{"id":"https://openalex.org/W3193282964","doi":"https://doi.org/10.1016/j.cca.2021.08.025","title":"Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease","display_name":"Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease","publication_year":2021,"publication_date":"2021-08-25","ids":{"openalex":"https://openalex.org/W3193282964","doi":"https://doi.org/10.1016/j.cca.2021.08.025","mag":"3193282964","pmid":"https://pubmed.ncbi.nlm.nih.gov/34453919"},"language":"en","primary_location":{"id":"doi:10.1016/j.cca.2021.08.025","doi":"https://doi.org/10.1016/j.cca.2021.08.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cca.2021.08.025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000989812100303X/pdf","source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S000989812100303X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111992506","display_name":"Takafumi Kawanami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takafumi Kawanami","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan. Electronic address: kawahagi@kanazawa-med.ac.jp","Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan. Electronic address: kawahagi@kanazawa-med.ac.jp","institution_ids":["https://openalex.org/I16568816"]},{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090521080","display_name":"Haruka Kawanami Iwao","orcid":"https://orcid.org/0000-0002-4986-5473","observed_orcids":["https://orcid.org/0000-0002-4986-5473"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Kawanami-Iwao","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4986-5473","affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026992868","display_name":"Takanobu Takata","orcid":"https://orcid.org/0000-0003-0514-8584","observed_orcids":["https://orcid.org/0000-0003-0514-8584"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanobu Takata","raw_affiliation_strings":["Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056449434","display_name":"Yasuhito Ishigaki","orcid":"https://orcid.org/0000-0003-1012-8430","observed_orcids":["https://orcid.org/0000-0003-1012-8430"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Ishigaki","raw_affiliation_strings":["Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1012-8430","affiliations":[{"raw_affiliation_string":"Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016190886","display_name":"Naohisa Tomosugi","orcid":"https://orcid.org/0000-0002-9328-8116","observed_orcids":["https://orcid.org/0000-0002-9328-8116","https://orcid.org/0009-0007-5809-722X"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohisa Tomosugi","raw_affiliation_strings":["Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111792189","display_name":"Tsutomu Takegami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Takegami","raw_affiliation_strings":["Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroto Yanagisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroto Yanagisawa","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077318071","display_name":"Shino Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shino Fujimoto","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069916638","display_name":"Tomoyuki Sakai","orcid":"https://orcid.org/0000-0002-5533-3465","observed_orcids":["https://orcid.org/0000-0002-5533-3465"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Sakai","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5533-3465","affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109831763","display_name":"Yoshimasa Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Fujita","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103735347","display_name":"Kazunori Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Yamada","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032219696","display_name":"Shuichi Mizuta","orcid":"https://orcid.org/0000-0001-6690-5409","observed_orcids":["https://orcid.org/0000-0001-6690-5409"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Mizuta","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020613096","display_name":"Hiroshi Kawabata","orcid":"https://orcid.org/0000-0002-1918-8635","observed_orcids":["https://orcid.org/0000-0002-1918-8635"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]},{"id":"https://openalex.org/I3017590076","display_name":"Kyoto Medical Center","ror":"https://ror.org/045kb1d14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3017590076","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kawabata","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan; Department of Hematology, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto, Japan","Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","Department of Hematology, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan; Department of Hematology, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I16568816","https://openalex.org/I3017590076"]},{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]},{"raw_affiliation_string":"Department of Hematology, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I3017590076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198096","display_name":"Toshihiro Fukushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Fukushima","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103428620","display_name":"Yuko Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Hirose","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061841627","display_name":"Yasufumi Masaki","orcid":"https://orcid.org/0000-0002-5658-3765","observed_orcids":["https://orcid.org/0000-0002-5658-3765"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasufumi Masaki","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan","institution_ids":["https://openalex.org/I16568816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061841627","https://openalex.org/A5111992506"],"corresponding_institution_ids":["https://openalex.org/I16568816"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":{"value":3200,"currency":"USD","value_usd":3200},"fwci":2.6288,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89967184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"523","issue":null,"first_page":"45","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igg4-related-disease","display_name":"IgG4-related disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/serum-protein-biomarkers","display_name":"serum protein biomarkers","score":0.718999981880188},{"id":"https://openalex.org/keywords/lrg1","display_name":"LRG1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/clusterin","display_name":"clusterin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/igg4-positive-plasma-cells","display_name":"IgG4-positive plasma cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/serum-proteomics","display_name":"serum proteomics","score":0.5879999995231628},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2779476363","wikidata":"https://www.wikidata.org/wiki/Q14864935","display_name":"Clusterin","level":3,"score":0.9100714921951294},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.67710942029953},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.5888489484786987},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.578719973564148},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5508947372436523},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5019664764404297},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49927592277526855},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4989745616912842},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4555531442165375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44720494747161865},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4446330666542053},{"id":"https://openalex.org/C2776855637","wikidata":"https://www.wikidata.org/wiki/Q10633013","display_name":"Serum protein electrophoresis","level":5,"score":0.44194725155830383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42329853773117065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36702412366867065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35818004608154297},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30357253551483154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11689594388008118},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1008918285369873},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.0},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077733","descriptor_name":"Immunoglobulin G4-Related Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cca.2021.08.025","doi":"https://doi.org/10.1016/j.cca.2021.08.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cca.2021.08.025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000989812100303X/pdf","source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:34453919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34453919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cca.2021.08.025","doi":"https://doi.org/10.1016/j.cca.2021.08.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cca.2021.08.025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S000989812100303X/pdf","source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1742328081","display_name":"Establishment of a new concept of lifestyle-related diseases:\"toxic advanced glycation end-products (Toxic AGEs) theory\"","funder_award_id":"21H04865","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2134391177","display_name":null,"funder_award_id":"General-058","funder_id":"https://openalex.org/F4320321945","funder_display_name":"Ministry of Health, Labour and Welfare"},{"id":"https://openalex.org/G2246900284","display_name":"Proteomics analysis in IgG4-related disease","funder_award_id":"24791010","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G350224976","display_name":null,"funder_award_id":"H2011\u201011","funder_id":"https://openalex.org/F4320322311","funder_display_name":"Kanazawa Medical University"},{"id":"https://openalex.org/G3913060655","display_name":"Proteomics analysis in IgG4-related disease","funder_award_id":"15K09537","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G405657340","display_name":"The significance of TRP channels in the pathogenesis of IgG4-related disease and the development of novel therapeutic targets","funder_award_id":"21K08483","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4796733024","display_name":"Inflammatory monocyoid expression and epitope cloning of immunoglobulin in patients with IgG4-related disease","funder_award_id":"15K09510","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5160108729","display_name":null,"funder_award_id":"S2007\u20105","funder_id":"https://openalex.org/F4320322311","funder_display_name":"Kanazawa Medical University"},{"id":"https://openalex.org/G5340426207","display_name":null,"funder_award_id":"K2011-7","funder_id":"https://openalex.org/F4320322311","funder_display_name":"Kanazawa Medical University"},{"id":"https://openalex.org/G5382291694","display_name":null,"funder_award_id":"AR2012\u201006","funder_id":"https://openalex.org/F4320322311","funder_display_name":"Kanazawa Medical University"},{"id":"https://openalex.org/G5515258113","display_name":null,"funder_award_id":"H29 Nanchi","funder_id":"https://openalex.org/F4320321945","funder_display_name":"Ministry of Health, Labour and Welfare"},{"id":"https://openalex.org/G5761563176","display_name":null,"funder_award_id":"17591060","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G5965223217","display_name":"Restoration of salivary gland function using adipose-derived stem cells","funder_award_id":"21K08449","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G657194838","display_name":null,"funder_award_id":"15 K09510","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6619939622","display_name":null,"funder_award_id":"S2004-16","funder_id":"https://openalex.org/F4320322311","funder_display_name":"Kanazawa Medical University"},{"id":"https://openalex.org/G6690787612","display_name":"Autoimwune multi-tagemlympliopmliferative syndrome (AMOLPS)-propoeal for a new clinical entily","funder_award_id":"17591060","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8324225169","display_name":"Mechanisms of cytotoxicity due to the generation and accumulation of toxic advanced glycation end-prodcuts (TAGE) in cardiomyocytes","funder_award_id":"21K11607","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8713315304","display_name":"The Role of Innate Immunity in IgG4-Related Diseases and the Search for Novel Therapeutic Targets","funder_award_id":"17K09999","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320322311","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3193282964.pdf","grobid_xml":"https://content.openalex.org/works/W3193282964.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W909689669","https://openalex.org/W1550678177","https://openalex.org/W1559648049","https://openalex.org/W1564267180","https://openalex.org/W1694898543","https://openalex.org/W1967028548","https://openalex.org/W1969615927","https://openalex.org/W1969912242","https://openalex.org/W1971119095","https://openalex.org/W1977687502","https://openalex.org/W1978791492","https://openalex.org/W2004241508","https://openalex.org/W2033668004","https://openalex.org/W2037307671","https://openalex.org/W2039479642","https://openalex.org/W2044953017","https://openalex.org/W2045070782","https://openalex.org/W2050753305","https://openalex.org/W2057491414","https://openalex.org/W2066552890","https://openalex.org/W2070656175","https://openalex.org/W2075734906","https://openalex.org/W2080468816","https://openalex.org/W2089207405","https://openalex.org/W2092649535","https://openalex.org/W2097697539","https://openalex.org/W2108302885","https://openalex.org/W2111531691","https://openalex.org/W2113328730","https://openalex.org/W2132177633","https://openalex.org/W2150463269","https://openalex.org/W2152078686","https://openalex.org/W2154556565","https://openalex.org/W2165608602","https://openalex.org/W2170465383","https://openalex.org/W2172116519","https://openalex.org/W2292510026","https://openalex.org/W2334701968","https://openalex.org/W2402191127","https://openalex.org/W2407616439","https://openalex.org/W2573868425","https://openalex.org/W2895779433","https://openalex.org/W2901863258","https://openalex.org/W2913470145","https://openalex.org/W3140754719","https://openalex.org/W3164046291","https://openalex.org/W4245265700"],"related_works":["https://openalex.org/W3032569045","https://openalex.org/W2994757008","https://openalex.org/W2615934035","https://openalex.org/W2619635773","https://openalex.org/W7203644792","https://openalex.org/W2773133954","https://openalex.org/W2890355771","https://openalex.org/W3081405464","https://openalex.org/W4380422493","https://openalex.org/W2952093413"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,41],"AIMS:":[2],"Immunoglobulin":[3],"4":[4],"(IgG4)-related":[5],"disease":[6,36,49,106],"(IgG4-RD)":[7],"is":[8],"a":[9,187],"lymphoproliferative":[10],"disorder":[11],"characterized":[12,108],"by":[13,109],"elevated":[14],"serum":[15,28,140],"IgG4":[16],"levels":[17,31,111,141,159,174],"and":[18,38,50,59,69,81,84,87,93,125,135,145],"tissue":[19],"infiltration":[20],"of":[21,112,142,165,180,190],"IgG4-positive":[22],"plasma":[23],"cells.":[24],"We":[25],"analyzed":[26],"the":[27,35,62,178],"proteins,":[29,74],"whose":[30,75],"varied":[32],"based":[33],"on":[34],"state":[37],"treatment.":[39,181],"MATERIALS":[40],"METHODS:":[42],"Serum":[43],"proteins":[44,63,126],"from":[45,102],"patients":[46,80,103],"with":[47,66,104,128,149],"IgG4-related":[48,105,191],"healthy":[51,82,171],"subjects":[52],"were":[53,64,91,160],"resolved":[54],"using":[55,95],"two-dimensional":[56],"electrophoresis,":[57],"silver-stained,":[58],"scanned.":[60],"Alternatively,":[61],"labeled":[65],"Cy2,":[67],"Cy3,":[68],"Cy5":[70],"before":[71,86],"electrophoresis.":[72],"The":[73,139],"expression":[76],"differed":[77],"significantly":[78],"between":[79,85],"individuals,":[83],"after":[88,162],"steroid":[89],"treatment,":[90,166],"identified":[92],"validated":[94],"enzyme-linked":[96],"immunosorbent":[97],"assays.":[98],"RESULTS:":[99],"Pre-treatment":[100],"sera":[101],"was":[107],"increased":[110],"immunoglobulins":[113],"such":[114,120,132],"as":[115,121,133,186],"IgG1,":[116],"IgG4;":[117],"inflammatory":[118],"factors":[119],"\u03b1-1":[122],"antitrypsin":[123],"(A1AT);":[124],"associated":[127],"immune":[129],"system":[130],"regulation":[131],"clusterin":[134],"leucine-rich":[136],"\u03b1-2-glycoprotein":[137],"(LRG-1).":[138],"A1AT,":[143],"LRG-1":[144,158,173,183],"clusterin,":[146],"during":[147],"treatment":[148],"prednisolone":[150],"for":[151],"up":[152],"to":[153,168],"12":[154],"months":[155],"revealed":[156],"that":[157],"halved":[161],"1":[163],"month":[164],"comparable":[167],"those":[169],"in":[170],"subjects;":[172],"remained":[175],"normal":[176],"until":[177],"end":[179],"CONCLUSION:":[182],"could":[184],"serve":[185],"novel":[188],"biomarker":[189],"diseases.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-30T00:00:00"}
