{"id":"https://openalex.org/W3190130751","doi":"https://doi.org/10.1166/jbt.2021.2844","title":"Bone Marrow Mesenchymal Stem Cells (BMSC)-Originated miR-133 Impedes Migration and Invasiveness of Glioma Cells While Enhancing Apoptosis via Targeting the Receptor for Activated C Kinase 1 (RACK1)","display_name":"Bone Marrow Mesenchymal Stem Cells (BMSC)-Originated miR-133 Impedes Migration and Invasiveness of Glioma Cells While Enhancing Apoptosis via Targeting the Receptor for Activated C Kinase 1 (RACK1)","publication_year":2021,"publication_date":"2021-08-05","ids":{"openalex":"https://openalex.org/W3190130751","doi":"https://doi.org/10.1166/jbt.2021.2844","mag":"3190130751"},"language":"en","primary_location":{"id":"doi:10.1166/jbt.2021.2844","doi":"https://doi.org/10.1166/jbt.2021.2844","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jbt.2021.2844","pdf_url":null,"source":{"id":"https://openalex.org/S2484002919","display_name":"Journal of Biomaterials and Tissue Engineering","issn_l":"2157-9083","issn":["2157-9083","2157-9091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials and Tissue Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036692798","display_name":"Jiangbo Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangbo Xiong","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101867778","display_name":"Sheng Liu","orcid":"https://orcid.org/0000-0002-4483-4512","observed_orcids":["https://orcid.org/0000-0002-4483-4512"]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Liu","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032472500","display_name":"Bin Xiang","orcid":"https://orcid.org/0009-0000-3392-9367","observed_orcids":["https://orcid.org/0009-0000-3392-9367"]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Xiang","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101414458","display_name":"Weibo Zhang","orcid":"https://orcid.org/0000-0002-9465-6507","observed_orcids":["https://orcid.org/0000-0002-9465-6507"]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weibo Zhang","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101807796","display_name":"Jun Du","orcid":"https://orcid.org/0000-0003-3057-8543","observed_orcids":["https://orcid.org/0000-0003-3057-8543"]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Du","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103086864","display_name":"Sheng Zhou","orcid":"https://orcid.org/0000-0002-8918-3469","observed_orcids":["https://orcid.org/0000-0002-8918-3469"]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Zhou","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huaizhong Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huaizhong Huang","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100718709","display_name":"Peng Wang","orcid":"https://orcid.org/0000-0002-2549-2780","observed_orcids":["https://orcid.org/0000-0002-2549-2780"]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]},{"author_position":"last","author":{"id":null,"display_name":"Li Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Luo","raw_affiliation_strings":["Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chongqing Qianjiang Central Hospital, Chongqing, 409099, China","institution_ids":["https://openalex.org/I4210112295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210112295"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"11","issue":"9","first_page":"1818","last_page":"1824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mir-133","display_name":"miR-133","score":0.9739999771118164},{"id":"https://openalex.org/keywords/rack1","display_name":"RACK1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.48899999260902405},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.671999990940094},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7293940186500549},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6567693948745728},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5948700904846191},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.5783909559249878},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5456829071044922},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5026347637176514},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4767471253871918},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4761676490306854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.460428923368454},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.44606107473373413},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4372252821922302},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4346265196800232},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42181113362312317},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31760546565055847},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30954548716545105},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22391822934150696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.044199138879776},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1166/jbt.2021.2844","doi":"https://doi.org/10.1166/jbt.2021.2844","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jbt.2021.2844","pdf_url":null,"source":{"id":"https://openalex.org/S2484002919","display_name":"Journal of Biomaterials and Tissue Engineering","issn_l":"2157-9083","issn":["2157-9083","2157-9091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials and Tissue Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3092567537","https://openalex.org/W4205089614","https://openalex.org/W4307329555","https://openalex.org/W4220996047","https://openalex.org/W3165799514","https://openalex.org/W3042458342","https://openalex.org/W2368352878","https://openalex.org/W1970338761","https://openalex.org/W4206208362","https://openalex.org/W4206135009"],"abstract_inverted_index":{"This":[0],"study":[1,141],"aims":[2],"to":[3],"dissect":[4],"the":[5,15,23,68,83,147,153,171,177],"effects":[6],"of":[7,19,50,70,149,159,179],"bone":[8],"marrow":[9],"mesenchymal":[10],"stem":[11],"cells":[12,21,28,102,114,160,181],"(BMSC)":[13],"on":[14],"in":[16,73,112],"vitro":[17],"activity":[18],"glioma":[20,27,101,113,180],"and":[22,38,42,63,77,82,88,126,138,156,173],"underlying":[24],"mechanisms.":[25],"The":[26],"were":[29],"transfected":[30],"with":[31,45,97,117,120],"miR-133":[32,39,51,87,107,109,144,168],"mimics,":[33],"RACK1-Vector,":[34],"negative":[35],"control":[36],"(NC)":[37],"mimic+RACK1-Vector,":[40],"respectively,":[41],"then":[43],"co-cultured":[44],"BMSC":[46],"followed":[47],"by":[48,79,90],"analysis":[49],"expression":[52,69,148],"via":[53,56,60,65,182],"PCR,":[54],"apoptosis":[55,178],"flow":[57],"cytometry,":[58],"proliferation":[59,123,157],"CCK-8,":[61],"invasion":[62,127,174],"migration":[64,125,155,172],"Transwell":[66],"assay,":[67],"proteins":[71],"involved":[72],"apoptosis,":[74],"anti-apoptosis,":[75],"invasiveness":[76],"RACK1":[78,89],"western":[80],"blot,":[81],"targeting":[84,183],"relationship":[85],"between":[86],"dual-luciferase":[91],"reporter":[92],"gene":[93],"assay.":[94],"In":[95,165],"comparison":[96],"normal":[98],"glial":[99],"cells,":[100],"exhibited":[103],"a":[104],"significantly":[105,121],"diminished":[106],"level.":[108],"was":[110],"upregulated":[111],"after":[115],"co-culture":[116],"BMSC,":[118],"along":[119],"restrained":[122],"rate,":[124],"activities":[128,158],"as":[129,131],"well":[130],"reduced":[132],"protein":[133],"levels":[134],"(MMP-2,":[135],"Vimentin,":[136],"N-cadherin":[137],"MMP-9).":[139],"Mechanistic":[140],"showed":[142],"that":[143],"can":[145,169],"retard":[146],"RACK1,":[150],"thereby":[151],"impeding":[152],"invasion,":[154],"while":[161,175],"triggering":[162],"cell":[163],"apoptosis.":[164],"conclusion,":[166],"BMSC-originated":[167],"impede":[170],"enhancing":[176],"RACK1.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-08-16T00:00:00"}