{"id":"https://openalex.org/W3183261111","doi":"https://doi.org/10.1152/ajpgi.00177.2021","title":"Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation","display_name":"Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation","publication_year":2021,"publication_date":"2021-07-21","ids":{"openalex":"https://openalex.org/W3183261111","doi":"https://doi.org/10.1152/ajpgi.00177.2021","mag":"3183261111","pmid":"https://pubmed.ncbi.nlm.nih.gov/34288725","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8461792"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00177.2021","doi":"https://doi.org/10.1152/ajpgi.00177.2021","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00177.2021","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8461792","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082644293","display_name":"Sarah Elizabeth Blutt","orcid":"https://orcid.org/0000-0002-4062-709X","observed_orcids":["https://orcid.org/0000-0002-4062-709X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah E. Blutt","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-4062-709X","affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012500318","display_name":"Sue E. Crawford","orcid":"https://orcid.org/0000-0001-8113-3806","observed_orcids":["https://orcid.org/0000-0001-8113-3806"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue E. Crawford","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062076154","display_name":"Carolyn Bomidi","orcid":"https://orcid.org/0009-0001-1459-2735","observed_orcids":["https://orcid.org/0009-0001-1459-2735"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn Bomidi","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109034606","display_name":"Xi\u2010Lei Zeng","orcid":"https://orcid.org/0000-0002-5353-1601","observed_orcids":["https://orcid.org/0000-0002-5353-1601"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi-Lei Zeng","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103116269","display_name":"James R. Broughman","orcid":"https://orcid.org/0000-0003-3456-6187","observed_orcids":["https://orcid.org/0000-0003-3456-6187"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Broughman","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109500573","display_name":"Matthew J. Robertson","orcid":"https://orcid.org/0009-0005-0150-9831","observed_orcids":["https://orcid.org/0009-0005-0150-9831"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Robertson","raw_affiliation_strings":["Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052755605","display_name":"Cristian Coarfa","orcid":"https://orcid.org/0000-0002-4183-4939","observed_orcids":["https://orcid.org/0000-0002-4183-4939"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristian Coarfa","raw_affiliation_strings":["Center for Precision and Environmental Health, Baylor College of Medicine, Houston, Texas","Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas","Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision and Environmental Health, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021062736","display_name":"Mary Elizabeth M. Tessier","orcid":"https://orcid.org/0000-0002-0341-5442","observed_orcids":["https://orcid.org/0000-0002-0341-5442"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Elizabeth M. Tessier","raw_affiliation_strings":["Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044356368","display_name":"Tor Savidge","orcid":"https://orcid.org/0000-0001-5716-5357","observed_orcids":["https://orcid.org/0000-0001-5716-5357"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tor Savidge","raw_affiliation_strings":["Department of Pathology and Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011012045","display_name":"F. Blaine Hollinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Blaine Hollinger","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas","Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042809748","display_name":"Steven A. Curley","orcid":"https://orcid.org/0000-0001-9533-2769","observed_orcids":["https://orcid.org/0000-0001-9533-2769"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Curley","raw_affiliation_strings":["Department of Surgery, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044859707","display_name":"Mark Donowitz","orcid":"https://orcid.org/0000-0003-0477-8824","observed_orcids":["https://orcid.org/0000-0003-0477-8824"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Donowitz","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087604589","display_name":"Mary Kolb Estes","orcid":"https://orcid.org/0000-0002-4813-4249","observed_orcids":["https://orcid.org/0000-0002-4813-4249"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Estes","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas","Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5082644293"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":1.0174,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78372243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"321","issue":"3","first_page":"G270","last_page":"G279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bile-acid-signaling","display_name":"bile acid signaling","score":0.8230000138282776},{"id":"https://openalex.org/keywords/inter-organ-communication","display_name":"inter-organ communication","score":0.8149999976158142},{"id":"https://openalex.org/keywords/intestinal-organoids","display_name":"intestinal organoids","score":0.8080000281333923},{"id":"https://openalex.org/keywords/liver-organoids","display_name":"liver organoids","score":0.9440000057220459},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.9649263620376587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6642190217971802},{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.6175729632377625},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5639423131942749},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5480272769927979},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4472985565662384},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.41934093832969666},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.3306396007537842},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20800119638442993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06872215867042542}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004764","descriptor_name":"Enterohepatic Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpgi.00177.2021","doi":"https://doi.org/10.1152/ajpgi.00177.2021","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00177.2021","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8461792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8461792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},{"id":"pmid:34288725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34288725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:baylor_docs-2353","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/baylor_docs/1377","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty and Staff Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8461792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8461792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2106694058","display_name":null,"funder_award_id":"P42-ES0327725","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3175189153","display_name":null,"funder_award_id":"152999","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3409574631","display_name":"A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity","funder_award_id":"UH3TR000503","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4449415799","display_name":null,"funder_award_id":"P42ES0327725","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5047066722","display_name":"Proteomics and Metabolomics Core Facility","funder_award_id":"RP170005","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G5437170232","display_name":null,"funder_award_id":"24290","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8464401390","display_name":null,"funder_award_id":"116497","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000888640","display_name":"Gulf Coast Center for Precision Environmental Health","funder_award_id":"P30ES030285","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000893404","display_name":"Texas Medical Center Digestive Diseases Center","funder_award_id":"P30DK056338","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000902408","display_name":"Baylor College of Medicine Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA125123","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1483496013","https://openalex.org/W1628437161","https://openalex.org/W1885550757","https://openalex.org/W1963587340","https://openalex.org/W1997114875","https://openalex.org/W1998861334","https://openalex.org/W2002050129","https://openalex.org/W2002513358","https://openalex.org/W2012853846","https://openalex.org/W2028890879","https://openalex.org/W2049515100","https://openalex.org/W2052390133","https://openalex.org/W2085652695","https://openalex.org/W2087577664","https://openalex.org/W2106014612","https://openalex.org/W2125168178","https://openalex.org/W2125632718","https://openalex.org/W2134354994","https://openalex.org/W2138207763","https://openalex.org/W2143605781","https://openalex.org/W2158609797","https://openalex.org/W2171398834","https://openalex.org/W2429031812","https://openalex.org/W2513284012","https://openalex.org/W2598595379","https://openalex.org/W2605037415","https://openalex.org/W2729116912","https://openalex.org/W2734880494","https://openalex.org/W2735092275","https://openalex.org/W2794480084","https://openalex.org/W2891446844","https://openalex.org/W2896518632","https://openalex.org/W2903148550","https://openalex.org/W2906590646","https://openalex.org/W2979712161","https://openalex.org/W3008709031","https://openalex.org/W3012771281","https://openalex.org/W3014899725"],"related_works":["https://openalex.org/W3129372153","https://openalex.org/W3171766833","https://openalex.org/W3008180923","https://openalex.org/W4360993503","https://openalex.org/W2750265290","https://openalex.org/W7125676166","https://openalex.org/W2295875942","https://openalex.org/W4401956952","https://openalex.org/W2925756114","https://openalex.org/W2029764034"],"abstract_inverted_index":{"Interorgan":[0],"signaling":[1],"is":[2],"a":[3],"critical":[4],"feature":[5],"of":[6,21,31,53,68],"human":[7,34,69],"biology":[8],"and":[9,36,64,71],"physiology,":[10],"yet":[11],"has":[12],"remained":[13],"difficult":[14],"to":[15,18,60],"study":[16],"due":[17],"the":[19],"lack":[20],"in":[22,42],"vitro":[23],"models.":[24],"Here,":[25],"we":[26],"demonstrate":[27],"that":[28,51],"physical":[29],"coupling":[30,52],"ex":[32],"vivo":[33,43],"intestine":[35],"liver":[37],"epithelial":[38],"organoid":[39,55],"cultures":[40],"recapitulates":[41],"interorgan":[44,62],"bile":[45],"acid":[46],"signaling.":[47],"These":[48],"results":[49],"suggest":[50],"multiple":[54],"systems":[56],"provides":[57],"new":[58],"models":[59],"investigate":[61],"communication":[63],"advances":[65],"our":[66],"knowledge":[67],"physiological":[70],"pathophysiological":[72],"processes.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-08-02T00:00:00"}
