{"id":"https://openalex.org/W3182034091","doi":"https://doi.org/10.1186/s13059-021-02414-y","title":"Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation","display_name":"Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation","publication_year":2021,"publication_date":"2021-07-05","ids":{"openalex":"https://openalex.org/W3182034091","doi":"https://doi.org/10.1186/s13059-021-02414-y","mag":"3182034091","pmid":"https://pubmed.ncbi.nlm.nih.gov/34225769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8258993"},"language":"en","primary_location":{"id":"doi:10.1186/s13059-021-02414-y","doi":"https://doi.org/10.1186/s13059-021-02414-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-021-02414-y","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-021-02414-y","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-021-02414-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089032499","display_name":"Melania Barile","orcid":"https://orcid.org/0009-0004-7740-473X","observed_orcids":["https://orcid.org/0009-0004-7740-473X"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melania Barile","raw_affiliation_strings":["Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","Department of Haematology, University of Cambridge, Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017024439","display_name":"Iv\u00e1n Imaz-Rosshandler","orcid":"https://orcid.org/0000-0001-5975-0138","observed_orcids":["https://orcid.org/0000-0001-5975-0138"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ivan Imaz-Rosshandler","raw_affiliation_strings":["Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","Department of Haematology, University of Cambridge, Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030958840","display_name":"Isabella Inzani","orcid":"https://orcid.org/0000-0003-2186-8370","observed_orcids":["https://orcid.org/0000-0003-2186-8370"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4387153067","display_name":"MRC Metabolic Diseases Unit","ror":"https://ror.org/037a8w620","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4387153067","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isabella Inzani","raw_affiliation_strings":["University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, CB2 0QQ Cambridge, UK","University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, CB2 0QQ Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4387153067"]},{"raw_affiliation_string":"University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4387153067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087355766","display_name":"Shila Ghazanfar","orcid":"https://orcid.org/0000-0001-7861-6997","observed_orcids":["https://orcid.org/0000-0001-7861-6997"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shila Ghazanfar","raw_affiliation_strings":["Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK","Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008565592","display_name":"Jennifer Nichols","orcid":"https://orcid.org/0000-0002-8650-1388","observed_orcids":["https://orcid.org/0000-0002-8650-1388"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Nichols","raw_affiliation_strings":["Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042376614","display_name":"John C. Marioni","orcid":"https://orcid.org/0000-0001-9092-0852","observed_orcids":["https://orcid.org/0000-0001-9092-0852"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John C. Marioni","raw_affiliation_strings":["Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK","European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, CB10 1SD Cambridge, UK","Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Cambridge, UK","Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK","Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, CB10 1SD Cambridge, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Cambridge, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078129467","display_name":"Carolina Guibentif","orcid":"https://orcid.org/0000-0003-1056-9922","observed_orcids":["https://orcid.org/0000-0003-1056-9922"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":true,"raw_author_name":"Carolina Guibentif","raw_affiliation_strings":["Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","Sahlgrenska Center for Cancer Research, Department of Microbiology and Immunology, University of Gothenburg, 413 90 Gothenburg, Sweden","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","Department of Haematology, University of Cambridge, Cambridge, UK","Sahlgrenska Center for Cancer Research, Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Sahlgrenska Center for Cancer Research, Department of Microbiology and Immunology, University of Gothenburg, 413 90 Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Sahlgrenska Center for Cancer Research, Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017318024","display_name":"Berthold G\u00f6ttgens","orcid":"https://orcid.org/0000-0001-6302-5705","observed_orcids":["https://orcid.org/0000-0001-6302-5705"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Berthold G\u00f6ttgens","raw_affiliation_strings":["Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","Department of Haematology, University of Cambridge, Cambridge, UK","Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5017318024","https://openalex.org/A5078129467"],"corresponding_institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I881427289"],"apc_list":{"value":4890,"currency":"USD","value_usd":4890},"apc_paid":{"value":4890,"currency":"USD","value_usd":4890},"fwci":2.7893,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.93278519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"22","issue":"1","first_page":"197","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-velocity","display_name":"RNA velocity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/erythroid-maturation","display_name":"erythroid maturation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gene-expression-kinetics","display_name":"gene expression kinetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/differentiation-trajectories","display_name":"differentiation trajectories","score":0.6019999980926514},{"id":"https://openalex.org/keywords/gata1","display_name":"GATA-1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.7919999957084656},{"id":"https://openalex.org/keywords/megakaryocyte-progenitors","display_name":"megakaryocyte progenitors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/epiblast","display_name":"epiblast","score":0.8050000071525574},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8598495721817017},{"id":"https://openalex.org/C192196715","wikidata":"https://www.wikidata.org/wiki/Q14916151","display_name":"GATA1","level":4,"score":0.8379513621330261},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.7836565375328064},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.5822563171386719},{"id":"https://openalex.org/C75059768","wikidata":"https://www.wikidata.org/wiki/Q519516","display_name":"Epiblast","level":5,"score":0.5229048132896423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5202547311782837},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.505608081817627},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4973283112049103},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4755123257637024},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4627736806869507},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4230552911758423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41929101943969727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4072355628013611},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2527594268321991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099232","descriptor_name":"Proto-Oncogene Protein Spi-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005775","descriptor_name":"Gastrula","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005775","descriptor_name":"Gastrula","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D041905","descriptor_name":"Erythroid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D041905","descriptor_name":"Erythroid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050982","descriptor_name":"GATA1 Transcription Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050982","descriptor_name":"GATA1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1186/s13059-021-02414-y","doi":"https://doi.org/10.1186/s13059-021-02414-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-021-02414-y","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-021-02414-y","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.12.21.423773","doi":"https://doi.org/10.1101/2020.12.21.423773","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.12.21.423773","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/03/02/2020.12.21.423773.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8258993","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8258993","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:34225769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34225769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/324888","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/324888","pdf_url":"https://www.repository.cam.ac.uk/handle/1810/324888","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:612c8ca067714602822b1e9460b4c3c2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/612c8ca067714602822b1e9460b4c3c2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/324305","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/324305","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/326557","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/326557","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"essn: 1474-760X","raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/330004","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/330004","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.71760","doi":"https://doi.org/10.17863/cam.71760","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.71760","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.17863/cam.72342","doi":"https://doi.org/10.17863/cam.72342","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.72342","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17863/cam.74006","doi":"https://doi.org/10.17863/cam.74006","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.74006","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17863/cam.77448","doi":"https://doi.org/10.17863/cam.77448","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.77448","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13059-021-02414-y","doi":"https://doi.org/10.1186/s13059-021-02414-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-021-02414-y","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-021-02414-y","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1305121252","display_name":null,"funder_award_id":"GB) (NIF\\R1\\181950","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G1313000080","display_name":"Defining the Haematopoietic System through Integrated Multi-Scale Analysis","funder_award_id":"206328/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1618624683","display_name":"Joint Wellcome and MRC Centre, \u2018Wellcome Trust \u2013 Medical Research Council Cambridge Stem Cell Institute\u2019","funder_award_id":"MC_PC_17230","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1982897207","display_name":"Establishment of the Cambridge Single Cell Analysis Clinical Core Facility [SCACCF]","funder_award_id":"MR/M008975/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2305061572","display_name":"From Mesoderm to Blood: a Transcriptional Roadmap at Single-Cell Resolution","funder_award_id":"2017-06278","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2700273953","display_name":"Tracing early mammalian lineage decisions by single cell genomics.","funder_award_id":"105031","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3187034290","display_name":null,"funder_award_id":"18002","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G5419101729","display_name":"Tracing early mammalian lineage decisions by single cell genomics.","funder_award_id":"105031/D/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G55385154","display_name":null,"funder_award_id":"NIF\\R1\\181950","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G6116745146","display_name":null,"funder_award_id":"105031/D/14/Z, 097922/Z/11/Z, 206328/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6364503916","display_name":null,"funder_award_id":"206328/Z/17/Z, 105031/D/14/Z, 097922/Z/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G654986153","display_name":null,"funder_award_id":"DRCPGM\\100015","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6633812446","display_name":null,"funder_award_id":"FS/18/56/35177","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7306926374","display_name":null,"funder_award_id":"105031/D/14/Z","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7654743609","display_name":"A protein-transcriptome atlas of haematopoiesis across the human life span","funder_award_id":"MR/S036113/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7802786893","display_name":"Cambridge Stem Cell Institute.","funder_award_id":"097922/Z/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8242440306","display_name":null,"funder_award_id":"GB) (18002","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G8938435353","display_name":"VISION: ValIdated Systematic IntegratiON of epigenomic data","funder_award_id":"R24DK106766","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314023","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334635","display_name":"Cambridge Institute for Medical Research, University of Cambridge","ror":null},{"id":"https://openalex.org/F4320337195","display_name":"Cancer Research UK Cambridge Institute, University of Cambridge","ror":null},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3182034091.pdf","grobid_xml":"https://content.openalex.org/works/W3182034091.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1522883299","https://openalex.org/W1590938212","https://openalex.org/W1822366055","https://openalex.org/W1912262500","https://openalex.org/W1913405185","https://openalex.org/W1977709885","https://openalex.org/W1981460612","https://openalex.org/W1992332701","https://openalex.org/W1994987603","https://openalex.org/W2002511118","https://openalex.org/W2008297559","https://openalex.org/W2011476899","https://openalex.org/W2020531684","https://openalex.org/W2033044605","https://openalex.org/W2049869441","https://openalex.org/W2054338068","https://openalex.org/W2055568103","https://openalex.org/W2058521801","https://openalex.org/W2080033371","https://openalex.org/W2103017472","https://openalex.org/W2111885793","https://openalex.org/W2118299921","https://openalex.org/W2145748272","https://openalex.org/W2268351591","https://openalex.org/W2278032101","https://openalex.org/W2286971754","https://openalex.org/W2290826747","https://openalex.org/W2295977118","https://openalex.org/W2342445549","https://openalex.org/W2469412979","https://openalex.org/W2473235403","https://openalex.org/W2505717852","https://openalex.org/W2508913677","https://openalex.org/W2516455020","https://openalex.org/W2531022537","https://openalex.org/W2766437506","https://openalex.org/W2794521141","https://openalex.org/W2794765397","https://openalex.org/W2800392236","https://openalex.org/W2802302382","https://openalex.org/W2861777839","https://openalex.org/W2892640601","https://openalex.org/W2912272542","https://openalex.org/W2940256315","https://openalex.org/W2950595506","https://openalex.org/W2980292232","https://openalex.org/W2980698015","https://openalex.org/W2980995354","https://openalex.org/W2982638381","https://openalex.org/W3002219094","https://openalex.org/W3012408807","https://openalex.org/W3027051073","https://openalex.org/W3039602595","https://openalex.org/W3047141442","https://openalex.org/W3048416090","https://openalex.org/W3067009413","https://openalex.org/W3111681797","https://openalex.org/W6912383329","https://openalex.org/W6990656925"],"related_works":["https://openalex.org/W6902041473","https://openalex.org/W6977052169","https://openalex.org/W6977460248","https://openalex.org/W1964622529","https://openalex.org/W2098407640","https://openalex.org/W1998071003","https://openalex.org/W2588444548","https://openalex.org/W2044354693","https://openalex.org/W1509489125","https://openalex.org/W4310099773"],"abstract_inverted_index":{"BACKGROUND:":[0],"Single-cell":[1],"technologies":[2],"are":[3,61],"transforming":[4],"biomedical":[5],"research,":[6],"including":[7],"the":[8,51,83,88,104,128,138,151,156,169,175,212],"recent":[9],"demonstration":[10],"that":[11,135,190],"unspliced":[12],"pre-mRNA":[13],"present":[14],"in":[15,100,117,140,150,172,192,203,218,229],"single-cell":[16],"RNA-Seq":[17],"permits":[18],"prediction":[19],"of":[20,94,123,158,180,184,211,221],"future":[21],"expression":[22,118,141,231],"states.":[23],"Here":[24],"we":[25,133,188,224],"apply":[26],"this":[27],"RNA":[28,44],"velocity":[29,45,108,214],"concept":[30],"to":[31,147,168],"an":[32],"extended":[33],"timecourse":[34],"dataset":[35,177],"covering":[36],"mouse":[37,125],"gastrulation":[38],"and":[39,67,182],"early":[40],"organogenesis.":[41],"RESULTS:":[42],"Intriguingly,":[43],"correctly":[46],"identifies":[47],"epiblast":[48],"cells":[49],"as":[50],"starting":[52],"point,":[53],"but":[54],"several":[55],"trajectory":[56],"predictions":[57],"at":[58],"later":[59],"stages":[60],"inconsistent":[62],"with":[63,79,96,137,217,235],"both":[64],"real-time":[65],"ordering":[66],"existing":[68],"knowledge.":[69],"The":[70],"most":[71],"striking":[72],"discrepancy":[73],"concerns":[74],"red":[75],"blood":[76],"cell":[77],"maturation,":[78,174],"velocity-inferred":[80],"trajectories":[81],"opposing":[82],"true":[84],"differentiation":[85,145,164,241],"path.":[86],"Investigating":[87],"underlying":[89],"causes":[90],"reveals":[91,178],"a":[92,97,163,200,209,226],"group":[93],"genes":[95,136],"coordinated":[98,201,227],"step-change":[99,202,228],"transcription,":[101],"thus":[102,154],"violating":[103],"assumptions":[105],"behind":[106],"current":[107,213],"analysis":[109,122,220],"suites,":[110],"which":[111],"do":[112],"not":[113],"accommodate":[114],"time-dependent":[115],"changes":[116],"dynamics.":[119],"Using":[120],"scRNA-Seq":[121],"chimeric":[124],"embryos":[126],"lacking":[127],"major":[129],"erythroid":[130,144,173],"regulator":[131],"Gata1,":[132],"show":[134,189],"step-changes":[139],"dynamics":[142],"during":[143,233],"fail":[146],"be":[148],"upregulated":[149],"mutant":[152,222],"cells,":[153,223],"underscoring":[155],"coordination":[157],"modulating":[159],"transcription":[160],"rate":[161],"along":[162],"trajectory.":[165],"In":[166],"addition":[167],"expected":[170],"block":[171],"Gata1-chimera":[176],"induction":[179],"PU.1":[181],"expansion":[183],"megakaryocyte":[185],"progenitors.":[186],"Finally,":[187],"erythropoiesis":[191],"human":[193],"fetal":[194],"liver":[195],"is":[196],"similarly":[197],"characterized":[198],"by":[199],"gene":[204,230],"expression.":[205],"CONCLUSIONS:":[206],"By":[207],"identifying":[208],"limitation":[210],"framework":[215],"coupled":[216],"vivo":[219],"reveal":[225],"kinetics":[232],"erythropoiesis,":[234],"likely":[236],"implications":[237],"for":[238],"many":[239],"other":[240],"processes.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-19T00:00:00"}