{"id":"https://openalex.org/W3194919829","doi":"https://doi.org/10.3389/fimmu.2021.644350","title":"Analysis of Bulk RNA Sequencing Data Reveals Novel Transcription Factors Associated With Immune Infiltration Among Multiple Cancers","display_name":"Analysis of Bulk RNA Sequencing Data Reveals Novel Transcription Factors Associated With Immune Infiltration Among Multiple Cancers","publication_year":2021,"publication_date":"2021-08-20","ids":{"openalex":"https://openalex.org/W3194919829","doi":"https://doi.org/10.3389/fimmu.2021.644350","mag":"3194919829","pmid":"https://pubmed.ncbi.nlm.nih.gov/34489925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8417605"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.644350","doi":"https://doi.org/10.3389/fimmu.2021.644350","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.644350","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.644350/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3194919829"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.644350/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100349606","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0002-9995-9080","observed_orcids":["https://orcid.org/0000-0002-9995-9080","https://orcid.org/0009-0000-4658-9322"]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066337172","display_name":"Qiuchen Zhao","orcid":"https://orcid.org/0000-0001-5026-2496","observed_orcids":["https://orcid.org/0000-0001-5026-2496"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuchen Zhao","raw_affiliation_strings":["Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","College of Life Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","institution_ids":[]},{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091645149","display_name":"Chao Cheng","orcid":"https://orcid.org/0000-0003-4330-9342","observed_orcids":["https://orcid.org/0000-0003-4330-9342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Cheng","raw_affiliation_strings":["Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074056720","display_name":"Jingwen Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Yi","raw_affiliation_strings":["Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063265167","display_name":"Hongyan Sun","orcid":"https://orcid.org/0000-0003-0140-6785","observed_orcids":["https://orcid.org/0000-0003-0140-6785"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Sun","raw_affiliation_strings":["Tissue Bank, China-Japan Union Hospital, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Bank, China-Japan Union Hospital, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341303","display_name":"Qi Wang","orcid":"https://orcid.org/0000-0002-5287-6050","observed_orcids":["https://orcid.org/0000-0002-5287-6050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062190256","display_name":"Weili Quan","orcid":"https://orcid.org/0000-0003-4861-8961","observed_orcids":["https://orcid.org/0000-0003-4861-8961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weili Quan","raw_affiliation_strings":["Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108275678","display_name":"Yaqiang Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaqiang Xue","raw_affiliation_strings":["Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055401764","display_name":"Luguo Sun","orcid":"https://orcid.org/0000-0002-0895-8120","observed_orcids":["https://orcid.org/0000-0002-0895-8120","https://orcid.org/0000-0002-1686-591X","https://orcid.org/0000-0001-8822-3062"]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luguo Sun","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China","Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047579560","display_name":"Xianling Cong","orcid":"https://orcid.org/0000-0002-5790-4188","observed_orcids":["https://orcid.org/0000-0002-5790-4188"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianling Cong","raw_affiliation_strings":["Tissue Bank, China-Japan Union Hospital, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Bank, China-Japan Union Hospital, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100388207","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0002-7329-5079","observed_orcids":["https://orcid.org/0000-0002-7329-5079"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Genome Analysis, ABLife BioBigData Institute, Wuhan, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047579560","https://openalex.org/A5055401764","https://openalex.org/A5100388207"],"corresponding_institution_ids":["https://openalex.org/I184983240","https://openalex.org/I194450716"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1982,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80616468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"644350","last_page":"644350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9639999866485596},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.734000027179718},{"id":"https://openalex.org/keywords/mybl2","display_name":"MYBL2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tal1","display_name":"TAL1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/erg","display_name":"ERG","score":0.9990000128746033},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gene-co-expression-modules","display_name":"gene co-expression modules","score":0.6650000214576721},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7789999842643738},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.824999988079071},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.906000018119812},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7991217374801636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7200913429260254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6912791728973389},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6043188571929932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5085245370864868},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.48861318826675415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3980035185813904},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34588056802749634}],"mesh":[{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2021.644350","doi":"https://doi.org/10.3389/fimmu.2021.644350","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.644350","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.644350/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:34489925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34489925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8417605","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8417605/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:14bb7ae411934135b606a2591558c464","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/14bb7ae411934135b606a2591558c464","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.644350","doi":"https://doi.org/10.3389/fimmu.2021.644350","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.644350","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.644350/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G35748818","display_name":null,"funder_award_id":"20200404124YY","funder_id":"https://openalex.org/F4320322174","funder_display_name":"People's Government of Jilin Province"}],"funders":[{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3194919829.pdf","grobid_xml":"https://content.openalex.org/works/W3194919829.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1553247507","https://openalex.org/W1797422316","https://openalex.org/W1966327575","https://openalex.org/W1968236774","https://openalex.org/W1975445997","https://openalex.org/W1984068087","https://openalex.org/W1985987855","https://openalex.org/W2005026459","https://openalex.org/W2023553115","https://openalex.org/W2027847170","https://openalex.org/W2037341816","https://openalex.org/W2049636267","https://openalex.org/W2050216284","https://openalex.org/W2056074255","https://openalex.org/W2076952890","https://openalex.org/W2087834037","https://openalex.org/W2091854488","https://openalex.org/W2100697281","https://openalex.org/W2108234281","https://openalex.org/W2114104545","https://openalex.org/W2119180969","https://openalex.org/W2140729960","https://openalex.org/W2142300779","https://openalex.org/W2147052402","https://openalex.org/W2159560463","https://openalex.org/W2164381970","https://openalex.org/W2507880739","https://openalex.org/W2522176191","https://openalex.org/W2600132724","https://openalex.org/W2607129810","https://openalex.org/W2718870674","https://openalex.org/W2732718283","https://openalex.org/W2737082469","https://openalex.org/W2750328162","https://openalex.org/W2760598931","https://openalex.org/W2761903097","https://openalex.org/W2772062014","https://openalex.org/W2773508782","https://openalex.org/W2782685575","https://openalex.org/W2792398055","https://openalex.org/W2795704805","https://openalex.org/W2886006442","https://openalex.org/W2892164007","https://openalex.org/W2896872272","https://openalex.org/W2904083151","https://openalex.org/W2906638098","https://openalex.org/W2907564726","https://openalex.org/W2910267023","https://openalex.org/W2928665623","https://openalex.org/W2963145050","https://openalex.org/W2981374905","https://openalex.org/W2987555895","https://openalex.org/W2990673109","https://openalex.org/W3001118548","https://openalex.org/W3007574826","https://openalex.org/W3009788614","https://openalex.org/W3010022505","https://openalex.org/W3017785112","https://openalex.org/W3026148136","https://openalex.org/W3026991696","https://openalex.org/W3082537053","https://openalex.org/W3094282922","https://openalex.org/W3097599046"],"related_works":["https://openalex.org/W4400116558","https://openalex.org/W4200147022","https://openalex.org/W3214236954","https://openalex.org/W3125895942","https://openalex.org/W3173512755","https://openalex.org/W4387098506","https://openalex.org/W7166841410","https://openalex.org/W4407228605","https://openalex.org/W4387393030","https://openalex.org/W3169452543"],"abstract_inverted_index":{"Tumor-infiltrating":[0],"immune":[1,28,40,138,205,220],"cells":[2,41],"shape":[3],"the":[4,24,36,48,59,62,79,103,106,130,141,150,184,187],"tumor":[5,44],"microenvironment":[6],"and":[7,27,61,78,88,98,126,140,231],"are":[8,100],"closely":[9],"related":[10],"to":[11,22,34],"clinical":[12],"outcomes.":[13],"Several":[14],"transcription":[15],"factors":[16],"(TFs)":[17],"have":[18],"also":[19,165],"been":[20],"reported":[21],"regulate":[23,219],"antitumor":[25],"activity":[26],"cell":[29],"infiltration.":[30,206,221],"This":[31],"study":[32,210],"aimed":[33],"quantify":[35],"populations":[37],"of":[38,81,105,115,132,152,193,200],"different":[39],"infiltrated":[42],"in":[43,102,183],"samples":[45,163],"based":[46],"on":[47,160],"bulk":[49],"RNA":[50],"sequencing":[51],"data":[52,122],"obtained":[53],"from":[54],"50":[55],"cancer":[56,121,229],"patients":[57,153],"using":[58],"CIBERSORT":[60],"EPIC":[63],"algorithm.":[64],"Weighted":[65],"gene":[66],"coexpression":[67],"network":[68],"analysis":[69,114,175],"(WGCNA)":[70],"identified":[71],"eigengene":[72,107],"modules":[73,108],"strongly":[74],"associated":[75,109,148],"with":[76,110,149,191],"tumorigenesis":[77],"activation":[80],"CD4+":[82],"memory":[83],"T":[84],"cells,":[85,87],"dendritic":[86],"macrophages.":[89],"TF":[90,135,188,202],"genes":[91,136,143,189,203,217,223],"FOXM1":[92],",":[93,95,97],"MYBL2":[94],"TAL1":[96],"ERG":[99],"central":[101],"subnetworks":[104],"immune-related":[111,142],"genes.":[112],"The":[113,116,169],"Cancer":[117],"Genome":[118],"Atlas":[119],"(TCGA)":[120],"confirmed":[123],"these":[124,133,201],"findings":[125],"further":[127],"showed":[128,176],"that":[129,144,164,177,218],"expression":[131,170],"potential":[134,226],"regulating":[137,204],"infiltration,":[139],"they":[145],"regulated,":[146],"was":[147,158],"survival":[151],"within":[154],"multiple":[155],"cancers.":[156],"Exome-seq":[157],"performed":[159],"24":[161],"paired":[162],"had":[166],"RNA-seq":[167],"data.":[168],"quantitative":[171],"trait":[172],"loci":[173],"(eQTL)":[174],"mutations":[178],"were":[179],"significantly":[180],"more":[181],"frequent":[182],"regions":[185],"flanking":[186],"compared":[190],"those":[192],"non-TF":[194],"genes,":[195],"suggesting":[196],"a":[197,212],"driver":[198],"role":[199],"Taken":[207],"together,":[208],"this":[209],"presented":[211],"practical":[213],"method":[214],"for":[215,228],"identifying":[216],"These":[222],"could":[224],"be":[225],"biomarkers":[227],"prognosis":[230],"possible":[232],"therapeutic":[233],"targets.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-08-30T00:00:00"}