{"id":"https://openalex.org/W3181661867","doi":"https://doi.org/10.3390/ijms22147290","title":"Chondroprotective Effects of a Histone Deacetylase Inhibitor, Panobinostat, on Pain Behavior and Cartilage Degradation in Anterior Cruciate Ligament Transection-Induced Experimental Osteoarthritic Rats","display_name":"Chondroprotective Effects of a Histone Deacetylase Inhibitor, Panobinostat, on Pain Behavior and Cartilage Degradation in Anterior Cruciate Ligament Transection-Induced Experimental Osteoarthritic Rats","publication_year":2021,"publication_date":"2021-07-07","ids":{"openalex":"https://openalex.org/W3181661867","doi":"https://doi.org/10.3390/ijms22147290","mag":"3181661867","pmid":"https://pubmed.ncbi.nlm.nih.gov/34298911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8306086"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22147290","doi":"https://doi.org/10.3390/ijms22147290","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22147290","pdf_url":"https://www.mdpi.com/1422-0067/22/14/7290/pdf?version=1625643514","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/14/7290/pdf?version=1625643514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017729534","display_name":"Zhi\u2010Hong Wen","orcid":"https://orcid.org/0000-0003-4411-044X","observed_orcids":["https://orcid.org/0000-0003-4411-044X"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Zhi-Hong Wen","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4411-044X","affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108950221","display_name":"Jhy-Shrian Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jhy-Shrian Huang","raw_affiliation_strings":["Section of Orthopedics, Department of Surgery, Antai Medical Care Corporation Anti Tian-Sheng Memorial Hospital, PingTong 92842, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Orthopedics, Department of Surgery, Antai Medical Care Corporation Anti Tian-Sheng Memorial Hospital, PingTong 92842, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067176135","display_name":"Yen\u2010You Lin","orcid":"https://orcid.org/0000-0002-7636-1115","observed_orcids":["https://orcid.org/0000-0002-7636-1115"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-You Lin","raw_affiliation_strings":["Department of Sports Medicine, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-7636-1115","affiliations":[{"raw_affiliation_string":"Department of Sports Medicine, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054185652","display_name":"Zhi\u2010Kang Yao","orcid":"https://orcid.org/0000-0003-4791-6078","observed_orcids":["https://orcid.org/0000-0003-4791-6078","https://orcid.org/0009-0009-2719-8487"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Zhi-Kang Yao","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung 81341, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4791-6078","affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung 81341, Taiwan","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101952203","display_name":"Yu\u2010Cheng Lai","orcid":"https://orcid.org/0000-0001-6992-6416","observed_orcids":["https://orcid.org/0000-0001-6992-6416"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I4405272354","display_name":"Asia University Hospital","ror":"https://ror.org/041pzja41","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4405272354"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Cheng Lai","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","Department of Orthopedics, Asia University Hospital, Taichung 41354, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Department of Orthopedics, Asia University Hospital, Taichung 41354, Taiwan","institution_ids":["https://openalex.org/I4405272354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070547261","display_name":"Wu-Fu Chen","orcid":"https://orcid.org/0000-0002-6910-2692","observed_orcids":["https://orcid.org/0000-0002-6910-2692"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wu-Fu Chen","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","Department of Neurosurgery, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Department of Neurosurgery, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064972271","display_name":"Hsin\u2010Tzu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800374468","display_name":"Tzu Chi Foundation","ror":"https://ror.org/022mrwt29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I2800374468"]},{"id":"https://openalex.org/I4210123378","display_name":"Hualien Tzu Chi Medical Center","ror":"https://ror.org/030k6vb67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210123378"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Tzu Liu","raw_affiliation_strings":["Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan","institution_ids":["https://openalex.org/I2800374468","https://openalex.org/I4210123378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112663807","display_name":"Sung\u2010Chun Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141770","display_name":"Pingtung Christian Hospital","ror":"https://ror.org/04bnbsh26","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210141770"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sung-Chun Lin","raw_affiliation_strings":["Department of Orthopedic Surgery, Pingtung Christian Hospital, No. 60 Dalian Road, Pingtung 90059, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Pingtung Christian Hospital, No. 60 Dalian Road, Pingtung 90059, Taiwan","institution_ids":["https://openalex.org/I4210141770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033412737","display_name":"Yu\u2010Chi Tsai","orcid":"https://orcid.org/0000-0002-3131-207X","observed_orcids":["https://orcid.org/0000-0002-3131-207X"]},"institutions":[{"id":"https://openalex.org/I4210125866","display_name":"National Museum of Marine Biology and Aquarium","ror":"https://ror.org/02apq7b82","country_code":"TW","type":"archive","lineage":["https://openalex.org/I4210125866","https://openalex.org/I4210141165","https://openalex.org/I4405257903"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chi Tsai","raw_affiliation_strings":["National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-3131-207X","affiliations":[{"raw_affiliation_string":"National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan","institution_ids":["https://openalex.org/I4210125866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111991982","display_name":"Tsung\u2010Chang Tsai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsung-Chang Tsai","raw_affiliation_strings":["Section of Nephrology, Department of Medicine, Antai Medical Care Corporation Anti Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Nephrology, Department of Medicine, Antai Medical Care Corporation Anti Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062736235","display_name":"Yen\u2010Hsuan Jean","orcid":"https://orcid.org/0000-0003-4104-5603","observed_orcids":["https://orcid.org/0000-0003-4104-5603"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yen-Hsuan Jean","raw_affiliation_strings":["Section of Orthopedics, Department of Surgery, Antai Medical Care Corporation Anti Tian-Sheng Memorial Hospital, PingTong 92842, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Orthopedics, Department of Surgery, Antai Medical Care Corporation Anti Tian-Sheng Memorial Hospital, PingTong 92842, Taiwan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5062736235"],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.4063,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78903492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"22","issue":"14","first_page":"7290","last_page":"7290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chondroprotection","display_name":"chondroprotection","score":0.8769999742507935},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-transection","display_name":"anterior cruciate ligament transection","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hdac7","display_name":"HDAC7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.8569999933242798},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/intra-articular-administration","display_name":"intra-articular administration","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780225316","wikidata":"https://www.wikidata.org/wiki/Q7131441","display_name":"Panobinostat","level":5,"score":0.8813892006874084},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7049442529678345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6748011708259583},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5280126929283142},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4476729929447174},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.42880699038505554},{"id":"https://openalex.org/C2778434673","wikidata":"https://www.wikidata.org/wiki/Q611127","display_name":"Anterior cruciate ligament","level":2,"score":0.4269621968269348},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.4252851605415344},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4195343852043152},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.39649710059165955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3390328288078308},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3388308882713318},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3010990619659424},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20179066061973572},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.20009812712669373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.195908784866333},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07275238633155823},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000070598","descriptor_name":"Anterior Cruciate Ligament Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000070598","descriptor_name":"Anterior Cruciate Ligament Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077767","descriptor_name":"Panobinostat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002357","descriptor_name":"Cartilage Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002357","descriptor_name":"Cartilage Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms22147290","doi":"https://doi.org/10.3390/ijms22147290","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22147290","pdf_url":"https://www.mdpi.com/1422-0067/22/14/7290/pdf?version=1625643514","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:34298911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34298911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8306086","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8306086/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms22147290","doi":"https://doi.org/10.3390/ijms22147290","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22147290","pdf_url":"https://www.mdpi.com/1422-0067/22/14/7290/pdf?version=1625643514","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3181661867.pdf","grobid_xml":"https://content.openalex.org/works/W3181661867.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1506578757","https://openalex.org/W1699088132","https://openalex.org/W1707747547","https://openalex.org/W1770522054","https://openalex.org/W1964806270","https://openalex.org/W1966195391","https://openalex.org/W1968826316","https://openalex.org/W1977586021","https://openalex.org/W1981981709","https://openalex.org/W1983579606","https://openalex.org/W1986409534","https://openalex.org/W1987226609","https://openalex.org/W1989013208","https://openalex.org/W1992763054","https://openalex.org/W1994259993","https://openalex.org/W2000809959","https://openalex.org/W2013913223","https://openalex.org/W2028469883","https://openalex.org/W2034030689","https://openalex.org/W2039871355","https://openalex.org/W2056374964","https://openalex.org/W2063783730","https://openalex.org/W2065173081","https://openalex.org/W2075950873","https://openalex.org/W2078211225","https://openalex.org/W2087193732","https://openalex.org/W2088858180","https://openalex.org/W2096874451","https://openalex.org/W2099427592","https://openalex.org/W2102439840","https://openalex.org/W2102884982","https://openalex.org/W2104804115","https://openalex.org/W2127382293","https://openalex.org/W2138960046","https://openalex.org/W2138984926","https://openalex.org/W2140513563","https://openalex.org/W2144200965","https://openalex.org/W2146548807","https://openalex.org/W2156953997","https://openalex.org/W2159491883","https://openalex.org/W2172201406","https://openalex.org/W2172496848","https://openalex.org/W2197102422","https://openalex.org/W2274971583","https://openalex.org/W2343496276","https://openalex.org/W2469562755","https://openalex.org/W2490456840","https://openalex.org/W2508846186","https://openalex.org/W2513947728","https://openalex.org/W2519009268","https://openalex.org/W2562849252","https://openalex.org/W2616438043","https://openalex.org/W2750354253","https://openalex.org/W2766514835","https://openalex.org/W2767813923","https://openalex.org/W2782340977","https://openalex.org/W2883019022","https://openalex.org/W2901820439","https://openalex.org/W2920818792","https://openalex.org/W2920832988","https://openalex.org/W2960461154","https://openalex.org/W2969336211","https://openalex.org/W2969810988","https://openalex.org/W2973144372","https://openalex.org/W3014070799","https://openalex.org/W3033601756","https://openalex.org/W3081140927","https://openalex.org/W3090031618","https://openalex.org/W3113720224","https://openalex.org/W3114190434","https://openalex.org/W3128044437","https://openalex.org/W4210254819","https://openalex.org/W4211067786","https://openalex.org/W4211204772","https://openalex.org/W6779191079"],"related_works":["https://openalex.org/W2069126652","https://openalex.org/W4295952099","https://openalex.org/W4401027457","https://openalex.org/W4410049831","https://openalex.org/W2067317498","https://openalex.org/W2960461154","https://openalex.org/W4205441354","https://openalex.org/W2750354253","https://openalex.org/W1491378069","https://openalex.org/W2469562755"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2],"the":[3,35,55,91,128,135,158,162],"most":[4],"common":[5],"articular":[6,131],"degenerative":[7],"disease":[8],"characterized":[9],"by":[10,22,133],"chronic":[11],"pain,":[12],"joint":[13],"inflammation,":[14],"and":[15,38,104,108,145],"movement":[16],"limitations,":[17],"which":[18],"are":[19],"significantly":[20,115],"influenced":[21],"aberrant":[23],"epigenetic":[24],"modifications":[25],"of":[26,41,58,76,81,130,138,165],"numerous":[27],"OA-susceptible":[28],"genes.":[29],"Recent":[30],"studies":[31],"revealed":[32],"that":[33,113,151,173],"both":[34],"abnormal":[36],"activation":[37],"differential":[39],"expression":[40],"histone":[42],"deacetylases":[43],"(HDACs)":[44],"might":[45,153],"contribute":[46],"to":[47,93],"OA":[48,71,166],"pathogenesis.":[49],"In":[50],"this":[51],"study,":[52],"we":[53],"investigated":[54],"chondroprotective":[56],"effects":[57,126],"a":[59,177],"marine-derived":[60],"HDAC":[61],"inhibitor,":[62],"panobinostat,":[63],"on":[64,157],"anterior":[65],"cruciate":[66],"ligament":[67],"transection":[68],"(ACLT)-induced":[69],"experimental":[70],"rats.":[72],"The":[73,148],"intra-articular":[74,122],"administration":[75],"2":[77],"or":[78],"10":[79],"\u00b5g":[80],"panobinostat":[82,114,123,174],"(each":[83],"group,":[84],"n":[85],"=":[86],"7)":[87],"per":[88],"week":[89,95],"from":[90],"6th":[92],"17th":[94],"attenuates":[96],"ACLT-induced":[97],"nociceptive":[98],"behaviors,":[99],"including":[100],"secondary":[101],"mechanical":[102],"allodynia":[103],"weight-bearing":[105],"distribution.":[106],"Histopathological":[107],"microcomputed":[109],"tomography":[110],"analysis":[111],"showed":[112],"prevents":[116],"cartilage":[117,132],"degeneration":[118],"after":[119],"ACLT.":[120],"Moreover,":[121],"exerts":[124],"hypertrophic":[125],"in":[127,161],"chondrocytes":[129],"regulating":[134],"protein":[136],"expressions":[137],"HDAC4,":[139],"HDAC6,":[140],"HDAC7,":[141],"runt-domain":[142],"transcription":[143],"factor-2,":[144],"matrix":[146],"metalloproteinase-13.":[147],"study":[149],"indicated":[150],"HDACs":[152],"have":[154],"different":[155],"modulations":[156],"chondrocyte":[159],"phenotype":[160],"early":[163],"stages":[164],"development.":[167],"These":[168],"results":[169],"provide":[170],"new":[171],"evidence":[172],"may":[175],"be":[176],"potential":[178],"therapeutic":[179],"drug":[180],"for":[181],"OA.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-07-19T00:00:00"}
