{"id":"https://openalex.org/W3188963010","doi":null,"title":"Beneficial effects of gingerenone A, a polyphenol present in ginger, on obesity and metabolic disorders","display_name":"Beneficial effects of gingerenone A, a polyphenol present in ginger, on obesity and metabolic disorders","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W3188963010","mag":"3188963010"},"language":"en","primary_location":{"id":"pmh:oai:s-space.snu.ac.kr:10371/120980","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/120980","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078863499","display_name":"\uc11d\uc218\uc9c4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\uc11d\uc218\uc9c4","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078863499"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gingerol","display_name":"gingerol","score":0.781000018119812},{"id":"https://openalex.org/keywords/shogaol","display_name":"shogaol","score":0.8259999752044678},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7170000076293945},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.6779999732971191},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7519999742507935},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.4519999921321869},{"id":"https://openalex.org/keywords/adipose-tissue-mass","display_name":"adipose tissue mass","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6743211150169373},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.538658082485199},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4873269498348236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4321099817752838},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3558890223503113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35439643263816833},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3217783570289612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21920901536941528},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15688592195510864},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.05371123552322388}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:s-space.snu.ac.kr:10371/120980","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/120980","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3188963010","doi":null,"is_oa":false,"landing_page_url":"http://s-space.snu.ac.kr/bitstream/10371/120980/1/000000066649.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1587875569","https://openalex.org/W1966241241","https://openalex.org/W1966336914","https://openalex.org/W2010139869","https://openalex.org/W2049965571","https://openalex.org/W2050764448","https://openalex.org/W2051051060","https://openalex.org/W2063131576","https://openalex.org/W2086922273","https://openalex.org/W2091578340","https://openalex.org/W2092422666","https://openalex.org/W2096252794","https://openalex.org/W2097447032","https://openalex.org/W2120071870","https://openalex.org/W2136024338","https://openalex.org/W2138673784","https://openalex.org/W2156260257","https://openalex.org/W2157559566","https://openalex.org/W2175474731","https://openalex.org/W2952783775"],"related_works":["https://openalex.org/W6967714338","https://openalex.org/W3196081650","https://openalex.org/W2602967021","https://openalex.org/W2943721419","https://openalex.org/W2615088204","https://openalex.org/W3152082781","https://openalex.org/W2618594632","https://openalex.org/W2296402263","https://openalex.org/W3047375149","https://openalex.org/W3036661570"],"abstract_inverted_index":{"The":[0,205,379],"World":[1],"Health":[2],"Organization":[3],"(WHO),":[4],"defines":[5],"both":[6],"overweight":[7],"and":[8,27,50,95,118,127,147,182,299,316,389,397,441,444,457,481,507,541,568],"obesity":[9,94,271,345,540,567],"as":[10,65,79,500,559],"potentially":[11],"hazardous":[12],"conditions":[13],"of":[14,58,74,90,104,125,143,180,194,240,248,278,307,365,387,405,433,460,475,489,539,566],"abnormal":[15],"or":[16],"excessive":[17,35],"fat":[18,274,279,367,418],"accumulation":[19,129,199,213,234],"arising":[20],"from":[21],"an":[22,80,477,525],"imbalance":[23],"between":[24],"energy":[25,28],"intake":[26],"expenditure.":[29],"Several":[30],"studies":[31],"have":[32,98,130],"shown":[33],"that":[34,157,208,223,341,382,446,534],"bodily":[36],"adipose":[37,59,348,376,438,450,504,542],"tissue":[38,60,349,377,412,439,451,505,543],"is":[39,76],"associated":[40,423],"with":[41,261,328,424,479],"metabolic":[42,96],"disorders":[43],"including":[44],"type":[45],"2":[46],"diabetes,":[47],"cardiovascular":[48],"disease,":[49],"non-alcoholic":[51],"fatty":[52,219,313,371,394],"liver":[53,300],"disease.":[54],"Therefore,":[55],"the":[56,70,101,105,123,135,141,144,160,171,178,192,195,238,246,262,291,305,335,359,363,385,403,430,461,472,487,537,564],"inhibition":[57],"expansion":[61],"has":[62,420],"been":[63,99,132,421],"proposed":[64],"a":[66,186,256,496,560],"promising":[67],"strategy":[68],"for":[69,122,557,563],"prevention":[71],"and/or":[72],"treatment":[73,327,565],"obesity.\\n\\tGinger":[75],"frequently":[77],"used":[78],"ingredient":[81],"in":[82,151,167,185,200,214,229,235,263,290,362,374,410,527,552],"nonprescription":[83],"weight-loss":[84],"products.":[85],"Although":[86],"several":[87],"pharmacological":[88],"effects":[89,502],"ginger":[91,108,173],"extract":[92],"on":[93,149,165,197,250,309,491,503],"disease":[97],"studied,":[100],"relative":[102],"potencies":[103],"major":[106],"bioactive":[107],"compounds":[109,196],"(6-gingerol":[110],"(6G),":[111],"8-gingerol":[112],"(8G),":[113],"10-gingerol":[114],"(10G),":[115],"6-shogaol":[116],"(6S)":[117],"gingerenone":[119],"A":[120],"(GA))":[121],"suppression":[124],"adipogenesis":[126,150,166,228],"lipid":[128,198,212,233,287,301],"not":[131,226,353],"clearly":[133],"elucidated.\\n\\tIn":[134],"present":[136],"study,":[137],"I":[138,189,243,294,369,427,485,532],"first":[139],"compared":[140,191],"effect":[142,164,193,247,306,432,488],"gingerols,":[145],"6S":[146],"GA":[148,158,175,210,224,249,266,308,329,342,383,434,447,470,490,515,535],"3T3-L1":[152,168,203],"preadipocytes.":[153],"Our":[154],"findings":[155],"show":[156],"elicits":[159],"most":[161],"potent":[162],"inhibitory":[163],"preadipocytes":[169,230],"among":[170],"five":[172],"compounds.":[174],"consistently":[176],"inhibited":[177],"expression":[179,386,459,473,509],"adipogenesis-":[181],"lipogenesis-related":[183,390],"proteins":[184],"concentration-dependent":[187],"manner.":[188],"next":[190],"fully":[201],"differentiated":[202],"adipocytes.":[204],"results":[206,339,380],"revealed":[207],"only":[209,227],"reduces":[211,384],"mature":[215,236],"adipocytes,":[216],"by":[217,255,272,326,346,415,453,494,521,550],"regulating":[218],"acid":[220,372,395],"metabolism,":[221,443],"showing":[222],"inhibits":[225],"but":[231,351],"also":[232,511],"adipocytes.\\n\\tOn":[237],"basis":[239],"these":[241],"results,":[242],"further":[244,357],"investigated":[245,428],"body":[251],"weight":[252],"gain":[253],"induced":[254,520,549],"high-fat":[257,522],"diet":[258],"(HFD).":[259],"Consistent":[260],"vitro":[264],"data,":[265],"supplementation":[267],"significantly":[268],"attenuated":[269],"HFD-induced":[270,344],"reducing":[273,347],"mass.":[275],"Significant":[276],"losses":[277],"mass":[280,419],"can":[281],"cause":[282],"lipodystrophy,":[283],"leading":[284],"to":[285,296,303,323,334],"ectopic":[286],"deposition,":[288],"particularly":[289],"liver.":[292],"Thus,":[293],"chose":[295],"investigate":[297,358],"serum":[298],"profiles":[302],"examine":[304],"lipodystrophy.":[310,355],"Circulating":[311],"free":[312],"acids":[314],"(FFAs)":[315],"hepatic":[317],"triacylglycerol":[318],"(TAG)":[319],"content":[320],"were":[321,332],"ameliorated":[322],"some":[324],"extent":[325],"when":[330],"comparisons":[331],"made":[333],"HFD-alone":[336],"group.":[337],"These":[338],"suggest":[340],"suppresses":[343],"mass,":[350,368],"does":[352],"affect":[354,512],"To":[356],"mechanisms":[360],"involved":[361],"reduction":[364],"GA-induced":[366],"evaluated":[370],"metabolism":[373],"epididymal":[375],"(EWAT).":[378],"showed":[381],"lipolysis-":[388],"proteins,":[391],"while":[392,545],"increasing":[393],"oxidation-":[396],"mitochondrial":[398],"biogenesis-related":[399],"transcript":[400],"levels":[401,474],"via":[402,524],"activation":[404],"AMP-activated":[406],"protein":[407],"kinase":[408],"(AMPK)":[409],"EWAT.\\n\\tAdipose":[411],"inflammation":[413,440,452,506],"caused":[414],"excessively":[416],"hypertrophied":[417],"closely":[422],"insulin":[425,492],"resistance.":[426],"whether":[429],"anti-obesity":[431],"might":[435],"be":[436],"influencing":[437],"glucose":[442,513,518,529,547],"found":[445],"effectively":[448,516],"suppressed":[449,536],"blocking":[454],"macrophage":[455],"recruitment":[456],"down-regulating":[458],"pro-inflammatory":[462],"cytokine,":[463],"tumor":[464],"necrosis":[465],"factor":[466],"\u03b1":[467],"(TNF-\u03b1).":[468],"Moreover,":[469],"increased":[471],"adiponectin,":[476],"adipokine":[478],"anti-inflammatory":[480],"insulin-sensitizing":[482],"properties.":[483],"Next,":[484],"examined":[486],"resistance":[493],"conducting":[495],"hyperinsulinemic-euglycemic":[497],"clamp":[498],"experiment,":[499],"such":[501],"adiponectin":[508],"may":[510],"metabolism.":[514],"improved":[517],"intolerance":[519,548],"feeding":[523],"increase":[526],"whole-body":[528],"utilization.\\n\\t\\tIn":[530],"conclusion,":[531],"observed":[533],"development":[538,558],"inflammation,":[544],"improving":[546],"HFD":[551],"mice,":[553],"highlighting":[554],"GAs":[555],"potential":[556],"therapeutic":[561],"agent":[562],"its":[569],"complications.":[570]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-08-16T00:00:00"}