{"id":"https://openalex.org/W3195831111","doi":null,"title":"Supervivencia de pacientes con c\u00e1ncer mamario temprano HER2 positivo tratadas con trastuzumab endovenoso en adyuvancia","display_name":"Supervivencia de pacientes con c\u00e1ncer mamario temprano HER2 positivo tratadas con trastuzumab endovenoso en adyuvancia","publication_year":2021,"publication_date":"2021-06-02","ids":{"openalex":"https://openalex.org/W3195831111","mag":"3195831111"},"language":"es","primary_location":{"id":"mag:3195831111","doi":null,"is_oa":false,"landing_page_url":"http://www.revoncologia.sld.cu/index.php/onc/article/download/91/50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112095435","display_name":"Iv\u00e1n Ram\u00f3n Concepci\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Ram\u00f3n Concepci\u00f3n","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102759414","display_name":"Jorge Luis Garc\u00eda","orcid":"https://orcid.org/0000-0001-7724-6541","observed_orcids":["https://orcid.org/0000-0001-7724-6541"]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Jorge Luis Garc\u00eda","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":"https://orcid.org/0000-0001-7724-6541","affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070874685","display_name":"Mar\u00eda de Lourdes Valenciano Estenoz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mar\u00eda de Lourdes Valenciano Estenoz","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028895575","display_name":"Noyde Batista Albuerne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Noyde Batista Albuerne","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001584190","display_name":"Mayt\u00e9 Lima P\u00e9rez","orcid":"https://orcid.org/0000-0001-6607-3913","observed_orcids":["https://orcid.org/0000-0001-6607-3913"]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mayt\u00e9 Lima P\u00e9rez","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":"https://orcid.org/0000-0001-6607-3913","affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001455376","display_name":"Dayanis Duvergel Calder\u00edn","orcid":"https://orcid.org/0000-0002-3637-5264","observed_orcids":["https://orcid.org/0000-0002-3637-5264","https://orcid.org/0000-0003-4452-5493"]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Dayanis Duvergel Calder\u00edn","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102061668","display_name":"Mar\u00eda Caridad de Armas Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Caridad de Armas Fern\u00e1ndez","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029611188","display_name":"Jorge L\u00e1zaro Loys Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Jorge L\u00e1zaro Loys Fern\u00e1ndez","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081217980","display_name":"Concepci\u00f3n del Castillo Carrillo","orcid":"https://orcid.org/0000-0002-9084-8712","observed_orcids":["https://orcid.org/0000-0002-9084-8712"]},"institutions":[{"id":"https://openalex.org/I2799943988","display_name":"Hermanos Ameijeiras Hospital","ror":"https://ror.org/05328fn02","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I2799943988"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Concepci\u00f3n del Castillo Carrillo","raw_affiliation_strings":["Hospital Hermanos Ameijeiras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Hermanos Ameijeiras","institution_ids":["https://openalex.org/I2799943988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799943988"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13986406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adjuvant-trastuzumab","display_name":"adjuvant trastuzumab","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9779999852180481},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":1.0},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7310000061988831},{"id":"https://openalex.org/keywords/lymph-node-status","display_name":"lymph node status","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.5600000023841858},{"id":"https://openalex.org/keywords/conservative-surgery","display_name":"conservative surgery","score":0.43799999356269836},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.4729999899864197},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.39399999380111694},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9360300302505493},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7999686002731323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6932839751243591},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6730407476425171},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5318170785903931},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4754471480846405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46175241470336914},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37950482964515686},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36926978826522827},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3573048710823059}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3195831111","doi":null,"is_oa":false,"landing_page_url":"http://www.revoncologia.sld.cu/index.php/onc/article/download/91/50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2400967664","https://openalex.org/W2032502319","https://openalex.org/W3028402684","https://openalex.org/W2984399641","https://openalex.org/W2135105801","https://openalex.org/W2378227197","https://openalex.org/W2125620887","https://openalex.org/W2480498680","https://openalex.org/W2010532193","https://openalex.org/W2511644994"],"abstract_inverted_index":{"Introduction:":[0],"The":[2,143,199],"prognosis":[3],"of":[4,14,17,26,100,109,133,202],"HER2-positive":[5,58,229],"breast":[6,59,231,244],"cancer":[7,60,232],"was":[8,52,98,131,146,168],"very":[9],"unfavorable":[10],"before":[11],"the":[12,24,57,149,159,196],"use":[13,130],"trastuzumab.":[15,250],"Use":[16],"this":[18],"therapy":[19,139],"in":[20,62,228],"early":[21,63,230,243],"stages":[22,64],"improves":[23,223],"survival":[25,84,227],"patients":[27,61,101],"receiving":[28],"it.":[29],"Objective:":[32],"Evaluate":[36],"overall":[37,172,224],"and":[38,68,82,125,140,155,179,225],"disease-free":[39,83,186,226],"survival.":[40,187],"Methods:":[43],"An":[47],"observational":[48],"retrospective":[49],"descriptive":[50],"study":[51],"conducted":[53],"which":[54],"included":[55],"all":[56],"who":[65],"underwent":[66],"surgery":[67],"received":[69],"intravenous":[70,219,249],"adjuvant":[71,247],"trastuzumab":[72,220],"plus":[73,221],"chemotherapy":[74,222],"from":[75],"January":[76],"2011":[77],"to":[78,148],"December":[79],"2014.":[80],"Overall":[81],"were":[85,88,182,191,205],"analyzed.":[86],"Toxicities":[87],"identified.":[89],"Results:":[92],"A":[96],"predominance":[97],"found":[99],"aged":[102],"over":[103],"50":[104],"years":[105],"with":[106,153,193,218,234],"a":[107,235],"history":[108],"hypertension,":[110],"infiltrating":[111],"ductal":[112],"histology,":[113],"vascular":[114],"permeation,":[115],"tumors":[116],"larger":[117],"than":[118],"two":[119],"centimeters,":[120],"negative":[121],"ganglia,":[122],"grade":[123,208],"3":[124],"positive":[126],"hormone":[127,138],"receptors.":[128],"Greater":[129],"observed":[132],"conservative":[134],"surgery,":[135],"ionizing":[136],"radiation,":[137],"sequential":[141],"chemotherapy.":[142],"relapse":[144],"rate":[145],"similar":[147],"one":[150],"reported":[151],"internationally,":[152],"bone":[154],"brain":[156],"metastases":[157],"as":[158,195,207],"most":[160,197],"frequent.":[161,198],"No":[162],"clinical,":[163],"histopathological":[164],"or":[165],"treatment":[166,217],"variable":[167],"statistically":[169,183],"significant":[170,184],"for":[171,185],"survival,":[173],"whereas":[174],"pathological":[175],"antecedents,":[176],"tumor":[177],"size":[178],"nodal":[180],"status":[181],"Intravenous":[188],"trastuzumab-related":[189],"toxicities":[190],"scant,":[192],"cardiotoxicity":[194],"vast":[200],"majority":[201],"adverse":[203],"events":[204],"classified":[206],"I-II.":[209],"Conclusions:":[212],"Adjuvant":[216],"patients,":[233],"good":[236],"safety":[237],"profile.":[238],"Key":[240],"words:":[241],"cancer,":[245],"HER2-positive,":[246],"treatment,":[248]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2021-08-30T00:00:00"}