{"id":"https://openalex.org/W3190386149","doi":"https://doi.org/10.1159/000518235","title":"Efficacy and Safety of Intravitreal Aflibercept Treat and Extend for Polypoidal Choroidal Vasculopathy in the ATLANTIC Study: A Randomized Clinical Trial","display_name":"Efficacy and Safety of Intravitreal Aflibercept Treat and Extend for Polypoidal Choroidal Vasculopathy in the ATLANTIC Study: A Randomized Clinical Trial","publication_year":2021,"publication_date":"2021-07-13","ids":{"openalex":"https://openalex.org/W3190386149","doi":"https://doi.org/10.1159/000518235","mag":"3190386149","pmid":"https://pubmed.ncbi.nlm.nih.gov/34348351"},"language":"en","primary_location":{"id":"doi:10.1159/000518235","doi":"https://doi.org/10.1159/000518235","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000518235","pdf_url":"https://www.karger.com/Article/Pdf/518235","source":{"id":"https://openalex.org/S204308127","display_name":"Ophthalmologica","issn_l":"0030-3755","issn":["0030-3755","1423-0267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.karger.com/Article/Pdf/518235","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031577547","display_name":"Rufino Martins da Silva","orcid":"https://orcid.org/0000-0001-8676-0833","observed_orcids":["https://orcid.org/0000-0001-8676-0833"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rufino Silva","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Espa\u00e7o M\u00e9dico de Coimbra, Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Espa\u00e7o M\u00e9dico de Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006138308","display_name":"Lu\u00eds Arias","orcid":"https://orcid.org/0000-0001-7041-5576","observed_orcids":["https://orcid.org/0000-0001-7041-5576"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Arias","raw_affiliation_strings":["Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083320525","display_name":"Sandrina Gon\u00e7alves Nunes","orcid":"https://orcid.org/0000-0001-5401-9637","observed_orcids":["https://orcid.org/0000-0001-5401-9637"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandrina Nunes","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029364514","display_name":"Cl\u00e1udia Farinha","orcid":"https://orcid.org/0000-0003-4596-0913","observed_orcids":["https://orcid.org/0000-0003-4596-0913"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Claudia Farinha","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-4596-0913","affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal","institution_ids":[]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104155903","display_name":"Rita Coimbra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita Coimbra","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080935669","display_name":"Jo\u00e3o Pedro Marques","orcid":"https://orcid.org/0000-0002-1014-0483","observed_orcids":["https://orcid.org/0000-0002-1014-0483"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o P. Marques","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal","institution_ids":[]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072016106","display_name":"Maria Luz Cachulo","orcid":"https://orcid.org/0000-0002-0900-4548","observed_orcids":["https://orcid.org/0000-0002-0900-4548"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria L. Cachulo","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017440565","display_name":"Jo\u00e3o Figueira","orcid":"https://orcid.org/0000-0002-3511-1515","observed_orcids":["https://orcid.org/0000-0002-3511-1515"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Figueira","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Espa\u00e7o M\u00e9dico de Coimbra, Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-3511-1515","affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Espa\u00e7o M\u00e9dico de Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046250282","display_name":"Patr\u00edcia Barreto","orcid":"https://orcid.org/0000-0001-7486-7828","observed_orcids":["https://orcid.org/0000-0001-7486-7828"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]},{"id":"https://openalex.org/I83863532","display_name":"Universidade T\u00e9cnica do Porto","ror":"https://ror.org/04988re48","country_code":"PT","type":"education","lineage":["https://openalex.org/I83863532"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Patricia Barreto","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Department of Orthoptics, School of Health, Polytechnic of Porto, Oporto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Department of Orthoptics, School of Health, Polytechnic of Porto, Oporto, Portugal","institution_ids":["https://openalex.org/I83863532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080311725","display_name":"Maria Helena Madeira","orcid":"https://orcid.org/0000-0001-6282-3553","observed_orcids":["https://orcid.org/0000-0001-6282-3553"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria H. Madeira","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6282-3553","affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034624503","display_name":"Isabel Pires","orcid":"https://orcid.org/0000-0002-5764-0178","observed_orcids":["https://orcid.org/0000-0002-5764-0178"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabel Pires","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101767222","display_name":"Jo\u00e3o Paulo Castro Sousa","orcid":"https://orcid.org/0000-0002-0025-1841","observed_orcids":["https://orcid.org/0000-0002-0025-1841"]},"institutions":[{"id":"https://openalex.org/I4403386522","display_name":"Centro Hospitalar Leiria EPE","ror":"https://ror.org/00ey4m741","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4403386522"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o C. Sousa","raw_affiliation_strings":["Centro Hospitalar de Leiria, Leiria, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Hospitalar de Leiria, Leiria, Portugal","institution_ids":["https://openalex.org/I4403386522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050457771","display_name":"Laura Dist\u00e9fano","orcid":"https://orcid.org/0000-0003-2319-1324","observed_orcids":["https://orcid.org/0000-0003-2319-1324"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Distefano","raw_affiliation_strings":["Vall d'Hebron Hospital, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2319-1324","affiliations":[{"raw_affiliation_string":"Vall d'Hebron Hospital, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113664266","display_name":"Paulo Caldeira Rosa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulo Rosa","raw_affiliation_strings":["Instituto Retina Diabetes Ocular de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Retina Diabetes Ocular de Lisboa, Lisbon, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005234046","display_name":"\u00c2ngela M. Carneiro","orcid":"https://orcid.org/0000-0002-3370-7243","observed_orcids":["https://orcid.org/0000-0002-3370-7243"]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"\u00c2ngela Carneiro","raw_affiliation_strings":["Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, EPE, Oporto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, EPE, Oporto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062828827","display_name":"Sara Vaz-Pereira","orcid":"https://orcid.org/0000-0001-6125-5486","observed_orcids":["https://orcid.org/0000-0001-6125-5486"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4210149283","display_name":"Hospital de Santa Maria","ror":"https://ror.org/05bz1tw26","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210149283"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sara Vaz-Pereira","raw_affiliation_strings":["Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio de Lisboa Norte, EPE - Hospital de Santa Maria, Lisbon, Portugal","Department of Ophthalmology, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6125-5486","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio de Lisboa Norte, EPE - Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210114390","https://openalex.org/I4210149283"]},{"raw_affiliation_string":"Department of Ophthalmology, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078334669","display_name":"Angelina Meireles","orcid":"https://orcid.org/0000-0001-9148-2786","observed_orcids":["https://orcid.org/0000-0001-9148-2786"]},"institutions":[{"id":"https://openalex.org/I4210127365","display_name":"Hospital de Santo Ant\u00f3nio","ror":"https://ror.org/02m9pj861","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210127365"]},{"id":"https://openalex.org/I4210154840","display_name":"Centro Hospitalar do Porto","ror":"https://ror.org/04dwpyh46","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210154840","https://openalex.org/I4405257367"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Angelina Meireles","raw_affiliation_strings":["Centro Hospitalar Porto-Hospital Santo Ant\u00f3nio, Oporto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-9148-2786","affiliations":[{"raw_affiliation_string":"Centro Hospitalar Porto-Hospital Santo Ant\u00f3nio, Oporto, Portugal","institution_ids":["https://openalex.org/I4210127365","https://openalex.org/I4210154840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francisco Cabrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799299272","display_name":"Hospital Universitario Insular de Gran Canaria","ror":"https://ror.org/04cbm7s05","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2799299272","https://openalex.org/I4210120310"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Cabrera","raw_affiliation_strings":["Hospital Insular de Gran Canaria (Las Palmas), Canarias, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Insular de Gran Canaria (Las Palmas), Canarias, Spain","institution_ids":["https://openalex.org/I2799299272"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086219599","display_name":"Anniken Bur\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131277","display_name":"Instituto de Microcirug\u00eda Ocular","ror":"https://ror.org/03xwv0k70","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210131277"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anniken Bures","raw_affiliation_strings":["Instituto Microcirugia Ocular, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Microcirugia Ocular, Barcelona, Spain","institution_ids":["https://openalex.org/I4210131277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103207025","display_name":"Luis S. Mendon\u00e7a","orcid":"https://orcid.org/0000-0001-9851-0751","observed_orcids":["https://orcid.org/0000-0001-9851-0751"]},"institutions":[{"id":"https://openalex.org/I4210125208","display_name":"Hospital de S\u00e3o Marcos","ror":"https://ror.org/040bb8882","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210125208"]},{"id":"https://openalex.org/I4210137968","display_name":"Hospital Braga","ror":"https://ror.org/04jjy0g33","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210137968"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Mendon\u00e7a","raw_affiliation_strings":["Department of Ophthalmology, Hospital Braga, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Hospital Braga, Braga, Portugal","institution_ids":["https://openalex.org/I4210125208","https://openalex.org/I4210137968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030763678","display_name":"Alvaro Fernandez-Vega-Sanz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109730","display_name":"Fern\u00e1ndez-Vega Ophthalmological Institute","ror":"https://ror.org/01d71vb80","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210109730"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alvaro Fernandez-Vega-Sanz","raw_affiliation_strings":["Instituto Oftalmol\u00f3gico Fernandez-Veja, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oftalmol\u00f3gico Fernandez-Veja, Oviedo, Spain","institution_ids":["https://openalex.org/I4210109730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021145595","display_name":"Sandra Barr\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405252744","display_name":"Instituto de Oftalmologia Dr Gama Pinto","ror":"https://ror.org/03m8mwm20","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252744"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandra Barr\u00e3o","raw_affiliation_strings":["Instituto de Oftalmologia Dr. Gama Pinto, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Oftalmologia Dr. Gama Pinto, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405252744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109381357","display_name":"Adrian Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109648","display_name":"Eye & Retina Surgeons","ror":"https://ror.org/01mhm7x58","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210109648"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Adrian Koh","raw_affiliation_strings":["Eye & Retina Surgeons, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye & Retina Surgeons, Singapore, Singapore","institution_ids":["https://openalex.org/I4210109648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078487748","display_name":"Chui Ming Gemmy Cheung","orcid":"https://orcid.org/0000-0003-3358-3516","observed_orcids":["https://orcid.org/0000-0003-3358-3516"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chui Ming Gemmy Cheung","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064272918","display_name":"Jos\u00e9 Guilherme Cunha-Vaz","orcid":"https://orcid.org/0000-0002-0947-9850","observed_orcids":["https://orcid.org/0000-0002-0947-9850"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 G. Cunha-Vaz","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Espa\u00e7o M\u00e9dico de Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Espa\u00e7o M\u00e9dico de Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077071955","display_name":"Joaquim Murta","orcid":"https://orcid.org/0000-0001-8926-5176","observed_orcids":["https://orcid.org/0000-0001-8926-5176"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joaquim Murta","raw_affiliation_strings":["Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Innovation and Biomedical Research in Light and Image (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal","institution_ids":[]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the EVICR.net ATLANTIC Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the EVICR.net ATLANTIC Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":21,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4849,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77746275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"245","issue":"1","first_page":"80","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polypoidal-choroidal-vasculopathy","display_name":"polypoidal choroidal vasculopathy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":0.9760000109672546},{"id":"https://openalex.org/keywords/treat-and-extend-regimen","display_name":"treat-and-extend regimen","score":0.9259999990463257},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/verteporfin","display_name":"verteporfin","score":0.996999979019165},{"id":"https://openalex.org/keywords/best-corrected-visual-acuity","display_name":"best-corrected visual acuity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/central-retinal-thickness","display_name":"central retinal thickness","score":0.8050000071525574},{"id":"https://openalex.org/keywords/indocyanine-green-angiography","display_name":"indocyanine green angiography","score":0.8199999928474426},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4740000069141388},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/white-patients","display_name":"Caucasian patients","score":0.5879999995231628},{"id":"https://openalex.org/keywords/atlantic-studies","display_name":"Atlantic studies","score":0.875}],"concepts":[{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.9362941980361938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9095592498779297},{"id":"https://openalex.org/C2781148688","wikidata":"https://www.wikidata.org/wiki/Q782318","display_name":"Verteporfin","level":4,"score":0.7235340476036072},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6307482123374939},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6283280849456787},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6055598855018616},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5699564218521118},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.4985017776489258},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4321848452091217},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3679429292678833},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.1590457558631897},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11365842819213867},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011127","descriptor_name":"Polyps","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011127","descriptor_name":"Polyps","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000518235","doi":"https://doi.org/10.1159/000518235","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000518235","pdf_url":"https://www.karger.com/Article/Pdf/518235","source":{"id":"https://openalex.org/S204308127","display_name":"Ophthalmologica","issn_l":"0030-3755","issn":["0030-3755","1423-0267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica","raw_type":"journal-article"},{"id":"pmid:34348351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34348351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/187948","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/187948","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Institut d'lnvestigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL))","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1159/000518235","doi":"https://doi.org/10.1159/000518235","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000518235","pdf_url":"https://www.karger.com/Article/Pdf/518235","source":{"id":"https://openalex.org/S204308127","display_name":"Ophthalmologica","issn_l":"0030-3755","issn":["0030-3755","1423-0267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3190386149.pdf","grobid_xml":"https://content.openalex.org/works/W3190386149.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1830707906","https://openalex.org/W1964763543","https://openalex.org/W1972743389","https://openalex.org/W1974272630","https://openalex.org/W1975838651","https://openalex.org/W1976433015","https://openalex.org/W1980768795","https://openalex.org/W2015616513","https://openalex.org/W2017115804","https://openalex.org/W2034867018","https://openalex.org/W2036516882","https://openalex.org/W2139115897","https://openalex.org/W2146716147","https://openalex.org/W2172292405","https://openalex.org/W2321748845","https://openalex.org/W2338221729","https://openalex.org/W2523147423","https://openalex.org/W2713266611","https://openalex.org/W2763376487","https://openalex.org/W2765825750","https://openalex.org/W2774223295","https://openalex.org/W2783373665","https://openalex.org/W2800507258","https://openalex.org/W2920941623","https://openalex.org/W2941829949","https://openalex.org/W3009362433","https://openalex.org/W3043747921","https://openalex.org/W3073727042","https://openalex.org/W3092417423","https://openalex.org/W4211020962"],"related_works":["https://openalex.org/W2752884651","https://openalex.org/W2804152448","https://openalex.org/W2800507258","https://openalex.org/W2920941623","https://openalex.org/W2580554851","https://openalex.org/W2727982083","https://openalex.org/W2059736977","https://openalex.org/W2024652862","https://openalex.org/W3124304292","https://openalex.org/W2713266611"],"abstract_inverted_index":{"IMPORTANCE:":[0],"Polypoidal":[1],"choroidal":[2],"vasculopathy":[3],"(PCV)":[4],"is":[5,300],"far":[6],"less":[7],"common":[8],"and":[9,20,99,118,215,260,330,341,396],"studied":[10],"in":[11,16,41,51,89,120,131,181,200,247,289,315,323,348,374,392],"a":[12,52,145,173,192,316,324,333,342],"Caucasian":[13,44,317,375],"population":[14,318],"than":[15],"an":[17],"Asian":[18],"population,":[19],"the":[21,127,132,137,203,212,216,290,301,353,362,367,397],"optimal":[22],"treatment":[23,371],"approach":[24],"remains":[25],"to":[26,67,96,304,327],"be":[27,328,379],"confirmed.":[28],"METHODS:":[29],"A":[30],"52-week,":[31],"double-masked,":[32],"sham-controlled,":[33],"phase":[34],"4,":[35],"investigator-initiated":[36],"randomized":[37,63],"clinical":[38,388],"trial":[39,389],"(RCT)":[40],"naive":[42],"symptomatic":[43],"patients":[45,129,135,164,376],"with":[46,49,81,172,309,319,332],"PCV":[47,373],"treated":[48],"aflibercept":[50,57,217,306,310],"treat-and-extend":[53],"regimen":[54],"(T&E)":[55],"(intravitreal":[56],"injection":[58],"[IVAI]":[59],"T&E).":[60],"Patients":[61],"were":[62,87,287],"at":[64,102,220,355],"week":[65,103,221],"16":[66],"receive":[68],"IVAI":[69],"T&E":[70,307,311,325],"plus":[71,312],"either":[72],"sham":[73,213],"photodynamic":[74],"therapy":[75],"(PDT)":[76],"or":[77,272],"standard":[78],"fluence":[79],"PDT":[80,214,218,314,365],"verteporfin.":[82],"The":[83,387],"main":[84],"outcome":[85],"measures":[86],"changes":[88],"best-corrected":[90],"visual":[91],"acuity":[92],"(BCVA)":[93],"from":[94,382],"baseline":[95],"52":[97,138],"weeks":[98,139],"polyp":[100,264],"occlusion":[101,194,344],"52.":[104],"Data":[105],"are":[106],"presented":[107],"as":[108],"median":[109,147,335],"(interquartile":[110],"range":[111],"[IQR])":[112],"for":[113,162,223,372],"BCVA,":[114],"number":[115,235],"of":[116,140,151,176,195,202,236,262,274,338,345,352,361,369],"IVAI,":[117],"change":[119,225,246],"central":[121,182],"retinal":[122],"thickness":[123,184],"(CRT).":[124],"RESULTS:":[125],"Of":[126],"50":[128],"included":[130],"study,":[133],"48":[134],"completed":[136],"follow-up.":[141],"During":[142],"this":[143,299,383],"period,":[144],"significant":[146,174,207,334],"(IQR)":[148],"BCVA":[149,224,336],"gain":[150],"6":[152,339],"[2-12]":[153],"Early":[154],"Treatment":[155],"Diabetic":[156],"Retinopathy":[157],"Study":[158],"letters":[159,231,340],"was":[160,198,209,390],"observed":[161],"all":[163],"(p":[165,185,232,243,269,279],"<":[166,186],"0.001),":[167],"after":[168],"8":[169,241],"(7-9)":[170],"injections,":[171],"reduction":[175],"-93.0":[177],"[-154.0,":[178],"-44.0]":[179],"\u00b5m":[180,256],"macular":[183],"0.001).":[187],"Using":[188],"indocyanine":[189],"green":[190],"angiography,":[191],"complete":[193,263,343],"polypoidal":[196,346],"lesions":[197,347],"documented":[199],"72%":[201],"cases.":[204],"Still,":[205],"no":[206],"difference":[208],"detected":[210],"between":[211],"arms,":[219],"52,":[222],"(6.5":[226],"[2-11]":[227],"vs.":[228,240,252],"5":[229],"[2-13]":[230],"=":[233,244,258,270,280],"0.98)),":[234],"IVAIs":[237],"(8.5":[238],"[7-9]":[239,242],"0.21)),":[245],"CRT":[248],"(-143":[249],"[-184;":[250],"-47]":[251],"-89":[253],"[-123;":[254],"-41.5]":[255],"[p":[257],"0.23]),":[259],"rates":[261],"occlusion:":[265],"77":[266],"versus":[267,277],"68%":[268],"0.53)":[271],"presence":[273],"fluid:":[275],"68":[276],"57%":[278],"0.56).":[281],"No":[282],"serious":[283],"ocular":[284],"adverse":[285],"events":[286],"registered":[288,391],"2":[291],"arms.":[292],"CONCLUSIONS":[293],"AND":[294],"RELEVANCE:":[295],"To":[296],"our":[297],"knowledge,":[298],"first":[302],"RCT":[303],"compare":[305],"monotherapy":[308,322],"verteporfin":[313],"PCV.":[320],"Aflibercept":[321],"showed":[326],"effective":[329],"safe":[331],"improvement":[337],"near":[349],"3":[350],"quarters":[351],"eyes,":[354],"1":[356],"year.":[357],"As":[358],"only":[359],"22%":[360],"eyes":[363],"underwent":[364],"treatment,":[366],"benefit":[368],"combined":[370],"could":[377],"not":[378],"definitively":[380],"elucidated":[381],"study.":[384],"TRIAL":[385],"REGISTRATION:":[386],"ClinicalTrials.gov":[393],"Identifier":[394],"NCT02495181":[395],"European":[398],"Union":[399],"Drug":[400],"Regulating":[401],"Authorities":[402],"Clinical":[403],"Trials":[404],"Database":[405],"EudraCT":[406],"No.":[407],"2015-001368-20.":[408]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-08-16T00:00:00"}