{"id":"https://openalex.org/W3185123796","doi":"https://doi.org/10.1038/s41598-021-94007-9","title":"An integrated machine learning framework for a discriminative analysis of schizophrenia using multi-biological data","display_name":"An integrated machine learning framework for a discriminative analysis of schizophrenia using multi-biological data","publication_year":2021,"publication_date":"2021-07-19","ids":{"openalex":"https://openalex.org/W3185123796","doi":"https://doi.org/10.1038/s41598-021-94007-9","mag":"3185123796","pmid":"https://pubmed.ncbi.nlm.nih.gov/34282208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8290033"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-94007-9","doi":"https://doi.org/10.1038/s41598-021-94007-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-94007-9","pdf_url":"https://www.nature.com/articles/s41598-021-94007-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-94007-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022537317","display_name":"Pengfei Ke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng-fei Ke","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dong-sheng Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-sheng Xiong","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102185225","display_name":"Jia-hui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-hui Li","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085401370","display_name":"Zhi-lin Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-lin Pan","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734088","display_name":"Jing Zhou","orcid":"https://orcid.org/0000-0003-4731-734X","observed_orcids":["https://orcid.org/0000-0003-4731-734X"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019008115","display_name":"Shi-jia Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-jia Li","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100612519","display_name":"Jie Song","orcid":"https://orcid.org/0000-0003-1144-1971","observed_orcids":["https://orcid.org/0000-0003-1144-1971"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Song","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001543692","display_name":"Xiao-yi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-yi Chen","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015830499","display_name":"Gui-xiang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gui-xiang Li","raw_affiliation_strings":["Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, 510500, China","National Engineering Research Center for Healthcare Devices, Guangzhou, 510500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, 510500, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Healthcare Devices, Guangzhou, 510500, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450190","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-4459-8804","observed_orcids":["https://orcid.org/0000-0002-4459-8804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Chen","raw_affiliation_strings":["Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, 510500, China","National Engineering Research Center for Healthcare Devices, Guangzhou, 510500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, 510500, China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Healthcare Devices, Guangzhou, 510500, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112611431","display_name":"Xiao-bo Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-bo Li","raw_affiliation_strings":["Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA","institution_ids":["https://openalex.org/I118118575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101063292","display_name":"Yu-Ping Ning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-ping Ning","raw_affiliation_strings":["Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043336955","display_name":"Fengchun Wu","orcid":"https://orcid.org/0000-0003-2817-2341","observed_orcids":["https://orcid.org/0000-0003-2817-2341"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng-chun Wu","raw_affiliation_strings":["Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China. 13580380071@163.com","The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China. 13580380071@163.com","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China. 13580380071@163.com","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China. 13580380071@163.com","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019258983","display_name":"Kai Wu","orcid":"https://orcid.org/0000-0003-4467-1597","observed_orcids":["https://orcid.org/0000-0003-4467-1597","https://orcid.org/0000-0002-3363-825X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]},{"id":"https://openalex.org/I4405286073","display_name":"Institute of Development, Aging and Cancer, Tohoku University","ror":"https://ror.org/012s2xh05","country_code":"JP","type":"facility","lineage":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","JP"],"is_corresponding":true,"raw_author_name":"Kai Wu","raw_affiliation_strings":["Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China. kaiwu@scut.edu.cn","Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan. kaiwu@scut.edu.cn","Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, 510500, China. kaiwu@scut.edu.cn","Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China. kaiwu@scut.edu.cn","Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China. kaiwu@scut.edu.cn","National Engineering Research Center for Healthcare Devices, Guangzhou, 510500, China. kaiwu@scut.edu.cn","National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China. kaiwu@scut.edu.cn","The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China. kaiwu@scut.edu.cn","Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan","Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, China. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou, 510500, China. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China. kaiwu@scut.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I4210098034","https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Center for Healthcare Devices, Guangzhou, 510500, China. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, 510370, Guangdong, China. kaiwu@scut.edu.cn","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]},{"raw_affiliation_string":"Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I90610280"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019258983","https://openalex.org/A5043336955"],"corresponding_institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4210098034","https://openalex.org/I4405286073","https://openalex.org/I90610280","https://openalex.org/I92039509"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":3.5811,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94021668,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"14636","last_page":"14636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/schizophrenia-diagnosis","display_name":"schizophrenia diagnosis","score":0.6790000200271606},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.996999979019165},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.8220000267028809},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.8769999742507935},{"id":"https://openalex.org/keywords/feature-selection","display_name":"feature selection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"support vector machine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8199999928474426},{"id":"https://openalex.org/keywords/haemophilus","display_name":"Haemophilus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prevotella","display_name":"Prevotella","score":0.9980000257492065},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/monocyte-to-lymphocyte-ratio","display_name":"monocyte-to-lymphocyte ratio","score":0.9950000047683716},{"id":"https://openalex.org/keywords/temporal-lobe","display_name":"temporal lobe","score":0.6370000243186951},{"id":"https://openalex.org/keywords/frontal-parietal-cortex","display_name":"frontal-parietal cortex","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.6466286778450012},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5975062847137451},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5749136209487915},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5729594230651855},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5684750080108643},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5172160863876343},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4999501705169678},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.48455610871315},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.42749500274658203},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.4120123088359833},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2749755084514618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22383996844291687},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-021-94007-9","doi":"https://doi.org/10.1038/s41598-021-94007-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-94007-9","pdf_url":"https://www.nature.com/articles/s41598-021-94007-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-181829/v1","doi":"https://doi.org/10.21203/rs.3.rs-181829/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-181829/v1","pdf_url":"https://www.researchsquare.com/article/rs-181829/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:34282208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34282208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8290033","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8290033/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cd9b79389a23479cb148f4150335e9d9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cd9b79389a23479cb148f4150335e9d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-94007-9","doi":"https://doi.org/10.1038/s41598-021-94007-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-94007-9","pdf_url":"https://www.nature.com/articles/s41598-021-94007-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1501270012","display_name":null,"funder_award_id":"2019YFC0118805","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1549423434","display_name":null,"funder_award_id":"2018B030335001]","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2908218230","display_name":null,"funder_award_id":"20211306","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3095285506","display_name":null,"funder_award_id":"2019YFC0118800","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3497006377","display_name":null,"funder_award_id":"201807010064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4147412066","display_name":null,"funder_award_id":"2019YFC0118804","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4475991468","display_name":null,"funder_award_id":"81802230","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G475902680","display_name":null,"funder_award_id":"2021B1515020064","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G5838897839","display_name":null,"funder_award_id":"32000980","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5906886770","display_name":null,"funder_award_id":"2019A1515110427","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G6487104788","display_name":null,"funder_award_id":"2020YFC2004301","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6790491401","display_name":null,"funder_award_id":"2019YFC0118805","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7233174348","display_name":null,"funder_award_id":"2020YFC2004300, 2020YFC2004301, 2019YFC0118800, 2019YFC0118802, 2019YFC0118804, 2019YFC0118805","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7561600809","display_name":null,"funder_award_id":"2020YFC2004300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7861043557","display_name":null,"funder_award_id":"2019YFC0118800","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G802251658","display_name":null,"funder_award_id":"202103000032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8244222018","display_name":null,"funder_award_id":"2021B1515020064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8466867919","display_name":null,"funder_award_id":"202103000032","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G8687025198","display_name":null,"funder_award_id":"2019YFC0118802","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8729614514","display_name":null,"funder_award_id":"31771074, 81802230","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8755760170","display_name":null,"funder_award_id":"31771074","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3185123796.pdf","grobid_xml":"https://content.openalex.org/works/W3185123796.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1603893961","https://openalex.org/W1967105793","https://openalex.org/W1979712026","https://openalex.org/W1981500982","https://openalex.org/W2001534244","https://openalex.org/W2001958879","https://openalex.org/W2004301758","https://openalex.org/W2009167361","https://openalex.org/W2009814577","https://openalex.org/W2010758493","https://openalex.org/W2030084429","https://openalex.org/W2037762661","https://openalex.org/W2042755650","https://openalex.org/W2059798329","https://openalex.org/W2061117571","https://openalex.org/W2061585838","https://openalex.org/W2067808181","https://openalex.org/W2068971988","https://openalex.org/W2076805502","https://openalex.org/W2077217095","https://openalex.org/W2080186368","https://openalex.org/W2094186021","https://openalex.org/W2096321911","https://openalex.org/W2098837671","https://openalex.org/W2116376209","https://openalex.org/W2135748590","https://openalex.org/W2147280251","https://openalex.org/W2167822639","https://openalex.org/W2171016495","https://openalex.org/W2177870565","https://openalex.org/W2179568988","https://openalex.org/W2289075896","https://openalex.org/W2336817596","https://openalex.org/W2401404581","https://openalex.org/W2510754953","https://openalex.org/W2512118283","https://openalex.org/W2558041282","https://openalex.org/W2605903991","https://openalex.org/W2606894917","https://openalex.org/W2676595659","https://openalex.org/W2729267312","https://openalex.org/W2768112290","https://openalex.org/W2769255827","https://openalex.org/W2783481349","https://openalex.org/W2792020945","https://openalex.org/W2805843535","https://openalex.org/W2807021761","https://openalex.org/W2810304135","https://openalex.org/W2899293414","https://openalex.org/W2904452934","https://openalex.org/W2913697733","https://openalex.org/W2921770371","https://openalex.org/W2940516365","https://openalex.org/W2966352467","https://openalex.org/W2982685163","https://openalex.org/W2983855864","https://openalex.org/W2986044976","https://openalex.org/W3011204839","https://openalex.org/W3024248489","https://openalex.org/W3027367435","https://openalex.org/W3034127869","https://openalex.org/W3045895528","https://openalex.org/W3099165740","https://openalex.org/W3100171194","https://openalex.org/W3101429571","https://openalex.org/W3110599003","https://openalex.org/W3126903066","https://openalex.org/W4241398143","https://openalex.org/W4312512934"],"related_works":["https://openalex.org/W4389988028","https://openalex.org/W4400623737","https://openalex.org/W2767625839","https://openalex.org/W4393220567","https://openalex.org/W2983706427","https://openalex.org/W7161110525","https://openalex.org/W4291148447","https://openalex.org/W2132554694","https://openalex.org/W1972238714","https://openalex.org/W2092628142"],"abstract_inverted_index":{"Finding":[0],"effective":[1],"and":[2,52,70,113,156,166,169,178,186,203],"objective":[3],"biomarkers":[4,205],"to":[5,77],"inform":[6],"the":[7,28,89,98,105,146,150,158,170,184,199],"diagnosis":[8,29],"of":[9,12,30,43,59,63,101,111,116,201],"schizophrenia":[10,81,134,202,207],"is":[11],"great":[13],"importance":[14],"yet":[15],"remains":[16],"challenging.":[17],"Relatively":[18],"little":[19],"work":[20],"has":[21],"been":[22],"conducted":[23],"on":[24],"multi-biological":[25,102,125,209],"data":[26,103,126],"for":[27,131,197,206],"schizophrenia.":[31],"In":[32],"this":[33],"cross-sectional":[34],"study,":[35],"we":[36],"extracted":[37],"multiple":[38],"features":[39,100,143,153,160,172],"from":[40,82,145],"three":[41,66],"types":[42],"biological":[44,137],"data,":[45,49,51],"including":[46],"gut":[47,151],"microbiota":[48,152],"blood":[50,159],"electroencephalogram":[53,171],"data.":[54,138,210],"Then,":[55],"an":[56,109,114],"integrated":[57,192],"framework":[58,193],"machine":[60,92],"learning":[61],"consisting":[62],"five":[64],"classifiers,":[65],"feature":[67,95],"selection":[68,96],"algorithms,":[69],"four":[71],"cross":[72],"validation":[73],"methods":[74],"was":[75],"used":[76],"discriminate":[78],"patients":[79,132],"with":[80,108,133],"healthy":[83],"controls.":[84],"Our":[85],"results":[86,122],"show":[87],"that":[88,124],"support":[90],"vector":[91],"classifier":[93],"without":[94],"using":[97,208],"input":[99],"achieved":[104],"best":[106],"performance,":[107],"accuracy":[110],"91.7%":[112],"AUC":[115],"96.5%":[117],"(p":[118],"<":[119],"0.05).":[120],"These":[121],"indicate":[123],"showed":[127],"better":[128],"discriminative":[129,142],"capacity":[130],"than":[135],"single":[136],"The":[139,190],"top":[140],"5%":[141],"selected":[144],"optimal":[147],"model":[148],"include":[149],"(Lactobacillus,":[154],"Haemophilus,":[155],"Prevotella),":[157],"(superoxide":[161],"dismutase":[162],"level,":[163],"monocyte-lymphocyte":[164],"ratio,":[165],"neutrophil":[167],"count),":[168],"(nodal":[173],"local":[174],"efficiency,":[175,177],"nodal":[176,179],"shortest":[180],"path":[181],"length":[182],"in":[183],"temporal":[185],"frontal-parietal":[187],"brain":[188],"areas).":[189],"proposed":[191],"may":[194],"be":[195],"helpful":[196],"understanding":[198],"pathophysiology":[200],"developing":[204]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-08-02T00:00:00"}
