{"id":"https://openalex.org/W3194820282","doi":"https://doi.org/10.4187/respcare.09308","title":"High-Dose Nitric Oxide From Pressurized Cylinders and Nitric Oxide Produced by an Electric Generator From Air","display_name":"High-Dose Nitric Oxide From Pressurized Cylinders and Nitric Oxide Produced by an Electric Generator From Air","publication_year":2021,"publication_date":"2021-08-19","ids":{"openalex":"https://openalex.org/W3194820282","doi":"https://doi.org/10.4187/respcare.09308","mag":"3194820282","pmid":"https://pubmed.ncbi.nlm.nih.gov/34413210"},"language":"en","primary_location":{"id":"doi:10.4187/respcare.09308","doi":"https://doi.org/10.4187/respcare.09308","is_oa":true,"landing_page_url":"https://doi.org/10.4187/respcare.09308","pdf_url":"http://rc.rcjournal.com/content/respcare/67/2/201.full.pdf","source":{"id":"https://openalex.org/S744042","display_name":"Respiratory Care","issn_l":"0020-1324","issn":["0020-1324","1943-3654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316455","host_organization_name":"American Association for Respiratory Care","host_organization_lineage":["https://openalex.org/P4310316455"],"host_organization_lineage_names":["American Association for Respiratory Care"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://rc.rcjournal.com/content/respcare/67/2/201.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048233034","display_name":"Stefano Gianni","orcid":"https://orcid.org/0000-0002-0838-3654","observed_orcids":["https://orcid.org/0000-0002-0838-3654"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Gianni","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083017627","display_name":"Raffaele Di Fenza","orcid":"https://orcid.org/0000-0002-5675-7139","observed_orcids":["https://orcid.org/0000-0002-5675-7139"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raffaele Di Fenza","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088359366","display_name":"Caio C. A. Morais","orcid":"https://orcid.org/0000-0002-8006-9475","observed_orcids":["https://orcid.org/0000-0002-8006-9475"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caio C Araujo Morais","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039568998","display_name":"Bijan Safaee Fakhr","orcid":"https://orcid.org/0000-0002-2841-1413","observed_orcids":["https://orcid.org/0000-0002-2841-1413"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bijan Safaee Fakhr","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005723596","display_name":"Ariel Mueller","orcid":"https://orcid.org/0000-0002-8420-1904","observed_orcids":["https://orcid.org/0000-0002-8420-1904"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariel L Mueller","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004313751","display_name":"Binglan Yu","orcid":"https://orcid.org/0000-0001-5496-2131","observed_orcids":["https://orcid.org/0000-0001-5496-2131"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binglan Yu","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088560766","display_name":"Ryan W. Carroll","orcid":"https://orcid.org/0000-0002-7513-7023","observed_orcids":["https://orcid.org/0000-0002-7513-7023"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan W Carroll","raw_affiliation_strings":["Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063212338","display_name":"Fumito Ichinose","orcid":"https://orcid.org/0000-0003-4535-1632","observed_orcids":["https://orcid.org/0000-0003-4535-1632"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fumito Ichinose","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073059702","display_name":"Warren M. Zapol","orcid":"https://orcid.org/0000-0002-0359-3660","observed_orcids":["https://orcid.org/0000-0002-0359-3660"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren M Zapol","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079746187","display_name":"Lorenzo M. Berra","orcid":"https://orcid.org/0000-0003-2702-2093","observed_orcids":["https://orcid.org/0000-0003-2702-2093"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Berra","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.621,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.84093702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"67","issue":"2","first_page":"201","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10990","display_name":"Infection Control and Ventilation","score":0.21060000360012054,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10990","display_name":"Infection Control and Ventilation","score":0.21060000360012054,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.9179999828338623},{"id":"https://openalex.org/keywords/covid-19-prevention","display_name":"COVID-19 prevention","score":0.7829999923706055},{"id":"https://openalex.org/keywords/healthcare-workers","display_name":"healthcare workers","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nitrogen-dioxide-exposure","display_name":"nitrogen dioxide exposure","score":0.8019999861717224},{"id":"https://openalex.org/keywords/safety-and-feasibility","display_name":"feasibility and safety","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.911670982837677},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6732174754142761},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5297324061393738},{"id":"https://openalex.org/C2780723490","wikidata":"https://www.wikidata.org/wiki/Q207895","display_name":"Nitrogen dioxide","level":2,"score":0.49813294410705566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16863125562667847},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000089382","descriptor_name":"Oxygen Saturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4187/respcare.09308","doi":"https://doi.org/10.4187/respcare.09308","is_oa":true,"landing_page_url":"https://doi.org/10.4187/respcare.09308","pdf_url":"http://rc.rcjournal.com/content/respcare/67/2/201.full.pdf","source":{"id":"https://openalex.org/S744042","display_name":"Respiratory Care","issn_l":"0020-1324","issn":["0020-1324","1943-3654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316455","host_organization_name":"American Association for Respiratory Care","host_organization_lineage":["https://openalex.org/P4310316455"],"host_organization_lineage_names":["American Association for Respiratory Care"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Care","raw_type":"journal-article"},{"id":"pmid:34413210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34413210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory care","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4187/respcare.09308","doi":"https://doi.org/10.4187/respcare.09308","is_oa":true,"landing_page_url":"https://doi.org/10.4187/respcare.09308","pdf_url":"http://rc.rcjournal.com/content/respcare/67/2/201.full.pdf","source":{"id":"https://openalex.org/S744042","display_name":"Respiratory Care","issn_l":"0020-1324","issn":["0020-1324","1943-3654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316455","host_organization_name":"American Association for Respiratory Care","host_organization_lineage":["https://openalex.org/P4310316455"],"host_organization_lineage_names":["American Association for Respiratory Care"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3194820282.pdf","grobid_xml":"https://content.openalex.org/works/W3194820282.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1597886774","https://openalex.org/W1992624760","https://openalex.org/W2080684729","https://openalex.org/W2094764102","https://openalex.org/W2100004104","https://openalex.org/W2109414012","https://openalex.org/W2166382871","https://openalex.org/W2171851508","https://openalex.org/W2218950717","https://openalex.org/W2340008871","https://openalex.org/W2507869129","https://openalex.org/W2770689729","https://openalex.org/W3034673454","https://openalex.org/W3036823275","https://openalex.org/W3080494764","https://openalex.org/W3081179290","https://openalex.org/W3087108488","https://openalex.org/W3111822968"],"related_works":["https://openalex.org/W4225416992","https://openalex.org/W4399661074","https://openalex.org/W3193631190","https://openalex.org/W4283170186","https://openalex.org/W1963939986","https://openalex.org/W7135219676","https://openalex.org/W4401056423","https://openalex.org/W3157691705","https://openalex.org/W2063756601","https://openalex.org/W3207497643"],"abstract_inverted_index":{"BACKGROUND:":[0],"High-dose":[1],"(\u2265":[2],"80":[3],"ppm)":[4,153,251],"inhaled":[5,86,129],"nitric":[6],"oxide":[7],"(INO)":[8,76],"has":[9],"antimicrobial":[10],"effects.":[11],"We":[12,54],"designed":[13],"a":[14,143],"trial":[15],"to":[16,44],"test":[17],"the":[18,45,128,211,224],"preventive":[19],"effects":[20],"of":[21,47,62,146,149],"high-dose":[22,150,248],"NO":[23,66,70,79,83,112,151,173,195,198,228],"on":[24,58],"coronavirus":[25],"disease":[26],"2019":[27],"(COVID-19)":[28],"in":[29,90,178,187,210,223],"health":[30,51,107,139],"care":[31,52,108,140],"providers":[32,109],"working":[33],"with":[34,36,266],"patients":[35],"COVID-19.":[37],"The":[38],"study":[39,246],"was":[40,85,120],"interrupted":[41],"prematurely":[42],"due":[43],"introduction":[46],"COVID-19":[48],"vaccines":[49],"for":[50,92,154,252],"professionals.":[53],"thereby":[55],"present":[56],"data":[57],"safety":[59],"and":[60,77,98,127,160,167,206,214,219,233,261],"feasibility":[61],"breathing":[63],"160":[64,88],"ppm":[65,89,204,208,217,221],"using":[67,257],"2":[68,133,199],"different":[69],"sources,":[71],"namely":[72],"pressurized":[73],"nitrogen/NO":[74],"cylinders":[75],"electric":[78],"(eNO)":[80],"generators.":[81],"METHODS:":[82],"gas":[84],"at":[87,190],"air":[91],"15":[93,155,253],"min":[94,156,192,254],"twice":[95,157,255],"daily,":[96],"before":[97],"after":[99,193],"each":[100],"work":[101],"shift,":[102],"over":[103],"14":[104,168],"d":[105],"by":[106,122,165,170],"(NCT04312243).":[110],"During":[111,172,227],"administration,":[113,174,229],"vital":[114],"signs":[115],"were":[116,163],"continuously":[117],"monitored.":[118],"Safety":[119],"assessed":[121],"measuring":[123],"transcutaneous":[124],"methemoglobinemia":[125],"(SpMet)":[126],"nitrogen":[130],"dioxide":[131],"(NO":[132],")":[134],"concentration.":[135],"RESULTS:":[136],"Twelve":[137],"healthy":[138],"professionals":[141],"received":[142],"collective":[144],"total":[145],"185":[147],"administrations":[148],"(160":[152,250],"daily.":[158],"One-hundred":[159],"seventy-one":[161],"doses":[162,169],"delivered":[164],"INO":[166,212,249],"eNO.":[171],"SpMet":[175],"increased":[176],"similarly":[177,262],"both":[179],"groups":[180],"(":[181],"P":[182],"=":[183],".82).":[184],"Methemoglobin":[185],"decreased":[186],"all":[188],"subjects":[189],"5":[191],"discontinuing":[194],"administration.":[196],"Inhaled":[197],"concentrations":[200],"remained":[201],"between":[202,215],"0.70":[203],"(0.63\u20130.79)":[205],"0.75":[207],"(0.67\u20130.83)":[209],"group":[213],"0.74":[216],"(0.68\u20130.78)":[218],"0.88":[220],"(0.70\u20130.93)":[222],"eNO":[225,258],"group.":[226],"peripheral":[230],"oxygen":[231],"saturation":[232],"heart":[234],"rate":[235],"did":[236],"not":[237],"change.":[238],"No":[239],"adverse":[240],"events":[241],"occurred.":[242],"CONCLUSIONS:":[243],"This":[244],"pilot":[245],"testing":[247],"daily":[256],"seems":[259],"feasible":[260],"safe":[263],"when":[264],"compared":[265],"INO.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-30T00:00:00"}
