{"id":"https://openalex.org/W3194501757","doi":null,"title":"An\u00e1lise da atividade da prolil-oligopeptidase (POP) frente ao tratamento de modelo animal para o estudo da esquizofrenia com antipsicoticos","display_name":"An\u00e1lise da atividade da prolil-oligopeptidase (POP) frente ao tratamento de modelo animal para o estudo da esquizofrenia com antipsicoticos","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3194501757","mag":"3194501757"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/61589","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.unifesp.br/handle/11600/61589","pdf_url":"https://repositorio.unifesp.br/handle/11600/61589","source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o de mestrado"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.unifesp.br/handle/11600/61589","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110796043","display_name":"Benjamin Rodriguez Hernandez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin Rodriguez Hernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110796043"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.24480000138282776,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.9330000281333923},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.7770000100135803},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6129999756813049},{"id":"https://openalex.org/keywords/animal-models-of-schizophrenia","display_name":"animal models of schizophrenia","score":0.5799999833106995},{"id":"https://openalex.org/keywords/serum-enzyme-activity","display_name":"serum enzyme activity","score":0.5080000162124634},{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.5389999747276306},{"id":"https://openalex.org/keywords/treatment-resistant-schizophrenia","display_name":"treatment-resistant schizophrenia","score":0.45399999618530273},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.34200000762939453},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.328000009059906},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6079999804496765},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.3709999918937683},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.3709999918937683},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.6209999918937683},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3417339622974396}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.unifesp.br:11600/61589","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.unifesp.br/handle/11600/61589","pdf_url":"https://repositorio.unifesp.br/handle/11600/61589","source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o de mestrado"},{"id":"mag:3194501757","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.unifesp.br/handle/11600/61589","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/61589","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.unifesp.br/handle/11600/61589","pdf_url":"https://repositorio.unifesp.br/handle/11600/61589","source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o de mestrado"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3194501757.pdf","grobid_xml":"https://content.openalex.org/works/W3194501757.grobid-xml"},"referenced_works_count":222,"referenced_works":["https://openalex.org/W21879210","https://openalex.org/W155621635","https://openalex.org/W571818384","https://openalex.org/W1444638254","https://openalex.org/W1487661483","https://openalex.org/W1489768309","https://openalex.org/W1490681631","https://openalex.org/W1512760943","https://openalex.org/W1594877745","https://openalex.org/W1599810938","https://openalex.org/W1729743715","https://openalex.org/W1764151989","https://openalex.org/W1879185436","https://openalex.org/W1958592565","https://openalex.org/W1964370958","https://openalex.org/W1964684914","https://openalex.org/W1964953424","https://openalex.org/W1966286804","https://openalex.org/W1966621863","https://openalex.org/W1971353842","https://openalex.org/W1971548259","https://openalex.org/W1972172786","https://openalex.org/W1979240985","https://openalex.org/W1980658725","https://openalex.org/W1981091336","https://openalex.org/W1981168987","https://openalex.org/W1983093846","https://openalex.org/W1983449826","https://openalex.org/W1983779471","https://openalex.org/W1985156855","https://openalex.org/W1986623293","https://openalex.org/W1986677503","https://openalex.org/W1990473626","https://openalex.org/W1993418823","https://openalex.org/W1995303402","https://openalex.org/W1995974096","https://openalex.org/W1996278518","https://openalex.org/W1996368170","https://openalex.org/W1997812546","https://openalex.org/W1997992794","https://openalex.org/W1998959104","https://openalex.org/W1998968327","https://openalex.org/W2003380425","https://openalex.org/W2003633697","https://openalex.org/W2006406145","https://openalex.org/W2007463705","https://openalex.org/W2007684964","https://openalex.org/W2007983824","https://openalex.org/W2011815930","https://openalex.org/W2012933599","https://openalex.org/W2013514700","https://openalex.org/W2013646009","https://openalex.org/W2015784694","https://openalex.org/W2017525042","https://openalex.org/W2019030450","https://openalex.org/W2022022071","https://openalex.org/W2022485312","https://openalex.org/W2026777107","https://openalex.org/W2027008192","https://openalex.org/W2027463370","https://openalex.org/W2028412969","https://openalex.org/W2029107640","https://openalex.org/W2029597597","https://openalex.org/W2030430356","https://openalex.org/W2036538226","https://openalex.org/W2037043137","https://openalex.org/W2039252375","https://openalex.org/W2044518616","https://openalex.org/W2045106504","https://openalex.org/W2047034879","https://openalex.org/W2048561931","https://openalex.org/W2051158737","https://openalex.org/W2052067496","https://openalex.org/W2053322055","https://openalex.org/W2054036316","https://openalex.org/W2055324229","https://openalex.org/W2057702186","https://openalex.org/W2058170527","https://openalex.org/W2058396853","https://openalex.org/W2058679727","https://openalex.org/W2060585506","https://openalex.org/W2060602451","https://openalex.org/W2064560881","https://openalex.org/W2068677067","https://openalex.org/W2068774622","https://openalex.org/W2073341848","https://openalex.org/W2075636841","https://openalex.org/W2078935572","https://openalex.org/W2081030321","https://openalex.org/W2081362935","https://openalex.org/W2081725205","https://openalex.org/W2082301907","https://openalex.org/W2084090386","https://openalex.org/W2084214834","https://openalex.org/W2086355751","https://openalex.org/W2087013895","https://openalex.org/W2089617519","https://openalex.org/W2089671853","https://openalex.org/W2090507556","https://openalex.org/W2091297212","https://openalex.org/W2099576957","https://openalex.org/W2100480405","https://openalex.org/W2102956183","https://openalex.org/W2103189992","https://openalex.org/W2103560303","https://openalex.org/W2108672634","https://openalex.org/W2114570352","https://openalex.org/W2117219243","https://openalex.org/W2119704634","https://openalex.org/W2131340220","https://openalex.org/W2132086610","https://openalex.org/W2136337975","https://openalex.org/W2136429865","https://openalex.org/W2136949209","https://openalex.org/W2141672742","https://openalex.org/W2144991048","https://openalex.org/W2147131319","https://openalex.org/W2147704323","https://openalex.org/W2159961735","https://openalex.org/W2159996636","https://openalex.org/W2161029109","https://openalex.org/W2175366611","https://openalex.org/W2201456750","https://openalex.org/W2234382447","https://openalex.org/W2286863815","https://openalex.org/W2288087911","https://openalex.org/W2288497293","https://openalex.org/W2314877083","https://openalex.org/W2317897431","https://openalex.org/W2324205500","https://openalex.org/W2326702844","https://openalex.org/W2330800087","https://openalex.org/W2342512713","https://openalex.org/W2417995715","https://openalex.org/W2486451269","https://openalex.org/W2487733919","https://openalex.org/W2512354308","https://openalex.org/W2517555306","https://openalex.org/W2517692093","https://openalex.org/W2524136091","https://openalex.org/W2529931105","https://openalex.org/W2560138349","https://openalex.org/W2564416809","https://openalex.org/W2567170624","https://openalex.org/W2568315975","https://openalex.org/W2586167867","https://openalex.org/W2588188283","https://openalex.org/W2613276313","https://openalex.org/W2633685052","https://openalex.org/W2703970226","https://openalex.org/W2746510778","https://openalex.org/W2747213553","https://openalex.org/W2751792491","https://openalex.org/W2751884637","https://openalex.org/W2765253344","https://openalex.org/W2765264947","https://openalex.org/W2765333215","https://openalex.org/W2765504358","https://openalex.org/W2770901977","https://openalex.org/W2774146678","https://openalex.org/W2777827753","https://openalex.org/W2781681020","https://openalex.org/W2785334206","https://openalex.org/W2789532180","https://openalex.org/W2792360176","https://openalex.org/W2792816402","https://openalex.org/W2793071403","https://openalex.org/W2880034555","https://openalex.org/W2883873335","https://openalex.org/W2885491854","https://openalex.org/W2889058327","https://openalex.org/W2889833794","https://openalex.org/W2890402394","https://openalex.org/W2893177211","https://openalex.org/W2895596606","https://openalex.org/W2896600824","https://openalex.org/W2899278991","https://openalex.org/W2901263152","https://openalex.org/W2901786880","https://openalex.org/W2902911660","https://openalex.org/W2906594252","https://openalex.org/W2906768105","https://openalex.org/W2908578463","https://openalex.org/W2909135489","https://openalex.org/W2909558500","https://openalex.org/W2912855512","https://openalex.org/W2916396305","https://openalex.org/W2916964394","https://openalex.org/W2920895695","https://openalex.org/W2943282778","https://openalex.org/W2947850792","https://openalex.org/W2949548602","https://openalex.org/W2952269264","https://openalex.org/W2969838846","https://openalex.org/W2972853210","https://openalex.org/W2972952069","https://openalex.org/W2972963191","https://openalex.org/W2980351107","https://openalex.org/W2985336761","https://openalex.org/W2989742697","https://openalex.org/W2990970921","https://openalex.org/W2991513562","https://openalex.org/W2993581711","https://openalex.org/W2998573564","https://openalex.org/W3000261500","https://openalex.org/W3007495014","https://openalex.org/W3009250386","https://openalex.org/W3010182921","https://openalex.org/W3012965257","https://openalex.org/W3022681608","https://openalex.org/W3033600689","https://openalex.org/W3034150063","https://openalex.org/W3044198291","https://openalex.org/W3048817349","https://openalex.org/W3066127083","https://openalex.org/W3082098748","https://openalex.org/W3087697844","https://openalex.org/W3089006132","https://openalex.org/W3089094591","https://openalex.org/W3097504524","https://openalex.org/W3124242100","https://openalex.org/W4240348615"],"related_works":["https://openalex.org/W3089241156","https://openalex.org/W1729743715","https://openalex.org/W4206350737","https://openalex.org/W7024287343","https://openalex.org/W1580229457","https://openalex.org/W3104075671","https://openalex.org/W2907258950","https://openalex.org/W4240421386","https://openalex.org/W7120548973","https://openalex.org/W941505228"],"abstract_inverted_index":{"A":[0,110],"esquizofrenia":[1],"(ESQ)":[2],"\u00e9":[3,22,85,113],"uma":[4,66,114,286],"doen\u00e7a":[5],"mental":[6],"cr\u00f4nica":[7],"e":[8,29,49,126,147,195],"grave,":[9],"com":[10,34,135,232,248,306,344,349],"v\u00e1rias":[11],"necessidades":[12],"cl\u00ednicas":[13],"ainda":[14,191,254,324],"n\u00e3o":[15,21,36,312,340],"atendidas.":[16],"O":[17,81,138,208],"tratamento":[18,168,247,304],"farmacol\u00f3gico":[19],"dispon\u00edvel":[20],"eficiente":[23],"no":[24,213,276],"controle":[25,103],"dos":[26,32],"sintomas":[27],"negativos,":[28],"um":[30,56,279],"ter\u00e7o":[31],"pacientes":[33,134],"ESQ":[35,222,338],"respondem":[37],"aos":[38],"tratamentos.":[39],"Os":[40],"neuropept\u00eddios":[41,54],"s\u00e3o":[42,163,206],"neurotransmissores":[43],"que":[44,116,158,302,325],"modulam":[45],"o":[46,60,167,177,199,219,233,256,303,335],"comportamento":[47],"animal,":[48],"a":[50,79,118,127,225,244,270,283,291,314,345,350],"sinaliza\u00e7\u00e3o":[51,105],"mediada":[52],"pelos":[53],"representa":[55],"potencial":[57,91,139,178,234,258],"alvo":[58,150,183,264],"para":[59,65,151,166,175,218,236,282,330,334],"desenvolvimento":[61],"de":[62,68,86,124,169,184,188,215,227,265,278,342],"novas":[63],"terapias":[64],"variedade":[67],"desordens":[69],"do":[70,102,246],"sistema":[71],"nervoso":[72],"central,":[73],"incluindo":[74],"os":[75,122,159,186,307,326],"transtornos":[76,145,204],"mentais,":[77,146],"como":[78,142,149,181,261],"ESQ.":[80],"estudo":[82,220,336],"das":[83,96],"oligopeptidases":[84],"especial":[87],"interesse":[88],"pelo":[89],"seu":[90],"papel":[92,200],"na":[93,250],"modula\u00e7\u00e3o":[94],"direta":[95],"vias":[97],"neuropeptid\u00e9rgicos,":[98],"atuando":[99],"por":[100,106,356],"meio":[101],"da":[104,140,161,179,201,210,221,259,272,293,337,352],"degrada\u00e7\u00e3o":[107],"destes":[108],"neurotransmissores.":[109],"prolil-oligopeptidase":[111],"(POP)":[112],"serino-endooligopeptidase":[115],"cliva":[117],"liga\u00e7\u00e3o":[119],"pept\u00eddica":[120],"ap\u00f3s":[121],"res\u00edduos":[123],"prolina,":[125],"atividade":[128,211,251,271,288,315,353],"POP":[129,141,162,180,202,212,252,260,273,289,316,354],"alterada":[130],"foi":[131,274],"descrita":[132,355],"em":[133,144],"dist\u00farbios":[136],"comportamentais.":[137],"biomarcador":[143,262],"tamb\u00e9m":[148],"fins":[152],"terap\u00eauticos,":[153],"despertou":[154],"muito":[155],"interesse,":[156],"j\u00e1":[157],"inibidores":[160],"potenciais":[164],"candidatos":[165],"diversas":[170],"disfun\u00e7\u00f5es":[171],"cerebrais.":[172],"No":[173,267],"entanto,":[174],"explorar":[176],"poss\u00edvel":[182,297],"f\u00e1rmacos,":[185],"mecanismos":[187],"a\u00e7\u00e3o":[189],"envolvidos":[190],"precisam":[192],"ser":[193],"esclarecidos,":[194],"mais":[196],"investiga\u00e7\u00f5es":[197],"sobre":[198],"nos":[203,317],"mentais":[205],"necess\u00e1rias.":[207],"monitoramento":[209],"sangue":[214,277],"modelos":[216],"animais":[217,292,318],"poderia":[223],"complementar":[224],"caracteriza\u00e7\u00e3o":[226],"aspectos":[228],"cruciais":[229],"desta":[230],"enzima,":[231],"adicional":[235],"elucidar":[237,255],"eventuais":[238],"fun\u00e7\u00f5es":[239],"patofisiol\u00f3gicas":[240],"dessa":[241],"oligopeptidase.":[242],"Avaliar":[243],"influ\u00eancia":[245],"antipsic\u00f3ticos":[249,308],"permitir\u00e1":[253],"real":[257],"ou":[263,310],"tratamento.":[266],"presente":[268],"estudo,":[269],"monitorada":[275],"modelo":[280,332],"animal":[281,333],"ESQ,":[284],"demonstrando":[285],"menor":[287],"comparado":[290],"linhagem":[294],"controle.":[295],"Foi":[296],"demonstrar":[298],"pela":[299],"primeira":[300],"vez":[301],"cr\u00f4nico":[305],"t\u00edpico":[309],"at\u00edpico":[311],"altera":[313],"destas":[319],"linhagens.":[320],"\u00c9":[321],"importante":[322],"ressaltar":[323],"resultados":[327],"aqui":[328],"apresentados":[329],"este":[331],"parece":[339],"estar":[341],"acordo":[343],"melhora":[346],"cognitiva":[347],"correlacionada":[348],"diminui\u00e7\u00e3o":[351],"outros.":[357]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-08-30T00:00:00"}
