{"id":"https://openalex.org/W3194765355","doi":null,"title":"One size does not fit all in thyroid disruption: distinct thyroid hormone profiles and adverse outcomes after developmental exposure to PTU (propylthiouracil), DE-71 (brominated flame retardant) and OMC (octyl methoxycinnamate)","display_name":"One size does not fit all in thyroid disruption: distinct thyroid hormone profiles and adverse outcomes after developmental exposure to PTU (propylthiouracil), DE-71 (brominated flame retardant) and OMC (octyl methoxycinnamate)","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3194765355","mag":"3194765355"},"language":"en","primary_location":{"id":"mag:3194765355","doi":null,"is_oa":false,"landing_page_url":"https://backend.orbit.dtu.dk/ws/files/236620582/2020Tox.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109524002","display_name":"Marta Axelstad","orcid":"https://orcid.org/0000-0002-2375-0918","observed_orcids":["https://orcid.org/0000-0002-2375-0918"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marta Axelstad Petersen","raw_affiliation_strings":["Research group for Molecular and Reproductive Toxicology","Technical University of Denmark, National Food Institute, DK"],"raw_orcid":"https://orcid.org/0000-0002-2375-0918","affiliations":[{"raw_affiliation_string":"Research group for Molecular and Reproductive Toxicology","institution_ids":[]},{"raw_affiliation_string":"Technical University of Denmark, National Food Institute, DK","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054350291","display_name":"Louise Ramh\u00f8j","orcid":"https://orcid.org/0000-0002-0298-8003","observed_orcids":["https://orcid.org/0000-0002-0298-8003"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Louise Ramh\u00f8j","raw_affiliation_strings":["Research group for Molecular and Reproductive Toxicology","Technical University of Denmark, National Food Institute, DK"],"raw_orcid":"https://orcid.org/0000-0002-0298-8003","affiliations":[{"raw_affiliation_string":"Research group for Molecular and Reproductive Toxicology","institution_ids":[]},{"raw_affiliation_string":"Technical University of Denmark, National Food Institute, DK","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045993118","display_name":"Martin Scholze","orcid":"https://orcid.org/0000-0002-9569-7562","observed_orcids":["https://orcid.org/0000-0002-9569-7562"]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Scholze","raw_affiliation_strings":["Brunel University London#TAB#"],"raw_orcid":"https://orcid.org/0000-0002-9569-7562","affiliations":[{"raw_affiliation_string":"Brunel University London#TAB#","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052536282","display_name":"Josef K\u00f6hrle","orcid":"https://orcid.org/0000-0002-9187-9078","observed_orcids":["https://orcid.org/0000-0002-9187-9078"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef K\u00f6hrle","raw_affiliation_strings":["Charit\u00e8-Universit\u00e4tsmedizin Berlin"],"raw_orcid":"https://orcid.org/0000-0002-9187-9078","affiliations":[{"raw_affiliation_string":"Charit\u00e8-Universit\u00e4tsmedizin Berlin","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063374927","display_name":"Andreas Kortenkamp","orcid":"https://orcid.org/0000-0001-9055-9729","observed_orcids":["https://orcid.org/0000-0001-9055-9729"]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreas Kortenkamp","raw_affiliation_strings":["Brunel University London#TAB#"],"raw_orcid":"https://orcid.org/0000-0001-9055-9729","affiliations":[{"raw_affiliation_string":"Brunel University London#TAB#","institution_ids":["https://openalex.org/I59433898"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20615425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"114","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-disruption","display_name":"thyroid hormone disruption","score":0.9139999747276306},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.9769999980926514},{"id":"https://openalex.org/keywords/de-71","display_name":"DE-71","score":0.9240000247955322},{"id":"https://openalex.org/keywords/brominated-flame-retardants","display_name":"brominated flame retardants","score":0.9860000014305115},{"id":"https://openalex.org/keywords/octyl-methoxycinnamate","display_name":"octyl methoxycinnamate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/uv-filters","display_name":"UV filters","score":0.9079999923706055},{"id":"https://openalex.org/keywords/offspring-neurodevelopment","display_name":"offspring neurodevelopment","score":0.6399999856948853},{"id":"https://openalex.org/keywords/hypothyroxinemia","display_name":"hypothyroxinemia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/thyroid-weight","display_name":"thyroid weight","score":0.7009999752044678},{"id":"https://openalex.org/keywords/liver-weight","display_name":"liver weight","score":0.9300000071525574},{"id":"https://openalex.org/keywords/serum-thyroid-hormones","display_name":"serum thyroid hormones","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.9517934918403625},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7684289216995239},{"id":"https://openalex.org/C205474432","wikidata":"https://www.wikidata.org/wiki/Q1354051","display_name":"Fire retardant","level":2,"score":0.5977601408958435},{"id":"https://openalex.org/C2780260993","wikidata":"https://www.wikidata.org/wiki/Q2723553","display_name":"Brominated flame retardant","level":3,"score":0.5469104051589966},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5274527072906494},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.4595685303211212},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42444485425949097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40609467029571533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38847190141677856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38763782382011414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38555631041526794},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08843284845352173}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3194765355","doi":null,"is_oa":false,"landing_page_url":"https://backend.orbit.dtu.dk/ws/files/236620582/2020Tox.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412287808","https://openalex.org/W2748279366","https://openalex.org/W2064815058","https://openalex.org/W2087378023","https://openalex.org/W7128307797","https://openalex.org/W4285797144","https://openalex.org/W2793014357","https://openalex.org/W2107608797","https://openalex.org/W2053362766","https://openalex.org/W2789483519"],"abstract_inverted_index":{"Correct":[0],"thyroid":[1,41,72,168,184,212,242,272],"hormone":[2,42,73,213,217,243,273],"economy":[3,74,214,244],"is":[4,238],"crucial":[5],"for":[6],"mammalian":[7],"brain":[8,53,195],"development.":[9,54],"In":[10],"humans,":[11],"even":[12],"mild,":[13],"non-clinical":[14],"hypothyroxinemia":[15],"during":[16,149],"pregnancy":[17],"has":[18],"been":[19],"linked":[20],"to":[21,50,61,91,96,175,240,254,263,291],"reduced":[22],"IQ":[23],"and":[24,75,134,137,144,169,215,223,262,288],"increased":[25,183],"risk":[26],"of":[27,35,68,121,164,179,229,271,283],"neurobehavioral":[28],"disorders":[29],"in":[30,142,194,199,221,233,252],"the":[31,102,110,150,156,216,226,230,250,258,268,281,284,296],"offspring.":[32,202],"Several":[33],"groups":[34],"environmental":[36],"chemicals":[37,64],"can":[38],"interfere":[39],"with":[40,65],"economy,":[43],"which":[44,171],"raises":[45],"concern":[46],"about":[47],"their":[48,176],"potential":[49],"disrupt":[51],"human":[52],"Here,":[55],"we":[56],"tested":[57],"how":[58],"developmental":[59,234],"exposure":[60,182],"three":[62,157,204],"thyroid-disrupting":[63],"differing":[66],"mechanisms":[67],"action":[69],"could":[70],"affect":[71],"cause":[76],"adverse":[77,269,293],"outcomes.":[78],"We":[79],"exposed":[80,201],"104":[81],"pregnant":[82],"Sprague":[83],"Dawley":[84],"rats":[85],"from":[86,267],"gestational":[87],"day":[88,93],"(GD)":[89],"7":[90],"postnatal":[92],"(PD)":[94],"22":[95],"either":[97],"corn":[98],"oil":[99],"(vehicle":[100],"control),":[101],"anti-thyroid":[103],"drug":[104],"PTU":[105,181],"(1":[106],"or":[107,114,117,127],"2.5":[108],"mg/kg/day),":[109],"UV-filter":[111],"OMC":[112,200],"(375":[113],"500":[115],"mg/kg/day)":[116],"a":[118,161],"commercial":[119],"mixture":[120],"brominated":[122],"flame":[123],"retardants":[124],"DE-71":[125,187],"(20":[126],"40":[128],"mg/kg/day).":[129],"Serum":[130],"hormones":[131],"(T3,":[132],"T4":[133],"TSH),":[135],"body-,":[136],"organ":[138],"weights":[139,196],"were":[140,197],"measured":[141],"dams":[143,222],"offspring":[145,224],"at":[146,245],"different":[147,158,209,285],"times":[148],"study.":[151,231],"Our":[152],"results":[153],"showed":[154,160],"that":[155],"compounds":[159,205],"distinct":[162],"pattern":[163],"effects":[165,210,270,294],"on":[166,211,279,295],"liver,":[167],"brain,":[170],"seemed":[172],"closely":[173],"related":[174],"primary":[177],"mechanism":[178],"action.":[180],"gland":[185],"weight,":[186],"caused":[188,207],"liver":[189],"weight":[190],"increases":[191],"whereas":[192],"reductions":[193],"seen":[198],"The":[203],"also":[206],"very":[208],"effect":[218,286],"patterns":[219,287],"varied":[220],"over":[225],"time":[227,247],"course":[228],"Thus,":[232],"toxicity":[235],"studies":[236,276],"it":[237],"important":[239],"assess":[241],"several":[246],"points":[248],"throughout":[249],"study,":[251],"order":[253],"obtain":[255],"better":[256],"understand":[257],"chemically":[259],"induced":[260],"changes":[261],"best":[264],"protect":[265],"humans":[266],"disruption.":[274],"Future":[275],"should":[277],"focus":[278],"elucidating":[280],"origin":[282],"link":[289],"them":[290],"possible":[292],"developing":[297],"brain.":[298]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2021-08-30T00:00:00"}