{"id":"https://openalex.org/W3193959639","doi":"https://doi.org/10.1038/s42003-021-02508-0","title":"LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma","display_name":"LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma","publication_year":2021,"publication_date":"2021-08-19","ids":{"openalex":"https://openalex.org/W3193959639","doi":"https://doi.org/10.1038/s42003-021-02508-0","mag":"3193959639","pmid":"https://pubmed.ncbi.nlm.nih.gov/34413441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8377056"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-021-02508-0","doi":"https://doi.org/10.1038/s42003-021-02508-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-021-02508-0","pdf_url":"https://www.nature.com/articles/s42003-021-02508-0.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-021-02508-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079658674","display_name":"Ang\u00e9lina Acier","orcid":"https://orcid.org/0000-0002-6788-0327","observed_orcids":["https://orcid.org/0000-0002-6788-0327"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ang\u00e9lina Acier","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","Vect-Horus, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-6788-0327","affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058814438","display_name":"Magali Godard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magali Godard","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024334800","display_name":"Fanny Gassiot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fanny Gassiot","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084660376","display_name":"Pascal Finetti","orcid":"https://orcid.org/0000-0002-2674-3123","observed_orcids":["https://orcid.org/0000-0002-2674-3123"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Finetti","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-2674-3123","affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080898174","display_name":"Marion Rubis","orcid":"https://orcid.org/0009-0004-0859-5958","observed_orcids":["https://orcid.org/0009-0004-0859-5958"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion Rubis","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151783503","display_name":"Jonathan Nowak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Nowak","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091721810","display_name":"Fran\u00e7ois Bertucci","orcid":"https://orcid.org/0000-0002-0157-0959","observed_orcids":["https://orcid.org/0000-0002-0157-0959"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Bertucci","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066948009","display_name":"Juan Iovanna","orcid":"https://orcid.org/0000-0003-1822-2237","observed_orcids":["https://orcid.org/0000-0003-1822-2237"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Juan L. Iovanna","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":"https://orcid.org/0000-0003-1822-2237","affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058115602","display_name":"Richard Tomasini","orcid":"https://orcid.org/0000-0003-0869-0811","observed_orcids":["https://orcid.org/0000-0003-0869-0811"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Richard Tomasini","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":"https://orcid.org/0000-0003-0869-0811","affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060406232","display_name":"Pascaline L\u00e9corch\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascaline L\u00e9corch\u00e9","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086916201","display_name":"Guillaume Jacquot","orcid":"https://orcid.org/0009-0006-4352-1609","observed_orcids":["https://orcid.org/0009-0006-4352-1609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guillaume Jacquot","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028036010","display_name":"Michel Khrestchatisky","orcid":"https://orcid.org/0000-0003-4797-8332","observed_orcids":["https://orcid.org/0000-0003-4797-8332"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210097886","display_name":"Institut de Neurophysiopathologie","ror":"https://ror.org/00w2q5j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210097886"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Khrestchatisky","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210097886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038738832","display_name":"Jamal Temsamani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamal Temsamani","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030396949","display_name":"C\u00e9dric Malicet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9dric Malicet","raw_affiliation_strings":["Vect-Horus, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vect-Horus, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082874632","display_name":"Sophie Vasseur","orcid":"https://orcid.org/0000-0002-2339-8854","observed_orcids":["https://orcid.org/0000-0002-2339-8854"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Vasseur","raw_affiliation_strings":["CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-2339-8854","affiliations":[{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047258963","display_name":"Fabienne Guillaumond","orcid":"https://orcid.org/0000-0001-7456-7315","observed_orcids":["https://orcid.org/0000-0001-7456-7315"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fabienne Guillaumond","raw_affiliation_strings":["CRCM U1068 - Pancreatic Cancer Team, 163 avenue de Luminy, Parc Scientifique de Luminy, Marseille, France. fabienne.guillaumond@inserm.fr","CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France. fabienne.guillaumond@inserm.fr","CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-7456-7315","affiliations":[{"raw_affiliation_string":"CRCM U1068 - Pancreatic Cancer Team, 163 avenue de Luminy, Parc Scientifique de Luminy, Marseille, France. fabienne.guillaumond@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144608"]},{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France. fabienne.guillaumond@inserm.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"raw_affiliation_string":"CRCM, Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes (IPC), Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5047258963"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":2680,"currency":"EUR","value_usd":2890},"fwci":1.2695,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.76334142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"987","last_page":"987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/peptide-conjugates","display_name":"peptide conjugates","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.7210000157356262},{"id":"https://openalex.org/keywords/near-infrared-fluorescence-imaging","display_name":"near-infrared fluorescence imaging","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.5320000052452087},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7632787227630615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6212797164916992},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5193606019020081},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5168352723121643},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.5128069519996643},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5029899477958679},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4878695011138916},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.47638624906539917},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43677592277526855},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4173696041107178},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.41515424847602844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3607960343360901},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.338161438703537},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.1611202359199524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1490345597267151},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.07387539744377136},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s42003-021-02508-0","doi":"https://doi.org/10.1038/s42003-021-02508-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-021-02508-0","pdf_url":"https://www.nature.com/articles/s42003-021-02508-0.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7348257","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8377056","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8377056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8377056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Biol","raw_type":"Text"},{"id":"pmid:34413441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34413441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications biology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03452855v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03452855v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, 2021, 4 (1), pp.987. ⟨10.1038/s42003-021-02508-0⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04235770v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04235770","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, 2021, 4 (1), pp.987. ⟨10.1038/s42003-021-02508-0⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5ab9785210c145ccb6dcb8b2d12b4fdb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ab9785210c145ccb6dcb8b2d12b4fdb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s42003-021-02508-0","doi":"https://doi.org/10.1038/s42003-021-02508-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-021-02508-0","pdf_url":"https://www.nature.com/articles/s42003-021-02508-0.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321663","display_name":"Association Nationale de la Recherche et de la Technologie","ror":"https://ror.org/00ht2ab73"},{"id":"https://openalex.org/F4320336384","display_name":"Inserm Transfert","ror":"https://ror.org/01wftfc57"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3193959639.pdf","grobid_xml":"https://content.openalex.org/works/W3193959639.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1508675434","https://openalex.org/W1583589401","https://openalex.org/W1964513663","https://openalex.org/W1968812902","https://openalex.org/W1977379410","https://openalex.org/W1977773843","https://openalex.org/W2024263101","https://openalex.org/W2035484411","https://openalex.org/W2065215232","https://openalex.org/W2104450983","https://openalex.org/W2108208627","https://openalex.org/W2118545618","https://openalex.org/W2118797060","https://openalex.org/W2126663928","https://openalex.org/W2140814324","https://openalex.org/W2149828028","https://openalex.org/W2155127143","https://openalex.org/W2301226317","https://openalex.org/W2510386957","https://openalex.org/W2521167514","https://openalex.org/W2564262333","https://openalex.org/W2568414132","https://openalex.org/W2571875265","https://openalex.org/W2724797371","https://openalex.org/W2726164542","https://openalex.org/W2741524908","https://openalex.org/W2774731752","https://openalex.org/W2781631849","https://openalex.org/W2791376627","https://openalex.org/W2800903809","https://openalex.org/W2807001820","https://openalex.org/W2808634372","https://openalex.org/W2884616676","https://openalex.org/W2895926103","https://openalex.org/W2904036648","https://openalex.org/W2979013857","https://openalex.org/W2980433869","https://openalex.org/W2989544844","https://openalex.org/W3012545048","https://openalex.org/W3023906975","https://openalex.org/W3031839955","https://openalex.org/W3045051771","https://openalex.org/W3134530972","https://openalex.org/W4211253487"],"related_works":["https://openalex.org/W3111779787","https://openalex.org/W7062359223","https://openalex.org/W4282968749","https://openalex.org/W2120522256","https://openalex.org/W2016645404","https://openalex.org/W2090514007","https://openalex.org/W4377042637","https://openalex.org/W2027578458","https://openalex.org/W7148912937","https://openalex.org/W7148660640"],"abstract_inverted_index":{"Despite":[0],"clinical":[1,38,107],"advances":[2],"in":[3,98,109],"diagnosis":[4],"and":[5,19,26,75,84],"treatment,":[6],"pancreatic":[7,95],"ductal":[8],"adenocarcinoma":[9],"(PDAC)":[10],"remains":[11],"the":[12,67,104,129],"third":[13],"leading":[14,124],"cause":[15],"of":[16,69,118,128],"cancer":[17,96],"death,":[18],"is":[20,40],"still":[21],"associated":[22],"with":[23],"poor":[24],"prognosis":[25],"dismal":[27],"survival":[28],"rates.":[29],"Identifying":[30],"novel":[31],"PDAC-targeted":[32],"tools":[33],"to":[34,72,125],"tackle":[35],"these":[36],"unmet":[37],"needs":[39],"thus":[41],"an":[42],"urgent":[43],"requirement.":[44],"Here":[45],"we":[46],"use":[47],"a":[48],"peptide":[49,113],"conjugate":[50,71,114],"that":[51],"specifically":[52,73],"targets":[53],"PDAC":[54,78,130],"through":[55],"low-density":[56],"lipoprotein":[57],"receptor":[58],"(LDLR).":[59],"We":[60],"demonstrate":[61],"by":[62],"using":[63],"near-infrared":[64],"fluorescence":[65],"imaging":[66,119],"potential":[68],"this":[70],"detect":[74,93],"discriminate":[76],"primary":[77],"from":[79,85],"healthy":[80,99],"organs":[81],"including":[82],"pancreas":[83],"benign":[86],"mass-forming":[87],"chronic":[88],"pancreatitis,":[89],"as":[90,92],"well":[91],"metastatic":[94],"cells":[97],"liver.":[100],"This":[101],"work":[102],"paves":[103],"way":[105],"towards":[106],"applications":[108],"which":[110],"safe":[111],"LDLR-targeting":[112],"promotes":[115],"tumor-specific":[116],"delivery":[117],"and/or":[120],"therapeutic":[121],"agents,":[122],"thereby":[123],"substantial":[126],"improvements":[127],"patient's":[131],"outcome.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-30T00:00:00"}