{"id":"https://openalex.org/W3194945673","doi":null,"title":"Anti-cancer activity and immunoadjuvant properties of edible bird's nest extracts on human breast cancer cell line","display_name":"Anti-cancer activity and immunoadjuvant properties of edible bird's nest extracts on human breast cancer cell line","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3194945673","mag":"3194945673"},"language":"en","primary_location":{"id":"pmh:oai:generic.eprints.org:86069","doi":null,"is_oa":false,"landing_page_url":"http://eprints.utm.my/86069/1/MYoshinySMaruthaiMSChE2019.pdf","pdf_url":"http://eprints.utm.my/86069/1/MYoshinySMaruthaiMSChE2019.pdf","source":{"id":"https://openalex.org/S4406922759","display_name":"UTM Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012058259","display_name":"M. Yoshiny S. Maruthai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M. Yoshiny S. Maruthai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012058259"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.1671999990940094,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.1671999990940094,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/edible-bird-s-nest","display_name":"edible bird's nest","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.9929999709129333},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pro-apoptotic-genes","display_name":"pro-apoptotic genes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/antiapoptotic-genes","display_name":"anti-apoptotic genes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd14-monocytes","display_name":"CD14+ monocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.7509999871253967},{"id":"https://openalex.org/keywords/adjuvant-cancer-therapy","display_name":"adjuvant cancer therapy","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5784560441970825},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5709629058837891},{"id":"https://openalex.org/C2909935589","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Immunoadjuvant","level":3,"score":0.512122392654419},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.5068507790565491},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4863062798976898},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4789198637008667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4618467688560486},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45592382550239563},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4536539614200592},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.449729859828949},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4230259656906128},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36605072021484375},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3642469346523285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33391183614730835},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13997706770896912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12714925408363342},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:generic.eprints.org:86069","doi":null,"is_oa":false,"landing_page_url":"http://eprints.utm.my/86069/1/MYoshinySMaruthaiMSChE2019.pdf","pdf_url":"http://eprints.utm.my/86069/1/MYoshinySMaruthaiMSChE2019.pdf","source":{"id":"https://openalex.org/S4406922759","display_name":"UTM Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3194945673","doi":null,"is_oa":false,"landing_page_url":"http://eprints.utm.my/id/eprint/91949/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":188,"referenced_works":["https://openalex.org/W39773280","https://openalex.org/W127053953","https://openalex.org/W244952756","https://openalex.org/W351570613","https://openalex.org/W631732028","https://openalex.org/W636855620","https://openalex.org/W1483733145","https://openalex.org/W1506333935","https://openalex.org/W1512072225","https://openalex.org/W1516464304","https://openalex.org/W1543006546","https://openalex.org/W1545030532","https://openalex.org/W1577320198","https://openalex.org/W1582565638","https://openalex.org/W1587675077","https://openalex.org/W1593119700","https://openalex.org/W1594653092","https://openalex.org/W1604828028","https://openalex.org/W1651239900","https://openalex.org/W1724358813","https://openalex.org/W1762255128","https://openalex.org/W1811117771","https://openalex.org/W1830525540","https://openalex.org/W1863901809","https://openalex.org/W1869143477","https://openalex.org/W1874616385","https://openalex.org/W1881540319","https://openalex.org/W1954317073","https://openalex.org/W1955443929","https://openalex.org/W1964603551","https://openalex.org/W1970160028","https://openalex.org/W1970318669","https://openalex.org/W1970678618","https://openalex.org/W1972188032","https://openalex.org/W1972584230","https://openalex.org/W1973215073","https://openalex.org/W1973677926","https://openalex.org/W1974583613","https://openalex.org/W1975582371","https://openalex.org/W1980220254","https://openalex.org/W1981015901","https://openalex.org/W1982233588","https://openalex.org/W1983172629","https://openalex.org/W1983734334","https://openalex.org/W1983879161","https://openalex.org/W1988286847","https://openalex.org/W1991026693","https://openalex.org/W1991294307","https://openalex.org/W1991417429","https://openalex.org/W1992705345","https://openalex.org/W1994424096","https://openalex.org/W1994682335","https://openalex.org/W1997219075","https://openalex.org/W1998702385","https://openalex.org/W2000770184","https://openalex.org/W2001108463","https://openalex.org/W2001628127","https://openalex.org/W2006749039","https://openalex.org/W2009183786","https://openalex.org/W2011357824","https://openalex.org/W2011814478","https://openalex.org/W2012110635","https://openalex.org/W2015879631","https://openalex.org/W2016374423","https://openalex.org/W2016410319","https://openalex.org/W2021219169","https://openalex.org/W2021533225","https://openalex.org/W2022133483","https://openalex.org/W2024107089","https://openalex.org/W2025922598","https://openalex.org/W2026578487","https://openalex.org/W2028763115","https://openalex.org/W2028964742","https://openalex.org/W2028996724","https://openalex.org/W2029076898","https://openalex.org/W2029726426","https://openalex.org/W2030070877","https://openalex.org/W2034269086","https://openalex.org/W2035623001","https://openalex.org/W2035724274","https://openalex.org/W2036926586","https://openalex.org/W2038392519","https://openalex.org/W2042042387","https://openalex.org/W2043228552","https://openalex.org/W2044252588","https://openalex.org/W2044587960","https://openalex.org/W2045687243","https://openalex.org/W2049784286","https://openalex.org/W2053480920","https://openalex.org/W2053928469","https://openalex.org/W2054211750","https://openalex.org/W2054666105","https://openalex.org/W2054678965","https://openalex.org/W2058050795","https://openalex.org/W2058352235","https://openalex.org/W2059255887","https://openalex.org/W2060347699","https://openalex.org/W2062244421","https://openalex.org/W2062773507","https://openalex.org/W2063874265","https://openalex.org/W2066380377","https://openalex.org/W2066490392","https://openalex.org/W2068046103","https://openalex.org/W2070692423","https://openalex.org/W2072412355","https://openalex.org/W2076111644","https://openalex.org/W2080526136","https://openalex.org/W2083443734","https://openalex.org/W2084657891","https://openalex.org/W2085099489","https://openalex.org/W2085486418","https://openalex.org/W2089187782","https://openalex.org/W2097105662","https://openalex.org/W2099044388","https://openalex.org/W2100820895","https://openalex.org/W2103865725","https://openalex.org/W2103885797","https://openalex.org/W2104017463","https://openalex.org/W2110127255","https://openalex.org/W2111980687","https://openalex.org/W2112922523","https://openalex.org/W2113423265","https://openalex.org/W2114510791","https://openalex.org/W2114918609","https://openalex.org/W2115993724","https://openalex.org/W2116904342","https://openalex.org/W2118382645","https://openalex.org/W2119809052","https://openalex.org/W2121795258","https://openalex.org/W2122589790","https://openalex.org/W2122792339","https://openalex.org/W2123621585","https://openalex.org/W2124993705","https://openalex.org/W2125988618","https://openalex.org/W2128957030","https://openalex.org/W2128984725","https://openalex.org/W2129353670","https://openalex.org/W2129702438","https://openalex.org/W2133202774","https://openalex.org/W2133832867","https://openalex.org/W2133986689","https://openalex.org/W2134487724","https://openalex.org/W2134492526","https://openalex.org/W2136505865","https://openalex.org/W2136508866","https://openalex.org/W2138509357","https://openalex.org/W2139272277","https://openalex.org/W2139427092","https://openalex.org/W2142906823","https://openalex.org/W2143346532","https://openalex.org/W2143580224","https://openalex.org/W2144396366","https://openalex.org/W2145852879","https://openalex.org/W2146934878","https://openalex.org/W2149967205","https://openalex.org/W2150705960","https://openalex.org/W2155567879","https://openalex.org/W2156013098","https://openalex.org/W2157167271","https://openalex.org/W2161863487","https://openalex.org/W2162568391","https://openalex.org/W2165304197","https://openalex.org/W2166320104","https://openalex.org/W2167017590","https://openalex.org/W2171195503","https://openalex.org/W2172394310","https://openalex.org/W2182318267","https://openalex.org/W2183961304","https://openalex.org/W2184159157","https://openalex.org/W2197896173","https://openalex.org/W2262446102","https://openalex.org/W2263207463","https://openalex.org/W2290082498","https://openalex.org/W2318272432","https://openalex.org/W2322375144","https://openalex.org/W2351117577","https://openalex.org/W2367506957","https://openalex.org/W2378581384","https://openalex.org/W2417204216","https://openalex.org/W2464675136","https://openalex.org/W2595346203","https://openalex.org/W2601282326","https://openalex.org/W2725974882","https://openalex.org/W2732246469","https://openalex.org/W2791857742","https://openalex.org/W2884895360","https://openalex.org/W2889892812","https://openalex.org/W2901513648"],"related_works":["https://openalex.org/W4376118643","https://openalex.org/W4404834591","https://openalex.org/W7093507168","https://openalex.org/W4220658072","https://openalex.org/W4280531937","https://openalex.org/W3092628978","https://openalex.org/W4409672431","https://openalex.org/W4312324761","https://openalex.org/W2743448291","https://openalex.org/W2069088530"],"abstract_inverted_index":{"Edible":[0],"Bird\u2019s":[1],"Nest":[2],"(EBN)":[3],"is":[4,68,284],"well":[5],"regarded":[6],"as":[7,91,307],"an":[8,308],"immune":[9,57,117,295,317],"enhancing":[10,311],"nutraceutical":[11],"food":[12],"especially":[13],"among":[14],"the":[15,42,48,71,99,124,153,159,218,225,234,277,315],"Chinese.":[16],"Current":[17],"cancer":[18,51],"therapies":[19],"bring":[20],"adverse":[21],"side":[22],"effects,":[23],"thus":[24],"identification":[25],"of":[26,44,65,77,87,123,168,184,200,222,230,236,243,248],"a":[27,35,285],"safe":[28],"adjuvant":[29],"medicine":[30],"like":[31],"EBN":[32,45,78,88,104,140,155],"can":[33],"provide":[34],"quality":[36],"life":[37],"for":[38,190],"patients.":[39],"Researches":[40],"on":[41,47,80,109],"effect":[43,162],"extract":[46,79,283],"human":[49,56,116,294,316],"breast":[50],"cell":[52,82,182],"line":[53],"(MCF-7)":[54],"and":[55,74,94,115,120,127,134,138,149,178,192,195,215,233,245,254,257,262,272,289,299],"cells":[58,118,136,165,180,197,259],"are":[59],"still":[60],"very":[61],"limited.":[62],"The":[63],"aim":[64],"this":[66],"study":[67,279],"to":[69,293],"evaluate":[70],"anti-cancer":[72,287],"activity":[73],"immunoadjuvant":[75,309],"properties":[76],"MCF-7":[81,114,164,240],"line.":[83],"Primarily,":[84],"3":[85,154],"types":[86],"extracts":[89,105],"coded":[90],"HMG,":[92],"EHMG":[93],"pHMG":[95],"were":[96,106,142],"prepared":[97],"using":[98],"water":[100],"extraction":[101],"method.":[102],"These":[103],"then":[107],"tested":[108],"their":[110],"cytotoxicity":[111],"level":[112],"against":[113],"(CD8+":[119],"CD14+).":[121],"Production":[122],"key":[125],"pro-apoptotic":[126,201,237,244,312],"anti-apoptotic":[128,206,231,249],"molecules":[129],"released":[130],"in":[131,213,239,260,270,314],"MCF-7,":[132],"CD8+":[133,177,194,256],"CD14+":[135,179,196,258],"before":[137],"after":[139,209,264],"treatment":[141],"measured":[143],"through":[144,227],"mRNA":[145],"expression":[146,203,208],"level,":[147],"ELISA":[148,271,298],"Multiplex":[150],"assay.":[151,274],"Among":[152],"extracts,":[156],"HMG":[157,172,212,223,267,282,305],"showed":[158,173,198,269,280],"highest":[160],"cytotoxic":[161],"towards":[163,176],"with":[166,181,211,266],"IC50":[167],"15":[169],"^g/mL.":[170],"However,":[171],"no":[174,291],"harm":[175,292],"viability":[183],"more":[185],"than":[186],"90%.":[187],"qRT-PCR":[188],"results":[189],"nonactivated":[191],"activated":[193,255],"increased":[199,224],"gene":[202,207],"while":[204],"lower":[205],"treated":[210,265],"single":[214,261],"co-culture.":[216],"At":[217],"same":[219],"time,":[220],"supplementation":[221],"apoptosis":[226],"down":[228,246],"regulation":[229,247],"genes":[232,238],"up-regulation":[235],"cells.":[241,296,318],"Enhancement":[242],"soluble":[250],"factors":[251],"by":[252,310],"non-activated":[253],"co-culture":[263],"also":[268,302],"multiplex":[273,300],"In":[275],"conclusion,":[276],"present":[278],"that":[281,304],"potential":[286],"agent":[288],"causes":[290],"qRT-PCR,":[297],"tests":[301],"verified":[303],"acts":[306],"function":[313]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-30T00:00:00"}