{"id":"https://openalex.org/W3195312901","doi":"https://doi.org/10.21203/rs.3.rs-769744/v1","title":"Genetic analyses of SERPINA5 in Alzheimer\u2019s disease","display_name":"Genetic analyses of SERPINA5 in Alzheimer\u2019s disease","publication_year":2021,"publication_date":"2021-08-17","ids":{"openalex":"https://openalex.org/W3195312901","doi":"https://doi.org/10.21203/rs.3.rs-769744/v1","mag":"3195312901"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-769744/v1","doi":"https://doi.org/10.21203/rs.3.rs-769744/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-769744/v1","pdf_url":"https://www.researchsquare.com/article/rs-769744/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-769744/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025446438","display_name":"Billie J. Matchett","orcid":"https://orcid.org/0000-0002-5941-7367","observed_orcids":["https://orcid.org/0000-0002-5941-7367"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Billie J. Matchett","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108784215","display_name":"Sarah Lincoln","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah J. Lincoln","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051295879","display_name":"Matt C. Baker","orcid":"https://orcid.org/0009-0001-2691-5757","observed_orcids":["https://orcid.org/0009-0001-2691-5757"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Baker","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064206155","display_name":"Nikoleta Tamvaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikoleta Tamvaka","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024040872","display_name":"Janisse N. Cabrera-Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janisse Cabrera-Rodriguez","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032661414","display_name":"Sydney A. Labuzan","orcid":"https://orcid.org/0000-0002-5967-4523","observed_orcids":["https://orcid.org/0000-0002-5967-4523"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sydney A. Labuzan","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026147079","display_name":"Jacqueline Helminger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Helminger","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045815061","display_name":"Kelly M. Hinkle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly M. Hinkle","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085264873","display_name":"Ranjan Duara","orcid":"https://orcid.org/0000-0001-8060-6309","observed_orcids":["https://orcid.org/0000-0001-8060-6309"]},"institutions":[{"id":"https://openalex.org/I4210095266","display_name":"Mount Sinai Medical Center","ror":"https://ror.org/00wgjpw02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095266"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjan Duara","raw_affiliation_strings":["Mount Sinai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Medical Center","institution_ids":["https://openalex.org/I4210095266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091046259","display_name":"Neill R. Graff\u2010Radford","orcid":"https://orcid.org/0000-0001-9847-9096","observed_orcids":["https://orcid.org/0000-0001-9847-9096"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neill R. Graff-Radford","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077545737","display_name":"Nil\u00fcfer Ertekin\u2010Taner","orcid":"https://orcid.org/0000-0003-4436-8889","observed_orcids":["https://orcid.org/0000-0003-4436-8889"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nil\u00fcfer Ertekin-Taner","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074593768","display_name":"Owen A. Ross","orcid":"https://orcid.org/0000-0003-4813-756X","observed_orcids":["https://orcid.org/0000-0003-4813-756X"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen A. Ross","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048408999","display_name":"Rosa Rademakers","orcid":"https://orcid.org/0000-0002-4049-0863","observed_orcids":["https://orcid.org/0000-0002-4049-0863"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Rademakers","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009533777","display_name":"Dennis W. Dickson","orcid":"https://orcid.org/0000-0001-7189-7917","observed_orcids":["https://orcid.org/0000-0001-7189-7917"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis W. Dickson","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046761674","display_name":"Melissa Erin Murray","orcid":"https://orcid.org/0000-0001-7379-2545","observed_orcids":["https://orcid.org/0000-0001-7379-2545"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melissa Murray","raw_affiliation_strings":["Mayo Clinic's Campus in Florida"],"raw_orcid":"https://orcid.org/0000-0001-7379-2545","affiliations":[{"raw_affiliation_string":"Mayo Clinic's Campus in Florida","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046761674"],"corresponding_institution_ids":["https://openalex.org/I4210146710"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9210000038146973},{"id":"https://openalex.org/keywords/serpina5","display_name":"SERPINA5","score":1.0},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.5619999766349792},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.996999979019165},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.6299999952316284},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.6909999847412109},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.7289999723434448},{"id":"https://openalex.org/keywords/early-onset-alzheimer-s-disease","display_name":"early-onset Alzheimer's disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5789543390274048},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4387511610984802},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43005385994911194},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38664358854293823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34308290481567383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3347531855106354},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32615697383880615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15063804388046265}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-769744/v1","doi":"https://doi.org/10.21203/rs.3.rs-769744/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-769744/v1","pdf_url":"https://www.researchsquare.com/article/rs-769744/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-769744/v1","doi":"https://doi.org/10.21203/rs.3.rs-769744/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-769744/v1","pdf_url":"https://www.researchsquare.com/article/rs-769744/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2656656055","display_name":"Molecular Underpinnings of Clinical and Neuropathologic Heterogeneity in AD","funder_award_id":"AARG-17-533458","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G3588056089","display_name":null,"funder_award_id":"8AZ06","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195312901.pdf","grobid_xml":"https://content.openalex.org/works/W3195312901.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W345484819","https://openalex.org/W1602614790","https://openalex.org/W1827982969","https://openalex.org/W1967823816","https://openalex.org/W1972662390","https://openalex.org/W1988472915","https://openalex.org/W1993023011","https://openalex.org/W1994653201","https://openalex.org/W2005321572","https://openalex.org/W2006122994","https://openalex.org/W2015020748","https://openalex.org/W2036362108","https://openalex.org/W2047668311","https://openalex.org/W2052742260","https://openalex.org/W2073589898","https://openalex.org/W2075444764","https://openalex.org/W2084366703","https://openalex.org/W2096963202","https://openalex.org/W2100864709","https://openalex.org/W2109623596","https://openalex.org/W2118117906","https://openalex.org/W2128228199","https://openalex.org/W2131725903","https://openalex.org/W2146539504","https://openalex.org/W2185296608","https://openalex.org/W2623521763","https://openalex.org/W2806965771","https://openalex.org/W2892051921","https://openalex.org/W2908499451","https://openalex.org/W2915624158","https://openalex.org/W2965717703","https://openalex.org/W2981642494","https://openalex.org/W3120576328","https://openalex.org/W3146341767","https://openalex.org/W3156735711","https://openalex.org/W3157186248","https://openalex.org/W4210821588","https://openalex.org/W4211036635"],"related_works":["https://openalex.org/W4380987141","https://openalex.org/W2969651751","https://openalex.org/W3152693716","https://openalex.org/W2766035972","https://openalex.org/W4408456232","https://openalex.org/W2178350640","https://openalex.org/W3116894097","https://openalex.org/W2063776423","https://openalex.org/W3132378316","https://openalex.org/W4388365130"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-08-30T00:00:00"}
