{"id":"https://openalex.org/W3195890558","doi":"https://doi.org/10.1155/2021/9970338","title":"Effective Extraction of Palmatine and Berberine from Coptis chinensis by Deep Eutectic Solvents-Based Ultrasound-Assisted Extraction","display_name":"Effective Extraction of Palmatine and Berberine from Coptis chinensis by Deep Eutectic Solvents-Based Ultrasound-Assisted Extraction","publication_year":2021,"publication_date":"2021-08-13","ids":{"openalex":"https://openalex.org/W3195890558","doi":"https://doi.org/10.1155/2021/9970338","mag":"3195890558","pmid":"https://pubmed.ncbi.nlm.nih.gov/34422435","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8378955"},"language":"en","primary_location":{"id":"doi:10.1155/2021/9970338","doi":"https://doi.org/10.1155/2021/9970338","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/9970338","pdf_url":"https://downloads.hindawi.com/journals/jamc/2021/9970338.pdf","source":{"id":"https://openalex.org/S4210240219","display_name":"Journal of Analytical Methods in Chemistry","issn_l":"2090-8873","issn":["2090-8873","2090-8865"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Methods in Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3195890558"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jamc/2021/9970338.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101593013","display_name":"Lijing Li","orcid":"https://orcid.org/0000-0002-9469-1644","observed_orcids":["https://orcid.org/0000-0002-9469-1644"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijing Li","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"],"raw_orcid":"https://orcid.org/0000-0002-9469-1644","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366104","display_name":"Dong Zhang","orcid":"https://orcid.org/0000-0002-3719-879X","observed_orcids":["https://orcid.org/0000-0002-3719-879X"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Zhang","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"],"raw_orcid":"https://orcid.org/0000-0002-3719-879X","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069468312","display_name":"Yuejie Wang","orcid":"https://orcid.org/0000-0003-0422-8072","observed_orcids":["https://orcid.org/0000-0003-0422-8072"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuejie Wang","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"],"raw_orcid":"https://orcid.org/0000-0003-0422-8072","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102816356","display_name":"Fangxin Liu","orcid":"https://orcid.org/0000-0003-3270-9471","observed_orcids":["https://orcid.org/0000-0003-3270-9471"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangxin Liu","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"],"raw_orcid":"https://orcid.org/0000-0003-3270-9471","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101575467","display_name":"Yang Xu","orcid":"https://orcid.org/0000-0003-2324-1299","observed_orcids":["https://orcid.org/0000-0003-2324-1299"]},"institutions":[{"id":"https://openalex.org/I4405278657","display_name":"Baicheng Medical College","ror":"https://ror.org/00bkcxt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Xu","raw_affiliation_strings":["College of Pharmacy, Baicheng Medical College, Baicheng 137000, China"],"raw_orcid":"https://orcid.org/0000-0003-2324-1299","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Baicheng Medical College, Baicheng 137000, China","institution_ids":["https://openalex.org/I4405278657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021061208","display_name":"Huiwei Bao","orcid":"https://orcid.org/0000-0002-5787-1814","observed_orcids":["https://orcid.org/0000-0002-5787-1814"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiwei Bao","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China"],"raw_orcid":"https://orcid.org/0000-0002-5787-1814","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China","institution_ids":["https://openalex.org/I4210128075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021061208","https://openalex.org/A5101575467"],"corresponding_institution_ids":["https://openalex.org/I4210128075","https://openalex.org/I4405278657"],"apc_list":{"value":2160,"currency":"USD","value_usd":2160},"apc_paid":{"value":2160,"currency":"USD","value_usd":2160},"fwci":1.1784,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.72342847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.3212999999523163,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12181","display_name":"Agricultural and Biological Research","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coptis-chinensis","display_name":"Coptis chinensis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/palmatine","display_name":"palmatine","score":0.996999979019165},{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":1.0},{"id":"https://openalex.org/keywords/deep-eutectic-solvents","display_name":"deep eutectic solvents","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ultrasound-assisted-extraction","display_name":"ultrasound-assisted extraction","score":0.9950000047683716},{"id":"https://openalex.org/keywords/choline-chloride","display_name":"choline chloride","score":0.972000002861023},{"id":"https://openalex.org/keywords/phenols","display_name":"phenols","score":0.9599999785423279},{"id":"https://openalex.org/keywords/extraction-optimization","display_name":"extraction optimization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/alkaloid-extraction","display_name":"alkaloid extraction","score":0.6499999761581421},{"id":"https://openalex.org/keywords/response-surface-optimization","display_name":"response surface optimization","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2778439678","wikidata":"https://www.wikidata.org/wiki/Q6634283","display_name":"Palmatine","level":3,"score":0.9642921686172485},{"id":"https://openalex.org/C2777397596","wikidata":"https://www.wikidata.org/wiki/Q842233","display_name":"Coptis chinensis","level":4,"score":0.9208287000656128},{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.8553769588470459},{"id":"https://openalex.org/C2780371645","wikidata":"https://www.wikidata.org/wiki/Q168033","display_name":"Deep eutectic solvent","level":4,"score":0.6028139591217041},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.579237699508667},{"id":"https://openalex.org/C2777073116","wikidata":"https://www.wikidata.org/wiki/Q135562","display_name":"Coptis","level":4,"score":0.574185848236084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5434226989746094},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.49872779846191406},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.44544732570648193},{"id":"https://openalex.org/C18168003","wikidata":"https://www.wikidata.org/wiki/Q628595","display_name":"Eutectic system","level":3,"score":0.42476779222488403},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18294712901115417},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2780026712","wikidata":"https://www.wikidata.org/wiki/Q37756","display_name":"Alloy","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/9970338","doi":"https://doi.org/10.1155/2021/9970338","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/9970338","pdf_url":"https://downloads.hindawi.com/journals/jamc/2021/9970338.pdf","source":{"id":"https://openalex.org/S4210240219","display_name":"Journal of Analytical Methods in Chemistry","issn_l":"2090-8873","issn":["2090-8873","2090-8865"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Methods in Chemistry","raw_type":"journal-article"},{"id":"pmid:34422435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34422435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of analytical methods in chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8378955","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8378955/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anal Methods Chem","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8b866e568686499782f57ba7f4b10ebf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8b866e568686499782f57ba7f4b10ebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Analytical Methods in Chemistry, Vol 2021 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2021/9970338","doi":"https://doi.org/10.1155/2021/9970338","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/9970338","pdf_url":"https://downloads.hindawi.com/journals/jamc/2021/9970338.pdf","source":{"id":"https://openalex.org/S4210240219","display_name":"Journal of Analytical Methods in Chemistry","issn_l":"2090-8873","issn":["2090-8873","2090-8865"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Methods in Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2984943806","display_name":null,"funder_award_id":"JJKH20200904KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"}],"funders":[{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320326270","display_name":"Education Department of Jilin Province","ror":"https://ror.org/05782e512"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195890558.pdf","grobid_xml":"https://content.openalex.org/works/W3195890558.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W148034077","https://openalex.org/W2124985647","https://openalex.org/W2236487316","https://openalex.org/W2320231375","https://openalex.org/W2321005010","https://openalex.org/W2329989147","https://openalex.org/W2376694644","https://openalex.org/W2507344435","https://openalex.org/W2610973917","https://openalex.org/W2626803262","https://openalex.org/W2740892682","https://openalex.org/W2790584972","https://openalex.org/W2790876884","https://openalex.org/W2791166586","https://openalex.org/W2801172935","https://openalex.org/W2805286725","https://openalex.org/W2883871681","https://openalex.org/W2896287529","https://openalex.org/W2903529093","https://openalex.org/W3199769757"],"related_works":["https://openalex.org/W4401634498","https://openalex.org/W4408801010","https://openalex.org/W4283271940","https://openalex.org/W2356670452","https://openalex.org/W2378397632","https://openalex.org/W2358715339","https://openalex.org/W7213446115","https://openalex.org/W2383851880","https://openalex.org/W4317438475","https://openalex.org/W2349069614"],"abstract_inverted_index":{"The":[0,75],"effective":[1],"components":[2],"of":[3,14,38,45,55,69,79,125,133,141,168,200],"Coptis":[4,24,84,173],"chinensis":[5,25,85,174],"were":[6,18,73,175,183],"extracted":[7],"by":[8,22,88],"ultrasound-assisted":[9],"technology,":[10],"and":[11,16,29,62,71,81,91,115,158,170,178,192],"the":[12,36,66,102,134,166,187,190,193],"contents":[13,167],"palmatine":[15,70,80,169],"berberine":[17,72,82,171],"used":[19],"as":[20,26,32,111,117,189],"indexes":[21],"using":[23],"raw":[27],"material":[28,142],"eutectic":[30,56,103,135],"solvent":[31,57,104,136,203],"extractant.":[33],"In":[34,129],"addition,":[35,130],"effects":[37],"hydrogen":[39,46,112,118],"bond":[40,47,113,119],"donor":[41,48],"type,":[42],"molar":[43,123],"ratio":[44,124,140],"to":[49,143,185],"acceptor,":[50],"material-liquid":[51],"ratio,":[52],"water":[53,131],"content":[54,132],"system,":[58],"sonication":[59],"time,":[60,165],"power,":[61],"ultrasonic":[63,148,153,159],"temperature":[64,160],"on":[65],"extraction":[67,77,194,202],"rate":[68],"studied.":[74],"optimum":[76],"technology":[78],"from":[83],"was":[86,106,138,145,150,155,161,196],"determined":[87],"single-factor":[89],"experiment":[90],"response":[92],"surface":[93],"optimization":[94],"test.":[95],"As":[96],"a":[97,122],"result,":[98],"it":[99],"showed":[100],"that":[101,199],"system":[105,137],"constructed":[107],"with":[108,121],"choline":[109],"chloride":[110],"acceptor":[114],"phenol":[116],"donor,":[120],"1":[126],":":[127],"3.":[128],"30%,":[139],"liquid":[144],"30":[146,151],"g/mL,":[147],"time":[149],"min,":[152],"power":[154],"200":[156],"W,":[157],"60\u00b0C.":[162],"At":[163],"this":[164],"in":[172],"16.7145":[176],"mg/g":[177],"57.4013":[179],"mg/g,":[180],"respectively,":[181],"which":[182],"predicted":[184],"be":[186],"same":[188],"value,":[191],"effect":[195],"better":[197],"than":[198],"traditional":[201],"method.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-08-30T00:00:00"}