{"id":"https://openalex.org/W3188009830","doi":"https://doi.org/10.1055/s-0041-1732444","title":"Cerebral Metabolic Crisis in Pediatric Cerebral Malaria","display_name":"Cerebral Metabolic Crisis in Pediatric Cerebral Malaria","publication_year":2021,"publication_date":"2021-08-10","ids":{"openalex":"https://openalex.org/W3188009830","doi":"https://doi.org/10.1055/s-0041-1732444","mag":"3188009830","pmid":"https://pubmed.ncbi.nlm.nih.gov/37970136"},"language":"en","primary_location":{"id":"doi:10.1055/s-0041-1732444","doi":"https://doi.org/10.1055/s-0041-1732444","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1732444","pdf_url":null,"source":{"id":"https://openalex.org/S2764736061","display_name":"Journal of Pediatric Intensive Care","issn_l":"2146-4618","issn":["2146-4618","2146-4626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Intensive Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10631841/pdf/10-1055-s-0041-1732444.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046806990","display_name":"Nicole Fortier O'Brien","orcid":"https://orcid.org/0000-0002-8826-8671","observed_orcids":["https://orcid.org/0000-0002-8826-8671"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole F. O'Brien","raw_affiliation_strings":["Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States"],"raw_orcid":"https://orcid.org/0000-0002-8826-8671","affiliations":[{"raw_affiliation_string":"Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086720270","display_name":"Karen Chetcuti","orcid":"https://orcid.org/0000-0002-9768-9494","observed_orcids":["https://orcid.org/0000-0002-9768-9494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Chetcuti","raw_affiliation_strings":["Department of Radiology, College of Medicine, Chichiri, Blantyre, Malawi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, College of Medicine, Chichiri, Blantyre, Malawi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048392953","display_name":"Yudy Fonseca","orcid":"https://orcid.org/0000-0002-1613-3858","observed_orcids":["https://orcid.org/0000-0002-1613-3858"]},"institutions":[{"id":"https://openalex.org/I1315496137","display_name":"University of Maryland Medical Center","ror":"https://ror.org/00sde4n60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315496137","https://openalex.org/I14285509"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yudy Fonseca","raw_affiliation_strings":["Division of Critical Care Medicine, Department of Pediatrics, University of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care Medicine, Department of Pediatrics, University of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I1315496137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018374040","display_name":"Lorenna Vidal","orcid":"https://orcid.org/0000-0003-3715-2510","observed_orcids":["https://orcid.org/0000-0003-3715-2510"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenna Vidal","raw_affiliation_strings":["Division of Neuroradiology, Department of Radiology Children's Hospital of Philadelphia, Clinical Instructor at Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"],"raw_orcid":"https://orcid.org/0000-0003-3715-2510","affiliations":[{"raw_affiliation_string":"Division of Neuroradiology, Department of Radiology Children's Hospital of Philadelphia, Clinical Instructor at Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002078491","display_name":"Prashant Raghavan","orcid":"https://orcid.org/0000-0001-6089-733X","observed_orcids":["https://orcid.org/0000-0001-6089-733X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashant Raghavan","raw_affiliation_strings":["Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051530186","display_name":"Douglas G. Postels","orcid":"https://orcid.org/0000-0001-5815-0691","observed_orcids":["https://orcid.org/0000-0001-5815-0691"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas G. Postels","raw_affiliation_strings":["Department of Neurology, George Washington University/Children's National Medical Center, Washington, District of Columbia, United States"],"raw_orcid":"https://orcid.org/0000-0001-5815-0691","affiliations":[{"raw_affiliation_string":"Department of Neurology, George Washington University/Children's National Medical Center, Washington, District of Columbia, United States","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072405390","display_name":"Yamikani F Chimalizeni","orcid":"https://orcid.org/0000-0003-0119-804X","observed_orcids":["https://orcid.org/0000-0003-0119-804X"]},"institutions":[{"id":"https://openalex.org/I157591606","display_name":"University of Malawi","ror":"https://ror.org/04vtx5s55","country_code":"MW","type":"education","lineage":["https://openalex.org/I157591606"]}],"countries":["MW"],"is_corresponding":false,"raw_author_name":"Yamikani Chimalizeni","raw_affiliation_strings":["Department of Pediatrics and Child Health, University of Malawi, Malawi College of Medicine, Chichiri, Blantyre, Malawi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, University of Malawi, Malawi College of Medicine, Chichiri, Blantyre, Malawi","institution_ids":["https://openalex.org/I157591606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077058444","display_name":"Stephen Ray","orcid":"https://orcid.org/0000-0001-5818-1228","observed_orcids":["https://orcid.org/0000-0001-5818-1228"]},"institutions":[{"id":"https://openalex.org/I2799451200","display_name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme","ror":"https://ror.org/03tebt685","country_code":"MW","type":"facility","lineage":["https://openalex.org/I157591606","https://openalex.org/I2799451200","https://openalex.org/I87048295"]}],"countries":["MW"],"is_corresponding":false,"raw_author_name":"Stephen Ray","raw_affiliation_strings":["Department of Paediatric, Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric, Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi","institution_ids":["https://openalex.org/I2799451200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065080750","display_name":"Karl B. Seydel","orcid":"https://orcid.org/0000-0001-9859-9549","observed_orcids":["https://orcid.org/0000-0001-9859-9549"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl B. Seydel","raw_affiliation_strings":["Blantyre Malaria Project, Blantyre, Malawi","Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blantyre Malaria Project, Blantyre, Malawi","institution_ids":[]},{"raw_affiliation_string":"Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033337244","display_name":"Terrie Ellen Taylor","orcid":"https://orcid.org/0000-0001-7416-3986","observed_orcids":["https://orcid.org/0000-0001-7416-3986"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrie E. Taylor","raw_affiliation_strings":["Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5046806990"],"corresponding_institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.13516345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"12","issue":"04","first_page":"278","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid-lactate","display_name":"cerebrospinal fluid lactate","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lactate-pyruvate-ratio","display_name":"lactate/pyruvate ratio","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cerebral-vasospasm","display_name":"cerebral vasospasm","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cerebral-blood-flow-velocity","display_name":"cerebral blood flow velocity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neurological-outcome","display_name":"neurological outcome","score":0.847000002861023},{"id":"https://openalex.org/keywords/pediatric-cerebral-performance-category","display_name":"Pediatric Cerebral Performance Category","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.967083215713501},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.7039540410041809},{"id":"https://openalex.org/C2908793570","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Cerebral Malaria","level":4,"score":0.6706575751304626},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5644286274909973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4836310148239136},{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.4793204069137573},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.44460222125053406},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4273325204849243},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.13789108395576477},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.10542985796928406},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09470728039741516}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0041-1732444","doi":"https://doi.org/10.1055/s-0041-1732444","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1732444","pdf_url":null,"source":{"id":"https://openalex.org/S2764736061","display_name":"Journal of Pediatric Intensive Care","issn_l":"2146-4618","issn":["2146-4618","2146-4626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Intensive Care","raw_type":"journal-article"},{"id":"pmid:37970136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37970136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric intensive care","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10631841","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10631841","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10631841/pdf/10-1055-s-0041-1732444.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Pediatr Intensive Care","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10631841","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10631841","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10631841/pdf/10-1055-s-0041-1732444.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Pediatr Intensive Care","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1858189645","display_name":null,"funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G9000266250","display_name":null,"funder_award_id":"CA016058","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3188009830.pdf","grobid_xml":"https://content.openalex.org/works/W3188009830.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1552036483","https://openalex.org/W1563193138","https://openalex.org/W1578695981","https://openalex.org/W1964269174","https://openalex.org/W1973356373","https://openalex.org/W1977684352","https://openalex.org/W1985965672","https://openalex.org/W1987849062","https://openalex.org/W1991087781","https://openalex.org/W1995096028","https://openalex.org/W1997122507","https://openalex.org/W1998210176","https://openalex.org/W2005062766","https://openalex.org/W2017094754","https://openalex.org/W2028546276","https://openalex.org/W2030166248","https://openalex.org/W2036725915","https://openalex.org/W2037024376","https://openalex.org/W2046754389","https://openalex.org/W2047859199","https://openalex.org/W2048238303","https://openalex.org/W2051912247","https://openalex.org/W2056220502","https://openalex.org/W2057463574","https://openalex.org/W2058801828","https://openalex.org/W2060927474","https://openalex.org/W2062534230","https://openalex.org/W2063600145","https://openalex.org/W2069760926","https://openalex.org/W2075445226","https://openalex.org/W2075500083","https://openalex.org/W2075511125","https://openalex.org/W2077794361","https://openalex.org/W2080824822","https://openalex.org/W2082498537","https://openalex.org/W2083391035","https://openalex.org/W2083554277","https://openalex.org/W2084366038","https://openalex.org/W2089811536","https://openalex.org/W2090613637","https://openalex.org/W2092482388","https://openalex.org/W2092599527","https://openalex.org/W2096365100","https://openalex.org/W2096970427","https://openalex.org/W2100721864","https://openalex.org/W2101228770","https://openalex.org/W2109447183","https://openalex.org/W2114864200","https://openalex.org/W2116666330","https://openalex.org/W2118493661","https://openalex.org/W2118846793","https://openalex.org/W2125670886","https://openalex.org/W2129153013","https://openalex.org/W2148256048","https://openalex.org/W2155080919","https://openalex.org/W2158752949","https://openalex.org/W2159783272","https://openalex.org/W2162331185","https://openalex.org/W2163498887","https://openalex.org/W2179947625","https://openalex.org/W2326999316","https://openalex.org/W2327530354","https://openalex.org/W2412824934","https://openalex.org/W2426613749","https://openalex.org/W2443186451","https://openalex.org/W2531335839","https://openalex.org/W2623298863","https://openalex.org/W2735489124","https://openalex.org/W2761367351","https://openalex.org/W2772125053","https://openalex.org/W2803205099","https://openalex.org/W2804299377","https://openalex.org/W2885186151","https://openalex.org/W2891629187","https://openalex.org/W2913263910","https://openalex.org/W2965420200","https://openalex.org/W3000249120","https://openalex.org/W4245264886","https://openalex.org/W4300875451"],"related_works":["https://openalex.org/W2487490720","https://openalex.org/W2793077515","https://openalex.org/W4292573045","https://openalex.org/W2126365059","https://openalex.org/W294293337","https://openalex.org/W4386009577","https://openalex.org/W2981615369","https://openalex.org/W3130621552","https://openalex.org/W2606644627","https://openalex.org/W2169285193"],"abstract_inverted_index":{"Abstract":[0],"Cerebral":[1,29,127],"metabolic":[2],"energy":[3],"crisis":[4],"(CMEC),":[5],"often":[6],"defined":[7],"as":[8],"a":[9,80,111,159,183],"cerebrospinal":[10],"fluid":[11],"(CSF)":[12],"lactate:":[13],"pyruvate":[14,72],"ratio":[15],"(LPR)":[16],">40,":[17],"occurs":[18],"in":[19,37,49,148,156,195],"various":[20],"diseases":[21],"and":[22,35,65,71,106,199,207],"is":[23],"associated":[24],"with":[25,61,150,158,167,182],"poor":[26],"neurologic":[27],"outcomes.":[28],"malaria":[30],"(CM)":[31],"causes":[32],"significant":[33],"mortality":[34],"neurodisability":[36],"children":[38,60,93,149,157],"worldwide.":[39],"Multiple":[40],"factors":[41],"that":[42],"could":[43],"lead":[44],"to":[45,134],"CMEC":[46,81,99,113,153,161,170,185,192],"are":[47],"plausible":[48],"these":[50],"patients,":[51],"but":[52],"its":[53],"frequency":[54],"has":[55],"not":[56],"been":[57],"explored.":[58],"Fifty-three":[59],"CM":[62],"were":[63,131],"enrolled":[64],"underwent":[66,122],"analysis":[67],"of":[68,85,92,102,116,178],"CSF":[69,83],"lactate":[70],"levels.":[73],"All":[74],"53":[75],"patients":[76],"met":[77,94,108],"criteria":[78,95,109,137],"for":[79,96,110,138,212],"(median":[82,100,114],"LPR":[84,101,115],"72.9":[86],"[interquartile":[87],"range":[88],"[IQR]:":[89],"58.5\u201393.3]).":[90],"Half":[91],"an":[97,151,168],"ischemic":[98,152,169],"85":[103],"[IQR:":[104,118],"73\u2013184])":[105],"half":[107],"nonischemic":[112,160,184],"60":[117],"54\u201379].":[119],"Children":[120,166],"also":[121],"transcranial":[123],"doppler":[124],"ultrasound":[125],"investigation.":[126],"blood":[128],"flow":[129,140],"velocities":[130],"more":[132],"likely":[133],"meet":[135],"diagnostic":[136],"low":[139],"(<2":[141],"standard":[142],"deviation":[143],"from":[144],"normal)":[145],"or":[146],"vasospasm":[147],"(73%)":[154],"than":[155,180],"(20%,":[162],"p":[163,189],"=":[164,190],"0.04).":[165],"had":[171],"poorer":[172],"outcomes":[173],"(pediatric":[174],"cerebral":[175],"performance":[176],"category":[177],"3\u20136)":[179],"those":[181],"(46":[186],"vs.":[187],"22%,":[188],"0.03).":[191],"was":[193],"ubiquitous":[194],"this":[196],"patient":[197],"population":[198],"the":[200,203],"processes":[201],"underlying":[202],"two":[204],"subtypes":[205],"(ischemic":[206],"nonischemic)":[208],"may":[209],"represent":[210],"targets":[211],"future":[213],"adjunctive":[214],"therapies.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}