{"id":"https://openalex.org/W3195216273","doi":"https://doi.org/10.1073/pnas.2107673118","title":"Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity","display_name":"Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity","publication_year":2021,"publication_date":"2021-08-26","ids":{"openalex":"https://openalex.org/W3195216273","doi":"https://doi.org/10.1073/pnas.2107673118","mag":"3195216273","pmid":"https://pubmed.ncbi.nlm.nih.gov/34446561","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8536340"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2107673118","doi":"https://doi.org/10.1073/pnas.2107673118","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2107673118","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8536340","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101625601","display_name":"Chunyi Liu","orcid":"https://orcid.org/0000-0001-5576-564X","observed_orcids":["https://orcid.org/0000-0001-5576-564X"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunyi Liu","raw_affiliation_strings":["Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054232440","display_name":"Thomas Jursa","orcid":"https://orcid.org/0000-0002-7264-904X","observed_orcids":["https://orcid.org/0000-0002-7264-904X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Jursa","raw_affiliation_strings":["Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064;"],"raw_orcid":"https://orcid.org/0000-0002-7264-904X","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064;","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035503566","display_name":"Michael Aschner","orcid":"https://orcid.org/0000-0002-2619-1656","observed_orcids":["https://orcid.org/0000-0002-2619-1656"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Aschner","raw_affiliation_strings":["Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461"],"raw_orcid":"https://orcid.org/0000-0002-2619-1656","affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074940124","display_name":"Donald R. Smith","orcid":"https://orcid.org/0000-0002-4919-1042","observed_orcids":["https://orcid.org/0000-0002-4919-1042"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R. Smith","raw_affiliation_strings":["Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064;","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081869093","display_name":"Somshuvra Mukhopadhyay","orcid":"https://orcid.org/0000-0002-3420-7830","observed_orcids":["https://orcid.org/0000-0002-3420-7830"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Somshuvra Mukhopadhyay","raw_affiliation_strings":["Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712;","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081869093"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":2.5975,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.90475763,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"118","issue":"35","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-toxicity","display_name":"manganese toxicity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/manganese-neurotoxicity","display_name":"manganese neurotoxicity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/slc30a10","display_name":"SLC30A10","score":0.9900000095367432},{"id":"https://openalex.org/keywords/manganese-transporter","display_name":"manganese transporter","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hif-2","display_name":"HIF-2","score":1.0},{"id":"https://openalex.org/keywords/prolyl-hydroxylation","display_name":"prolyl hydroxylation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/prolyl-hydroxylase-inhibitors","display_name":"prolyl hydroxylase inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/manganese-homeostasis","display_name":"manganese homeostasis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.765999972820282},{"id":"https://openalex.org/keywords/neuromotor-deficits","display_name":"neuromotor deficits","score":0.843999981880188},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7589434385299683},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6436782479286194},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5815593004226685},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.5798567533493042},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4746937155723572},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.46703407168388367},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4459958076477051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4456527531147003},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4356548488140106},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4149683117866516},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33239126205444336},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27729713916778564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1946764886379242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19373035430908203},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10224932432174683},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2107673118","doi":"https://doi.org/10.1073/pnas.2107673118","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2107673118","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8536340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8536340","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:34446561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34446561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8536340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8536340","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000865315","display_name":"Role and mechanisms of excretion in manganese neurotoxicity","funder_award_id":"R01ES031574","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000903511","display_name":"Neuronal Targets and Mechanisms of Manganese Neurotoxicity","funder_award_id":"R01ES024812","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W120404398","https://openalex.org/W1595408600","https://openalex.org/W1601604062","https://openalex.org/W1802842643","https://openalex.org/W1970630357","https://openalex.org/W1976699788","https://openalex.org/W1977707491","https://openalex.org/W1981573507","https://openalex.org/W1987851328","https://openalex.org/W1991811149","https://openalex.org/W1995312949","https://openalex.org/W1995940893","https://openalex.org/W1997934335","https://openalex.org/W1998556219","https://openalex.org/W2000860219","https://openalex.org/W2003195563","https://openalex.org/W2004917142","https://openalex.org/W2005729255","https://openalex.org/W2007138098","https://openalex.org/W2010413751","https://openalex.org/W2015858981","https://openalex.org/W2020172108","https://openalex.org/W2022451432","https://openalex.org/W2027122369","https://openalex.org/W2027917639","https://openalex.org/W2028662420","https://openalex.org/W2033803279","https://openalex.org/W2034220860","https://openalex.org/W2034413100","https://openalex.org/W2045012993","https://openalex.org/W2046186373","https://openalex.org/W2048726603","https://openalex.org/W2059234945","https://openalex.org/W2061488891","https://openalex.org/W2062512166","https://openalex.org/W2065239727","https://openalex.org/W2067354437","https://openalex.org/W2070782607","https://openalex.org/W2073271820","https://openalex.org/W2075363163","https://openalex.org/W2079121632","https://openalex.org/W2081843742","https://openalex.org/W2083511611","https://openalex.org/W2085452364","https://openalex.org/W2088655915","https://openalex.org/W2088886257","https://openalex.org/W2090868713","https://openalex.org/W2095750277","https://openalex.org/W2095908732","https://openalex.org/W2097833748","https://openalex.org/W2108886647","https://openalex.org/W2112583900","https://openalex.org/W2116102471","https://openalex.org/W2118484233","https://openalex.org/W2126861972","https://openalex.org/W2129302190","https://openalex.org/W2129805824","https://openalex.org/W2134694407","https://openalex.org/W2149370666","https://openalex.org/W2164098001","https://openalex.org/W2165832884","https://openalex.org/W2178101235","https://openalex.org/W2181444673","https://openalex.org/W2181502677","https://openalex.org/W2187897300","https://openalex.org/W2196899564","https://openalex.org/W2265555029","https://openalex.org/W2290851825","https://openalex.org/W2334920121","https://openalex.org/W2345293647","https://openalex.org/W2353139052","https://openalex.org/W2401922463","https://openalex.org/W2410056921","https://openalex.org/W2444460391","https://openalex.org/W2520158967","https://openalex.org/W2552571643","https://openalex.org/W2580449060","https://openalex.org/W2610163363","https://openalex.org/W2611858761","https://openalex.org/W2620344049","https://openalex.org/W2738378996","https://openalex.org/W2752803677","https://openalex.org/W2753894251","https://openalex.org/W2785329869","https://openalex.org/W2793944650","https://openalex.org/W2811390437","https://openalex.org/W2894305622","https://openalex.org/W2904338229","https://openalex.org/W2905343767","https://openalex.org/W2910620025","https://openalex.org/W2911486911","https://openalex.org/W2921671377","https://openalex.org/W2941701972","https://openalex.org/W2952291710","https://openalex.org/W2968115814","https://openalex.org/W2970670654","https://openalex.org/W2974384203","https://openalex.org/W2999190607","https://openalex.org/W3004020029","https://openalex.org/W3012380876","https://openalex.org/W3014052338","https://openalex.org/W3045462993","https://openalex.org/W3047989378","https://openalex.org/W3096813908","https://openalex.org/W4210994720"],"related_works":["https://openalex.org/W4414122059","https://openalex.org/W4391309583","https://openalex.org/W7134824219","https://openalex.org/W4399907547","https://openalex.org/W4399215442","https://openalex.org/W2065239727","https://openalex.org/W2904338229","https://openalex.org/W4361304873","https://openalex.org/W2316327826","https://openalex.org/W2744769444"],"abstract_inverted_index":{"promoter":[0],"was":[1],"necessary,":[2],"3)":[3],"the":[4,19,29,42,86,137],"transcriptional":[5],"activities":[6],"of":[7,32,45,139],"hypoxia-inducible":[8],"factor":[9],"(HIF)":[10],"1":[11],"or":[12],"HIF2":[13,110],"were":[14],"required":[15],"and":[16,39,51,63,76,83,109,119,123],"sufficient":[17],"for":[18,36,69,136],"SLC30A10":[20,46],"response,":[21],"4)":[22],"elevated":[23],"Mn":[24,49,53,74,81,103,105,121,140],"activated":[25],"HIF1/HIF2":[26],"by":[27],"blocking":[28,41],"prolyl":[30,56,133],"hydroxylation":[31],"HIF":[33,61],"proteins":[34,62],"necessary":[35],"their":[37],"degradation,":[38],"5)":[40],"Mn-induced":[43,89],"up-regulation":[44],"increased":[47],"intracellular":[48,73],"levels":[50,75,106],"enhanced":[52],"toxicity.":[54],"Finally,":[55],"hydroxylase":[57,134],"inhibitors":[58,135],"that":[59,126],"stabilize":[60],"are":[64],"in":[65,87,92,115],"advanced":[66],"clinical":[67],"trials":[68],"other":[70],"diseases":[71],"reduced":[72],"afforded":[77],"cellular":[78,118],"protection":[79],"against":[80],"toxicity":[82],"also":[84],"ameliorated":[85],"vivo":[88],"neuromotor":[90],"deficits":[91],"mice.":[93],"These":[94],"findings":[95],"define":[96],"a":[97],"fundamental":[98],"homeostatic":[99],"protective":[100],"response":[101],"to":[102,111,131],"toxicity-elevated":[104],"activate":[107],"HIF1":[108],"up-regulate":[112],"SLC30A10,":[113],"which":[114],"turn":[116],"reduces":[117],"organismal":[120],"levels,":[122],"further":[124],"indicate":[125],"it":[127],"may":[128],"be":[129],"possible":[130],"repurpose":[132],"management":[138],"neurotoxicity.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-30T00:00:00"}