{"id":"https://openalex.org/W319497155","doi":null,"title":"Epidermal growth factor receptor (EGFR) mutation testing, from bench to practice: a single institute experience.","display_name":"Epidermal growth factor receptor (EGFR) mutation testing, from bench to practice: a single institute experience.","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W319497155","mag":"319497155","pmid":"https://pubmed.ncbi.nlm.nih.gov/25226713"},"language":"en","primary_location":{"id":"pmid:25226713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25226713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Irish medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004098677","display_name":"Hassan Shikhrakab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"H Shikhrakab","raw_affiliation_strings":["Trinity Coll Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Coll Dublin","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072939839","display_name":"Yasir Y. Elamin","orcid":"https://orcid.org/0000-0002-5312-909X","observed_orcids":["https://orcid.org/0000-0002-5312-909X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Y Elamin","raw_affiliation_strings":["Thoracic Head & Neck Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Head & Neck Medical Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039986459","display_name":"Cathal P. O\u2019Brien","orcid":"https://orcid.org/0000-0001-9099-7462","observed_orcids":["https://orcid.org/0000-0001-9099-7462"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C O'Brien","raw_affiliation_strings":["Trinity Coll Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Coll Dublin","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011765580","display_name":"Kathy A. Gately","orcid":"https://orcid.org/0000-0002-9616-424X","observed_orcids":["https://orcid.org/0000-0002-9616-424X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"K Gately","raw_affiliation_strings":["Trinity Coll Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Coll Dublin","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009285897","display_name":"Stephen P. Finn","orcid":"https://orcid.org/0000-0002-8628-5814","observed_orcids":["https://orcid.org/0000-0002-8628-5814","https://orcid.org/0000-0002-7616-5229"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"S Finn","raw_affiliation_strings":["Trinity Coll Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Coll Dublin","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033519199","display_name":"Kenneth John O'Byrne","orcid":"https://orcid.org/0000-0002-6754-5633","observed_orcids":["https://orcid.org/0000-0002-6754-5633"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"K O'Byrne","raw_affiliation_strings":["Trinity Coll Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Coll Dublin","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082273060","display_name":"Nemer Osman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"N Osman","raw_affiliation_strings":["Trinity Coll Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Coll Dublin","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4845,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68994927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"107","issue":"7","first_page":"201","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.828000009059906},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/exon-19-deletion","display_name":"exon 19 deletion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/egfr-l858r-mutation","display_name":"L858R mutation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/irish-patients","display_name":"Irish patients","score":0.6840000152587891},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.4950000047683716},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8178390264511108},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7918221950531006},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7564902305603027},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.548592746257782},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5055122375488281},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.504226803779602},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4962044358253479},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.47608983516693115},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4312279224395752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4120497405529022},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3444538116455078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31439679861068726},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29777956008911133},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18709149956703186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1846514642238617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12650686502456665},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:25226713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25226713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Irish medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.qut.edu.au:205115","doi":null,"is_oa":false,"landing_page_url":"http://archive.imj.ie//ViewArticleDetails.aspx?ArticleID=12886","pdf_url":null,"source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Irish Medical Journal","raw_type":"Contribution to Journal"},{"id":"pmh:oai:www.lenus.ie:10147/324633","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/324633","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:319497155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25226713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1819148429","https://openalex.org/W1984852348","https://openalex.org/W2043696829","https://openalex.org/W2078897254","https://openalex.org/W2081801534","https://openalex.org/W2095618958","https://openalex.org/W2106915761","https://openalex.org/W2127919472","https://openalex.org/W2129360604","https://openalex.org/W2154662831","https://openalex.org/W2156228829","https://openalex.org/W2160982674","https://openalex.org/W2163351155","https://openalex.org/W2163798887","https://openalex.org/W2166084034","https://openalex.org/W2168691181","https://openalex.org/W2171981784"],"related_works":["https://openalex.org/W2965729454","https://openalex.org/W3008564975","https://openalex.org/W4402569116","https://openalex.org/W2055949948","https://openalex.org/W2782611472","https://openalex.org/W4312920086","https://openalex.org/W2051479010","https://openalex.org/W2914978038","https://openalex.org/W2587184184","https://openalex.org/W2898601853"],"abstract_inverted_index":{"Epidermal":[0],"growth":[1],"factor":[2],"receptor":[3],"(EGFR)":[4],"gene":[5,94],"mutations":[6,27,38,50,83],"determine":[7],"the":[8,23,34,40,60,92],"treatment":[9,80,128],"and":[10,17,89,126],"prognosis":[11],"in":[12,39,70,84,97],"lung":[13],"adenocarcinoma.":[14],"Exon":[15],"19":[16],"exon":[18],"21":[19,90],"(L858R)":[20],"deletions":[21],"represent":[22],"most":[24],"common":[25],"recognised":[26],"detected.":[28],"To":[29],"date,":[30],"no":[31],"figures":[32],"regarding":[33],"prevalence":[35,47],"of":[36,48,62,77,91,124],"EGFR":[37,49,63,82,93,134],"Irish":[41,73,99],"population":[42],"have":[43],"been":[44],"published.":[45],"The":[46,75],"was":[51,95],"retrospectively":[52],"analysed":[53,108],"for":[54],"all":[55],"patient":[56],"samples":[57,106],"tested":[58,96],"since":[59],"introduction":[61],"testing":[64],"routinely":[65],"(Mar":[66],"to":[67,131],"Dec":[68],"2012)":[69],"a":[71,110],"single":[72],"institute.":[74],"presence":[76],"41":[78],"known":[79],"linked":[81],"exons":[85],"18,":[86],"19,":[87],"20":[88],"209":[98],"patients.":[100],"Resection,":[101],"core":[102],"biopsy":[103],"or":[104],"FNA":[105],"were":[107,120],"using":[109],"commercially":[111],"available":[112],"CE-IVD":[113],"marked":[114],"multiplex":[115],"real-time":[116],"PCR":[117],"assay.":[118],"Samples":[119],"included":[121],"from":[122],"patients":[123],"curative":[125],"palliative":[127],"intent":[129],"likely":[130],"harbour":[132],"an":[133],"mutation.":[135]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}