{"id":"https://openalex.org/W3189242018","doi":"https://doi.org/10.2967/jnumed.121.262542","title":"Phase I Trial of 99mTc-(HE)3-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer","display_name":"Phase I Trial of 99mTc-(HE)3-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer","publication_year":2021,"publication_date":"2021-08-12","ids":{"openalex":"https://openalex.org/W3189242018","doi":"https://doi.org/10.2967/jnumed.121.262542","mag":"3189242018","pmid":"https://pubmed.ncbi.nlm.nih.gov/34385343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8973295"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.121.262542","doi":"https://doi.org/10.2967/jnumed.121.262542","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.121.262542","pdf_url":"https://jnm.snmjournals.org/content/jnumed/early/2021/08/12/jnumed.121.262542.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnm.snmjournals.org/content/jnumed/early/2021/08/12/jnumed.121.262542.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036926482","display_name":"Olga Bragina","orcid":"https://orcid.org/0000-0001-5281-7758","observed_orcids":["https://orcid.org/0000-0001-5281-7758"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Bragina","raw_affiliation_strings":["Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088872401","display_name":"\u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440 \u0418\u0432\u0430\u043d\u043e\u0432\u0438\u0447 \u0427\u0435\u0440\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-5524-9546","observed_orcids":["https://orcid.org/0000-0002-5524-9546"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir Chernov","raw_affiliation_strings":["Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Cancer Research Institute, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Cancer Research Institute, Russian Federation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031750428","display_name":"Alexey A. Schulga","orcid":"https://orcid.org/0000-0003-3425-0828","observed_orcids":["https://orcid.org/0000-0003-3425-0828"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Schulga","raw_affiliation_strings":["Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080347903","display_name":"\u0415. \u0412. \u041a\u043e\u043d\u043e\u0432\u0430\u043b\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-4187-376X","observed_orcids":["https://orcid.org/0000-0002-4187-376X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena Konovalova","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002021947","display_name":"\u0415. Yu. Garbukov","orcid":"https://orcid.org/0000-0002-6016-7078","observed_orcids":["https://orcid.org/0000-0002-6016-7078"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"id":"https://openalex.org/I4210157628","display_name":"Tomsk Cancer Research Institute","ror":"https://ror.org/05gf3n961","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210157628"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Eugeniy Garbukov","raw_affiliation_strings":["Department of General Oncology, Cancer Research Institute, Tomsk National Research Medical Center Russian Academy of Sciences, Tomsk, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences,, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Oncology, Cancer Research Institute, Tomsk National Research Medical Center Russian Academy of Sciences, Tomsk, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499","https://openalex.org/I4210157628"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences,, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002404985","display_name":"Anzhelika Vorobyeva","orcid":"https://orcid.org/0000-0002-4778-3909","observed_orcids":["https://orcid.org/0000-0002-4778-3909"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]}],"countries":["RU","SE"],"is_corresponding":false,"raw_author_name":"Anzhelika Vorobyeva","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Uppsala University, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Uppsala University, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014071440","display_name":"Anna Orlova","orcid":"https://orcid.org/0000-0001-6120-2683","observed_orcids":["https://orcid.org/0000-0001-6120-2683"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]}],"countries":["RU","SE"],"is_corresponding":false,"raw_author_name":"Anna Orlova","raw_affiliation_strings":["Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden","Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Uppsala University, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Uppsala University, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011698763","display_name":"\u041b. \u0410. \u0422\u0430\u0448\u0438\u0440\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0003-2061-8417","observed_orcids":["https://orcid.org/0000-0003-2061-8417"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Liubov Tashireva","raw_affiliation_strings":["Department of General and Molecular Pathology, Tomsk National Research Medical Center, Tomsk, Russia; and","Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Molecular Pathology, Tomsk National Research Medical Center, Tomsk, Russia; and","institution_ids":["https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101477428","display_name":"Jens S\u00f8rensen","orcid":"https://orcid.org/0000-0001-5738-9983","observed_orcids":["https://orcid.org/0000-0001-5738-9983"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jens S\u00f6rensen","raw_affiliation_strings":["Radiology and Nuclear Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden","Uppsala University, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology and Nuclear Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Uppsala University, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112336489","display_name":"Roman Zelchan","orcid":"https://orcid.org/0000-0002-4568-1781","observed_orcids":["https://orcid.org/0000-0002-4568-1781"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Roman Zelchan","raw_affiliation_strings":["Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001315014","display_name":"\u0410. A. Medvedeva","orcid":"https://orcid.org/0000-0003-2113-6436","observed_orcids":["https://orcid.org/0000-0003-2113-6436"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna Medvedeva","raw_affiliation_strings":["Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058335791","display_name":"Sergey Mikhailovich Deyev","orcid":"https://orcid.org/0000-0002-3952-0631","observed_orcids":["https://orcid.org/0000-0002-3952-0631"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey Deyev","raw_affiliation_strings":["Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences,, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences,, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090698986","display_name":"\u0422\u043e\u043b\u043c\u0430\u0447\u0435\u0432 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440 \u041c\u0430\u043a\u0441\u0438\u043c\u0438\u043b\u0438\u0430\u043d\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-6122-1734","observed_orcids":["https://orcid.org/0000-0002-6122-1734"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]}],"countries":["RU","SE"],"is_corresponding":true,"raw_author_name":"Vladimir Tolmachev","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia; vladimir.tolmachev@igp.uu.se","Uppsala University, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia; vladimir.tolmachev@igp.uu.se","institution_ids":["https://openalex.org/I30849647"]},{"raw_affiliation_string":"Uppsala University, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5090698986"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I30849647"],"apc_list":null,"apc_paid":null,"fwci":5.5346,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.9713678,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"63","issue":"4","first_page":"528","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/designed-ankyrin-repeat-proteins","display_name":"DARPin","score":0.7599999904632568},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dosimetry","display_name":"dosimetry","score":0.9610000252723694},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-to-background-ratio","display_name":"tumor-to-background ratio","score":0.6439999938011169},{"id":"https://openalex.org/keywords/spect-ct","display_name":"SPECT/CT","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.6766232252120972},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6413712501525879},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5624039173126221},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.5378050208091736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5340536832809448},{"id":"https://openalex.org/C522557706","wikidata":"https://www.wikidata.org/wiki/Q1054","display_name":"Technetium","level":2,"score":0.4667976498603821},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46415409445762634},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.46409645676612854},{"id":"https://openalex.org/C2780285475","wikidata":"https://www.wikidata.org/wiki/Q7433939","display_name":"Scintimammography","level":5,"score":0.4428976774215698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32091832160949707},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.20043537020683289},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.17941957712173462},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1277342140674591},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.11455774307250977},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090922","descriptor_name":"Designed Ankyrin Repeat Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2967/jnumed.121.262542","doi":"https://doi.org/10.2967/jnumed.121.262542","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.121.262542","pdf_url":"https://jnm.snmjournals.org/content/jnumed/early/2021/08/12/jnumed.121.262542.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8973295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8973295","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nucl Med","raw_type":"Text"},{"id":"pmid:34385343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34385343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.2967/jnumed.121.262542","doi":"https://doi.org/10.2967/jnumed.121.262542","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.121.262542","pdf_url":"https://jnm.snmjournals.org/content/jnumed/early/2021/08/12/jnumed.121.262542.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G6444257319","display_name":null,"funder_award_id":"075-15-","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G8552561307","display_name":null,"funder_award_id":"075-15-2019-1925","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3189242018.pdf","grobid_xml":"https://content.openalex.org/works/W3189242018.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2115813710","https://openalex.org/W2136802861","https://openalex.org/W2154568434","https://openalex.org/W2165238581","https://openalex.org/W2171070913","https://openalex.org/W2190644725","https://openalex.org/W2198899045","https://openalex.org/W2259270597","https://openalex.org/W2267591082","https://openalex.org/W2285875128","https://openalex.org/W2560406314","https://openalex.org/W2618756196","https://openalex.org/W2791476909","https://openalex.org/W2806209829","https://openalex.org/W2954328971","https://openalex.org/W2999754980","https://openalex.org/W3005982665","https://openalex.org/W3037832279","https://openalex.org/W3050283202","https://openalex.org/W3121365664"],"related_works":["https://openalex.org/W3163058394","https://openalex.org/W2805694548","https://openalex.org/W4224120443","https://openalex.org/W4254687968","https://openalex.org/W3050283202","https://openalex.org/W1573555225","https://openalex.org/W2171070913","https://openalex.org/W3208286551","https://openalex.org/W4214485394","https://openalex.org/W2079903188"],"abstract_inverted_index":{"Radionuclide":[0],"molecular":[1],"imaging":[2,100,124,257],"of":[3,25,48,60,65,94,145,239,273],"human":[4],"epidermal":[5],"growth":[6],"factor":[7],"type":[8],"2":[9,231],"(HER2)":[10],"expression":[11,241],"may":[12],"enable":[13],"a":[14,33,249],"non-invasive":[15],"discrimination":[16],"between":[17,210],"HER2-positive":[18,83,260],"and":[19,58,79,110,117,125,147,154,171,178,232,247,261],"HER2-negative":[20,78,229,262],"breast":[21,69,263],"cancers":[22],"for":[23,27,219,228],"stratification":[24],"patients":[26,66,76,81],"HER2-targeted":[28],"treatments.":[29],"DARPin":[30],"G3":[31],"is":[32,244],"small":[34,179],"(molecular":[35],"weigh":[36],"14":[37],"kDa)":[38],"scaffold":[39],"protein":[40],"with":[41,67,77,82,87,187,201],"picomolar":[42],"affinity":[43],"to":[44,53,127],"HER2.":[45],"The":[46,143,163,182],"aim":[47],"this":[49],"first-in-human":[50],"study":[51,267],"was":[52,104,166,192],"evaluate":[54],"the":[55,161,169,175,197],"safety,":[56],"biodistribution":[57],"dosimetry":[59],"99mTc-(HE)3-G3.":[61,274],"Methods:":[62],"Three":[63],"cohorts":[64,211],"primary":[68],"cancer":[70],"(each":[71],"including":[72],"at":[73,106,230],"least":[74],"4":[75,233],"5":[80],"tumors)":[84],"were":[85,121,135,141,222],"injected":[86],"either":[88],"1000,":[89],"2000":[90,188],"or":[91,189],"3000":[92,190],"\u00b5g":[93,191],"99mTc-(HE)3-G3":[95,157,243],"(287\u00b1170":[96],"MBq).":[97],"Whole-body":[98],"planar":[99],"followed":[101,173],"by":[102,174],"SPECT":[103],"performed":[105],"2,":[107],"4,":[108],"6":[109],"24":[111],"h":[112,234],"after":[113,130,155,185,199,235],"injection.":[114,131,236],"Vital":[115],"signs":[116],"possible":[118],"side":[119,139],"effects":[120,140],"monitored":[122],"during":[123],"up":[126],"7":[128],"days":[129],"Results:":[132],"All":[133],"injections":[134],"well":[136],"tolerated.":[137],"No":[138],"observed.":[142],"results":[144],"blood":[146],"urine":[148],"analyses":[149],"did":[150,206],"not":[151,207],"differ":[152,208],"before":[153],"studies.":[156],"cleared":[158],"rapidly":[159],"from":[160],"blood.":[162],"highest":[164],"uptake":[165,184,198],"detected":[167],"in":[168],"kidneys":[170],"liver":[172],"lungs,":[176],"breasts":[177],"intestinal":[180],"content.":[181],"hepatic":[183],"injecting":[186,200],"significantly":[193,209,223],"(p<0.05)":[194],"lower":[195],"than":[196,227],"1000":[202],"\u00b5g.":[203],"Effective":[204],"doses":[205],"(average":[212],"0.011\u00b1":[213],"0.004":[214],"mSv/MBq).":[215],"Tumor-to-contralateral":[216],"site":[217],"ratios":[218],"HER-positive":[220],"tumors":[221],"(p<":[224],"0.05)":[225],"higher":[226],"Conclusion:":[237],"Imaging":[238],"HER2":[240],"using":[242],"safe,":[245],"well-tolerated":[246],"provides":[248],"low":[250],"absorbed":[251],"dose":[252],"burden":[253],"on":[254],"patients.":[255],"This":[256],"enables":[258],"discerning":[259],"cancer.":[264],"Phase":[265],"I":[266],"data":[268],"justifies":[269],"further":[270],"clinical":[271],"development":[272]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-16T00:00:00"}