{"id":"https://openalex.org/W3191031280","doi":"https://doi.org/10.1080/21505594.2021.1935613","title":"Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2","display_name":"Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2","publication_year":2021,"publication_date":"2021-08-02","ids":{"openalex":"https://openalex.org/W3191031280","doi":"https://doi.org/10.1080/21505594.2021.1935613","mag":"3191031280","pmid":"https://pubmed.ncbi.nlm.nih.gov/34338586","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8331042"},"language":"en","primary_location":{"id":"doi:10.1080/21505594.2021.1935613","doi":"https://doi.org/10.1080/21505594.2021.1935613","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21505594.2021.1935613","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1935613?needAccess=true","source":{"id":"https://openalex.org/S2484688887","display_name":"Virulence","issn_l":"2150-5594","issn":["2150-5594","2150-5608"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virulence","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1935613?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036810939","display_name":"Elisa Fanunza","orcid":"https://orcid.org/0000-0002-2044-8473","observed_orcids":["https://orcid.org/0000-0002-2044-8473"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Fanunza","raw_affiliation_strings":["University of Cagliari","Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2044-8473","affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102817051","display_name":"Fabrizio Carletti","orcid":"https://orcid.org/0000-0003-1952-5117","observed_orcids":["https://orcid.org/0000-0003-1952-5117"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Carletti","raw_affiliation_strings":["National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS","Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS","institution_ids":["https://openalex.org/I4210091493"]},{"raw_affiliation_string":"Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041612613","display_name":"Marina Quartu","orcid":"https://orcid.org/0000-0002-1884-3597","observed_orcids":["https://orcid.org/0000-0002-1884-3597"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Quartu","raw_affiliation_strings":["University of Cagliari","Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031679263","display_name":"Nicole Grandi","orcid":"https://orcid.org/0000-0003-0666-4361","observed_orcids":["https://orcid.org/0000-0003-0666-4361"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicole Grandi","raw_affiliation_strings":["University of Cagliari","Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021377190","display_name":"Laura Ermellino","orcid":"https://orcid.org/0000-0002-3378-1785","observed_orcids":["https://orcid.org/0000-0002-3378-1785"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Ermellino","raw_affiliation_strings":["University of Cagliari","Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009869800","display_name":"Jessica Milia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jessica Milia","raw_affiliation_strings":["University of Cagliari","Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056464448","display_name":"Angela Corona","orcid":"https://orcid.org/0000-0002-6630-8636","observed_orcids":["https://orcid.org/0000-0002-6630-8636"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Corona","raw_affiliation_strings":["University of Cagliari","Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6630-8636","affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078608594","display_name":"Maria Rosaria Capobianchi","orcid":"https://orcid.org/0000-0003-3465-0071","observed_orcids":["https://orcid.org/0000-0003-3465-0071"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Rosaria Capobianchi","raw_affiliation_strings":["National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS","Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS","institution_ids":["https://openalex.org/I4210091493"]},{"raw_affiliation_string":"Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071671768","display_name":"Giuseppe Ippolito","orcid":"https://orcid.org/0000-0002-1076-2979","observed_orcids":["https://orcid.org/0000-0002-1076-2979"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Ippolito","raw_affiliation_strings":["National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS","Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS","institution_ids":["https://openalex.org/I4210091493"]},{"raw_affiliation_string":"Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani\u035f IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037425032","display_name":"Enzo Tramontano","orcid":"https://orcid.org/0000-0002-4849-0980","observed_orcids":["https://orcid.org/0000-0002-4849-0980"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Enzo Tramontano","raw_affiliation_strings":["University of Cagliari","Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4849-0980","affiliations":[{"raw_affiliation_string":"University of Cagliari","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy","institution_ids":["https://openalex.org/I172446870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037425032"],"corresponding_institution_ids":["https://openalex.org/I172446870"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":{"value":2085,"currency":"GBP","value_usd":2557},"fwci":2.6532,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91731256,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"1580","last_page":"1596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/stat1-degradation","display_name":"STAT1 degradation","score":0.871999979019165},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.8500000238418579},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ifn-stimulated-genes","display_name":"IFN-stimulated genes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/virus-virulence","display_name":"viral virulence","score":0.7319999933242798},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2776239193","wikidata":"https://www.wikidata.org/wiki/Q18031750","display_name":"STAT2","level":5,"score":0.9120303392410278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7860790491104126},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7103542685508728},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6351373195648193},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.6061859130859375},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.532869815826416},{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.5187745094299316},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5097653269767761},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4980931282043457},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42664068937301636},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.42529192566871643},{"id":"https://openalex.org/C2778506107","wikidata":"https://www.wikidata.org/wiki/Q3272916","display_name":"MG132","level":4,"score":0.4224478602409363},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3830299377441406},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37542468309402466},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34055158495903015},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.292853981256485},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2619505226612091},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25224408507347107},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.23796346783638},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.23213380575180054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21650323271751404},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.1475122570991516},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.08070290088653564},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1080/21505594.2021.1935613","doi":"https://doi.org/10.1080/21505594.2021.1935613","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21505594.2021.1935613","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1935613?needAccess=true","source":{"id":"https://openalex.org/S2484688887","display_name":"Virulence","issn_l":"2150-5594","issn":["2150-5594","2150-5608"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virulence","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8331042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8331042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virulence","raw_type":"Text"},{"id":"pmid:34338586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34338586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virulence","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unica.it:11584/316823","doi":null,"is_oa":true,"landing_page_url":"https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1935613?scroll=top&needAccess=true","pdf_url":"https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1935613?scroll=top&needAccess=true","source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:a7df37b3a5d94795925e98e0eb86f66e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7df37b3a5d94795925e98e0eb86f66e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Virulence, Vol 12, Iss 1, Pp 1580-1596 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/21505594.2021.1935613","doi":"https://doi.org/10.1080/21505594.2021.1935613","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21505594.2021.1935613","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1935613?needAccess=true","source":{"id":"https://openalex.org/S2484688887","display_name":"Virulence","issn_l":"2150-5594","issn":["2150-5594","2150-5608"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virulence","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3191031280.pdf","grobid_xml":"https://content.openalex.org/works/W3191031280.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W8677296","https://openalex.org/W1558143285","https://openalex.org/W1857453373","https://openalex.org/W1973619678","https://openalex.org/W1980084515","https://openalex.org/W2006447162","https://openalex.org/W2012588545","https://openalex.org/W2014049842","https://openalex.org/W2015936607","https://openalex.org/W2033573754","https://openalex.org/W2034310945","https://openalex.org/W2053958361","https://openalex.org/W2071225095","https://openalex.org/W2071229331","https://openalex.org/W2078844752","https://openalex.org/W2079162651","https://openalex.org/W2087649656","https://openalex.org/W2091064323","https://openalex.org/W2095148741","https://openalex.org/W2097140631","https://openalex.org/W2100878564","https://openalex.org/W2111482162","https://openalex.org/W2121780828","https://openalex.org/W2125333406","https://openalex.org/W2127322768","https://openalex.org/W2128880918","https://openalex.org/W2135103913","https://openalex.org/W2136920638","https://openalex.org/W2152207030","https://openalex.org/W2160378127","https://openalex.org/W2163413830","https://openalex.org/W2163588232","https://openalex.org/W2235594643","https://openalex.org/W2297404408","https://openalex.org/W2303241697","https://openalex.org/W2326233293","https://openalex.org/W2395416726","https://openalex.org/W2400827254","https://openalex.org/W2498976249","https://openalex.org/W2513864153","https://openalex.org/W2521079522","https://openalex.org/W2538612363","https://openalex.org/W2584547672","https://openalex.org/W2596232252","https://openalex.org/W2598033793","https://openalex.org/W2598783947","https://openalex.org/W2600979648","https://openalex.org/W2618263911","https://openalex.org/W2762425132","https://openalex.org/W2783080373","https://openalex.org/W2790441311","https://openalex.org/W2790933579","https://openalex.org/W2794159346","https://openalex.org/W2797350331","https://openalex.org/W2805118976","https://openalex.org/W2805286501","https://openalex.org/W2809050289","https://openalex.org/W2809345862","https://openalex.org/W2894362615","https://openalex.org/W2895892541","https://openalex.org/W2905015036","https://openalex.org/W2908039851","https://openalex.org/W2913494638","https://openalex.org/W2917685269","https://openalex.org/W2936936485","https://openalex.org/W2969176196","https://openalex.org/W2972026792","https://openalex.org/W2972946514","https://openalex.org/W2980160480","https://openalex.org/W2981015902","https://openalex.org/W2982703661","https://openalex.org/W2990742438","https://openalex.org/W2998220949","https://openalex.org/W3001446400","https://openalex.org/W3015494074","https://openalex.org/W3021362263","https://openalex.org/W3086404765","https://openalex.org/W3091888054","https://openalex.org/W3093191490","https://openalex.org/W3096653538"],"related_works":["https://openalex.org/W6901992766","https://openalex.org/W3203657275","https://openalex.org/W2395416726","https://openalex.org/W2982703661","https://openalex.org/W2602603511","https://openalex.org/W4313381450","https://openalex.org/W2598783947","https://openalex.org/W3111508870","https://openalex.org/W7117537422","https://openalex.org/W4200015045"],"abstract_inverted_index":{"The":[0],"Interferon":[1],"(IFN)":[2],"response":[3,48,132],"is":[4,19],"crucial":[5],"to":[6,21,32,62,139,144],"restrain":[7],"pathogenic":[8],"infections.":[9],"Investigations":[10],"into":[11],"flavivirus-host":[12],"interactions":[13],"reported":[14],"that":[15,40,79,111],"the":[16,34,41,46,52,69,95,102,105,109,112,119,124,130,134,141],"high":[17],"virulence":[18],"linked":[20],"innate":[22,35],"immune":[23,36],"evasion.":[24],"Zika":[25],"Virus":[26],"(ZIKV)":[27],"has":[28,115],"developed":[29],"diversified":[30],"strategies":[31,138],"evade":[33],"system.":[37,107],"We":[38,77],"report":[39],"viral":[42],"protein":[43],"NS2A":[44,55,80,89],"counteracts":[45],"IFN":[47,53,113,131],"by":[49,122],"strongly":[50],"suppressing":[51,68],"signaling.":[54],"targets":[56],"transcription":[57,70,99],"factors":[58],"STAT1":[59,84],"and":[60,74,85,143],"STAT2,":[61],"impede":[63],"their":[64],"nuclear":[65],"localization,":[66],"thereby":[67],"of":[71,83,88,97,104],"ISRE":[72],"promoter":[73],"IFN-stimulated":[75],"genes.":[76],"found":[78],"promotes":[81],"degradation":[82],"STAT2.":[86],"Treatment":[87],"transfected":[90],"cells":[91],"with":[92],"MG132":[93],"restores":[94],"levels":[96],"both":[98],"factors,":[100],"suggesting":[101],"involvement":[103],"proteasome":[106],"Given":[108],"impact":[110],"antagonism":[114],"on":[116],"flavivirus":[117],"virulence,":[118],"knowledge":[120],"gained":[121],"characterizing":[123],"mechanism":[125],"through":[126],"which":[127],"ZIKV":[128],"evades":[129],"paves":[133],"ground":[135],"for":[136],"new":[137],"attenuate":[140],"pathogenesis":[142],"develop":[145],"countermeasures":[146],"against":[147],"effective":[148],"pharmacological":[149],"targets.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-16T00:00:00"}
