{"id":"https://openalex.org/W3190989155","doi":"https://doi.org/10.5603/gp.a2021.0159","title":"The perinatal outcomes of frozen-thawed blastocyst transfer are better than fresh blastocyst transfer: a systematic review and meta-analysis","display_name":"The perinatal outcomes of frozen-thawed blastocyst transfer are better than fresh blastocyst transfer: a systematic review and meta-analysis","publication_year":2021,"publication_date":"2021-08-03","ids":{"openalex":"https://openalex.org/W3190989155","doi":"https://doi.org/10.5603/gp.a2021.0159","mag":"3190989155","pmid":"https://pubmed.ncbi.nlm.nih.gov/34541647"},"language":"en","primary_location":{"id":"doi:10.5603/gp.a2021.0159","doi":"https://doi.org/10.5603/gp.a2021.0159","is_oa":true,"landing_page_url":"https://doi.org/10.5603/gp.a2021.0159","pdf_url":"https://journals.viamedica.pl/ginekologia_polska/article/download/GP.a2021.0159/63714","source":{"id":"https://openalex.org/S184151110","display_name":"Ginekologia Polska","issn_l":"0017-0011","issn":["0017-0011","2543-6767"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ginekologia Polska","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.viamedica.pl/ginekologia_polska/article/download/GP.a2021.0159/63714","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006113332","display_name":"Caihong Li","orcid":"https://orcid.org/0000-0002-1879-3366","observed_orcids":["https://orcid.org/0000-0002-1879-3366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caihong Li","raw_affiliation_strings":["licaihong6812@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"licaihong6812@126.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017409133","display_name":"Dongkai Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongkai Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032940834","display_name":"Hongjun Yu","orcid":"https://orcid.org/0000-0002-1483-2962","observed_orcids":["https://orcid.org/0000-0002-1483-2962","https://orcid.org/0009-0007-5806-7370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongjun Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728490","display_name":"Chunyi Li","orcid":"https://orcid.org/0000-0001-7275-4440","observed_orcids":["https://orcid.org/0000-0001-7275-4440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunyi Li","raw_affiliation_strings":["licaihong6812@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"licaihong6812@126.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432747","display_name":"Peng Li","orcid":"https://orcid.org/0000-0002-9026-9999","observed_orcids":["https://orcid.org/0000-0002-9026-9999","https://orcid.org/0000-0002-0428-7761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027939227","display_name":"Peng Xu","orcid":"https://orcid.org/0000-0001-7698-266X","observed_orcids":["https://orcid.org/0000-0001-7698-266X","https://orcid.org/0000-0003-2487-9163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":400,"currency":"EUR","value_usd":431},"apc_paid":{"value":400,"currency":"EUR","value_usd":431},"fwci":0.0531,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10810811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frozen-thawed-blastocyst-transfer","display_name":"frozen-thawed blastocyst transfer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/perinatal-outcomes","display_name":"perinatal outcomes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9559999704360962},{"id":"https://openalex.org/keywords/small-for-gestational-age","display_name":"small for gestational age","score":0.9629999995231628},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.765999972820282},{"id":"https://openalex.org/keywords/perinatal-mortality","display_name":"perinatal mortality","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cesarean-section","display_name":"cesarean section","score":0.9649999737739563},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.996999979019165},{"id":"https://openalex.org/keywords/large-for-gestational-age","display_name":"large for gestational age","score":0.875},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.8629999756813049},{"id":"https://openalex.org/keywords/singleton-pregnancy","display_name":"singleton pregnancy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/embryo-transfer-timing","display_name":"embryo transfer timing","score":0.5550000071525574},{"id":"https://openalex.org/keywords/frozen-embryo-transfer","display_name":"frozen embryo transfer","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8861679434776306},{"id":"https://openalex.org/C2910541586","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Blastocyst Transfer","level":5,"score":0.6940093040466309},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6664047837257385},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.6207044720649719},{"id":"https://openalex.org/C2780938740","wikidata":"https://www.wikidata.org/wiki/Q1298973","display_name":"Small for gestational age","level":4,"score":0.5204775333404541},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5068326592445374},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.5025343894958496},{"id":"https://openalex.org/C2778279030","wikidata":"https://www.wikidata.org/wiki/Q1543380","display_name":"Live birth","level":3,"score":0.49193358421325684},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.4559843838214874},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45333558320999146},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4464951753616333},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4257059693336487},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.35667598247528076},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.3136182427406311},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0870111882686615},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.060387104749679565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.051929861307144165},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5603/gp.a2021.0159","doi":"https://doi.org/10.5603/gp.a2021.0159","is_oa":true,"landing_page_url":"https://doi.org/10.5603/gp.a2021.0159","pdf_url":"https://journals.viamedica.pl/ginekologia_polska/article/download/GP.a2021.0159/63714","source":{"id":"https://openalex.org/S184151110","display_name":"Ginekologia Polska","issn_l":"0017-0011","issn":["0017-0011","2543-6767"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ginekologia Polska","raw_type":"journal-article"},{"id":"pmid:34541647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34541647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ginekologia polska","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5603/gp.a2021.0159","doi":"https://doi.org/10.5603/gp.a2021.0159","is_oa":true,"landing_page_url":"https://doi.org/10.5603/gp.a2021.0159","pdf_url":"https://journals.viamedica.pl/ginekologia_polska/article/download/GP.a2021.0159/63714","source":{"id":"https://openalex.org/S184151110","display_name":"Ginekologia Polska","issn_l":"0017-0011","issn":["0017-0011","2543-6767"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ginekologia Polska","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3190989155.pdf","grobid_xml":"https://content.openalex.org/works/W3190989155.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1572565029","https://openalex.org/W1746091885","https://openalex.org/W1974978813","https://openalex.org/W2014157403","https://openalex.org/W2080404248","https://openalex.org/W2082484095","https://openalex.org/W2091849572","https://openalex.org/W2113697813","https://openalex.org/W2126460503","https://openalex.org/W2136072435","https://openalex.org/W2143564115","https://openalex.org/W2144408960","https://openalex.org/W2147038326","https://openalex.org/W2148812281","https://openalex.org/W2153569531","https://openalex.org/W2283819174","https://openalex.org/W2410663019","https://openalex.org/W2430037891","https://openalex.org/W2510325016","https://openalex.org/W2559327025","https://openalex.org/W2594230894","https://openalex.org/W2604188477","https://openalex.org/W2612427761","https://openalex.org/W2743259080","https://openalex.org/W2766026824","https://openalex.org/W2784276145","https://openalex.org/W2799503709","https://openalex.org/W2891839832","https://openalex.org/W2916530067","https://openalex.org/W4246833565"],"related_works":["https://openalex.org/W3092191236","https://openalex.org/W2766026824","https://openalex.org/W3089108387","https://openalex.org/W3150635704","https://openalex.org/W2430037891","https://openalex.org/W1974978813","https://openalex.org/W2091849572","https://openalex.org/W2768946593","https://openalex.org/W4413052052","https://openalex.org/W4366257132"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Transfer":[1],"of":[2,10,16,29,51,69,81,135,140,164,199,280],"cryopreserved-warmed":[3],"blastocysts":[4,30],"is":[5,19],"common":[6],"in":[7,11,38,52,159,187,196,273],"the":[8,17,22,133,141,147,197],"practice":[9],"vitro":[12,53],"fertilization.":[13],"The":[14,79,110,138,162,269],"purpose":[15],"study":[18],"to":[20,131,296],"examine":[21],"available":[23],"evidence":[24],"and":[25,31,59,74,108,122,174,210,222,255],"determine":[26],"whether":[27],"cryopreservation":[28],"subsequent":[32],"frozen":[33,60,188,228,270],"blastocyst":[34],"transfer":[35],"(BT)":[36],"result":[37],"better":[39,274],"outcomes":[40,50,80,276],"than":[41],"fresh":[42,58,223,259,281,291],"BT.":[43,224,282],"MATERIAL":[44],"AND":[45],"METHODS:":[46],"Related":[47],"studies":[48,143,154],"comparing":[49,288],"fertilization":[54],"(IVF)":[55],"cycles":[56,293],"between":[57,220],"BTs":[61],"were":[62,83,125],"retrieved":[63],"from":[64],"Medline,":[65],"Cochrane":[66],"Central":[67],"Register":[68],"Clinical":[70],"Trials,":[71],"EMBASE,":[72],"DARE,":[73],"CINAHL":[75],"through":[76],"March":[77],"2020.":[78],"interest":[82],"preterm":[84,87,165],"birth,":[85,88],"extremely":[86,100],"small":[89,175],"for":[90,94,176,235],"gestational":[91,95,177,236],"age,":[92,96],"large":[93,234],"low":[97,101,186,200],"birth":[98,102,166,201],"weight,":[99,103],"caesarean":[104,245],"section,":[105],"perinatal":[106,211,275],"mortality":[107,212],"preeclampsia.":[109],"analysis":[111],"was":[112,144,185,192,230],"performed":[113],"using":[114,146],"Rev":[115],"Man":[116],"5.1":[117],"software.":[118],"Risk":[119],"ratios":[120],"(RRs)":[121],"risk":[123,198],"differences":[124],"calculated":[126],"with":[127,155,232,258,278,290],"95%":[128,170,182,206,216,241,251,264],"confidence":[129],"intervals,":[130],"evaluate":[132],"results":[134,272],"each":[136],"outcome.":[137],"quality":[139],"referenced":[142],"assessed":[145],"Newcastle-Ottawa":[148],"scale":[149],"(NOS)":[150],"checklists.":[151],"RESULTS:":[152],"Nine":[153],"42,342":[156],"women":[157],"incorporated":[158],"this":[160],"meta-analysis.":[161],"incidence":[163],"(RR":[167,179,203,213,238,248,261],"=":[168,180,204,214,239,249,262],"0.89,":[169,205],"CI:":[171,207,217,242,252,265],"0.82,":[172],"0.97)":[173],"age":[178,237],"0.55,":[181],"CI":[183],"0.41-0.74)":[184],"BT":[189,229,260,271,292],"group.":[190],"There":[191],"no":[193],"significant":[194],"difference":[195],"weight":[202],"0.67,":[208],"1.19)":[209],"1.47,":[215,240],"0.85,":[218],"2.55)":[219],"frozen-thawed":[221],"Singleton":[225],"pregnancy":[226],"after":[227],"associated":[231],"higher":[233],"1.37,":[243],"1.57),":[244],"section":[246],"rates":[247],"1.24,":[250],"1.13,":[253],"1.36)":[254],"preeclampsia":[256],"compared":[257,277],"1.85,":[263],"1.22,":[266],"2.82).":[267],"CONCLUSIONS:":[268],"that":[279],"Furthermore,":[283],"comprehensive":[284],"randomized":[285],"clinical":[286],"trials":[287],"freeze-all":[289],"are":[294],"needed":[295],"draw":[297],"sound":[298],"conclusions.":[299]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-16T00:00:00"}