{"id":"https://openalex.org/W3192486404","doi":"https://doi.org/10.1016/j.coph.2021.06.012","title":"Systems modeling of metabolic dysregulation in neurodegenerative diseases","display_name":"Systems modeling of metabolic dysregulation in neurodegenerative diseases","publication_year":2021,"publication_date":"2021-08-02","ids":{"openalex":"https://openalex.org/W3192486404","doi":"https://doi.org/10.1016/j.coph.2021.06.012","mag":"3192486404","pmid":"https://pubmed.ncbi.nlm.nih.gov/34352486","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8511060"},"language":"en","primary_location":{"id":"doi:10.1016/j.coph.2021.06.012","doi":"https://doi.org/10.1016/j.coph.2021.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2021.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8511060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047843839","display_name":"Priyanka Baloni","orcid":"https://orcid.org/0000-0002-3382-4941","observed_orcids":["https://orcid.org/0000-0002-3382-4941"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Baloni","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3382-4941","affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085629786","display_name":"Cory C. Funk","orcid":"https://orcid.org/0000-0002-5229-9011","observed_orcids":["https://orcid.org/0000-0002-5229-9011"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory C. Funk","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5229-9011","affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013411206","display_name":"Ben Readhead","orcid":"https://orcid.org/0000-0003-4353-9965","observed_orcids":["https://orcid.org/0000-0003-4353-9965"]},"institutions":[{"id":"https://openalex.org/I4405266904","display_name":"Thorne HealthTech, Inc. (United States)","ror":"https://ror.org/00a0rwr60","country_code":"US","type":"company","lineage":["https://openalex.org/I4405266904"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Readhead","raw_affiliation_strings":["Onegevity, a Division of Thorne HealthTech, New York, NY, USA; Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA","Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA","Onegevity, a Division of Thorne HealthTech, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-4353-9965","affiliations":[{"raw_affiliation_string":"Onegevity, a Division of Thorne HealthTech, New York, NY, USA; Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA","institution_ids":["https://openalex.org/I4405266904","https://openalex.org/I55732556"]},{"raw_affiliation_string":"Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Onegevity, a Division of Thorne HealthTech, New York, NY, USA","institution_ids":["https://openalex.org/I4405266904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034589050","display_name":"Nathan D. Price","orcid":"https://orcid.org/0000-0002-4157-0267","observed_orcids":["https://orcid.org/0000-0002-4157-0267"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4405266904","display_name":"Thorne HealthTech, Inc. (United States)","ror":"https://ror.org/00a0rwr60","country_code":"US","type":"company","lineage":["https://openalex.org/I4405266904"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathan D. Price","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, USA; Onegevity, a Division of Thorne HealthTech, New York, NY, USA. Electronic address: nathan.price@isbscience.org","Institute for Systems Biology, Seattle, WA, USA","Onegevity, a Division of Thorne HealthTech, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA; Onegevity, a Division of Thorne HealthTech, New York, NY, USA. Electronic address: nathan.price@isbscience.org","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I4405266904"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Onegevity, a Division of Thorne HealthTech, New York, NY, USA","institution_ids":["https://openalex.org/I4405266904"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034589050"],"corresponding_institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I4405266904"],"apc_list":{"value":3210,"currency":"USD","value_usd":3210},"apc_paid":null,"fwci":0.262,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.21956712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"60","issue":null,"first_page":"59","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2793000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":1.0},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genome-scale-metabolic-models","display_name":"genome-scale metabolic models","score":0.9729999899864197},{"id":"https://openalex.org/keywords/network-approach","display_name":"network approach","score":0.7129999995231628},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8949999809265137},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.7889999747276306},{"id":"https://openalex.org/keywords/in-silico-modeling","display_name":"in silico modeling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.7710000276565552},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7639999985694885},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9610000252723694},{"id":"https://openalex.org/keywords/disease-pathophysiology","display_name":"disease pathophysiology","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7253595590591431},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6196675300598145},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5341856479644775},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5238621234893799},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.4371614456176758},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42801859974861145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41803786158561707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3483428955078125},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3217421770095825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09461197257041931},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07680609822273254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.coph.2021.06.012","doi":"https://doi.org/10.1016/j.coph.2021.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2021.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},{"id":"pmid:34352486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34352486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8511060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8511060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8511060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8511060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1668898329","display_name":"Metabolic Network Analysis of Biochemical Trajectories in Alzheimer's Disease","funder_award_id":"RF1AG057452","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G242391869","display_name":"Integrated understanding of complex viral network biology in Alzheimer's Disease","funder_award_id":"RF1AG058469","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5210324727","display_name":"Identification of the genetic and transcriptomic networks of cognitive and neuropathological resilience to Alzheimer\u00c3\u00a2\u00c2\u0080\u00c2\u0099s disease associated viruses","funder_award_id":"U01AG061835","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5491362581","display_name":"SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)","funder_award_id":"RF1AG059319","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5909743191","display_name":"Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD","funder_award_id":"U01AG061359","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7530966857","display_name":"A Systems Approach to Targeting Innate Immunity in AD","funder_award_id":"U01AG046139","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7642859251","display_name":"Harnessing Molecular Networks of Resilience for Therapeutic Discoveries in AD","funder_award_id":"R01AG061796","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8077927406","display_name":"Modulation of Alzheimers disease by Herpes simplex virus infection\u00a0","funder_award_id":"R01AG062514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8788198978","display_name":"Investigation of chromosomally integrated Human Herpesvirus 6 as a risk factor for Alzheimer's disease","funder_award_id":"R21AG063068","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W2069652505","https://openalex.org/W2070925211","https://openalex.org/W2124481332","https://openalex.org/W2128776645","https://openalex.org/W2142430469","https://openalex.org/W2170974939","https://openalex.org/W2319949533","https://openalex.org/W2433831087","https://openalex.org/W2465261455","https://openalex.org/W2499550905","https://openalex.org/W2533189950","https://openalex.org/W2549856864","https://openalex.org/W2556383887","https://openalex.org/W2586955604","https://openalex.org/W2634812549","https://openalex.org/W2746640787","https://openalex.org/W2762019694","https://openalex.org/W2786608785","https://openalex.org/W2790008564","https://openalex.org/W2794227656","https://openalex.org/W2806146174","https://openalex.org/W2808994158","https://openalex.org/W2810164974","https://openalex.org/W2811255424","https://openalex.org/W2886367104","https://openalex.org/W2897346149","https://openalex.org/W2899506695","https://openalex.org/W2903267043","https://openalex.org/W2903687253","https://openalex.org/W2937307539","https://openalex.org/W2948674477","https://openalex.org/W2949125436","https://openalex.org/W2951171318","https://openalex.org/W2952015518","https://openalex.org/W2952288446","https://openalex.org/W2966476674","https://openalex.org/W2972368830","https://openalex.org/W2979519350","https://openalex.org/W2981449190","https://openalex.org/W2996164725","https://openalex.org/W3008786370","https://openalex.org/W3033892147","https://openalex.org/W3036619794","https://openalex.org/W3040900020","https://openalex.org/W3047197192","https://openalex.org/W3048036301","https://openalex.org/W3059136655","https://openalex.org/W3087094819","https://openalex.org/W3093298383","https://openalex.org/W3095321129","https://openalex.org/W3099584915","https://openalex.org/W3101637373","https://openalex.org/W3103161857","https://openalex.org/W3107836337","https://openalex.org/W3110796948","https://openalex.org/W3113667044","https://openalex.org/W3118582440","https://openalex.org/W3118773559","https://openalex.org/W3130727496","https://openalex.org/W3157186248","https://openalex.org/W4211238543","https://openalex.org/W4238443188","https://openalex.org/W6783047519","https://openalex.org/W6786044658"],"related_works":["https://openalex.org/W2895875447","https://openalex.org/W7203903423","https://openalex.org/W4416232041","https://openalex.org/W1945853828","https://openalex.org/W1987335374","https://openalex.org/W4399755700","https://openalex.org/W3026287029","https://openalex.org/W4238089770","https://openalex.org/W2883647943","https://openalex.org/W7204831154"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-16T00:00:00"}