{"id":"https://openalex.org/W3192809398","doi":"https://doi.org/10.1111/cyt.13045","title":"Molecular cytology of the respiratory tract and pleura","display_name":"Molecular cytology of the respiratory tract and pleura","publication_year":2021,"publication_date":"2021-08-01","ids":{"openalex":"https://openalex.org/W3192809398","doi":"https://doi.org/10.1111/cyt.13045","mag":"3192809398","pmid":"https://pubmed.ncbi.nlm.nih.gov/34333812"},"language":"en","primary_location":{"id":"doi:10.1111/cyt.13045","doi":"https://doi.org/10.1111/cyt.13045","is_oa":false,"landing_page_url":"https://doi.org/10.1111/cyt.13045","pdf_url":null,"source":{"id":"https://openalex.org/S86895130","display_name":"Cytopathology","issn_l":"0956-5507","issn":["0956-5507","1365-2303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytopathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057600816","display_name":"Fang Zhou","orcid":"https://orcid.org/0000-0002-5542-2994","observed_orcids":["https://orcid.org/0000-0002-5542-2994"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Zhou","raw_affiliation_strings":["Department of Pathology New York University Langone Health New York NY USA"],"raw_orcid":"https://orcid.org/0000-0002-5542-2994","affiliations":[{"raw_affiliation_string":"Department of Pathology New York University Langone Health New York NY USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076708638","display_name":"Elaine Shum","orcid":"https://orcid.org/0000-0002-0390-5716","observed_orcids":["https://orcid.org/0000-0002-0390-5716"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Shum","raw_affiliation_strings":["Division of Hematology and Medical Oncology Department of Medicine New York University Langone Health New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Medical Oncology Department of Medicine New York University Langone Health New York NY USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037786634","display_name":"Andre Luis Moreira","orcid":"https://orcid.org/0000-0003-1857-3774","observed_orcids":["https://orcid.org/0000-0003-1857-3774"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andre L. Moreira","raw_affiliation_strings":["Department of Pathology New York University Langone Health New York NY USA"],"raw_orcid":"https://orcid.org/0000-0003-1857-3774","affiliations":[{"raw_affiliation_string":"Department of Pathology New York University Langone Health New York NY USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.0804,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.1453463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"1","first_page":"14","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-testing","display_name":"molecular testing","score":0.7279999852180481},{"id":"https://openalex.org/keywords/respiratory-tract-cytology","display_name":"respiratory tract cytology","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pleural-fluid-cytology","display_name":"pleural fluid cytology","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pulmonary-malignancy","display_name":"pulmonary malignancy","score":0.625},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6779999732971191},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9020000100135803},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/test-validation","display_name":"test validation","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8093775510787964},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.794667661190033},{"id":"https://openalex.org/C2778654104","wikidata":"https://www.wikidata.org/wiki/Q1881849","display_name":"Cytopathology","level":3,"score":0.5063086748123169},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4834776520729065},{"id":"https://openalex.org/C2993292583","wikidata":"https://www.wikidata.org/wiki/Q192398","display_name":"Pleural fluid","level":3,"score":0.47023457288742065},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.44589897990226746},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3775308132171631},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.2280445098876953},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15161284804344177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003581","descriptor_name":"Cytodiagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010994","descriptor_name":"Pleura","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/cyt.13045","doi":"https://doi.org/10.1111/cyt.13045","is_oa":false,"landing_page_url":"https://doi.org/10.1111/cyt.13045","pdf_url":null,"source":{"id":"https://openalex.org/S86895130","display_name":"Cytopathology","issn_l":"0956-5507","issn":["0956-5507","1365-2303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytopathology","raw_type":"journal-article"},{"id":"pmid:34333812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34333812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytopathology : official journal of the British Society for Clinical Cytology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1573292320","https://openalex.org/W1827919153","https://openalex.org/W1934727085","https://openalex.org/W1940246291","https://openalex.org/W1996854467","https://openalex.org/W1999874075","https://openalex.org/W2013733453","https://openalex.org/W2048084350","https://openalex.org/W2054323652","https://openalex.org/W2057152418","https://openalex.org/W2074674409","https://openalex.org/W2087630768","https://openalex.org/W2093993887","https://openalex.org/W2098746581","https://openalex.org/W2111991867","https://openalex.org/W2142480586","https://openalex.org/W2154203453","https://openalex.org/W2169215908","https://openalex.org/W2274239653","https://openalex.org/W2344181299","https://openalex.org/W2419639280","https://openalex.org/W2474214108","https://openalex.org/W2515089874","https://openalex.org/W2516399807","https://openalex.org/W2538686606","https://openalex.org/W2625121650","https://openalex.org/W2745710777","https://openalex.org/W2774146893","https://openalex.org/W2784538417","https://openalex.org/W2792635798","https://openalex.org/W2801629054","https://openalex.org/W2804957255","https://openalex.org/W2889694623","https://openalex.org/W2900675193","https://openalex.org/W2900831612","https://openalex.org/W2902576964","https://openalex.org/W2903909248","https://openalex.org/W2905425697","https://openalex.org/W2923364601","https://openalex.org/W2939507613","https://openalex.org/W2941623718","https://openalex.org/W2943216613","https://openalex.org/W2954550813","https://openalex.org/W2963477960","https://openalex.org/W2967420480","https://openalex.org/W2979936960","https://openalex.org/W2983766759","https://openalex.org/W2992528311","https://openalex.org/W2994716574","https://openalex.org/W2995123342","https://openalex.org/W2995159341","https://openalex.org/W2997191402","https://openalex.org/W3008414132","https://openalex.org/W3024185395","https://openalex.org/W3027318054","https://openalex.org/W3037858365","https://openalex.org/W3045381641","https://openalex.org/W3045624916","https://openalex.org/W3082069936","https://openalex.org/W3083408667","https://openalex.org/W3083763192","https://openalex.org/W3095426280","https://openalex.org/W3096568637","https://openalex.org/W3109885115","https://openalex.org/W3111472756","https://openalex.org/W3119005666","https://openalex.org/W3119562444","https://openalex.org/W3121116309","https://openalex.org/W3124846598","https://openalex.org/W3125117701","https://openalex.org/W3129293811","https://openalex.org/W3150167681","https://openalex.org/W3157633109","https://openalex.org/W3159002932","https://openalex.org/W6785489213"],"related_works":["https://openalex.org/W2543288208","https://openalex.org/W4308555172","https://openalex.org/W2923364601","https://openalex.org/W2884792131","https://openalex.org/W2794166433","https://openalex.org/W1544082798","https://openalex.org/W2080371579","https://openalex.org/W2902576964","https://openalex.org/W2218173600","https://openalex.org/W2340263198"],"abstract_inverted_index":{"There":[0],"is":[1,7,16,108],"growing":[2],"evidence":[3],"that":[4],"molecular":[5,53,77],"testing":[6],"feasible":[8],"on":[9],"all":[10],"types":[11],"of":[12,52,68,101],"cytological":[13],"preparation,":[14],"which":[15,84],"fortunate":[17],"as":[18],"more":[19],"diagnostic":[20,56],"markers":[21,59],"and":[22,33,45,57,62,73,103],"biomarkers":[23],"for":[24,29,49,55,98],"targeted":[25],"therapies":[26],"are":[27,70,85],"discovered":[28],"use":[30],"in":[31,60,110],"pulmonary":[32],"pleural":[34,63],"malignancies.":[35],"In":[36],"this":[37],"article":[38],"we":[39],"will":[40],"discuss":[41],"the":[42,111],"pre-analytic,":[43],"analytic,":[44],"post-analytic":[46],"(interpretive)":[47],"considerations":[48],"successful":[50],"implementation":[51],"tests":[54],"predictive":[58],"respiratory":[61],"cytology.":[64],"The":[65],"vast":[66],"majority":[67],"laboratories":[69],"familiar":[71],"with,":[72],"have":[74],"validated":[75],"their":[76],"protocols":[78],"for,":[79],"formalin-fixed":[80],"paraffin-embedded":[81],"surgical":[82],"specimens,":[83],"not":[86],"directly":[87],"applicable":[88],"to":[89],"cytology":[90,104],"specimens.":[91],"Thus,":[92],"rigorous":[93],"validation":[94],"must":[95],"be":[96],"performed":[97],"each":[99],"type":[100],"fixative":[102],"preparation":[105],"before":[106],"it":[107],"implemented":[109],"clinical":[112],"setting.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-16T00:00:00"}
