{"id":"https://openalex.org/W3191542811","doi":"https://doi.org/10.3126/jbsfn.v2i1.39000","title":"Role of Natalizumab in Relapsing-Remitting Multiple Sclerosis: A review","display_name":"Role of Natalizumab in Relapsing-Remitting Multiple Sclerosis: A review","publication_year":2021,"publication_date":"2021-08-10","ids":{"openalex":"https://openalex.org/W3191542811","doi":"https://doi.org/10.3126/jbsfn.v2i1.39000","mag":"3191542811"},"language":"en","primary_location":{"id":"doi:10.3126/jbsfn.v2i1.39000","doi":"https://doi.org/10.3126/jbsfn.v2i1.39000","is_oa":true,"landing_page_url":"https://doi.org/10.3126/jbsfn.v2i1.39000","pdf_url":"https://www.nepjol.info/index.php/jbsfn/article/download/39000/29892","source":{"id":"https://openalex.org/S4210211372","display_name":"Journal of Brain and Spine Foundation Nepal","issn_l":"2738-9561","issn":["2738-9561","2738-960X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Brain and Spine Foundation Nepal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.nepjol.info/index.php/jbsfn/article/download/39000/29892","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055885965","display_name":"Anuj Krishna Paudel","orcid":"https://orcid.org/0000-0003-1321-7658","observed_orcids":["https://orcid.org/0000-0003-1321-7658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anuj Krishna Paudel","raw_affiliation_strings":["Metrocity Hospital and Research Center, Pokhara, Nepal"],"raw_orcid":"https://orcid.org/0000-0003-1321-7658","affiliations":[{"raw_affiliation_string":"Metrocity Hospital and Research Center, Pokhara, Nepal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020692340","display_name":"Sanjiv Bastakoti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjiv Bastakoti","raw_affiliation_strings":["Arughat Hospital, Gorkha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arughat Hospital, Gorkha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051775630","display_name":"Nitesh Raj Dulal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nitesh Raj Dulal","raw_affiliation_strings":["Bharatpur District Hospital, Bharatpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bharatpur District Hospital, Bharatpur","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022314595","display_name":"Gunja Piya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802686301","display_name":"College of Medical Sciences","ror":"https://ror.org/01f4y0525","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2802686301"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Gunja Piya","raw_affiliation_strings":["College of Medical Sciences, Bharatpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical Sciences, Bharatpur","institution_ids":["https://openalex.org/I2802686301"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037405432","display_name":"Sashi Bhusan Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154879","display_name":"KIST Medical College","ror":"https://ror.org/04zz3m093","country_code":"NP","type":"education","lineage":["https://openalex.org/I4210154879"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Sashi Bhusan Singh","raw_affiliation_strings":["KIST Medical College and Teaching Hospital, Kathmandu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KIST Medical College and Teaching Hospital, Kathmandu","institution_ids":["https://openalex.org/I4210154879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":"2","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natalizumab","display_name":"natalizumab","score":1.0},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lymphocyte-adhesion","display_name":"lymphocyte adhesion","score":0.5730000138282776},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9810000061988831},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.7620000243186951},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.921999990940094},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6439999938011169},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2781004633","wikidata":"https://www.wikidata.org/wiki/Q386119","display_name":"Natalizumab","level":3,"score":0.9888941049575806},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.9256701469421387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8590222597122192},{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.8395681381225586},{"id":"https://openalex.org/C3020694758","wikidata":"https://www.wikidata.org/wiki/Q42417392","display_name":"Relapsing remitting","level":3,"score":0.49989914894104004},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.4711246192455292},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.43798407912254333},{"id":"https://openalex.org/C2778583010","wikidata":"https://www.wikidata.org/wiki/Q3237081","display_name":"Leukoencephalopathy","level":3,"score":0.437073677778244},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37914174795150757},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2735779881477356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25378966331481934},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09405416250228882}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3126/jbsfn.v2i1.39000","doi":"https://doi.org/10.3126/jbsfn.v2i1.39000","is_oa":true,"landing_page_url":"https://doi.org/10.3126/jbsfn.v2i1.39000","pdf_url":"https://www.nepjol.info/index.php/jbsfn/article/download/39000/29892","source":{"id":"https://openalex.org/S4210211372","display_name":"Journal of Brain and Spine Foundation Nepal","issn_l":"2738-9561","issn":["2738-9561","2738-960X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Brain and Spine Foundation Nepal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3126/jbsfn.v2i1.39000","doi":"https://doi.org/10.3126/jbsfn.v2i1.39000","is_oa":true,"landing_page_url":"https://doi.org/10.3126/jbsfn.v2i1.39000","pdf_url":"https://www.nepjol.info/index.php/jbsfn/article/download/39000/29892","source":{"id":"https://openalex.org/S4210211372","display_name":"Journal of Brain and Spine Foundation Nepal","issn_l":"2738-9561","issn":["2738-9561","2738-960X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Brain and Spine Foundation Nepal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3191542811.pdf","grobid_xml":"https://content.openalex.org/works/W3191542811.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1895561430","https://openalex.org/W1970702615","https://openalex.org/W1995385281","https://openalex.org/W2011257051","https://openalex.org/W2011500179","https://openalex.org/W2012420334","https://openalex.org/W2019582599","https://openalex.org/W2044022462","https://openalex.org/W2050919205","https://openalex.org/W2054459929","https://openalex.org/W2073757924","https://openalex.org/W2103758700","https://openalex.org/W2105159132","https://openalex.org/W2106747769","https://openalex.org/W2108212495","https://openalex.org/W2281748493","https://openalex.org/W2337953242","https://openalex.org/W2460433998","https://openalex.org/W2524779870","https://openalex.org/W2650093893","https://openalex.org/W2691302834","https://openalex.org/W2728662268","https://openalex.org/W2923273291","https://openalex.org/W2932465897","https://openalex.org/W2964648183","https://openalex.org/W2973164339","https://openalex.org/W2990338348","https://openalex.org/W6685083576"],"related_works":["https://openalex.org/W1996512360","https://openalex.org/W2010823833","https://openalex.org/W2113288736","https://openalex.org/W2462850731","https://openalex.org/W2650093893","https://openalex.org/W2084518230","https://openalex.org/W2027769620","https://openalex.org/W2997592964","https://openalex.org/W2470605326","https://openalex.org/W4408376854"],"abstract_inverted_index":{"Introduction:":[0],"Multiple":[1],"sclerosis":[2,29],"is":[3,49,172,201],"a":[4,15,50,158],"non-traumatic":[5],"neurological":[6],"disease":[7,40,151],"caused":[8],"by":[9,55],"an":[10],"immune-mediated":[11],"reaction":[12],"leading":[13],"to":[14,79],"chronic":[16],"inflammatory":[17],"demyelinating":[18],"disorder":[19],"of":[20,37,59,64,85,146,149,174,179,203,208],"the":[21,57,62,65,72,81,113,144,150,175,204],"central":[22,73],"nervous":[23,74],"system.":[24,75],"The":[25,92,117,137,182],"treatments":[26],"for":[27],"multiple":[28,89,128,166,195],"are":[30],"mainly":[31],"divided":[32],"into":[33,61,71],"three":[34],"categories:":[35],"treatment":[36],"exacerbation,":[38],"slowing":[39],"progression":[41,148],"with":[42,157,164,193],"disease-modifying":[43],"therapies,":[44],"and":[45,83,152,154],"symptomatic":[46],"therapies.":[47],"Natalizumab":[48,187],"monoclonal":[51],"antibody":[52],"that":[53,141,186],"works":[54],"preventing":[56],"adhesion":[58],"lymphocytes":[60],"endothelium":[63],"blood-brain":[66],"barrier,":[67],"reducing":[68],"lymphocyte":[69],"infiltration":[70],"This":[76],"review":[77,93,139,184],"aims":[78],"study":[80],"efficacy":[82],"safety":[84],"natalizumab":[86,142],"in":[87,133,162,191],"relapsing-remitting":[88,165,194],"sclerosis.":[90,167,196],"Methods:":[91],"was":[94,155],"performed":[95],"using":[96],"databases":[97],"like":[98],"PubMed,":[99],"Cochrane":[100],"library,":[101],"Google":[102],"scholar":[103],"from":[104],"which":[105],"48":[106],"relevant":[107],"articles":[108],"were":[109,120],"selected":[110],"based":[111],"on":[112],"various":[114],"inclusion":[115],"criteria.":[116],"following":[118],"keywords":[119],"used:":[121],"\u201cNatalizumab\u201d,":[122],"\u201cMultiple":[123],"sclerosis\u201d,":[124,129],"\u201cside":[125],"effects\u201d,":[126],"\u201cRelapsing-remitting":[127],"\u201cprogressive":[130],"multifocal":[131,170,199],"leukoencephalopathy\u201d":[132],"different":[134],"combinations.":[135],"Results:":[136],"literature":[138,183],"suggests":[140,185],"reduces":[143],"rate":[145,161],"sustained":[147],"disability,":[153],"associated":[156],"lower":[159],"relapse":[160],"patients":[163,192],"However,":[168],"Progressive":[169],"leukoencephalopathy":[171,200],"one":[173,202],"serious":[176,205],"side":[177,206],"effects":[178,207],"natalizumab.":[180],"Conclusion:":[181],"has":[188],"favorable":[189],"outcomes":[190],"Since":[197],"progressive":[198],"natalizumab,":[209],"risk":[210],"stratification":[211],"should":[212],"be":[213],"done.":[214]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-16T00:00:00"}