{"id":"https://openalex.org/W3195547110","doi":"https://doi.org/10.1371/journal.ppat.1009869","title":"BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments","display_name":"BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments","publication_year":2021,"publication_date":"2021-08-20","ids":{"openalex":"https://openalex.org/W3195547110","doi":"https://doi.org/10.1371/journal.ppat.1009869","mag":"3195547110","pmid":"https://pubmed.ncbi.nlm.nih.gov/34415955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8409650"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1009869","doi":"https://doi.org/10.1371/journal.ppat.1009869","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1009869","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009869&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009869&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018171758","display_name":"Hunter W. Kuhn","orcid":"https://orcid.org/0000-0002-7876-3521","observed_orcids":["https://orcid.org/0000-0002-7876-3521"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter W. Kuhn","raw_affiliation_strings":["Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7876-3521","affiliations":[{"raw_affiliation_string":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036765108","display_name":"Amanda G. Lasseter","orcid":"https://orcid.org/0000-0003-1859-4065","observed_orcids":["https://orcid.org/0000-0003-1859-4065"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda G. Lasseter","raw_affiliation_strings":["Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1859-4065","affiliations":[{"raw_affiliation_string":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025363580","display_name":"Philip P. Adams","orcid":"https://orcid.org/0000-0002-2575-6328","observed_orcids":["https://orcid.org/0000-0002-2575-6328"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"id":"https://openalex.org/I4210152124","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210152124"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip P. Adams","raw_affiliation_strings":["Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America","Postdoctoral Research Associate Program, National Institute of General Medical Sciences, National Institute of Health, Bethesda, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2575-6328","affiliations":[{"raw_affiliation_string":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Postdoctoral Research Associate Program, National Institute of General Medical Sciences, National Institute of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210152124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102265750","display_name":"Carlos Flores Avile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Flores Avile","raw_affiliation_strings":["Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036319597","display_name":"Brandee L. Stone","orcid":"https://orcid.org/0000-0002-0685-1215","observed_orcids":["https://orcid.org/0000-0002-0685-1215"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandee L. Stone","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0685-1215","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070150746","display_name":"Darrin R. Akins","orcid":"https://orcid.org/0000-0002-4007-8246","observed_orcids":["https://orcid.org/0000-0002-4007-8246"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrin R. Akins","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046052844","display_name":"Travis J. Jewett","orcid":"https://orcid.org/0000-0001-8753-4934","observed_orcids":["https://orcid.org/0000-0001-8753-4934"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis J. Jewett","raw_affiliation_strings":["Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065097421","display_name":"Mollie W. Jewett","orcid":"https://orcid.org/0000-0003-3130-3795","observed_orcids":["https://orcid.org/0000-0003-3130-3795"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mollie W. Jewett","raw_affiliation_strings":["Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3130-3795","affiliations":[{"raw_affiliation_string":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065097421"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":2575,"currency":"USD","value_usd":2575},"apc_paid":{"value":2575,"currency":"USD","value_usd":2575},"fwci":1.5129,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78529747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"17","issue":"8","first_page":"e1009869","last_page":"e1009869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipase-activity","display_name":"lipase activity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lyme-disease","display_name":"Lyme disease","score":0.6129999756813049},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tick-bite-transmission","display_name":"tick bite transmission","score":0.7260000109672546},{"id":"https://openalex.org/keywords/in-vivo-expression-technology","display_name":"in vivo expression technology","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gxsxg-motif","display_name":"GXSXG motif","score":0.7170000076293945},{"id":"https://openalex.org/keywords/fatty-acid-deficiency","display_name":"fatty acid deficiency","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7878159284591675},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7373524904251099},{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.6987825036048889},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5795152187347412},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5332028269767761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4509826898574829},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4292583465576172},{"id":"https://openalex.org/C2780508971","wikidata":"https://www.wikidata.org/wiki/Q115528","display_name":"Borrelia","level":4,"score":0.4112316370010376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32641565799713135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15261390805244446},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07523652911186218}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018884","descriptor_name":"Ixodes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.ppat.1009869","doi":"https://doi.org/10.1371/journal.ppat.1009869","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1009869","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009869&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8409650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8409650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:34415955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34415955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:83133a61316f4c7694a6b07daadd1c8f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/83133a61316f4c7694a6b07daadd1c8f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 17, Iss 8, p e1009869 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1009869","doi":"https://doi.org/10.1371/journal.ppat.1009869","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1009869","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009869&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2379876015","display_name":"Outer Membrane Proteins of Borrelia burgdorferi","funder_award_id":"R01AI059373","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7658914264","display_name":null,"funder_award_id":"FI2 GM133345","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7683644515","display_name":"RNA-mediated gene regulation of the Lyme disease pathogen","funder_award_id":"1fi2gm133345-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G964567952","display_name":"Determination of the genetic basis for B. burgdorferi mammalian infectivity","funder_award_id":"R01AI099094","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195547110.pdf","grobid_xml":"https://content.openalex.org/works/W3195547110.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W205578041","https://openalex.org/W1587983189","https://openalex.org/W1630566704","https://openalex.org/W1650944514","https://openalex.org/W1841463464","https://openalex.org/W1912214366","https://openalex.org/W1926303070","https://openalex.org/W1944107535","https://openalex.org/W1969762827","https://openalex.org/W1969796579","https://openalex.org/W1974951285","https://openalex.org/W1977904572","https://openalex.org/W1987581698","https://openalex.org/W1997698750","https://openalex.org/W1997882690","https://openalex.org/W2006080034","https://openalex.org/W2008006104","https://openalex.org/W2012200136","https://openalex.org/W2013636685","https://openalex.org/W2017583646","https://openalex.org/W2023402337","https://openalex.org/W2028409160","https://openalex.org/W2030510935","https://openalex.org/W2031977066","https://openalex.org/W2034264527","https://openalex.org/W2036154785","https://openalex.org/W2037310526","https://openalex.org/W2037993016","https://openalex.org/W2055735551","https://openalex.org/W2057249567","https://openalex.org/W2061361289","https://openalex.org/W2064660210","https://openalex.org/W2073247834","https://openalex.org/W2088089656","https://openalex.org/W2088837736","https://openalex.org/W2093772258","https://openalex.org/W2094761728","https://openalex.org/W2096065240","https://openalex.org/W2097870001","https://openalex.org/W2104373250","https://openalex.org/W2105281406","https://openalex.org/W2106759423","https://openalex.org/W2108693862","https://openalex.org/W2110408657","https://openalex.org/W2111485154","https://openalex.org/W2121033175","https://openalex.org/W2123283534","https://openalex.org/W2124242639","https://openalex.org/W2131492700","https://openalex.org/W2136026618","https://openalex.org/W2137451384","https://openalex.org/W2142117803","https://openalex.org/W2143591164","https://openalex.org/W2144624675","https://openalex.org/W2145254159","https://openalex.org/W2150762214","https://openalex.org/W2153544371","https://openalex.org/W2158023121","https://openalex.org/W2158738482","https://openalex.org/W2158906453","https://openalex.org/W2206173760","https://openalex.org/W2277841353","https://openalex.org/W2278843557","https://openalex.org/W2288746230","https://openalex.org/W2290785671","https://openalex.org/W2467475258","https://openalex.org/W2509156297","https://openalex.org/W2535630741","https://openalex.org/W2559191318","https://openalex.org/W2560397218","https://openalex.org/W2560560741","https://openalex.org/W2588853073","https://openalex.org/W2589551634","https://openalex.org/W2618820367","https://openalex.org/W2761260201","https://openalex.org/W2763454568","https://openalex.org/W2770277250","https://openalex.org/W2781504369","https://openalex.org/W2807954347","https://openalex.org/W2884466758","https://openalex.org/W2898153501","https://openalex.org/W2913035670","https://openalex.org/W2914215949","https://openalex.org/W2922294927","https://openalex.org/W2971833257","https://openalex.org/W2980955740","https://openalex.org/W3015079638","https://openalex.org/W3030401145","https://openalex.org/W3092012811","https://openalex.org/W3123426018","https://openalex.org/W4211094317","https://openalex.org/W4211183226"],"related_works":["https://openalex.org/W1630566704","https://openalex.org/W7117469912","https://openalex.org/W7099628274","https://openalex.org/W7099181397","https://openalex.org/W7099530420","https://openalex.org/W2118316271","https://openalex.org/W7162187024","https://openalex.org/W4396624895","https://openalex.org/W2726227974","https://openalex.org/W2099277528"],"abstract_inverted_index":{"The":[0],"Lyme":[1],"disease":[2],"spirochete":[3,123,141,282],"Borrelia":[4],"burgdorferi":[5,44,154],"relies":[6],"on":[7,250],"uptake":[8],"of":[9,28,58,62,90,130,151,160,182,186,192,206,217,238],"essential":[10],"nutrients":[11],"from":[12,220],"its":[13],"host":[14],"environments":[15,285],"for":[16,104,140,214,225,281],"survival":[17,124,283],"and":[18,76,93,96,110,116,147,226],"infection.":[19,131],"Therefore,":[20,222],"nutrient":[21],"acquisition":[22],"mechanisms":[23,33],"constitute":[24],"key":[25],"virulence":[26,270],"properties":[27],"the":[29,79,82,126,148,158,180,189,196,203,207,215,236,251,256,292],"pathogen,":[30],"yet":[31],"these":[32],"remain":[34],"largely":[35],"unknown.":[36],"In":[37,169,259],"vivo":[38],"expression":[39],"technology":[40],"applied":[41],"to":[42,137,195,240,277],"B.":[43,153],"(BbIVET)":[45],"during":[46,125],"mammalian":[47,293],"infection":[48,107],"identified":[49,227],"gene":[50],"bb0562,":[51,91],"which":[52],"encodes":[53],"a":[54,59,267,273],"hypothetical":[55,73],"protein":[56],"comprised":[57],"conserved":[60],"domain":[61],"unknown":[63],"function,":[64],"DUF3996.":[65],"DUF3996":[66],"is":[67,266],"also":[68,135],"found":[69,136],"across":[70],"adjacent":[71],"encoded":[72],"proteins":[74,84],"BB0563":[75],"BB0564,":[77],"suggesting":[78,209],"possibility":[80],"that":[81,99,264,275],"three":[83],"could":[85],"be":[86,138,212],"functionally":[87],"related.":[88],"Deletion":[89],"bb0563":[92],"bb0564":[94],"individually":[95],"together":[97],"demonstrated":[98,246],"bb0562":[100,121,133,210,265],"alone":[101],"was":[102,134,155],"important":[103,139,213],"optimal":[105],"disseminated":[106],"in":[108,143,176,179,284,287],"immunocompetent":[109],"immunocompromised":[111],"mice":[112],"by":[113],"needle":[114],"inoculation":[115],"tick":[117],"bite":[118],"transmission.":[119],"Moreover,":[120],"promoted":[122],"blood":[127],"dissemination":[128],"phase":[129],"Gene":[132],"growth":[142,149,204],"low":[144,197],"serum":[145,198],"media":[146,199],"defect":[150,205],"\u0394bb0562":[152],"rescued":[156],"with":[157],"addition":[159,185],"various":[161],"long":[162],"chain":[163],"fatty":[164,171,218,278,289],"acids,":[165],"particularly":[166],"oleic":[167,193],"acid.":[168],"mammals,":[170],"acids":[172,219,290],"are":[173],"primarily":[174],"stored":[175],"fat":[177],"droplets":[178],"form":[181,191],"triglycerides.":[183,221],"Strikingly,":[184],"glyceryl":[187],"trioleate,":[188],"triglyceride":[190],"acid,":[194],"did":[200],"not":[201],"rescue":[202],"mutant,":[208],"may":[211],"release":[216],"we":[223,261],"searched":[224],"two":[228,257],"canonical":[229],"GXSXG":[230],"lipase":[231,274],"motifs":[232],"within":[233,255],"BB0562,":[234],"despite":[235],"lack":[237],"homology":[239],"known":[241],"bacterial":[242],"lipases.":[243],"Purified":[244],"BB0562":[245],"lipolytic":[247],"activity":[248],"dependent":[249],"catalytic":[252],"serine":[253],"residues":[254],"motifs.":[258],"sum,":[260],"have":[262],"established":[263],"novel":[268],"nutritional":[269],"determinant,":[271],"encoding":[272],"contributes":[276],"acid":[279],"scavenge":[280],"deficient":[286],"free":[288],"including":[291],"host.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-30T00:00:00"}
