2044268235","https://openalex.org/W2074472861","https://openalex.org/W2114115725","https://openalex.org/W2127547407","https://openalex.org/W2128911553","https://openalex.org/W2133030338","https://openalex.org/W2141187870","https://openalex.org/W2143532751","https://openalex.org/W2165624352","https://openalex.org/W2302032525","https://openalex.org/W2411760145","https://openalex.org/W2509676484","https://openalex.org/W2516351633","https://openalex.org/W2540007944","https://openalex.org/W2569910055","https://openalex.org/W2575600667","https://openalex.org/W2604575858","https://openalex.org/W2623268824","https://openalex.org/W2782412406","https://openalex.org/W2792261741","https://openalex.org/W2800105293","https://openalex.org/W2887629426","https://openalex.org/W2943032204","https://openalex.org/W2945925246","https://openalex.org/W2969949762","https://openalex.org/W2982075015","https://openalex.org/W3006095099","https://openalex.org/W6607729981"],"related_works":["https://openalex.org/W2604575858","https://openalex.org/W2051459270","https://openalex.org/W3024638470","https://openalex.org/W2160809506","https://openalex.org/W2806317860","https://openalex.org/W4388339842","https://openalex.org/W4255672152","https://openalex.org/W4394859799","https://openalex.org/W2330402612","https://openalex.org/W2113294346"],"abstract_inverted_index":{"Objective":[0],"There":[1],"is":[2,261],"no":[3,226],"coordinated":[4],"cascade":[5,21,92,150,240,253],"testing":[6,23,94,151,171,215,242,255],"program":[7],"for":[8,50,97,256],"familial":[9],"hypercholesterolemia":[10],"(FH)":[11],"in":[12,126,157,258,268,276],"the":[13,17,136,259],"U.S.":[14,128,260],"We":[15],"evaluated":[16],"contemporary":[18],"cost-effectiveness":[19],"of":[20,25,75,80,99,144,161,188,207,223,232],"genetic":[22,93,241,254],"relatives":[24,76,98,271],"FH":[26,51,100,257],"probands":[27,101],"with":[28,43,199,218],"a":[29,47,64,158,200,219,230],"pathogenic":[30,48],"variant.":[31],"A":[32],"simulation":[33,251],"model":[34,83,137],"was":[35,95,172,179,193,216,243],"created":[36],"to":[37,62,71],"simulate":[38],"multiple":[39,78],"family":[40,65],"trees":[41],"starting":[42],"progenitor":[44],"individuals":[45],"carrying":[46],"variant":[49],"who":[52,106],"were":[53,107,124,138],"followed":[54],"through":[55,103],"several":[56],"generations.":[57],"This":[58],"approach":[59],"allowed":[60],"us":[61],"examine":[63],"tree":[66],"that":[67],"had":[68],"grown":[69],"sufficiently":[70],"have":[72],"large":[73],"numbers":[74],"across":[77],"degrees":[79],"relatedness.":[81],"The":[82],"estimated":[84],"costs":[85,131],"and":[86,132,190,272],"life":[87],"years":[88],"gained":[89],"(LYG)":[90],"when":[91],"implemented":[96],"identified":[102],"standard":[104],"care":[105],"at":[108,140,152,174,184,195,229],"or":[109,234,246],"older":[110,191],"than":[111,209],"designated":[112],"age":[113,154,176,186,197,221,266,274],"thresholds":[114],"(5,":[115],"10,":[116],"15,":[117],"20,":[118],"25,":[119],"30,":[120],"35,":[121],"40).":[122],"Costs":[123],"valued":[125],"2018":[127],"dollars.":[129],"Future":[130],"LYG":[133,163,204],"projected":[134],"by":[135],"discounted":[139,201],"an":[141,185],"annual":[142],"rate":[143],"3%.":[145],"For":[146,211],"1st":[147,269],"degree":[148,213,270,278],"relatives,":[149,214,239],"every":[153],"threshold":[155,187,222,231],"resulted":[156],"positive":[159],"number":[160,168],"average":[162],"per":[164,203,205],"person,":[165],"though":[166],"this":[167],"decreased":[169],"as":[170],"started":[173,264],"higher":[175],"thresholds.":[177],"Testing":[178],"not":[180,244],"cost-effective":[181,194,217,228,262],"if":[182,263],"initiated":[183],"40":[189,267],"but":[192,225],"younger":[196],"thresholds,":[198],"cost":[202],"person":[206],"less":[208],"$50,000.":[210],"2nd":[212,277],"screening":[220],"10":[224],"longer":[227],"15":[233,275],"higher.":[235],"In":[236],"more":[237],"distant":[238],"beneficial":[245],"cost-effective.":[247],"Based":[248],"on":[249],"our":[250],"model,":[252],"before":[265,273],"relatives.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-08-30T00:00:00"}