{"id":"https://openalex.org/W3182021998","doi":"https://doi.org/10.1177/0271678x211032029","title":"Integrative cerebral blood flow regulation in ischemic stroke","display_name":"Integrative cerebral blood flow regulation in ischemic stroke","publication_year":2021,"publication_date":"2021-07-14","ids":{"openalex":"https://openalex.org/W3182021998","doi":"https://doi.org/10.1177/0271678x211032029","mag":"3182021998","pmid":"https://pubmed.ncbi.nlm.nih.gov/34259070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8985438"},"language":"en","primary_location":{"id":"doi:10.1177/0271678x211032029","doi":"https://doi.org/10.1177/0271678x211032029","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0271678x211032029","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8985438/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jui-Lin Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Jui-Lin Fan","raw_affiliation_strings":["Manaaki M\u0101nawa \u2013 The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manaaki M\u0101nawa \u2013 The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010890539","display_name":"Patrice Brassard","orcid":"https://orcid.org/0000-0002-6254-5044","observed_orcids":["https://orcid.org/0000-0002-6254-5044"]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrice Brassard","raw_affiliation_strings":["Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Canada","Research Center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Research Center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Canada","institution_ids":["https://openalex.org/I4210135357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012591267","display_name":"Caroline Alice Rickards","orcid":"https://orcid.org/0000-0002-5759-6912","observed_orcids":["https://orcid.org/0000-0002-5759-6912"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline A Rickards","raw_affiliation_strings":["Department of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ricardo C Nogueira","orcid":"https://orcid.org/0000-0003-3309-3760","observed_orcids":["https://orcid.org/0000-0003-3309-3760"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I3017888287","display_name":"Universidade Nove de Julho","ror":"https://ror.org/005mpbw70","country_code":"BR","type":"education","lineage":["https://openalex.org/I3017888287"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo C Nogueira","raw_affiliation_strings":["Neurology Department, Hospital Nove de Julho, S\u00e3o Paulo, Brazil","Neurology Department, School of Medicine, Hospital das Clinicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3309-3760","affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital Nove de Julho, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I3017888287"]},{"raw_affiliation_string":"Neurology Department, School of Medicine, Hospital das Clinicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002018044","display_name":"Nathalie Nasr","orcid":"https://orcid.org/0009-0003-8196-5196","observed_orcids":["https://orcid.org/0009-0003-8196-5196"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Nasr","raw_affiliation_strings":["Department of Neurology, Toulouse University Hospital, NSERM UMR 1297, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Toulouse University Hospital, NSERM UMR 1297, Toulouse, France","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210147779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068408647","display_name":"Fiona Dianne McBryde","orcid":"https://orcid.org/0000-0002-5687-9101","observed_orcids":["https://orcid.org/0000-0002-5687-9101"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Fiona D McBryde","raw_affiliation_strings":["Manaaki M\u0101nawa \u2013 The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manaaki M\u0101nawa \u2013 The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James P Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"James P Fisher","raw_affiliation_strings":["Manaaki M\u0101nawa \u2013 The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manaaki M\u0101nawa \u2013 The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yu-Chieh Tzeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Yu-Chieh Tzeng","raw_affiliation_strings":["Department of Surgery & Anaesthesia, Centre for Translational Physiology, University of Otago, Wellington, New Zealand","Wellington Medical Technology Group, Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery & Anaesthesia, Centre for Translational Physiology, University of Otago, Wellington, New Zealand","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"Wellington Medical Technology Group, Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.707,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.88231448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"42","issue":"3","first_page":"387","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"cerebral autoregulation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9120000004768372},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.9380000233650208},{"id":"https://openalex.org/keywords/collateral-circulation","display_name":"collateral circulation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cerebral-perfusion-pressure","display_name":"cerebral perfusion pressure","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cerebrovascular-resistance","display_name":"cerebrovascular resistance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cerebral-perfusion","display_name":"cerebral perfusion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/salvageable-brain-tissue","display_name":"salvageable brain tissue","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8111000061035156},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.7745000123977661},{"id":"https://openalex.org/C154281038","wikidata":"https://www.wikidata.org/wiki/Q629232","display_name":"Cerebral perfusion pressure","level":3,"score":0.6815999746322632},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6065000295639038},{"id":"https://openalex.org/C2776599846","wikidata":"https://www.wikidata.org/wiki/Q5145979","display_name":"Collateral circulation","level":2,"score":0.573199987411499},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5482000112533569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4918000102043152},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.491100013256073},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.48500001430511475},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4697999954223633},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.45179998874664307},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.44190001487731934},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4032000005245209},{"id":"https://openalex.org/C84359808","wikidata":"https://www.wikidata.org/wiki/Q13365173","display_name":"Cerebral autoregulation","level":4,"score":0.4020000100135803},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.38609999418258667},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C2910811945","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebrovascular Circulation","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2909286980","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Cerebral ischaemia","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2567000091075897},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.2542000114917755}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003097","descriptor_name":"Collateral Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/0271678x211032029","doi":"https://doi.org/10.1177/0271678x211032029","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0271678x211032029","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},{"id":"pmid:34259070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34259070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8985438","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8985438/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cereb Blood Flow Metab","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04885502v1","doi":null,"is_oa":false,"landing_page_url":"https://ut3-toulouseinp.hal.science/hal-04885502","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cerebral Blood Flow and Metabolism, 2022, 42 (3), pp.387-403. ⟨10.1177/0271678X211032029⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/75225","doi":null,"is_oa":false,"landing_page_url":"https://researchspace.auckland.ac.nz/bitstreams/d491c2b8-e2a9-412f-ab22-05a14d4a59db/download","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8985438","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8985438/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cereb Blood Flow Metab","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":164,"referenced_works":["https://openalex.org/W95416326","https://openalex.org/W188652514","https://openalex.org/W1489427667","https://openalex.org/W1521859463","https://openalex.org/W1540025214","https://openalex.org/W1750473197","https://openalex.org/W1844296510","https://openalex.org/W1900037312","https://openalex.org/W1964668951","https://openalex.org/W1965750453","https://openalex.org/W1968672298","https://openalex.org/W1971724551","https://openalex.org/W1972911854","https://openalex.org/W1976026317","https://openalex.org/W1980087231","https://openalex.org/W1982328405","https://openalex.org/W1985705755","https://openalex.org/W1986238296","https://openalex.org/W1987396922","https://openalex.org/W1988795669","https://openalex.org/W1989169682","https://openalex.org/W1991332521","https://openalex.org/W1993225687","https://openalex.org/W1994923112","https://openalex.org/W1995459690","https://openalex.org/W1995869006","https://openalex.org/W1996649237","https://openalex.org/W1996999807","https://openalex.org/W1998504790","https://openalex.org/W1999903381","https://openalex.org/W2001401458","https://openalex.org/W2001552996","https://openalex.org/W2002137001","https://openalex.org/W2006799924","https://openalex.org/W2008573332","https://openalex.org/W2010200211","https://openalex.org/W2012637857","https://openalex.org/W2017589565","https://openalex.org/W2021350878","https://openalex.org/W2023733792","https://openalex.org/W2030162941","https://openalex.org/W2034130761","https://openalex.org/W2036472881","https://openalex.org/W2037159781","https://openalex.org/W2039161146","https://openalex.org/W2040490831","https://openalex.org/W2042698075","https://openalex.org/W2049129828","https://openalex.org/W2051846405","https://openalex.org/W2054797196","https://openalex.org/W2061561342","https://openalex.org/W2061967736","https://openalex.org/W2062556835","https://openalex.org/W2068421282","https://openalex.org/W2073896069","https://openalex.org/W2075556735","https://openalex.org/W2075934269","https://openalex.org/W2076183773","https://openalex.org/W2076958402","https://openalex.org/W2077166140","https://openalex.org/W2081912648","https://openalex.org/W2082209139","https://openalex.org/W2082315120","https://openalex.org/W2084875076","https://openalex.org/W2087421438","https://openalex.org/W2088078770","https://openalex.org/W2090114724","https://openalex.org/W2090218862","https://openalex.org/W2090554395","https://openalex.org/W2095800632","https://openalex.org/W2099868609","https://openalex.org/W2103142908","https://openalex.org/W2107020808","https://openalex.org/W2107831538","https://openalex.org/W2111605706","https://openalex.org/W2114214167","https://openalex.org/W2115398282","https://openalex.org/W2117369222","https://openalex.org/W2117676608","https://openalex.org/W2117701155","https://openalex.org/W2119556059","https://openalex.org/W2119942112","https://openalex.org/W2120283551","https://openalex.org/W2122732933","https://openalex.org/W2123312526","https://openalex.org/W2125062701","https://openalex.org/W2125281293","https://openalex.org/W2129282529","https://openalex.org/W2134196374","https://openalex.org/W2134982225","https://openalex.org/W2135694398","https://openalex.org/W2137899413","https://openalex.org/W2139391075","https://openalex.org/W2139725823","https://openalex.org/W2143372332","https://openalex.org/W2143987433","https://openalex.org/W2144832916","https://openalex.org/W2147048340","https://openalex.org/W2147346575","https://openalex.org/W2147745919","https://openalex.org/W2157623707","https://openalex.org/W2158995031","https://openalex.org/W2159689462","https://openalex.org/W2162084318","https://openalex.org/W2163135201","https://openalex.org/W2164193096","https://openalex.org/W2164390703","https://openalex.org/W2165422874","https://openalex.org/W2166278864","https://openalex.org/W2168825706","https://openalex.org/W2173135046","https://openalex.org/W2180873525","https://openalex.org/W2215912404","https://openalex.org/W2257879056","https://openalex.org/W2262333767","https://openalex.org/W2318345184","https://openalex.org/W2322944274","https://openalex.org/W2327531341","https://openalex.org/W2329268395","https://openalex.org/W2336161314","https://openalex.org/W2344156774","https://openalex.org/W2368388378","https://openalex.org/W2406890588","https://openalex.org/W2409181187","https://openalex.org/W2409612189","https://openalex.org/W2495600458","https://openalex.org/W2519798424","https://openalex.org/W2525975480","https://openalex.org/W2546786025","https://openalex.org/W2548772556","https://openalex.org/W2558721179","https://openalex.org/W2586140222","https://openalex.org/W2588944390","https://openalex.org/W2596456503","https://openalex.org/W2607007516","https://openalex.org/W2607109655","https://openalex.org/W2610790448","https://openalex.org/W2744420041","https://openalex.org/W2749732598","https://openalex.org/W2753404243","https://openalex.org/W2766811534","https://openalex.org/W2775135709","https://openalex.org/W2800065914","https://openalex.org/W2806156457","https://openalex.org/W2807495507","https://openalex.org/W2883861999","https://openalex.org/W2887089239","https://openalex.org/W2891384509","https://openalex.org/W2911196419","https://openalex.org/W2913164855","https://openalex.org/W2914098214","https://openalex.org/W2948694954","https://openalex.org/W2962838618","https://openalex.org/W2966439723","https://openalex.org/W2969506396","https://openalex.org/W2982099630","https://openalex.org/W2982303713","https://openalex.org/W2999195688","https://openalex.org/W3006810105","https://openalex.org/W3035781781","https://openalex.org/W3047732842","https://openalex.org/W3094179140","https://openalex.org/W4211175359","https://openalex.org/W4409121504"],"related_works":["https://openalex.org/W3183663518","https://openalex.org/W2167571528","https://openalex.org/W2020225542","https://openalex.org/W2058157419","https://openalex.org/W2034197458","https://openalex.org/W2033213536","https://openalex.org/W2800273900","https://openalex.org/W2167644661","https://openalex.org/W1965312345","https://openalex.org/W2164884198"],"abstract_inverted_index":{"Optimizing":[0],"cerebral":[1,17,35,126],"perfusion":[2,127],"is":[3,63,102],"key":[4],"to":[5,54,81],"rescuing":[6],"salvageable":[7],"ischemic":[8,90,159],"brain":[9],"tissue.":[10],"Despite":[11],"being":[12],"an":[13,72],"important":[14,110],"determinant":[15],"of":[16,34,42,75,95,112,119,125,135,142],"perfusion,":[18],"there":[19],"are":[20,46],"no":[21],"effective":[22],"guidelines":[23],"for":[24,49,85,155],"blood":[25,36],"pressure":[26,128],"(BP)":[27],"management":[28,87],"in":[29,50,88,99,132,158],"acute":[30,89],"stroke.":[31,136,160],"The":[32],"control":[33,101],"flow":[37],"(CBF)":[38],"involves":[39],"a":[40,67,92],"myriad":[41],"complex":[43],"pathways":[44],"which":[45],"largely":[47],"unaccounted":[48],"stroke":[51],"management.":[52],"Due":[53],"its":[55],"unique":[56],"anatomy":[57],"and":[58,115,130,147,150],"physiology,":[59],"the":[60,76,83,96,109,117,123,133,140],"cerebrovascular":[61,148],"circulation":[62,114],"often":[64],"treated":[65],"as":[66],"stand-alone":[68],"system":[69],"rather":[70],"than":[71],"integral":[73],"component":[74],"cardiovascular":[77,146],"system.":[78],"In":[79,104],"order":[80],"optimize":[82],"strategies":[84],"BP":[86],"stroke,":[91],"critical":[93],"reappraisal":[94],"mechanisms":[97],"involved":[98],"CBF":[100,120],"needed.":[103],"this":[105],"review,":[106],"we":[107,138],"highlight":[108],"role":[111],"collateral":[113],"re-examine":[116],"pathophysiology":[118],"control,":[121],"namely":[122],"determinants":[124],"gradient":[129],"resistance,":[131],"context":[134],"Finally,":[137],"summarize":[139],"state":[141],"our":[143],"knowledge":[144],"regarding":[145],"interaction":[149],"explore":[151],"some":[152],"potential":[153],"avenues":[154],"future":[156],"research":[157]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-07-19T00:00:00"}