{"id":"https://openalex.org/W3194426737","doi":"https://doi.org/10.1007/s12032-021-01582-y","title":"Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling","display_name":"Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling","publication_year":2021,"publication_date":"2021-09-28","ids":{"openalex":"https://openalex.org/W3194426737","doi":"https://doi.org/10.1007/s12032-021-01582-y","mag":"3194426737","pmid":"https://pubmed.ncbi.nlm.nih.gov/34581895","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8478748"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-021-01582-y","doi":"https://doi.org/10.1007/s12032-021-01582-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12032-021-01582-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12032-021-01582-y.pdf","source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12032-021-01582-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037053199","display_name":"Erika H\u00e9ninger","orcid":"https://orcid.org/0000-0003-0166-9972","observed_orcids":["https://orcid.org/0000-0003-0166-9972"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Heninger","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080086801","display_name":"David Kosoff","orcid":"https://orcid.org/0000-0001-8559-6357","observed_orcids":["https://orcid.org/0000-0001-8559-6357"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kosoff","raw_affiliation_strings":["Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030232317","display_name":"Tamara S. Rodems","orcid":"https://orcid.org/0000-0001-6582-9379","observed_orcids":["https://orcid.org/0000-0001-6582-9379"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara S. Rodems","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054300212","display_name":"Nan Sethakorn","orcid":"https://orcid.org/0000-0002-7395-3182","observed_orcids":["https://orcid.org/0000-0002-7395-3182"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Sethakorn","raw_affiliation_strings":["Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008896954","display_name":"Anupama Singh","orcid":"https://orcid.org/0000-0001-9109-1304","observed_orcids":["https://orcid.org/0000-0001-9109-1304"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupama Singh","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031214371","display_name":"Harshitha Gungurthi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harshitha Gungurthi","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091767275","display_name":"Kristin N. Carlson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin N. Carlson","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016291949","display_name":"Bing Yang","orcid":"https://orcid.org/0000-0002-0408-4518","observed_orcids":["https://orcid.org/0000-0002-0408-4518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Yang","raw_affiliation_strings":["Department of Urology, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086575526","display_name":"Cole S. Gilsdorf","orcid":"https://orcid.org/0009-0004-5455-919X","observed_orcids":["https://orcid.org/0009-0004-5455-919X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cole Gilsdorf","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078538809","display_name":"Cheri A. Pasch","orcid":"https://orcid.org/0009-0005-9683-7378","observed_orcids":["https://orcid.org/0009-0005-9683-7378"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheri A. Pasch","raw_affiliation_strings":["University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048019436","display_name":"Dustin A. Deming","orcid":"https://orcid.org/0000-0003-2394-9836","observed_orcids":["https://orcid.org/0000-0003-2394-9836"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin A. Deming","raw_affiliation_strings":["Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081026905","display_name":"Leigh Ellis","orcid":"https://orcid.org/0000-0003-4739-5049","observed_orcids":["https://orcid.org/0000-0003-4739-5049"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leigh Ellis","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001024092","display_name":"David J. Beebe","orcid":"https://orcid.org/0000-0002-0415-9006","observed_orcids":["https://orcid.org/0000-0002-0415-9006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Beebe","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004593069","display_name":"David Frazier Jarrard","orcid":"https://orcid.org/0000-0001-8444-7165","observed_orcids":["https://orcid.org/0000-0001-8444-7165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David F. Jarrard","raw_affiliation_strings":["Department of Urology, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010695005","display_name":"Joshua Michael Lang","orcid":"https://orcid.org/0000-0002-0943-8872","observed_orcids":["https://orcid.org/0000-0002-0943-8872"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua M. Lang","raw_affiliation_strings":["Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA. jmlang@medicine.wisc.edu","University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA. jmlang@medicine.wisc.edu","Wisconsin Institutes for Medical Research, Rm 7151, 1111 Highland Ave., Madison, WI, 53705, USA. jmlang@medicine.wisc.edu","Wisconsin Institutes for Medical Research, Rm 7151, 1111 Highland Ave., Madison, WI, 53705, USA"],"raw_orcid":"https://orcid.org/0000-0002-0943-8872","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin, Madison, 1111 Highland Ave., Madison, WI, 53705, USA. jmlang@medicine.wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin Carbone Cancer Center, 1111 Highland Ave., Madison, USA. jmlang@medicine.wisc.edu","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Wisconsin Institutes for Medical Research, Rm 7151, 1111 Highland Ave., Madison, WI, 53705, USA. jmlang@medicine.wisc.edu","institution_ids":[]},{"raw_affiliation_string":"Wisconsin Institutes for Medical Research, Rm 7151, 1111 Highland Ave., Madison, WI, 53705, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010695005"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":2.2694,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89056669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"38","issue":"11","first_page":"135","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/androgen-receptor-signaling","display_name":"androgen receptor signaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7070000171661377},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gstp1","display_name":"GSTP1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/rassf1","display_name":"RASSF1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.9739999771118164},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-beta","display_name":"retinoic acid receptor beta","score":0.7639999985694885},{"id":"https://openalex.org/keywords/multifocal-prostate-cancer","display_name":"multifocal prostate cancer","score":0.6510000228881836},{"id":"https://openalex.org/keywords/locally-advanced-prostate-cancer","display_name":"locally advanced prostate cancer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/organoid-culture","display_name":"organoid culture","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6587239503860474},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6227017641067505},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6210719347000122},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6045952439308167},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5750714540481567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5742842555046082},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.4313701391220093},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39443305134773254},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.30894777178764343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11111000180244446},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s12032-021-01582-y","doi":"https://doi.org/10.1007/s12032-021-01582-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12032-021-01582-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12032-021-01582-y.pdf","source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-819532/v1","doi":"https://doi.org/10.21203/rs.3.rs-819532/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-819532/v1","pdf_url":"https://www.researchsquare.com/article/rs-819532/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:7390177","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8478748","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8478748","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8478748","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Oncol","raw_type":"Text"},{"id":"pmid:34581895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34581895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s12032-021-01582-y","doi":"https://doi.org/10.1007/s12032-021-01582-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12032-021-01582-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12032-021-01582-y.pdf","source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1212259405","display_name":null,"funder_award_id":"19CHAL12","funder_id":"https://openalex.org/F4320306163","funder_display_name":"Prostate Cancer Foundation"},{"id":"https://openalex.org/G1712026730","display_name":null,"funder_award_id":"CA014520","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G21146293","display_name":null,"funder_award_id":"W81XWH-16","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G3821986886","display_name":null,"funder_award_id":"21702-5014","funder_id":"https://openalex.org/F4320338478","funder_display_name":"U.S. Army Medical Research Acquisition Activity"},{"id":"https://openalex.org/G3826210423","display_name":null,"funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G3970896122","display_name":null,"funder_award_id":"MD 21702-5014","funder_id":"https://openalex.org/F4320338478","funder_display_name":"U.S. Army Medical Research Acquisition Activity"},{"id":"https://openalex.org/G4004214011","display_name":null,"funder_award_id":"P30 CA 014520","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5978997916","display_name":"Optical imaging to predict cell-level genetic heterogeneity and treatment sensitivity in colorectal cancer","funder_award_id":"R37CA226526","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6291298690","display_name":null,"funder_award_id":"Grant P30 CA014520","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G6461774203","display_name":null,"funder_award_id":"HL07899","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G6748645702","display_name":null,"funder_award_id":"P30 CA014520","funder_id":"https://openalex.org/F4320338478","funder_display_name":"U.S. Army Medical Research Acquisition Activity"},{"id":"https://openalex.org/G7139631174","display_name":null,"funder_award_id":"21702-5014","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7411968050","display_name":null,"funder_award_id":"T32 HL07899","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G7592059842","display_name":null,"funder_award_id":"W81XWH-16-1-0511","funder_id":"https://openalex.org/F4320333578","funder_display_name":"Office of the Under Secretary of Defense"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000912755","display_name":"Research Training in Hematology","funder_award_id":"T32HL007899","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320310176","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/02mqqhj42"},{"id":"https://openalex.org/F4320333578","display_name":"Office of the Under Secretary of Defense","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338478","display_name":"U.S. Army Medical Research Acquisition Activity","ror":null},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3194426737.pdf","grobid_xml":"https://content.openalex.org/works/W3194426737.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1483496013","https://openalex.org/W1968724564","https://openalex.org/W1978070289","https://openalex.org/W1993617434","https://openalex.org/W2001670844","https://openalex.org/W2002513358","https://openalex.org/W2005274657","https://openalex.org/W2005968909","https://openalex.org/W2009937235","https://openalex.org/W2047918294","https://openalex.org/W2049700579","https://openalex.org/W2059586354","https://openalex.org/W2076157007","https://openalex.org/W2106513086","https://openalex.org/W2115314035","https://openalex.org/W2116144898","https://openalex.org/W2141091746","https://openalex.org/W2162250780","https://openalex.org/W2166845840","https://openalex.org/W2255555283","https://openalex.org/W2261112339","https://openalex.org/W2314220291","https://openalex.org/W2403309454","https://openalex.org/W2501821639","https://openalex.org/W2511579172","https://openalex.org/W2512050299","https://openalex.org/W2808350668","https://openalex.org/W2886808870","https://openalex.org/W2895899985","https://openalex.org/W2900889949","https://openalex.org/W2922343610","https://openalex.org/W2960647564","https://openalex.org/W2967054009","https://openalex.org/W2982214814","https://openalex.org/W3023117662","https://openalex.org/W3150467866","https://openalex.org/W3159100616","https://openalex.org/W4249815350"],"related_works":["https://openalex.org/W7118721123","https://openalex.org/W2811314408","https://openalex.org/W2891347789","https://openalex.org/W7148631895","https://openalex.org/W4409631744","https://openalex.org/W4414708591","https://openalex.org/W3008229845","https://openalex.org/W3159100616","https://openalex.org/W4416223020","https://openalex.org/W4390913367"],"abstract_inverted_index":{"Prostate":[0],"Cancer":[1],"(PC)":[2],"is":[3,41],"a":[4,82,91,166,205,220],"disease":[5,38],"with":[6,17,75,215],"remarkable":[7],"tumor":[8,55,187,222],"heterogeneity":[9],"that":[10,113,125,175],"often":[11],"manifests":[12],"in":[13,100],"significant":[14],"intra-patient":[15],"variability":[16],"regards":[18],"to":[19,49,136,198,209,218],"clinical":[20],"outcomes":[21],"and":[22,39,97,124,159,161,212],"treatment":[23],"response.":[24],"Commonly":[25],"available":[26],"PC":[27,191],"cell":[28],"lines":[29],"do":[30],"not":[31],"accurately":[32],"reflect":[33],"the":[34,51,87,101,138,141,146,156,182,185,200,216],"complexity":[35,183],"of":[36,46,54,73,86,119,130,140,148,155,184,189],"this":[37,176],"there":[40],"critical":[42],"need":[43],"for":[44,94],"development":[45],"new":[47],"models":[48],"recapitulate":[50],"intricate":[52],"hierarchy":[53],"pathogenesis.":[56],"In":[57],"current":[58],"study,":[59],"we":[60,111,143,196],"established":[61],"ex":[62,177],"vivo":[63,178],"primary":[64,114],"patient-derived":[65],"cancer":[66],"organoid":[67],"(PDCO)":[68],"cultures":[69],"from":[70],"prostatectomy":[71],"specimens":[72],"patients":[74],"locally":[76],"advanced":[77],"PC.":[78],"We":[79],"then":[80],"performed":[81],"comprehensive":[83],"multi-parameter":[84],"characterization":[85],"cellular":[88],"composition":[89],"utilizing":[90],"novel":[92,167],"approach":[93],"live-cell":[95],"staining":[96],"direct":[98],"imaging":[99],"integrated":[102],"microfluidic":[103,168,202],"Stacks":[104,201],"device.":[105],"Using":[106],"orthogonal":[107,193],"flow":[108],"cytometry":[109],"analysis,":[110],"demonstrate":[112,174],"PDCOs":[115,142],"maintain":[116],"distinct":[117],"subsets":[118],"epithelial":[120,186],"cells":[121,127],"throughout":[122],"culture":[123],"these":[126],"conserve":[128],"expression":[129,147],"androgen":[131],"receptor":[132],"(AR)-related":[133],"elements.":[134],"Furthermore,":[135,195],"confirm":[137],"tumor-origin":[139],"have":[144],"analyzed":[145],"PC-associated":[149],"epigenetic":[150],"biomarkers":[151],"including":[152],"promoter":[153],"methylation":[154],"GSTP1,":[157],"RASSF1":[158],"APC":[160],"RARb":[162],"genes":[163],"by":[164],"employing":[165],"rare-event":[169],"screening":[170],"protocol.":[171],"These":[172],"results":[173],"PDCO":[179],"model":[180],"recapitulates":[181],"microenvironment":[188],"multifocal":[190],"using":[192],"analyses.":[194],"propose":[197],"leverage":[199],"device":[203],"as":[204],"high-throughput,":[206],"translational":[207],"platform":[208],"interrogate":[210],"phenotypic":[211],"molecular":[213],"endpoints":[214],"capacity":[217],"incorporate":[219],"complex":[221],"microenvironment.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-30T00:00:00"}