{"id":"https://openalex.org/W3192546495","doi":"https://doi.org/10.1021/acs.jafc.1c01651","title":"Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound","display_name":"Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound","publication_year":2021,"publication_date":"2021-08-06","ids":{"openalex":"https://openalex.org/W3192546495","doi":"https://doi.org/10.1021/acs.jafc.1c01651","mag":"3192546495","pmid":"https://pubmed.ncbi.nlm.nih.gov/34355907"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.1c01651","doi":"https://doi.org/10.1021/acs.jafc.1c01651","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.1c01651","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101512193","display_name":"Weibo Wang","orcid":"https://orcid.org/0000-0001-7516-4999","observed_orcids":["https://orcid.org/0000-0001-7516-4999"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weibo Wang","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-7516-4999","affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038467333","display_name":"Zhixinyi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixinyi Li","raw_affiliation_strings":["School of Medicine, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044750171","display_name":"Wei Gao","orcid":"https://orcid.org/0000-0002-6301-2055","observed_orcids":["https://orcid.org/0000-0002-6301-2055"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Gao","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101515197","display_name":"Xiaoyu Liu","orcid":"https://orcid.org/0000-0003-1072-7695","observed_orcids":["https://orcid.org/0000-0003-1072-7695"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Liu","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061488332","display_name":"You Lv","orcid":"https://orcid.org/0000-0002-9586-9504","observed_orcids":["https://orcid.org/0000-0002-9586-9504"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"You Lv","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-9586-9504","affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040480940","display_name":"Zesheng Hao","orcid":"https://orcid.org/0000-0002-8460-4076","observed_orcids":["https://orcid.org/0000-0002-8460-4076"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zesheng Hao","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109938001","display_name":"Liang\u2010Fu Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangfu Tang","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783570","display_name":"Kun Li","orcid":"https://orcid.org/0009-0003-0039-7167","observed_orcids":["https://orcid.org/0009-0003-0039-7167"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Li","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619509","display_name":"Bin Zhao","orcid":"https://orcid.org/0000-0002-0383-097X","observed_orcids":["https://orcid.org/0000-0002-0383-097X"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Zhao","raw_affiliation_strings":["State Key Laboratory of North China Crop Improvement and Regulation, College of Plant Protection, Hebei Agricultural University, Baoding 071001, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-0383-097X","affiliations":[{"raw_affiliation_string":"State Key Laboratory of North China Crop Improvement and Regulation, College of Plant Protection, Hebei Agricultural University, Baoding 071001, P. R. China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044916751","display_name":"Zhijin Fan","orcid":"https://orcid.org/0000-0001-5565-0949","observed_orcids":["https://orcid.org/0000-0001-5565-0949"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhijin Fan","raw_affiliation_strings":["Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-5565-0949","affiliations":[{"raw_affiliation_string":"Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044916751","https://openalex.org/A5101619509"],"corresponding_institution_ids":["https://openalex.org/I108160477","https://openalex.org/I205237279"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.4696,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88429935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"69","issue":"32","first_page":"9461","last_page":"9471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyruvate-kinase","display_name":"pyruvate kinase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fungicide-targets","display_name":"fungicide targets","score":0.5600000023841858},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.6259999871253967},{"id":"https://openalex.org/keywords/rhizoctonia-solani","display_name":"Rhizoctonia solani","score":0.9810000061988831},{"id":"https://openalex.org/keywords/fusarium-graminearum","display_name":"Fusarium graminearum","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erysiphe-graminis","display_name":"Erysiphe graminis","score":0.953000009059906},{"id":"https://openalex.org/keywords/puccinia-sorghi","display_name":"Puccinia sorghi","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6690000295639038},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lead-compound-design","display_name":"lead compound design","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2781209517","wikidata":"https://www.wikidata.org/wiki/Q419746","display_name":"Isothiazole","level":2,"score":0.8268758058547974},{"id":"https://openalex.org/C96529984","wikidata":"https://www.wikidata.org/wiki/Q286136","display_name":"EC50","level":3,"score":0.6844576597213745},{"id":"https://openalex.org/C74600772","wikidata":"https://www.wikidata.org/wiki/Q193237","display_name":"Fungicide","level":2,"score":0.6727811098098755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5604767799377441},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.5573997497558594},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4828232228755951},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.43364065885543823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36970192193984985},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3692418038845062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27941471338272095},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20604059100151062},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1197618842124939},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07833713293075562},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005659","descriptor_name":"Fungicides, Industrial","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012232","descriptor_name":"Rhizoctonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jafc.1c01651","doi":"https://doi.org/10.1021/acs.jafc.1c01651","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.1c01651","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:34355907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34355907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.8409000039100647,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2154124006","display_name":null,"funder_award_id":"2014DFR41030","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G2231100927","display_name":null,"funder_award_id":"2017YFD0200900","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G309827326","display_name":null,"funder_award_id":"31872007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8476429284","display_name":null,"funder_award_id":"63181206","funder_id":"https://openalex.org/F4320323021","funder_display_name":"Nankai University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320323021","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1988980906","https://openalex.org/W2015207840","https://openalex.org/W2024268390","https://openalex.org/W2027769989","https://openalex.org/W2059893123","https://openalex.org/W2060306923","https://openalex.org/W2064006868","https://openalex.org/W2080563337","https://openalex.org/W2794661192","https://openalex.org/W2798031953","https://openalex.org/W2806920091","https://openalex.org/W2808757592","https://openalex.org/W2897513885","https://openalex.org/W2909113377","https://openalex.org/W2914347154","https://openalex.org/W2944045222","https://openalex.org/W2944654484","https://openalex.org/W2953017343","https://openalex.org/W2973072453","https://openalex.org/W2997424853","https://openalex.org/W3033500969","https://openalex.org/W3034234040","https://openalex.org/W3046265732","https://openalex.org/W3084682077","https://openalex.org/W3086320945","https://openalex.org/W3099793945","https://openalex.org/W3121755650","https://openalex.org/W3129025318","https://openalex.org/W3155872970","https://openalex.org/W4232855613","https://openalex.org/W4254101593"],"related_works":["https://openalex.org/W4406088229","https://openalex.org/W4206954751","https://openalex.org/W4290844489","https://openalex.org/W4220831271","https://openalex.org/W2897513885","https://openalex.org/W2017672395","https://openalex.org/W4408026260","https://openalex.org/W4397022322","https://openalex.org/W2902629722","https://openalex.org/W3150463372"],"abstract_inverted_index":{"Target":[0],"identification":[1],"is":[2],"one":[3],"of":[4,59,67,75,88,122,167,179,195,208],"the":[5,29,176,180],"most":[6],"important":[7],"bases":[8],"for":[9],"novel":[10,33],"pesticide":[11],"development;":[12],"pyruvate":[13],"kinase":[14],"(PK)":[15],"was":[16,63,172,185],"discovered":[17,200],"as":[18],"a":[19],"potent":[20],"fungicide":[21,31],"target":[22,181],"in":[23,49,130],"our":[24],"previous":[25],"studies.":[26],"To":[27],"continue":[28],"PK-based":[30,79,204],"development,":[32],"isothiazole-purine":[34],"derivatives":[35],"were":[36,203],"rationally":[37],"designed":[38],"and":[39,78,95,113,136,146,170],"synthesized.":[40],"Bioassay":[41],"results":[42],"showed":[43,118,158],"that":[44,201],"compound":[45],"5ai":[46,157],"displayed":[47,99],"excellent":[48],"vitro":[50],"activity":[51,132,162],"against":[52,102,133,152],"Rhizoctonia":[53],"solani":[54],"with":[55,71,84,105,140,163,191],"an":[56,119,164],"EC":[57,73,86,107,120],"50":[58,74,87,108,121,166,194],"1.5":[60],"\u03bcg/mL,":[61,115],"which":[62,184],"superior":[64],"to":[65],"those":[66],"positive":[68],"controls":[69],"diflumetorim":[70],"its":[72,85,192],"19.8":[76],"\u03bcg/mL":[77,145,151],"lead":[80],"YZK":[81],"-":[82],"C22":[83],"4.2":[89],"\u03bcg/mL.":[90,124],"Compounds":[91],"3b":[92],"(5.2":[93],"\u03bcg/mL)":[94,98],"3c":[96],"(4.5":[97],"better":[100],"activities":[101],"Gibberella":[103],"zeae":[104],"their":[106],"s":[109],"falling":[110],"between":[111],"4.0":[112],"5.5":[114],"while":[116],"YZK-C22":[117,190],"6.4":[123],"In":[125],"addition,":[126],"5ah":[127],"exhibited":[128],"promising":[129],"vivo":[131],"Erysiphe":[134],"graminis":[135],"Puccinia":[137],"sorghi":[138,154],"Schw.":[139,155],"100%":[141],"efficacy":[142,148],"at":[143,149],"10":[144],"90%":[147],"2":[150],"P.":[153],"Compound":[156],"good":[159],"PK":[160],"inhibitory":[161],"IC":[165,193],"38.8":[168],"\u03bcmol/L,":[169],"it":[171],"well":[173],"docked":[174],"into":[175],"active":[177,188],"site":[178],"enzyme":[182],"PK,":[183],"slightly":[186],"more":[187],"than":[189],"42.4":[196],"\u03bcmol/L.":[197],"Our":[198],"studies":[199],"isothiazole-purines":[202],"fungicidal":[205],"leads":[206],"deserving":[207],"further":[209],"study.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-08-16T00:00:00"}