{"id":"https://openalex.org/W3191087331","doi":"https://doi.org/10.3389/fcell.2021.676910","title":"Essential Role of CFAP53 in Sperm Flagellum Biogenesis","display_name":"Essential Role of CFAP53 in Sperm Flagellum Biogenesis","publication_year":2021,"publication_date":"2021-05-28","ids":{"openalex":"https://openalex.org/W3191087331","doi":"https://doi.org/10.3389/fcell.2021.676910","mag":"3191087331","pmid":"https://pubmed.ncbi.nlm.nih.gov/34124066","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8195676"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2021.676910","doi":"https://doi.org/10.3389/fcell.2021.676910","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.676910","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.676910/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.676910/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043936197","display_name":"Bingbing Wu","orcid":"https://orcid.org/0000-0001-9269-4414","observed_orcids":["https://orcid.org/0000-0001-9269-4414"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4210167311","display_name":"Institute of Zoology","ror":"https://ror.org/05skxkv18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]},{"id":"https://openalex.org/I4391767720","display_name":"State Key Laboratory of Stem Cell and Reproductive Biology","ror":"https://ror.org/00eeef580","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingbing Wu","raw_affiliation_strings":["College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China","State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China","College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]},{"raw_affiliation_string":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108125487","display_name":"Xiaochen Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaochen Yu","raw_affiliation_strings":["Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, Shandong, 250012, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China","Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, Shandong, 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China","institution_ids":[]},{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362936","display_name":"Chao Liu","orcid":"https://orcid.org/0000-0002-8844-0697","observed_orcids":["https://orcid.org/0000-0002-8844-0697"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210167311","display_name":"Institute of Zoology","ror":"https://ror.org/05skxkv18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]},{"id":"https://openalex.org/I4391767720","display_name":"State Key Laboratory of Stem Cell and Reproductive Biology","ror":"https://ror.org/00eeef580","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Liu","raw_affiliation_strings":["State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China","State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]},{"raw_affiliation_string":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385962","display_name":"Lina Wang","orcid":"https://orcid.org/0009-0002-8518-8032","observed_orcids":["https://orcid.org/0009-0002-8518-8032"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210144404","display_name":"Beijing Children\u2019s Hospital","ror":"https://ror.org/04skmn292","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Wang","raw_affiliation_strings":["China National Clinical Research Center of Respiratory Diseases; Respiratory Department of Beijing Children\u2019s Hospital, Capital Medical University; National Center for Children\u2019s Health, China","Department of Respiratory Medicine, National Clinical Research Center of Respiratory Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Clinical Research Center of Respiratory Diseases; Respiratory Department of Beijing Children\u2019s Hospital, Capital Medical University; National Center for Children\u2019s Health, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210144404"]},{"raw_affiliation_string":"Department of Respiratory Medicine, National Clinical Research Center of Respiratory Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210144404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038436626","display_name":"Tao Huang","orcid":"https://orcid.org/0000-0002-7086-570X","observed_orcids":["https://orcid.org/0000-0002-7086-570X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Huang","raw_affiliation_strings":["Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, Shandong, 250012, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China","Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, Shandong, 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China","institution_ids":[]},{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057444662","display_name":"Gang L\u00fc","orcid":"https://orcid.org/0000-0001-5921-1839","observed_orcids":["https://orcid.org/0000-0001-5921-1839"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Gang Lu","raw_affiliation_strings":["CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong","Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108064842","display_name":"Zi\u2010Jiang Chen","orcid":"https://orcid.org/0000-0001-6637-6631","observed_orcids":["https://orcid.org/0000-0001-6637-6631"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Zi-Jiang Chen","raw_affiliation_strings":["CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong","Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318238","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-6235-0749","observed_orcids":["https://orcid.org/0000-0002-6235-0749"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4210167311","display_name":"Institute of Zoology","ror":"https://ror.org/05skxkv18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]},{"id":"https://openalex.org/I4391767720","display_name":"State Key Laboratory of Stem Cell and Reproductive Biology","ror":"https://ror.org/00eeef580","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Li","raw_affiliation_strings":["College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China","State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China","College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-6235-0749","affiliations":[{"raw_affiliation_string":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]},{"raw_affiliation_string":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311","https://openalex.org/I4391767720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065500318","display_name":"Hongbin Liu","orcid":"https://orcid.org/0000-0003-2550-7492","observed_orcids":["https://orcid.org/0000-0003-2550-7492"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Hongbin Liu","raw_affiliation_strings":["CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong","Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","Shandong Key Laboratory of Reproductive Medicine, Jinan, China","Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Key laboratory of Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong Key Laboratory of Reproductive Medicine, Jinan, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5065500318","https://openalex.org/A5100318238"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I177725633","https://openalex.org/I19820366","https://openalex.org/I4210165038","https://openalex.org/I4210167311","https://openalex.org/I4391767720"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":6.9082,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.97954456,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"676910","last_page":"676910"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermiogenesis","display_name":"spermiogenesis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/manchette","display_name":"manchette","score":0.8899999856948853},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.8180000185966492},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.4519999921321869},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6100000143051147},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.9931986331939697},{"id":"https://openalex.org/C2778619154","wikidata":"https://www.wikidata.org/wiki/Q3493046","display_name":"Spermiogenesis","level":3,"score":0.8023444414138794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7689186334609985},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.6780432462692261},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.6468413472175598},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5887780785560608},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5472478866577148},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.5274401307106018},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.511776864528656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4010826349258423},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.30123376846313477},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2021.676910","doi":"https://doi.org/10.3389/fcell.2021.676910","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.676910","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.676910/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2021.02.04.429673","doi":"https://doi.org/10.1101/2021.02.04.429673","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.02.04.429673","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/02/04/2021.02.04.429673.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8195676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8195676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:34124066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34124066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5cba73423119405292541facfe0f2863","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5cba73423119405292541facfe0f2863","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2021.676910","doi":"https://doi.org/10.3389/fcell.2021.676910","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.676910","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.676910/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2841764129","display_name":null,"funder_award_id":"XDA16020701","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4537060995","display_name":null,"funder_award_id":"81925015","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6632015078","display_name":null,"funder_award_id":"XDA16020701","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320326880","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210"},{"id":"https://openalex.org/F4320335645","display_name":"Institute of Zoology, Chinese Academy of Sciences","ror":"https://ror.org/05skxkv18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3191087331.pdf","grobid_xml":"https://content.openalex.org/works/W3191087331.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1564068567","https://openalex.org/W1574791786","https://openalex.org/W1914681604","https://openalex.org/W1967600199","https://openalex.org/W1973200084","https://openalex.org/W1973632178","https://openalex.org/W1997381325","https://openalex.org/W2008293557","https://openalex.org/W2014623841","https://openalex.org/W2039186803","https://openalex.org/W2062594942","https://openalex.org/W2069548461","https://openalex.org/W2072278366","https://openalex.org/W2074793941","https://openalex.org/W2124608202","https://openalex.org/W2126879318","https://openalex.org/W2136639827","https://openalex.org/W2152931318","https://openalex.org/W2156060190","https://openalex.org/W2159778526","https://openalex.org/W2184272884","https://openalex.org/W2195069967","https://openalex.org/W2277698104","https://openalex.org/W2291532532","https://openalex.org/W2518975446","https://openalex.org/W2524643649","https://openalex.org/W2533955468","https://openalex.org/W2588077108","https://openalex.org/W2617398306","https://openalex.org/W2752455371","https://openalex.org/W2755934757","https://openalex.org/W2782108629","https://openalex.org/W2783709319","https://openalex.org/W2787552855","https://openalex.org/W2791358533","https://openalex.org/W2794917660","https://openalex.org/W2883636371","https://openalex.org/W2888673899","https://openalex.org/W2890763910","https://openalex.org/W2897434931","https://openalex.org/W2900569176","https://openalex.org/W2916416419","https://openalex.org/W2933180953","https://openalex.org/W2943756277","https://openalex.org/W2944835126","https://openalex.org/W2952740887","https://openalex.org/W2955895400","https://openalex.org/W2962711399","https://openalex.org/W2973155278","https://openalex.org/W2981311269","https://openalex.org/W2982167912","https://openalex.org/W2984206624","https://openalex.org/W2989498024","https://openalex.org/W2989859078","https://openalex.org/W2995704318","https://openalex.org/W3000595084","https://openalex.org/W3002750325","https://openalex.org/W3003912000","https://openalex.org/W3005977348","https://openalex.org/W3016314448","https://openalex.org/W3038657332","https://openalex.org/W3048729698","https://openalex.org/W3095999021","https://openalex.org/W3114950737","https://openalex.org/W3116795805","https://openalex.org/W3191087331","https://openalex.org/W4286855125"],"related_works":["https://openalex.org/W3002750325","https://openalex.org/W2617398306","https://openalex.org/W7215867748","https://openalex.org/W3091831670","https://openalex.org/W4378070379","https://openalex.org/W7117476097","https://openalex.org/W3181007691","https://openalex.org/W2794917660","https://openalex.org/W2897434931","https://openalex.org/W2069548461"],"abstract_inverted_index":{"Abstract":[0],"The":[1,59,109],"sperm":[2,56,82,100,138],"flagellum":[3,28,57,92,139],"is":[4,46,53,133],"essential":[5,54,135],"for":[6,55,137],"male":[7,69],"fertility.":[8],"Despite":[9],"vigorous":[10],"research":[11],"progress":[12],"towards":[13],"understanding":[14],"the":[15,24,27,35,74,79,86,114],"pathogenesis":[16],"of":[17,61,88,111,117],"flagellum-related":[18],"diseases,":[19],"much":[20],"remains":[21],"unknown":[22],"about":[23],"mechanisms":[25],"underlying":[26],"biogenesis":[29],"itself.":[30],"Here,":[31],"we":[32,95],"show":[33],"that":[34,103,131],"cilia":[36],"and":[37,51,81,99,121,141],"flagella":[38],"associated":[39,146],"protein":[40,136],"53":[41],"(":[42],"Cfap53":[43,112],")":[44],"gene":[45,63,90],"predominantly":[47],"expressed":[48],"in":[49,65,68,73,125],"testes,":[50],"it":[52],"biogenesis.":[58,93],"knockout":[60,87],"this":[62,89],"resulted":[64],"complete":[66],"infertility":[67],"mice":[70],"but":[71],"not":[72],"females.":[75],"CFAP53":[76,106,132],"localized":[77],"to":[78],"manchette":[80,98],"tail":[83],"during":[84,107],"spermiogenesis,":[85],"impaired":[91],"Furthermore,":[94],"identified":[96],"two":[97,119],"tail-associated":[101],"proteins":[102,120],"interacted":[104],"with":[105,147],"spermiogenesis.":[108],"disruption":[110],"decreased":[113],"expression":[115],"level":[116],"these":[118],"disrupted":[122],"their":[123],"localization":[124],"spermatids.":[126],"Together,":[127],"our":[128],"results":[129],"suggest":[130],"an":[134],"biogenesis,":[140],"its":[142],"mutations":[143],"might":[144],"be":[145],"MMAF.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-08-16T00:00:00"}