{"id":"https://openalex.org/W3190934026","doi":"https://doi.org/10.1080/15548627.2021.1961075","title":"Delineating the lipidated Atg8 structure for unveiling its hidden activity in autophagy","display_name":"Delineating the lipidated Atg8 structure for unveiling its hidden activity in autophagy","publication_year":2021,"publication_date":"2021-08-12","ids":{"openalex":"https://openalex.org/W3190934026","doi":"https://doi.org/10.1080/15548627.2021.1961075","mag":"3190934026","pmid":"https://pubmed.ncbi.nlm.nih.gov/34382913","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8525951"},"language":"en","primary_location":{"id":"doi:10.1080/15548627.2021.1961075","doi":"https://doi.org/10.1080/15548627.2021.1961075","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15548627.2021.1961075","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2021.1961075?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2021.1961075?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018585311","display_name":"Tatsuro Maruyama","orcid":"https://orcid.org/0009-0007-2550-9064","observed_orcids":["https://orcid.org/0009-0007-2550-9064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuro Maruyama","raw_affiliation_strings":["Laboratory of Structural Biology, Institute of Microbial Chemistry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Institute of Microbial Chemistry, Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063705886","display_name":"Nobuo N. Noda","orcid":"https://orcid.org/0000-0002-6940-8069","observed_orcids":["https://orcid.org/0000-0002-6940-8069"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nobuo N. Noda","raw_affiliation_strings":["Laboratory of Structural Biology, Institute of Microbial Chemistry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Institute of Microbial Chemistry, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063705886"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"10","first_page":"3271","last_page":"3272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atg8","display_name":"ATG8","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lipidation","display_name":"lipid modification","score":0.765999972820282},{"id":"https://openalex.org/keywords/autophagosome-biogenesis","display_name":"autophagosome formation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/membrane-perturbation","display_name":"membrane perturbation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-membrane-interactions","display_name":"protein-membrane interactions","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cargo-binding","display_name":"cargo binding","score":0.6880000233650208},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2780042272","wikidata":"https://www.wikidata.org/wiki/Q27548992","display_name":"ATG8","level":4,"score":0.9777904748916626},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.8227930068969727},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.7758105397224426},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7504914999008179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6762523055076599},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6019811630249023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.585382878780365},{"id":"https://openalex.org/C193469717","wikidata":"https://www.wikidata.org/wiki/Q6556349","display_name":"Lipid-anchored protein","level":4,"score":0.5580468773841858},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.506194531917572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24863749742507935},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.05966410040855408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071190","descriptor_name":"Autophagy-Related Protein 8 Family","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/15548627.2021.1961075","doi":"https://doi.org/10.1080/15548627.2021.1961075","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15548627.2021.1961075","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2021.1961075?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8525951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8525951","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Text"},{"id":"pmid:34382913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34382913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/15548627.2021.1961075","doi":"https://doi.org/10.1080/15548627.2021.1961075","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15548627.2021.1961075","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2021.1961075?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1071522568","display_name":"\u591a\u968e\u5c64\u9ad8\u6b21\u69cb\u9020\u4f53\u7fa4\u304c\u99c6\u52d5\u3059\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30c0\u30a4\u30ca\u30df\u30af\u30b9","funder_award_id":"JPMJCR20E3","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G3252535643","display_name":null,"funder_award_id":"JPMJCR20E3","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G4411413224","display_name":"\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u819c\u52d5\u614b\u89e3\u660e\u3092\u5fd7\u5411\u3057\u305f\u69cb\u9020\u751f\u547d\u79d1\u5b66","funder_award_id":"JPMJCR13M7","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G6190782070","display_name":"Elucidation of the function of the pre-autophagosomal structure through in vitro reconstitution","funder_award_id":"18H03989","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6589428684","display_name":null,"funder_award_id":"19H05707","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6896205142","display_name":"Mechanism of autophagosome-selective membrane degradation by Atg15","funder_award_id":"21K15045","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7978840039","display_name":null,"funder_award_id":"JPMJCR13M7","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320312698","display_name":"Tokyo Biochemical Research Foundation","ror":"https://ror.org/04bxrzx68"},{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3190934026.pdf","grobid_xml":"https://content.openalex.org/works/W3190934026.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3177890355"],"related_works":["https://openalex.org/W3179689307","https://openalex.org/W3177890355","https://openalex.org/W4311954623","https://openalex.org/W4406882365","https://openalex.org/W7048746228","https://openalex.org/W6957941292","https://openalex.org/W2140437307","https://openalex.org/W2603422729","https://openalex.org/W7098360536","https://openalex.org/W6901558119"],"abstract_inverted_index":{"Atg8":[0,20,45,54,113],"has":[1],"attracted":[2],"attention":[3],"as":[4,25],"a":[5,12,56],"central":[6],"factor":[7],"in":[8],"autophagosome":[9,104],"biogenesis":[10],"for":[11,102],"long":[13],"time.":[14],"However,":[15],"the":[16,22,26,39,47,60,63,70,78,109],"molecular":[17],"activities":[18],"of":[19,43,112],"on":[21,59,108],"phagophore":[23],"membranes":[24,88],"physiologically":[27],"functional":[28],"lipidated":[29,44,53],"form":[30],"remain":[31,114],"enigmatic.":[32],"In":[33],"our":[34],"recent":[35],"study,":[36],"we":[37],"unveiled":[38],"hidden":[40],"physicochemical":[41],"activity":[42,96],"toward":[46],"membrane.":[48],"Structural":[49],"analysis":[50],"revealed":[51],"that":[52],"adopts":[55],"preferred":[57],"orientation":[58],"membrane,":[61],"contacting":[62],"membrane":[64,94],"using":[65],"aromatic":[66],"residues":[67],"and":[68,86],"at":[69],"same":[71],"time":[72],"exposing":[73],"cargo":[74],"binding":[75],"pockets":[76],"to":[77,84,99],"solvent,":[79],"enabling":[80],"this":[81],"small":[82],"protein":[83],"perturb":[85],"transform":[87],"while":[89],"recognizing":[90],"autophagic":[91],"cargos.":[92],"The":[93],"perturbation":[95],"was":[97],"shown":[98],"be":[100],"essential":[101],"efficient":[103],"biogenesis,":[105],"yet":[106],"questions":[107],"mechanistic":[110],"roles":[111],"open.":[115]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-08-16T00:00:00"}