{"id":"https://openalex.org/W3190154751","doi":"https://doi.org/10.1093/clinchem/hvab117","title":"Analytical Quality Controls for ddPCR Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia","display_name":"Analytical Quality Controls for ddPCR Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia","publication_year":2021,"publication_date":"2021-06-25","ids":{"openalex":"https://openalex.org/W3190154751","doi":"https://doi.org/10.1093/clinchem/hvab117","mag":"3190154751","pmid":"https://pubmed.ncbi.nlm.nih.gov/39506256"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/hvab117","doi":"https://doi.org/10.1093/clinchem/hvab117","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/hvab117","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100443992","display_name":"Dan Chen","orcid":"https://orcid.org/0000-0001-8118-4443","observed_orcids":["https://orcid.org/0000-0001-8118-4443"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dan Chen","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076557705","display_name":"Rosemary Sutton","orcid":"https://orcid.org/0000-0002-0188-6005","observed_orcids":["https://orcid.org/0000-0002-0188-6005"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rosemary Sutton","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","School of Women\u2019s and Children\u2019s Health, UNSW Medicine , Randwick,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","School of Women's and Children's Health, UNSW Medicine, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Women\u2019s and Children\u2019s Health, UNSW Medicine , Randwick,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Women's and Children's Health, UNSW Medicine, Randwick, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109385880","display_name":"Jodie E. Giles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jodie Giles","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063358141","display_name":"Nicola C. Venn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicola C Venn","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087311572","display_name":"Libby Huang","orcid":"https://orcid.org/0000-0001-7398-0570","observed_orcids":["https://orcid.org/0000-0001-7398-0570"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Libby Huang","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109143727","display_name":"Tamara Law","orcid":"https://orcid.org/0009-0000-4869-3588","observed_orcids":["https://orcid.org/0009-0000-4869-3588"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tamara Law","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012541057","display_name":"Vinod Vijay Subhash","orcid":"https://orcid.org/0000-0001-6050-9915","observed_orcids":["https://orcid.org/0000-0001-6050-9915"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vinod Vijay Subhash","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022402043","display_name":"Toby N. Trahair","orcid":"https://orcid.org/0000-0002-3295-228X","observed_orcids":["https://orcid.org/0000-0002-3295-228X"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210125633","display_name":"Sydney Children's Hospital","ror":"https://ror.org/02tj04e91","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210125633","https://openalex.org/I4210149013"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Toby N Trahair","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","Kids Cancer Centre, Sydney Children\u2019s Hospital , Randwick,","School of Women\u2019s and Children\u2019s Health, UNSW Medicine , Randwick,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia","School of Women's and Children's Health, UNSW Medicine, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Kids Cancer Centre, Sydney Children\u2019s Hospital , Randwick,","institution_ids":["https://openalex.org/I4210125633"]},{"raw_affiliation_string":"School of Women\u2019s and Children\u2019s Health, UNSW Medicine , Randwick,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia","institution_ids":["https://openalex.org/I4210125633"]},{"raw_affiliation_string":"School of Women's and Children's Health, UNSW Medicine, Randwick, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015873058","display_name":"Michelle J. Henderson","orcid":"https://orcid.org/0000-0003-2741-3852","observed_orcids":["https://orcid.org/0000-0003-2741-3852"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Michelle J Henderson","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","School of Women\u2019s and Children\u2019s Health, UNSW Medicine , Randwick,","Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","School of Women's and Children's Health, UNSW Medicine, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, UNSW , Sydney, NSW,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Women\u2019s and Children\u2019s Health, UNSW Medicine , Randwick,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Women's and Children's Health, UNSW Medicine, Randwick, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015873058"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":{"value":3745,"currency":"USD","value_usd":3745},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"67","issue":"10","first_page":"1373","last_page":"1383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/droplet-digital-pcr","display_name":"droplet digital PCR","score":0.9869999885559082},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":1.0},{"id":"https://openalex.org/keywords/analytical-quality-control","display_name":"analytical quality control","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mrd-quantification","display_name":"MRD quantification","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.813640296459198},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.7659063935279846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5593257546424866},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.5301680564880371},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4773942828178406},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42686328291893005},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34966525435447693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32083314657211304},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2944873571395874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28854191303253174},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14153316617012024},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/clinchem/hvab117","doi":"https://doi.org/10.1093/clinchem/hvab117","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/hvab117","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:39506256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39506256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1147404897","https://openalex.org/W1978239142","https://openalex.org/W1989672787","https://openalex.org/W2042194227","https://openalex.org/W2045991264","https://openalex.org/W2051804704","https://openalex.org/W2064543601","https://openalex.org/W2069085828","https://openalex.org/W2071899049","https://openalex.org/W2081495071","https://openalex.org/W2089624490","https://openalex.org/W2099066165","https://openalex.org/W2103225182","https://openalex.org/W2159325547","https://openalex.org/W2382665027","https://openalex.org/W2398174031","https://openalex.org/W2486629951","https://openalex.org/W2607428315","https://openalex.org/W2610953960","https://openalex.org/W2765626054","https://openalex.org/W2781046194","https://openalex.org/W2783450169","https://openalex.org/W2787046878","https://openalex.org/W2796244978","https://openalex.org/W2800303197","https://openalex.org/W2802372704","https://openalex.org/W2808096238","https://openalex.org/W2892005049","https://openalex.org/W2942811651","https://openalex.org/W2944596426","https://openalex.org/W2964177223","https://openalex.org/W2981754892","https://openalex.org/W3013776441","https://openalex.org/W3016696556","https://openalex.org/W3031327439","https://openalex.org/W3033686038"],"related_works":["https://openalex.org/W4282941976","https://openalex.org/W2382665027","https://openalex.org/W4224076789","https://openalex.org/W2949962309","https://openalex.org/W4319461762","https://openalex.org/W6887640428","https://openalex.org/W2911469270","https://openalex.org/W1147404897","https://openalex.org/W3193280623","https://openalex.org/W2796244978"],"abstract_inverted_index":{"BACKGROUND:":[0],"Droplet":[1],"digital":[2],"PCR":[3,42],"(ddPCR)":[4],"is":[5,24],"a":[6,80,89],"promising":[7],"technique":[8],"for":[9,39,53,75,113,120,125,132,202,222],"absolute":[10],"quantification":[11],"of":[12,67,166,195],"minimal":[13],"residual":[14],"disease":[15],"(MRD)":[16],"in":[17,34,64,182,225],"acute":[18],"lymphoblastic":[19],"leukemia":[20],"(ALL),":[21],"but":[22],"there":[23,161],"no":[25],"comprehensive":[26],"quality":[27,106,199],"assurance":[28],"program":[29],"to":[30,55,88,94,148,209,218],"enable":[31],"its":[32],"application":[33],"clinical":[35],"laboratories.":[36],"Current":[37],"guidelines":[38],"real-time":[40],"quantitative":[41,158],"(qPCR)":[43],"assays":[44,74,153],"targeting":[45],"immunoglobulin/T-cell":[46],"receptor":[47],"(Ig/TCR)":[48],"gene":[49,77,84],"rearrangements":[50,78],"needed":[51],"adaptation":[52],"ddPCR":[54,90,114,127,152,172,203],"cover":[56],"droplet":[57,121],"generation,":[58],"intraassay":[59],"variation,":[60],"and":[61,79,92,111,131,143,157,171,179,213],"interassay":[62],"variation":[63],"the":[65,151,207],"absence":[66],"standard":[68,81,211],"curves.":[69],"METHODS:":[70],"Six":[71],"qPCR":[72,170,220],"MRD":[73,115,167,204,223],"Ig/TCR":[76],"albumin":[82,126],"control":[83,200],"assay":[85,128,135],"were":[86,109,138],"migrated":[87],"platform":[91],"used":[93],"test":[95],"82":[96],"remission":[97],"samples":[98,185],"from":[99],"6":[100],"patients":[101],"with":[102,140],"ALL.":[103,226],"Three":[104],"analytical":[105],"controls":[107],"(QC)":[108],"developed":[110,198],"evaluated":[112],"detection.":[116],"RESULTS:":[117],"Analytical":[118],"QC":[119,145],"number":[122],"generation":[123],"(DN-QC),":[124],"performance":[129,136],"(Alb-QC)":[130],"patient-specific":[133],"marker":[134],"(PS-QC)":[137],"established":[139,149],"pass/fail":[141],"limits":[142],"corresponding":[144],"rules.":[146],"Compared":[147],"qPCRs,":[150],"had":[154],"comparable":[155,217],"sensitivity":[156],"range.":[159],"Overall,":[160],"was":[162],"close":[163],"agreement":[164],"(91%)":[165],"results":[168,216],"between":[169],"(\u03ba":[173],"=":[174,187],"0.86,":[175],"P":[176,189],"<":[177,190],"0.0001)":[178],"stronger":[180],"concordance":[181],"32":[183],"quantifiable":[184],"(R2":[186],"0.97,":[188],"0.0001).":[191],"CONCLUSIONS:":[192],"The":[193],"use":[194],"this":[196],"newly":[197],"system":[201],"testing":[205],"avoids":[206],"need":[208],"repeat":[210],"curves":[212],"provides":[214],"reliable":[215],"standardized":[219],"methods":[221],"detection":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-16T00:00:00"}
