{"id":"https://openalex.org/W3194836775","doi":"https://doi.org/10.1016/j.yexcr.2021.112786","title":"AGTR1 blocker attenuates activation of Tenon's capsule fibroblasts after glaucoma filtration surgery via the NF-\u03baB signaling pathway","display_name":"AGTR1 blocker attenuates activation of Tenon's capsule fibroblasts after glaucoma filtration surgery via the NF-\u03baB signaling pathway","publication_year":2021,"publication_date":"2021-08-16","ids":{"openalex":"https://openalex.org/W3194836775","doi":"https://doi.org/10.1016/j.yexcr.2021.112786","mag":"3194836775","pmid":"https://pubmed.ncbi.nlm.nih.gov/34411608"},"language":"en","primary_location":{"id":"doi:10.1016/j.yexcr.2021.112786","doi":"https://doi.org/10.1016/j.yexcr.2021.112786","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yexcr.2021.112786","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077008836","display_name":"Lijun Wang","orcid":"https://orcid.org/0000-0003-3062-3738","observed_orcids":["https://orcid.org/0000-0003-3062-3738"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Wang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China"],"raw_orcid":"https://orcid.org/0000-0003-3062-3738","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049400795","display_name":"Hongsong Li","orcid":"https://orcid.org/0000-0002-5681-3073","observed_orcids":["https://orcid.org/0000-0002-5681-3073"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongsong Li","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China"],"raw_orcid":"https://orcid.org/0000-0002-5681-3073","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360015","display_name":"Wenyi Zhang","orcid":"https://orcid.org/0000-0001-8033-3558","observed_orcids":["https://orcid.org/0000-0001-8033-3558"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyi Zhang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076554341","display_name":"Meimei Ren","orcid":"https://orcid.org/0000-0003-1412-279X","observed_orcids":["https://orcid.org/0000-0003-1412-279X"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meimei Ren","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085471413","display_name":"Meilin Shao","orcid":"https://orcid.org/0000-0002-2400-6517","observed_orcids":["https://orcid.org/0000-0002-2400-6517"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meilin Shao","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035598952","display_name":"Jianming Wang","orcid":"https://orcid.org/0000-0003-4118-6289","observed_orcids":["https://orcid.org/0000-0003-4118-6289"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianming Wang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China. Electronic address: xajdwjm@163.com","Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China"],"raw_orcid":"https://orcid.org/0000-0003-4118-6289","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China. Electronic address: xajdwjm@163.com","institution_ids":["https://openalex.org/I4210131893"]},{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035598952"],"corresponding_institution_ids":["https://openalex.org/I4210131893"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":null,"fwci":0.2121,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.425575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"407","issue":"1","first_page":"112786","last_page":"112786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tenon-s-capsule-fibroblasts","display_name":"Tenon's capsule fibroblasts","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glaucoma-filtering-surgery","display_name":"glaucoma filtration surgery","score":0.9940000176429749},{"id":"https://openalex.org/keywords/surgical-scar","display_name":"postoperative scarring","score":0.7749999761581421},{"id":"https://openalex.org/keywords/subconjunctival-fibrosis","display_name":"subconjunctival fibrosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/fibrogenesis","display_name":"fibrogenesis","score":0.628000020980835},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.921999990940094},{"id":"https://openalex.org/keywords/bay-11-7082","display_name":"BAY 11-7082","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5784311890602112},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5033318400382996},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.48861628770828247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46203070878982544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46189773082733154},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.456226646900177},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.4396834373474121},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.4381892681121826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3446652889251709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3391779661178589},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3203551769256592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2945420444011688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2767646014690399},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.11494475603103638},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07364562153816223}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058475","descriptor_name":"Tenon Capsule","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.yexcr.2021.112786","doi":"https://doi.org/10.1016/j.yexcr.2021.112786","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yexcr.2021.112786","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:34411608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34411608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6068048359","display_name":null,"funder_award_id":"2018ZDXM-SF-045","funder_id":"https://openalex.org/F4320336035","funder_display_name":"Shanxi Provincial Key Research and Development Project"}],"funders":[{"id":"https://openalex.org/F4320336035","display_name":"Shanxi Provincial Key Research and Development Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1839325201","https://openalex.org/W1966801103","https://openalex.org/W1982964107","https://openalex.org/W1984870942","https://openalex.org/W2012568931","https://openalex.org/W2013455727","https://openalex.org/W2014693894","https://openalex.org/W2028670147","https://openalex.org/W2029020203","https://openalex.org/W2043764841","https://openalex.org/W2054190869","https://openalex.org/W2056416450","https://openalex.org/W2060085062","https://openalex.org/W2062935758","https://openalex.org/W2075138825","https://openalex.org/W2094693111","https://openalex.org/W2155616119","https://openalex.org/W2157364557","https://openalex.org/W2171075888","https://openalex.org/W2230137271","https://openalex.org/W2291150585","https://openalex.org/W2318651854","https://openalex.org/W2319397046","https://openalex.org/W2345230484","https://openalex.org/W2398014082","https://openalex.org/W2403994912","https://openalex.org/W2413040867","https://openalex.org/W2513478959","https://openalex.org/W2594223845","https://openalex.org/W2610552028","https://openalex.org/W2625821852","https://openalex.org/W2753731895","https://openalex.org/W2766393824","https://openalex.org/W2801620222","https://openalex.org/W2806295635","https://openalex.org/W2903131220","https://openalex.org/W2913819594","https://openalex.org/W2938991623","https://openalex.org/W2956103258","https://openalex.org/W2981991478","https://openalex.org/W2995619852","https://openalex.org/W2995924251","https://openalex.org/W2997977624","https://openalex.org/W2999636760","https://openalex.org/W3046504338","https://openalex.org/W3081774080","https://openalex.org/W3112983600","https://openalex.org/W3115497489","https://openalex.org/W4229825080","https://openalex.org/W6751251847"],"related_works":["https://openalex.org/W4408288257","https://openalex.org/W3087910349","https://openalex.org/W4391302738","https://openalex.org/W2413040867","https://openalex.org/W4391783597","https://openalex.org/W4396748672","https://openalex.org/W2047969385","https://openalex.org/W2149850003","https://openalex.org/W3191415478","https://openalex.org/W7138950602"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-08-30T00:00:00"}
