{"id":"https://openalex.org/W3195094751","doi":"https://doi.org/10.1002/1873-3468.14182","title":"Interface\u2010based design of the favipiravir\u2010binding site in SARS\u2010CoV\u20102 RNA\u2010dependent RNA polymerase reveals mutations conferring resistance to chain termination","display_name":"Interface\u2010based design of the favipiravir\u2010binding site in SARS\u2010CoV\u20102 RNA\u2010dependent RNA polymerase reveals mutations conferring resistance to chain termination","publication_year":2021,"publication_date":"2021-08-19","ids":{"openalex":"https://openalex.org/W3195094751","doi":"https://doi.org/10.1002/1873-3468.14182","mag":"3195094751","pmid":"https://pubmed.ncbi.nlm.nih.gov/34409597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8426738"},"language":"en","primary_location":{"id":"doi:10.1002/1873-3468.14182","doi":"https://doi.org/10.1002/1873-3468.14182","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.14182","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14182","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14182","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080510069","display_name":"Aditya Kumar Padhi","orcid":"https://orcid.org/0000-0001-6732-2547","observed_orcids":["https://orcid.org/0000-0001-6732-2547"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210116810","display_name":"RIKEN Center for Biosystems Dynamics Research","ror":"https://ror.org/023rffy11","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210116810"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aditya K. Padhi","raw_affiliation_strings":["Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, Yokohama, Japan","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210116810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061764624","display_name":"Jagneshwar Dandapat","orcid":"https://orcid.org/0000-0003-0928-1585","observed_orcids":["https://orcid.org/0000-0003-0928-1585"]},"institutions":[{"id":"https://openalex.org/I70699430","display_name":"Utkal University","ror":"https://ror.org/0034eez47","country_code":"IN","type":"education","lineage":["https://openalex.org/I70699430"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jagneshwar Dandapat","raw_affiliation_strings":["Centre of Excellence in Integrated Omics and Computational Biology, Utkal University, Bhubaneswar, India","Post Graduate Department of Biotechnology, Utkal University, Bhubaneswar, India"],"raw_orcid":"https://orcid.org/0000-0003-0928-1585","affiliations":[{"raw_affiliation_string":"Centre of Excellence in Integrated Omics and Computational Biology, Utkal University, Bhubaneswar, India","institution_ids":["https://openalex.org/I70699430"]},{"raw_affiliation_string":"Post Graduate Department of Biotechnology, Utkal University, Bhubaneswar, India","institution_ids":["https://openalex.org/I70699430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002634001","display_name":"Prakash Saudagar","orcid":"https://orcid.org/0000-0001-7211-0581","observed_orcids":["https://orcid.org/0000-0001-7211-0581"]},"institutions":[{"id":"https://openalex.org/I121750182","display_name":"National Institute of Technology Warangal","ror":"https://ror.org/017ebfz38","country_code":"IN","type":"education","lineage":["https://openalex.org/I121750182"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prakash Saudagar","raw_affiliation_strings":["Department of Biotechnology, National Institute of Technology-Warangal, India"],"raw_orcid":"https://orcid.org/0000-0001-7211-0581","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Institute of Technology-Warangal, India","institution_ids":["https://openalex.org/I121750182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-4037-5857","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210140006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063182718","display_name":"Timir Tripathi","orcid":"https://orcid.org/0000-0001-5559-289X","observed_orcids":["https://orcid.org/0000-0001-5559-289X"]},"institutions":[{"id":"https://openalex.org/I197465736","display_name":"North Eastern Hill University","ror":"https://ror.org/055m2tx54","country_code":"IN","type":"education","lineage":["https://openalex.org/I197465736"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Timir Tripathi","raw_affiliation_strings":["Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Shillong, India"],"raw_orcid":"https://orcid.org/0000-0001-5559-289X","affiliations":[{"raw_affiliation_string":"Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Shillong, India","institution_ids":["https://openalex.org/I197465736"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5063182718"],"corresponding_institution_ids":["https://openalex.org/I197465736"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":2.0413,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89672576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"595","issue":"18","first_page":"2366","last_page":"2382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/favipiravir","display_name":"favipiravir","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chain-termination","display_name":"chain termination","score":0.6930000185966492},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.6349999904632568},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.8140000104904175},{"id":"https://openalex.org/keywords/covid-19-antiviral-therapy","display_name":"COVID-19 antiviral therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/virus-adaptation","display_name":"viral adaptation","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2779772310","wikidata":"https://www.wikidata.org/wiki/Q16934561","display_name":"Favipiravir","level":5,"score":0.9522431492805481},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.619327187538147},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.5990621447563171},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5727853178977966},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.563544511795044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5507661700248718},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5427229404449463},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44484761357307434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42379218339920044},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3794008493423462},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3152979016304016},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1681998372077942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11358121037483215},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/1873-3468.14182","doi":"https://doi.org/10.1002/1873-3468.14182","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.14182","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14182","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202105.0492.v1","doi":"https://doi.org/10.20944/preprints202105.0492.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202105.0492.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:34409597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34409597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8426738","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8426738/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Lett","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.usf.edu:mme_facpub-1920","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/mme_facpub/898","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Medicine Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1002/1873-3468.14182","doi":"https://doi.org/10.1002/1873-3468.14182","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.14182","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14182","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195094751.pdf","grobid_xml":"https://content.openalex.org/works/W3195094751.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W2013539008","https://openalex.org/W2018928802","https://openalex.org/W2060514161","https://openalex.org/W2067643341","https://openalex.org/W2084146166","https://openalex.org/W2084493621","https://openalex.org/W2088164673","https://openalex.org/W2102211745","https://openalex.org/W2108367829","https://openalex.org/W2156788262","https://openalex.org/W2166280456","https://openalex.org/W2172241314","https://openalex.org/W2405362382","https://openalex.org/W2409859084","https://openalex.org/W2463475606","https://openalex.org/W2474251565","https://openalex.org/W2560264526","https://openalex.org/W2606439133","https://openalex.org/W2622319469","https://openalex.org/W2765633603","https://openalex.org/W2895861302","https://openalex.org/W2949985558","https://openalex.org/W3003217347","https://openalex.org/W3008666619","https://openalex.org/W3014708904","https://openalex.org/W3015429854","https://openalex.org/W3021283406","https://openalex.org/W3022734398","https://openalex.org/W3025511956","https://openalex.org/W3035920796","https://openalex.org/W3039901154","https://openalex.org/W3083866604","https://openalex.org/W3084240008","https://openalex.org/W3084653951","https://openalex.org/W3087747244","https://openalex.org/W3092613758","https://openalex.org/W3093768302","https://openalex.org/W3095251247","https://openalex.org/W3098266159","https://openalex.org/W3098697637","https://openalex.org/W3101992496","https://openalex.org/W3102258632","https://openalex.org/W3110503905","https://openalex.org/W3110809981","https://openalex.org/W3111105324","https://openalex.org/W3117386561","https://openalex.org/W3127273912","https://openalex.org/W3136588845","https://openalex.org/W3147267762","https://openalex.org/W3184062579","https://openalex.org/W4301242352"],"related_works":["https://openalex.org/W3160518820","https://openalex.org/W3117386561","https://openalex.org/W3087747244","https://openalex.org/W3213957746","https://openalex.org/W3025979430","https://openalex.org/W3087748002","https://openalex.org/W3196399655","https://openalex.org/W4206934854","https://openalex.org/W4385796237","https://openalex.org/W3038925213"],"abstract_inverted_index":{"Favipiravir":[0],"is":[1],"a":[2,74],"broad\u2010spectrum":[3],"inhibitor":[4],"of":[5,18,56,60,77,93,126,130],"viral":[6],"RNA\u2010dependent":[7],"RNA":[8],"polymerase":[9],"(RdRp)":[10],"currently":[11],"being":[12],"used":[13,45],"to":[14,50],"manage":[15],"COVID\u201019.":[16],"Accumulation":[17],"mutations":[19,95,103],"in":[20,97,109,132],"severe":[21],"acute":[22],"respiratory":[23],"syndrome":[24],"coronavirus":[25],"2":[26],"(SARS\u2010CoV\u20102)":[27],"RdRp":[28,61],"may":[29],"facilitate":[30],"antigenic":[31],"drift,":[32],"generating":[33],"favipiravir":[34,87],"resistance.":[35],"Focussing":[36],"on":[37],"the":[38,57,98,118,127],"chain\u2010termination":[39],"mechanism":[40],"utilized":[41],"by":[42],"favipiravir,":[43],"we":[44],"high\u2010throughput":[46],"interface\u2010based":[47],"protein":[48],"design":[49],"generate":[51],">":[52],"100":[53],"000":[54],"designs":[55,72],"favipiravir\u2010binding":[58],"site":[59],"and":[62,71],"identify":[63],"mutational":[64],"hotspots.":[65],"We":[66],"identified":[67],"several":[68],"single\u2010point":[69],"mutants":[70],"having":[73],"sequence":[75],"identity":[76],"97%\u201398%":[78],"with":[79,89,117],"wild\u2010type":[80],"RdRp,":[81],"suggesting":[82],"that":[83],"SARS\u2010CoV\u20102":[84,133],"can":[85],"develop":[86],"resistance":[88],"few":[90],"mutations.":[91],"Out":[92],"134":[94],"documented":[96],"CoV\u2010GLUE":[99],"database,":[100],"63":[101],"specific":[102],"were":[104],"already":[105],"predicted":[106],"as":[107],"resistant":[108],"our":[110,124],"calculations,":[111],"thus":[112],"attaining":[113],"\u02dc":[114],"47%":[115],"correlation":[116],"sequencing":[119],"data.":[120],"These":[121],"findings":[122],"improve":[123],"understanding":[125],"potential":[128],"signatures":[129],"adaptation":[131],"against":[134],"favipiravir.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-08-30T00:00:00"}