{"id":"https://openalex.org/W3188008250","doi":"https://doi.org/10.1002/cncr.33789","title":"Phase 1 trial of adavosertib (AZD1775) in combination with concurrent radiation and cisplatin for intermediate\u2010risk and high\u2010risk head and neck squamous cell carcinoma","display_name":"Phase 1 trial of adavosertib (AZD1775) in combination with concurrent radiation and cisplatin for intermediate\u2010risk and high\u2010risk head and neck squamous cell carcinoma","publication_year":2021,"publication_date":"2021-08-11","ids":{"openalex":"https://openalex.org/W3188008250","doi":"https://doi.org/10.1002/cncr.33789","mag":"3188008250","pmid":"https://pubmed.ncbi.nlm.nih.gov/34379792"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.33789","doi":"https://doi.org/10.1002/cncr.33789","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.33789","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.33789","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.33789","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080673740","display_name":"Bhishamjit S. Chera","orcid":"https://orcid.org/0000-0002-6775-7986","observed_orcids":["https://orcid.org/0000-0002-6775-7986","https://orcid.org/0009-0003-2816-3557"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bhishamjit S. Chera","raw_affiliation_strings":["Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0002-6775-7986","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017793416","display_name":"Siddharth H Sheth","orcid":"https://orcid.org/0000-0002-1923-2309","observed_orcids":["https://orcid.org/0000-0002-1923-2309"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth H. Sheth","raw_affiliation_strings":["Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0002-1923-2309","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082058259","display_name":"Shetal Arvind Patel","orcid":"https://orcid.org/0000-0002-7210-5085","observed_orcids":["https://orcid.org/0000-0002-7210-5085"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shetal A. Patel","raw_affiliation_strings":["Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027125708","display_name":"Dan Goldin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Goldin","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050190029","display_name":"Kathe Douglas","orcid":"https://orcid.org/0000-0002-0225-6064","observed_orcids":["https://orcid.org/0000-0002-0225-6064"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathe E. Douglas","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0002-0225-6064","affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019271449","display_name":"Rebecca L. Green","orcid":"https://orcid.org/0000-0003-1181-9532","observed_orcids":["https://orcid.org/0000-0003-1181-9532"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca L. Green","raw_affiliation_strings":["Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040202861","display_name":"Colette J. Shen","orcid":"https://orcid.org/0000-0002-3855-7360","observed_orcids":["https://orcid.org/0000-0002-3855-7360"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colette J. Shen","raw_affiliation_strings":["Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112864074","display_name":"Gaorav P. Gupta","orcid":"https://orcid.org/0000-0001-9177-552X","observed_orcids":["https://orcid.org/0000-0001-9177-552X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaorav P. Gupta","raw_affiliation_strings":["Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106628122","display_name":"Dominic T. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominic T. Moore","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051696173","display_name":"Juneko E. Grilley Olson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juneko E. Grilley Olson","raw_affiliation_strings":["Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022384270","display_name":"Jared M. Weiss","orcid":"https://orcid.org/0000-0003-2961-4447","observed_orcids":["https://orcid.org/0000-0003-2961-4447"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared M. Weiss","raw_affiliation_strings":["Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0003-2961-4447","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080673740"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210123841","https://openalex.org/I4390039329"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":6.5075,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.98149278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"127","issue":"23","first_page":"4447","last_page":"4454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adavosertib","display_name":"adavosertib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/azd1775","display_name":"AZD1775","score":0.9959999918937683},{"id":"https://openalex.org/keywords/wee1-kinase-inhibitor","display_name":"Wee1 kinase inhibitor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/intensity-modulated-radiotherapy","display_name":"intensity-modulated radiotherapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.925000011920929},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/p16-status","display_name":"p16 status","score":0.6830000281333923},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.8849999904632568},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hypopharyngeal-cancer","display_name":"hypopharyngeal cancer","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9144670367240906},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6820200681686401},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6410579681396484},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.6276013255119324},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5962602496147156},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5808954238891602},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5801260471343994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4708371162414551},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42432254552841187},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2732369899749756},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19054096937179565}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.33789","doi":"https://doi.org/10.1002/cncr.33789","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.33789","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.33789","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:34379792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34379792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1002/cncr.33789","doi":"https://doi.org/10.1002/cncr.33789","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.33789","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.33789","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337683","display_name":"School of Medicine, University of North Carolina at Chapel Hill","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3188008250.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W165173872","https://openalex.org/W1986241711","https://openalex.org/W1991403537","https://openalex.org/W2033200231","https://openalex.org/W2100467915","https://openalex.org/W2109883979","https://openalex.org/W2110664940","https://openalex.org/W2118708119","https://openalex.org/W2138512717","https://openalex.org/W2142325694","https://openalex.org/W2146823569","https://openalex.org/W2159264690","https://openalex.org/W2163186602","https://openalex.org/W2186944346","https://openalex.org/W2771191081","https://openalex.org/W2790069485","https://openalex.org/W2968502728","https://openalex.org/W3041891326","https://openalex.org/W3088159776","https://openalex.org/W3088237161"],"related_works":["https://openalex.org/W2892282848","https://openalex.org/W3011273846","https://openalex.org/W3126149503","https://openalex.org/W4328119048","https://openalex.org/W2890375767","https://openalex.org/W3004857819","https://openalex.org/W2041355142","https://openalex.org/W4382396967","https://openalex.org/W4400272633","https://openalex.org/W2111216464"],"abstract_inverted_index":{"Background":[0],"Adavosertib":[1,233],"(AZD1775)":[2],"is":[3,264],"an":[4,82],"inhibitor":[5],"of":[6,21,56,61,70,74,85,115,140,227,243,257],"the":[7,19,57,62,71,130,135,153,265],"Wee1":[8],"kinase.":[9],"The":[10,124,193,199,213,223],"authors":[11],"conducted":[12],"a":[13,168],"phase":[14,137,267],"1b":[15],"trial":[16],"to":[17,128,151],"evaluate":[18],"safety":[20],"adavosertib":[22,107,141,189,228],"in":[23,96,252],"combination":[24,253],"with":[25,30,46,53,64,81,144,188,254,272],"definitive":[26],"chemoradiotherapy":[27],"for":[28,270],"patients":[29,45,78,165,271],"newly":[31],"diagnosed,":[32],"intermediate\u2010risk/high\u2010risk,":[33],"locally":[34],"advanced":[35],"head":[36],"and":[37,68,106,113,122,134,146,158,160,177,216,241,250,260],"neck":[38],"squamous":[39],"cell":[40],"carcinoma":[41],"(HNSCC).":[42],"Methods":[43],"Twelve":[44],"intermediate\u2010risk/high\u2010risk":[47],"HNSCC":[48],"were":[49,79,150,220],"enrolled,":[50],"including":[51,171],"those":[52],"p16\u2010negative":[54],"tumors":[55,60,69],"oropharynx,":[58],"p16\u2010positive":[59],"oropharynx":[63],"\u226510":[65],"tobacco":[66],"pack\u2010years,":[67],"larynx/hypopharynx":[72],"regardless":[73],"p16":[75],"status.":[76],"All":[77],"treated":[80],"8\u2010week":[83],"course":[84],"concurrent":[86],"intensity\u2010modulated":[87,258],"radiotherapy":[88,259],"at":[89,190],"70":[90,255],"grays":[91],"(Gy)":[92],"(2":[93],"Gy":[94,256],"daily":[95,109,237],"weeks":[97,104,116,244],"1\u20107),":[98,105],"cisplatin":[99,261],"30":[100,262],"mg/m2":[101],"weekly":[102],"(in":[103],"(twice":[108,236],"on":[110,238],"Monday,":[111,239],"Tuesday,":[112,240],"Wednesday":[114,242],"1,":[117,245],"2,":[118,246],"4,":[119,247],"5,":[120,248],"7,":[121,249],"8).":[123],"primary":[125],"objective":[126,155,202],"was":[127,196,211,229],"determine":[129,152],"maximum":[131,224],"tolerated":[132,225],"dose":[133,139,226,269],"recommended":[136,266],"2":[138,268],"given":[142],"concurrently":[143],"radiation":[145],"cisplatin.":[147],"Secondary":[148],"objectives":[149],"12\u2010week":[154,200],"response":[156,203],"rate":[157,204],"progression\u2010free":[159,215],"overall":[161,217],"survival.":[162],"Results":[163],"Three":[164],"(25%)":[166],"experienced":[167],"dose\u2010limiting":[169,185],"toxicity,":[170],"febrile":[172],"neutropenia":[173],"(n":[174,181],"=":[175,182],"2)":[176],"grade":[178],"4":[179],"thromboembolism":[180],"1).":[183],"Two":[184],"toxicities":[186],"occurred":[187],"150":[191],"mg.":[192,231],"median":[194],"follow\u2010up":[195],"14.7":[197],"months.":[198],"posttreatment":[201],"determined":[205],"by":[206],"positron":[207],"emission":[208],"tomography/computed":[209],"tomography":[210],"100%.":[212],"1\u2010year":[214],"survival":[218],"rates":[219],"both":[221],"90%.":[222],"100":[230,234],"Conclusions":[232],"mg":[235],"8),":[251],"mg/m2,":[263],"HNSCC.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-08-16T00:00:00"}
