{"id":"https://openalex.org/W3189241713","doi":"https://doi.org/10.25276/0235-4160-2021-2-40-47","title":"Research of the developed gel intracorneal colored implants for keratopigmentation based on various materials. Experimental study","display_name":"Research of the developed gel intracorneal colored implants for keratopigmentation based on various materials. Experimental study","publication_year":2021,"publication_date":"2021-07-15","ids":{"openalex":"https://openalex.org/W3189241713","doi":"https://doi.org/10.25276/0235-4160-2021-2-40-47","mag":"3189241713"},"language":"en","primary_location":{"id":"doi:10.25276/0235-4160-2021-2-40-47","doi":"https://doi.org/10.25276/0235-4160-2021-2-40-47","is_oa":true,"landing_page_url":"https://doi.org/10.25276/0235-4160-2021-2-40-47","pdf_url":null,"source":{"id":"https://openalex.org/S4210176926","display_name":"Fyodorov journal of ophthalmic surgery","issn_l":"0235-4160","issn":["0235-4160","2312-4970"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fyodorov journal of ophthalmic surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.25276/0235-4160-2021-2-40-47","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","raw_affiliation_strings":["Fyodorov Eye Microsurgery Federal State Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fyodorov Eye Microsurgery Federal State Institution","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S.B. Izmailova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136268261","display_name":"Russian University of Medicine","ror":"https://ror.org/04bgrkn57","country_code":"RU","type":"education","lineage":["https://openalex.org/I136268261"]},{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.B. Izmailova","raw_affiliation_strings":["Fyodorov Eye Microsurgery Federal State Institution; Yevdokimov Moscow State University of Medicine and Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fyodorov Eye Microsurgery Federal State Institution; Yevdokimov Moscow State University of Medicine and Dentistry","institution_ids":["https://openalex.org/I136268261","https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057329591","display_name":"\u0411\u043e\u0440\u0437\u0435\u043d\u043e\u043a \u0421\u0435\u0440\u0433\u0435\u0439 \u0410\u043d\u0430\u0442\u043e\u043b\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-9160-6240","observed_orcids":["https://orcid.org/0000-0001-9160-6240"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.A. Borzenok","raw_affiliation_strings":["Fyodorov Eye Microsurgery Federal State Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fyodorov Eye Microsurgery Federal State Institution","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","raw_affiliation_strings":["Fyodorov Eye Microsurgery Federal State Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fyodorov Eye Microsurgery Federal State Institution","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"O.Y. Komarova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O.Y. Komarova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024795412","display_name":"Dmitriy S. Ostrovskiy","orcid":"https://orcid.org/0000-0002-2817-7102","observed_orcids":["https://orcid.org/0000-0002-2817-7102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.S. Ostrovkiy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2121,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.425575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":"2","first_page":"40","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-hyaluronate","display_name":"sodium hyaluronate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inorganic-pigments","display_name":"inorganic pigments","score":0.8330000042915344},{"id":"https://openalex.org/keywords/donor-cornea","display_name":"donor cornea","score":0.593999981880188},{"id":"https://openalex.org/keywords/keratocyte-apoptosis","display_name":"keratocyte apoptosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/caspase-expression","display_name":"caspase expression","score":0.6690000295639038},{"id":"https://openalex.org/keywords/implant-biocompatibility","display_name":"implant biocompatibility","score":0.7289999723434448},{"id":"https://openalex.org/keywords/aniridia","display_name":"aniridia","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.6263402700424194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6076047420501709},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5476356148719788},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4731006622314453},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.4514842629432678},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.4366018772125244},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.432228147983551},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3285713195800781},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18836814165115356},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18695855140686035},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.16256612539291382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12605223059654236},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09199303388595581},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.25276/0235-4160-2021-2-40-47","doi":"https://doi.org/10.25276/0235-4160-2021-2-40-47","is_oa":true,"landing_page_url":"https://doi.org/10.25276/0235-4160-2021-2-40-47","pdf_url":null,"source":{"id":"https://openalex.org/S4210176926","display_name":"Fyodorov journal of ophthalmic surgery","issn_l":"0235-4160","issn":["0235-4160","2312-4970"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fyodorov journal of ophthalmic surgery","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:999bb7a0218d4bd599b11e1338246122","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/999bb7a0218d4bd599b11e1338246122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041e\u0444\u0442\u0430\u043b\u044c\u043c\u043e\u0445\u0438\u0440\u0443\u0440\u0433\u0438\u044f, Vol 0, Iss 2, Pp 40-47 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.25276/0235-4160-2021-2-40-47","doi":"https://doi.org/10.25276/0235-4160-2021-2-40-47","is_oa":true,"landing_page_url":"https://doi.org/10.25276/0235-4160-2021-2-40-47","pdf_url":null,"source":{"id":"https://openalex.org/S4210176926","display_name":"Fyodorov journal of ophthalmic surgery","issn_l":"0235-4160","issn":["0235-4160","2312-4970"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fyodorov journal of ophthalmic surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089233352","https://openalex.org/W2012222744","https://openalex.org/W1035318190","https://openalex.org/W2607254577","https://openalex.org/W2055950004","https://openalex.org/W1978924918","https://openalex.org/W1418333413","https://openalex.org/W2425721312","https://openalex.org/W2443413696","https://openalex.org/W2088191076"],"abstract_inverted_index":{"Purpose.":[0],"Evaluation":[1],"of":[2,5,32,72,78,85,90,110,142,146,158,235,252],"the":[3,6,19,70,73,76,86,104,108,114,136,143,159,182,199,203,242,272],"impact":[4],"developed":[7],"intracorneal":[8,33,245,280],"gel":[9,34,120,223],"stained":[10,35],"implants":[11,36,75],"for":[12,207,238],"keratopigmentation":[13],"based":[14,41,50,60,122,188,250,260],"on":[15,18,42,51,61,123,189,261],"various":[16],"materials":[17],"donor":[20],"human":[21],"cornea":[22],"during":[23],"organotypic":[24,236],"cultivation.":[25],"Material":[26],"and":[27,57,127,150,153,161,173,179,196,229,254,268],"methods.":[28],"Three":[29],"experimental":[30,274],"samples":[31,170],"were":[37],"investigated:":[38],"sample":[39,48,58,185],"1":[40,172],"sodium":[43],"hyaluronate":[44],"with":[45,54,65,130],"organic":[46,66],"pigment,":[47,56],"2":[49,187,249],"collagen":[52,125,190,221,253,262],"hydrolyzate":[53,126,191,222,251,263],"inorganic":[55,132,255],"3":[59,175],"hydroxypropyl":[62],"methylcellulose":[63],"(HPMC)":[64],"pigment.":[67],"To":[68],"determine":[69],"toxicity":[71],"studied":[74],"apoptosis":[77,147],"keratocytes":[79],"was":[80,92,100,167],"determined":[81],"in":[82,107,135,198],"cryostat":[83],"sections":[84],"cornea.":[87],"The":[88,219],"method":[89],"immunohistochemistry":[91],"used":[93,101],"to":[94,102],"study":[95],"apoptosis.":[96],"Scanning":[97],"electron":[98],"microscopy":[99],"visualize":[103],"corneal":[105,200],"structures":[106],"presence":[109],"implants.":[111],"Results.":[112],"During":[113],"investigation":[115],"we":[116],"showed":[117,214,241],"that":[118,169],"a":[119,124,128,139,193,233,265],"implant":[121,224,247,259],"pigment":[129],"an":[131,216],"toner":[133],"(28%":[134],"composition)":[137],"causes":[138],"weak":[140],"expression":[141,157],"initiator":[144],"proteins":[145,163],"Caspasa":[148,164],"8":[149],"Cytochrome":[151],"C,":[152],"there":[154],"is":[155,213],"no":[156],"BAX":[160],"effector":[162],"3/7.":[165],"It":[166],"revealed":[168],"No.":[171,174,186],"undergo":[176],"partial":[177],"dissolution":[178],"washout":[180],"from":[181],"intrastromal":[183],"tunnel,":[184],"has":[192,264],"dense":[194,269],"structure":[195,270],"remains":[197],"tunnel":[201],"throughout":[202],"entire":[204],"cultivation":[205,237],"period,":[206],"at":[208],"least":[209],"7":[210,239],"days,":[211],"which":[212],"using":[215],"electron-scanning":[217],"microscopy.":[218],"proposed":[220],"can":[225],"be":[226],"considered":[227],"compact":[228,267],"non-toxic.":[230],"Conclusion.":[231],"As":[232],"result":[234],"days":[240],"best":[243],"results":[244],"colored":[246,258,281],"\u2116":[248],"toner.":[256],"Intracorneal":[257],"more":[266],"than":[271],"accompanying":[273],"samples.":[275],"Key":[276],"words:":[277],"keratopigmentation,":[278],"aniridia,":[279],"implant.":[282]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-08-16T00:00:00"}