{"id":"https://openalex.org/W31809986","doi":null,"title":"Protective effect of alpha-tocopherol and L-ascorbic acid against the ischemic-reperfusion injury in patients during open-heart surgery.","display_name":"Protective effect of alpha-tocopherol and L-ascorbic acid against the ischemic-reperfusion injury in patients during open-heart surgery.","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W31809986","mag":"31809986","pmid":"https://pubmed.ncbi.nlm.nih.gov/2029659"},"language":"en","primary_location":{"id":"pmid:2029659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2029659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislavske lekarske listy","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037816277","display_name":"E B\u00e1rta","orcid":"https://orcid.org/0000-0002-7695-5941","observed_orcids":["https://orcid.org/0000-0002-7695-5941"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"E Barta","raw_affiliation_strings":["Institute for Cardiovascular Diseases, Medical Faculty, Comenius University, Bratislava, CSFR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Diseases, Medical Faculty, Comenius University, Bratislava, CSFR","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026065818","display_name":"Ivan Pech\u00e1\u0148","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Pech\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110390237","display_name":"V Corn\u00e1k","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Corn\u00e1k","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067999278","display_name":"O Lukn\u00e1rov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Lukn\u00e1rov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112170282","display_name":"V Rendekov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Rendekov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045414486","display_name":"P Verchovodko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Verchovodko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6649,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.64991023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"92","issue":"3-4","first_page":"174","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8579999804496765},{"id":"https://openalex.org/keywords/open-heart-surgery","display_name":"open heart surgery","score":0.7870000004768372},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.6769999861717224},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":1.0},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/n-acetyl-beta-d-glucosaminidase","display_name":"N-acetyl-beta-D-glucosaminidase","score":0.902999997138977},{"id":"https://openalex.org/keywords/coronary-sinus-blood","display_name":"coronary sinus blood","score":0.6140000224113464},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.7260000109672546},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/adenine-nucleotide-degradation","display_name":"adenine nucleotide degradation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.6740598678588867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6715513467788696},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.5780739784240723},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.5699692964553833},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5400773286819458},{"id":"https://openalex.org/C2778259205","wikidata":"https://www.wikidata.org/wiki/Q629460","display_name":"Coronary sinus","level":2,"score":0.5348407626152039},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5316455960273743},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.5235414505004883},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5081379413604736},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.4823245704174042},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4750549793243408},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46969151496887207},{"id":"https://openalex.org/C2992339995","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Free radical scavenger","level":3,"score":0.4407283067703247},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3831004500389099},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3309691548347473},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.28665441274642944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23466038703918457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22194954752922058},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.16730350255966187},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2029659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2029659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislavske lekarske listy","raw_type":"Clinical Trial"},{"id":"mag:31809986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2029659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W65877288","https://openalex.org/W1777018690","https://openalex.org/W1968588337","https://openalex.org/W1988580155","https://openalex.org/W2015254392","https://openalex.org/W2034147808","https://openalex.org/W2063933123","https://openalex.org/W2069766526","https://openalex.org/W2084768640","https://openalex.org/W2085693813","https://openalex.org/W2112534549","https://openalex.org/W2115416118","https://openalex.org/W2174803828","https://openalex.org/W2176865656","https://openalex.org/W2254050631","https://openalex.org/W2320707747","https://openalex.org/W2412291070","https://openalex.org/W2496911238","https://openalex.org/W2528991729","https://openalex.org/W2617110182","https://openalex.org/W2758343255","https://openalex.org/W2782546695","https://openalex.org/W3014850286"],"related_works":["https://openalex.org/W2067811178","https://openalex.org/W2098503753","https://openalex.org/W2037634782","https://openalex.org/W2048522189","https://openalex.org/W2156183407","https://openalex.org/W1944409733","https://openalex.org/W2087787388","https://openalex.org/W2037536804","https://openalex.org/W2065118282","https://openalex.org/W2014068888"],"abstract_inverted_index":{"The":[0,182,214],"purpose":[1],"of":[2,11,18,29,39,48,60,77,83,95,105,133,139,145,152,180,184,190,211,228,231,243,250,265],"the":[3,9,16,27,54,100,103,120,131,137,143,150,153,159,172,177,197,209,248,251,263],"investigation":[4],"was:":[5],"1.":[6,123],"to":[7,24,58,89],"examine":[8],"effect":[10],"cardiopulmonary":[12],"bypass":[13],"(CPB)":[14],"on":[15,102],"generation":[17,38],"cytotoxic":[19],"oxygen-derived":[20],"radicals":[21],"and":[22,34,56,92,111,175,206,220,260],"2.":[23,126],"determine":[25],"if":[26],"pretreatment":[28,256],"patients":[30,43,78],"with":[31,80,257],"vitamins":[32,204,258],"E":[33,85,205,259],"C":[35,97,207,261],"will":[36],"combat":[37],"such":[40],"radicals.":[41],"Twenty":[42],"undergoing":[44],"CPB":[45],"for":[46,115],"treatment":[47],"cardiac":[49],"disease":[50],"were":[51,117,162],"entered":[52],"into":[53],"study":[55],"randomized":[57],"one":[59],"two":[61],"groups.":[62],"Group":[63,71],"1":[64],"(n":[65,73],"=":[66,74],"9)":[67],"served":[68],"as":[69,187,189],"control.":[70],"2":[72,93],"11)":[75],"consisted":[76],"pretreated":[79,238],"2000":[81],"IU":[82],"vitamin":[84,96],"12":[86],"h":[87],"prior":[88],"surgical":[90],"intervention":[91],"g":[94],"given":[98],"in":[99,149,196,225,237,247,268],"morning":[101,151],"day":[104],"operation.":[106],"Blood":[107,156],"samples":[108],"from":[109,158],"arterial":[110],"mixed":[112],"venous":[113],"blood":[114],"analysis":[116],"obtained":[118],"at":[119,130,136,142],"following":[121,154],"intervals:":[122],"before":[124,127],"anesthesia,":[125],"sternotomy,":[128],"3.":[129],"start":[132],"CPB,":[134,140],"4.":[135],"end":[138],"5.":[141],"time":[144],"skin":[146],"closure,":[147],"6.":[148],"day.":[155],"specimens":[157],"coronary":[160],"sinus":[161],"withdrawn":[163],"A--before":[164],"aortic":[165,169],"cross-clamping,":[166],"B--immediately":[167],"after":[168],"declamping,":[170],"C--in":[171],"5th":[173],"min,":[174],"D--in":[176],"15th":[178],"min":[179],"reperfusion.":[181],"concentration":[183,227],"inorganic":[185],"phosphate":[186],"well":[188],"uric":[191],"acid":[192],"was":[193,223,234,245],"significantly":[194,235],"higher":[195],"control":[198,221],"group":[199],"what":[200],"might":[201],"indicate":[202],"that":[203],"attenuate":[208],"degradation":[210],"adenine":[212],"nucleotides.":[213],"most":[215],"important":[216],"difference":[217],"between":[218],"treated":[219],"groups":[222],"observed":[224,267],"plasma":[226],"malondialdehyde--a":[229],"marker":[230],"lipid":[232],"peroxidation--which":[233],"lower":[236],"patients.":[239],"A":[240],"similar":[241],"pattern":[242],"changes":[244],"found":[246],"level":[249],"lysosomal":[252],"enzyme":[253],"N-acetyl-glucosaminidase.":[254],"Finally,":[255],"inhibited":[262],"decrease":[264],"catalase,":[266],"controls.":[269]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}