{"id":"https://openalex.org/W3194842353","doi":"https://doi.org/10.1039/d1nr04999b","title":"Biomolecules in cell-derived extracellular vesicle chariots as warriors to repair damaged tissues","display_name":"Biomolecules in cell-derived extracellular vesicle chariots as warriors to repair damaged tissues","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3194842353","doi":"https://doi.org/10.1039/d1nr04999b","mag":"3194842353","pmid":"https://pubmed.ncbi.nlm.nih.gov/34570853"},"language":"en","primary_location":{"id":"doi:10.1039/d1nr04999b","doi":"https://doi.org/10.1039/d1nr04999b","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d1nr04999b","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021871347","display_name":"Yingshu Guo","orcid":"https://orcid.org/0000-0002-6926-6152","observed_orcids":["https://orcid.org/0000-0002-6926-6152"]},"institutions":[{"id":"https://openalex.org/I152269853","display_name":"Qilu University of Technology","ror":"https://ror.org/04hyzq608","country_code":"CN","type":"education","lineage":["https://openalex.org/I152269853"]},{"id":"https://openalex.org/I4210142748","display_name":"Shandong Academy of Sciences","ror":"https://ror.org/04y8d6y55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingshu Guo","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"],"raw_orcid":"https://orcid.org/0000-0002-6926-6152","affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China","institution_ids":["https://openalex.org/I152269853","https://openalex.org/I4210142748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113318506","display_name":"Di Wu","orcid":"https://orcid.org/0009-0009-7526-8961","observed_orcids":["https://orcid.org/0009-0009-7526-8961"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081351303","display_name":"Xu Zhang","orcid":"https://orcid.org/0000-0003-3492-4618","observed_orcids":["https://orcid.org/0000-0003-3492-4618"]},"institutions":[{"id":"https://openalex.org/I152269853","display_name":"Qilu University of Technology","ror":"https://ror.org/04hyzq608","country_code":"CN","type":"education","lineage":["https://openalex.org/I152269853"]},{"id":"https://openalex.org/I4210142748","display_name":"Shandong Academy of Sciences","ror":"https://ror.org/04y8d6y55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China","institution_ids":["https://openalex.org/I152269853","https://openalex.org/I4210142748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035916046","display_name":"Kaixiang Zhang","orcid":"https://orcid.org/0000-0002-6812-6342","observed_orcids":["https://orcid.org/0000-0002-6812-6342"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kaixiang Zhang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060247412","display_name":"Yang Luo","orcid":"https://orcid.org/0000-0002-0166-9027","observed_orcids":["https://orcid.org/0000-0002-0166-9027"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Luo","raw_affiliation_strings":["Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0166-9027","affiliations":[{"raw_affiliation_string":"Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, P.R. China","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021871347","https://openalex.org/A5035916046","https://openalex.org/A5060247412"],"corresponding_institution_ids":["https://openalex.org/I152269853","https://openalex.org/I158842170","https://openalex.org/I38877650","https://openalex.org/I4210142748"],"apc_list":null,"apc_paid":null,"fwci":0.2549,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.20913333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"38","first_page":"16017","last_page":"16033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.9539999961853027},{"id":"https://openalex.org/keywords/biomolecules","display_name":"biomolecules","score":0.7360000014305115},{"id":"https://openalex.org/keywords/proteins","display_name":"proteins","score":0.4970000088214874},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.8569999933242798},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.6060000061988831},{"id":"https://openalex.org/keywords/organ-damage","display_name":"organ damage","score":0.6690000295639038},{"id":"https://openalex.org/keywords/therapeutic-mechanisms","display_name":"therapeutic mechanisms","score":0.5989999771118164},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.8587625026702881},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5728931427001953},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.4955998659133911},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40179258584976196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3406077027320862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27524614334106445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2613171339035034},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19188901782035828}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d1nr04999b","doi":"https://doi.org/10.1039/d1nr04999b","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d1nr04999b","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:34570853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34570853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1925454411","display_name":null,"funder_award_id":"81871733","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3086491097","display_name":"\u529f\u80fd\u5316\u4eff\u751f\u7cfb\u7edf\u7684\u6784\u5efa\u53ca\u5176\u5bf9\u7ec6\u80de\u5185\u8fd8\u539f\u6027\u5def\u57fa\u5316\u5408\u7269\u7684\u68c0\u6d4b\u53ca\u6210\u50cf\u5206\u6790\u7684\u7814\u7a76","funder_award_id":"21575056","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W1612482630","https://openalex.org/W2098259366","https://openalex.org/W2145142940","https://openalex.org/W2211541075","https://openalex.org/W2264590390","https://openalex.org/W2273521760","https://openalex.org/W2281134225","https://openalex.org/W2325305253","https://openalex.org/W2416609191","https://openalex.org/W2461985525","https://openalex.org/W2463806122","https://openalex.org/W2486665380","https://openalex.org/W2490529699","https://openalex.org/W2516516170","https://openalex.org/W2546088870","https://openalex.org/W2565271826","https://openalex.org/W2574266062","https://openalex.org/W2588350828","https://openalex.org/W2593763693","https://openalex.org/W2613739181","https://openalex.org/W2615498501","https://openalex.org/W2673542445","https://openalex.org/W2730553355","https://openalex.org/W2738491178","https://openalex.org/W2754168513","https://openalex.org/W2755806464","https://openalex.org/W2770270415","https://openalex.org/W2772306649","https://openalex.org/W2786202610","https://openalex.org/W2789460242","https://openalex.org/W2790927266","https://openalex.org/W2790987851","https://openalex.org/W2792315201","https://openalex.org/W2792617097","https://openalex.org/W2794184574","https://openalex.org/W2794260489","https://openalex.org/W2794946498","https://openalex.org/W2797594483","https://openalex.org/W2798033749","https://openalex.org/W2801108382","https://openalex.org/W2811343415","https://openalex.org/W2883384705","https://openalex.org/W2885340691","https://openalex.org/W2892397780","https://openalex.org/W2895877601","https://openalex.org/W2896358322","https://openalex.org/W2902282736","https://openalex.org/W2911533047","https://openalex.org/W2911991236","https://openalex.org/W2914833536","https://openalex.org/W2917107183","https://openalex.org/W2918126309","https://openalex.org/W2923614429","https://openalex.org/W2933304441","https://openalex.org/W2939364088","https://openalex.org/W2946298500","https://openalex.org/W2946938666","https://openalex.org/W2950151274","https://openalex.org/W2950481872","https://openalex.org/W2959357913","https://openalex.org/W2962176767","https://openalex.org/W2962922400","https://openalex.org/W2965527105","https://openalex.org/W2969502145","https://openalex.org/W2970718184","https://openalex.org/W2971554550","https://openalex.org/W2971886371","https://openalex.org/W2974569074","https://openalex.org/W2979140946","https://openalex.org/W2982103201","https://openalex.org/W2982589442","https://openalex.org/W2984907234","https://openalex.org/W2989402686","https://openalex.org/W2991674051","https://openalex.org/W2995494472","https://openalex.org/W2996134710","https://openalex.org/W2996620173","https://openalex.org/W2999723972","https://openalex.org/W2999901765","https://openalex.org/W3005104290","https://openalex.org/W3008588181","https://openalex.org/W3009979587","https://openalex.org/W3010132504","https://openalex.org/W3010444759","https://openalex.org/W3011097693","https://openalex.org/W3011630841","https://openalex.org/W3023667710","https://openalex.org/W3023738419","https://openalex.org/W3023935082","https://openalex.org/W3028234091","https://openalex.org/W3028960763","https://openalex.org/W3034592342","https://openalex.org/W3036585709","https://openalex.org/W3039138684","https://openalex.org/W3041716749","https://openalex.org/W3042217302","https://openalex.org/W3043385276","https://openalex.org/W3048098039","https://openalex.org/W3048274163","https://openalex.org/W3080227974","https://openalex.org/W3080919003","https://openalex.org/W3081789544","https://openalex.org/W3088250693","https://openalex.org/W3092764768","https://openalex.org/W3092810054","https://openalex.org/W3092969909","https://openalex.org/W3093740262","https://openalex.org/W3095647303","https://openalex.org/W3096575601","https://openalex.org/W3102927044","https://openalex.org/W3112446989","https://openalex.org/W3112449868","https://openalex.org/W3113089813","https://openalex.org/W3131575773","https://openalex.org/W3132106277","https://openalex.org/W3133046408","https://openalex.org/W3135459743","https://openalex.org/W3137909614","https://openalex.org/W3138191692","https://openalex.org/W3139352757","https://openalex.org/W3143842282","https://openalex.org/W3145227709","https://openalex.org/W3154868467","https://openalex.org/W3160635643","https://openalex.org/W3162814957","https://openalex.org/W3163542642","https://openalex.org/W3165053539","https://openalex.org/W3167040407","https://openalex.org/W3170068038","https://openalex.org/W3171839010","https://openalex.org/W3175183767","https://openalex.org/W3175628958","https://openalex.org/W3176014217","https://openalex.org/W3180023247","https://openalex.org/W3183381852","https://openalex.org/W4249579699"],"related_works":["https://openalex.org/W3092764768","https://openalex.org/W3154868467","https://openalex.org/W2518923981","https://openalex.org/W4403664008","https://openalex.org/W3213843792","https://openalex.org/W3002310885","https://openalex.org/W2178782268","https://openalex.org/W4388023998","https://openalex.org/W2592150007","https://openalex.org/W2926339741"],"abstract_inverted_index":{"In":[0,37,93],"this":[1,195,204],"review,":[2],"we":[3],"highlight":[4],"the":[5,28,47,60,74,81,118,124,165,172],"innovative":[6],"applications":[7],"of":[8,34,49,62,78,85,104,117,130],"biomolecules":[9,64,119,174,182],"from":[10,133],"parent":[11],"cell-derived":[12],"extracellular":[13],"vesicles":[14],"(EVs)":[15],"for":[16,97,140,190],"tissue":[17,52,68,87,98,141,154,191],"repair":[18,53,99,115,142,167,192],"that":[19,180],"have":[20,183],"been":[21],"developed":[22],"in":[23,51,65,67,162,203],"recent":[24],"years.":[25],"We":[26,178],"evaluate":[27],"underlying":[29],"mechanisms":[30,116],"and":[31,76,83,108,114,127,164,186,193],"therapeutic":[32,113],"efficacy":[33],"each":[35],"therapy.":[36],"previous":[38],"literature":[39],"reviews,":[40],"it":[41],"was":[42],"most":[43],"common":[44],"to":[45,149,197],"classify":[46],"use":[48],"EVs":[50,66,90,146,158],"by":[54,171,176],"disease":[55],"type.":[56],"This":[57,70],"article":[58],"reviews":[59],"role":[61,161],"three":[63,101],"repair.":[69],"review":[71,196],"first":[72],"summarizes":[73],"definitions":[75],"classifications":[77],"EVs.":[79,177],"Then,":[80],"importance":[82],"significance":[84],"treating":[86],"damage":[88],"with":[89],"are":[91,100,120,143,147],"discussed.":[92],"particular,":[94],"EV":[95,131,181],"contents":[96,132],"main":[102],"types":[103],"biomolecules:":[105],"proteins,":[106],"RNAs":[107],"cell":[109],"growth":[110],"factors.":[111],"The":[112],"discussed":[121],"respectively.":[122],"Finally,":[123],"development":[125],"prospect":[126],"potential":[128,189],"challenges":[129],"highly":[134],"differentiated":[135],"cells":[136],"as":[137,153],"specific":[138],"agents":[139],"summarized.":[144],"When":[145],"used":[148],"treat":[150],"diseases":[151],"such":[152],"or":[155],"organ":[156],"damage,":[157],"play":[159],"a":[160],"delivery,":[163],"real":[166],"effect":[168],"is":[169],"effected":[170],"various":[173],"carried":[175],"believe":[179],"unparalleled":[184],"advantages":[185],"clinical":[187],"transformation":[188],"expect":[194],"inspire":[198],"more":[199],"intensive":[200],"research":[201],"work":[202],"field.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-08-30T00:00:00"}