{"id":"https://openalex.org/W3195437467","doi":"https://doi.org/10.1007/s11912-021-01124-9","title":"The Landscape of Immunotherapy in Advanced NSCLC: Driving Beyond PD-1/PD-L1 Inhibitors (CTLA-4, LAG3, IDO, OX40, TIGIT, Vaccines)","display_name":"The Landscape of Immunotherapy in Advanced NSCLC: Driving Beyond PD-1/PD-L1 Inhibitors (CTLA-4, LAG3, IDO, OX40, TIGIT, Vaccines)","publication_year":2021,"publication_date":"2021-08-27","ids":{"openalex":"https://openalex.org/W3195437467","doi":"https://doi.org/10.1007/s11912-021-01124-9","mag":"3195437467","pmid":"https://pubmed.ncbi.nlm.nih.gov/34453261","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8397682"},"language":"en","primary_location":{"id":"doi:10.1007/s11912-021-01124-9","doi":"https://doi.org/10.1007/s11912-021-01124-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11912-021-01124-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11912-021-01124-9.pdf","source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11912-021-01124-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082172565","display_name":"Andrea De Giglio","orcid":"https://orcid.org/0000-0002-0731-5721","observed_orcids":["https://orcid.org/0000-0002-0731-5721"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Andrea De Giglio","raw_affiliation_strings":["Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy. dr.degiglio@gmail.com","Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, Bologna, Italy. dr.degiglio@gmail.com","Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy. dr.degiglio@gmail.com","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, Bologna, Italy. dr.degiglio@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071447422","display_name":"Alessandro Di Federico","orcid":"https://orcid.org/0000-0001-8877-4315","observed_orcids":["https://orcid.org/0000-0001-8877-4315"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Di Federico","raw_affiliation_strings":["Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078751201","display_name":"Giacomo Nuvola","orcid":"https://orcid.org/0000-0002-9498-5466","observed_orcids":["https://orcid.org/0000-0002-9498-5466"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Nuvola","raw_affiliation_strings":["Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076642857","display_name":"Chiara Deiana","orcid":"https://orcid.org/0000-0002-0652-5049","observed_orcids":["https://orcid.org/0000-0002-0652-5049"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Deiana","raw_affiliation_strings":["Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021943811","display_name":"Francesco Gelsomino","orcid":"https://orcid.org/0000-0002-9204-1728","observed_orcids":["https://orcid.org/0000-0002-9204-1728"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Gelsomino","raw_affiliation_strings":["Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082172565"],"corresponding_institution_ids":["https://openalex.org/I9360294"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":2.1174,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.90797362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"23","issue":"11","first_page":"126","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pd-1-pd-l1-inhibitors","display_name":"PD-1/PD-L1 inhibitors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ctla-4-inhibitors","display_name":"CTLA-4 inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ido","display_name":"IDO","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":1.0},{"id":"https://openalex.org/keywords/tigit","display_name":"TIGIT","score":1.0},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.9750000238418579},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8124517798423767},{"id":"https://openalex.org/C2779118045","wikidata":"https://www.wikidata.org/wiki/Q21114021","display_name":"TIGIT","level":4,"score":0.798637866973877},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7684118747711182},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.6047871708869934},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.5134273767471313},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.44775834679603577},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.4329390525817871},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4253348112106323},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.416224867105484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3441805839538574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3141631484031677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.304169237613678},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2996451258659363},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.19209718704223633}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000093322","descriptor_name":"Lymphocyte Activation Gene 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s11912-021-01124-9","doi":"https://doi.org/10.1007/s11912-021-01124-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11912-021-01124-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11912-021-01124-9.pdf","source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7333241","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8397682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8397682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8397682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Oncol Rep","raw_type":"Text"},{"id":"pmid:34453261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34453261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current oncology reports","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/918543","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11585/918543","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s11912-021-01124-9","doi":"https://doi.org/10.1007/s11912-021-01124-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11912-021-01124-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11912-021-01124-9.pdf","source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195437467.pdf","grobid_xml":"https://content.openalex.org/works/W3195437467.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W316189023","https://openalex.org/W1630133385","https://openalex.org/W1702502468","https://openalex.org/W1841418760","https://openalex.org/W1964056896","https://openalex.org/W1970570647","https://openalex.org/W1975060729","https://openalex.org/W1981114263","https://openalex.org/W1983812780","https://openalex.org/W1984075836","https://openalex.org/W1988474688","https://openalex.org/W1992979622","https://openalex.org/W1993615391","https://openalex.org/W1998006783","https://openalex.org/W2002507218","https://openalex.org/W2003423800","https://openalex.org/W2003896199","https://openalex.org/W2015260577","https://openalex.org/W2029399624","https://openalex.org/W2034869164","https://openalex.org/W2046409157","https://openalex.org/W2050457398","https://openalex.org/W2054831292","https://openalex.org/W2054873994","https://openalex.org/W2081118119","https://openalex.org/W2086167770","https://openalex.org/W2094530868","https://openalex.org/W2094901950","https://openalex.org/W2099854994","https://openalex.org/W2101840064","https://openalex.org/W2103767560","https://openalex.org/W2104347254","https://openalex.org/W2110930460","https://openalex.org/W2113906692","https://openalex.org/W2114017759","https://openalex.org/W2114300639","https://openalex.org/W2116169737","https://openalex.org/W2118122421","https://openalex.org/W2128083415","https://openalex.org/W2136364651","https://openalex.org/W2136700890","https://openalex.org/W2136807515","https://openalex.org/W2136890067","https://openalex.org/W2137236250","https://openalex.org/W2139591061","https://openalex.org/W2142169541","https://openalex.org/W2147996829","https://openalex.org/W2149827944","https://openalex.org/W2155741470","https://openalex.org/W2156353875","https://openalex.org/W2156763707","https://openalex.org/W2158216603","https://openalex.org/W2159931881","https://openalex.org/W2166662937","https://openalex.org/W2198093519","https://openalex.org/W2198405808","https://openalex.org/W2260067559","https://openalex.org/W2263759961","https://openalex.org/W2288565689","https://openalex.org/W2334995532","https://openalex.org/W2344221521","https://openalex.org/W2537734913","https://openalex.org/W2547310148","https://openalex.org/W2549933167","https://openalex.org/W2560367415","https://openalex.org/W2560704457","https://openalex.org/W2567564314","https://openalex.org/W2570766240","https://openalex.org/W2572174216","https://openalex.org/W2623782848","https://openalex.org/W2703678370","https://openalex.org/W2711497375","https://openalex.org/W2763833329","https://openalex.org/W2767343890","https://openalex.org/W2777225646","https://openalex.org/W2792883957","https://openalex.org/W2807434325","https://openalex.org/W2886825992","https://openalex.org/W2890454711","https://openalex.org/W2891215230","https://openalex.org/W2892047621","https://openalex.org/W2894313087","https://openalex.org/W2898194176","https://openalex.org/W2902185751","https://openalex.org/W2904895988","https://openalex.org/W2910245285","https://openalex.org/W2912593557","https://openalex.org/W2914232380","https://openalex.org/W2916451481","https://openalex.org/W2921527695","https://openalex.org/W2923986778","https://openalex.org/W2924289105","https://openalex.org/W2944530862","https://openalex.org/W2946955088","https://openalex.org/W2949375297","https://openalex.org/W2972242424","https://openalex.org/W2976744492","https://openalex.org/W2979770544","https://openalex.org/W2994000660","https://openalex.org/W2995440672","https://openalex.org/W3000339487","https://openalex.org/W3015860015","https://openalex.org/W3031115858","https://openalex.org/W3049304916","https://openalex.org/W3088387563","https://openalex.org/W3121907365","https://openalex.org/W3124587416","https://openalex.org/W4234119286"],"related_works":["https://openalex.org/W2092997044","https://openalex.org/W4387353012","https://openalex.org/W4404226886","https://openalex.org/W1781719481","https://openalex.org/W4200470293","https://openalex.org/W1849856752","https://openalex.org/W2346602269","https://openalex.org/W2469120040","https://openalex.org/W4283275538","https://openalex.org/W3027700376"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"In":[3],"this":[4],"review,":[5],"we":[6,91],"analyzed":[7],"the":[8,24,32,80,86,95,120,126,129],"current":[9],"landscape":[10],"of":[11,19,31,53,109,115,125,128,131],"non-PD-(L)1":[12],"targeting":[13],"immunotherapy.":[14],"RECENT":[15],"FINDINGS:":[16],"The":[17],"advent":[18],"immunotherapy":[20,132],"has":[21],"completely":[22],"changed":[23],"standard":[25],"approach":[26],"toward":[27],"advanced":[28],"NSCLC.":[29,83],"Inhibitors":[30],"PD-1/PD-L1":[33,136],"axis":[34],"have":[35],"quickly":[36],"taken":[37],"place":[38],"as":[39,75,101,103],"first-line":[40],"treatment":[41],"for":[42],"NSCLC":[43,99,134],"patients":[44,54],"without":[45],"targetable":[46],"\"driver\"":[47],"mutations.":[48],"However,":[49],"a":[50,122],"non-negligible":[51],"portion":[52],"derive":[55],"modest":[56],"benefit":[57],"from":[58,85],"immune-checkpoint":[59],"inhibitors,":[60,90],"and":[61,73],"valid":[62],"second-line":[63],"alternatives":[64],"are":[65],"lacking,":[66],"pushing":[67],"researchers":[68],"to":[69,117,119],"analyze":[70],"other":[71,105],"molecules":[72],"pathways":[74],"potentially":[76],"viable":[77],"targets":[78],"in":[79,111,133],"struggle":[81],"against":[82],"Starting":[84],"better":[87],"characterized":[88],"CTLA-4":[89],"then":[92],"critically":[93],"collected":[94],"actual":[96],"knowledge":[97],"on":[98,104],"vaccines":[100],"well":[102],"emerging":[106],"molecules,":[107],"many":[108],"them":[110],"their":[112],"early":[113],"phase":[114],"testing,":[116],"provide":[118],"reader":[121],"comprehensive":[123],"overview":[124],"state":[127],"art":[130],"beyond":[135],"inhibitors.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-30T00:00:00"}