{"id":"https://openalex.org/W3180210461","doi":"https://doi.org/10.1158/1538-7445.am2021-463","title":"Abstract 463: Features consistent with a small-cell neuroendocrine like (SC/NE-L) transformation can be readily detected and quantified in circulating tumor cells (CTCs)","display_name":"Abstract 463: Features consistent with a small-cell neuroendocrine like (SC/NE-L) transformation can be readily detected and quantified in circulating tumor cells (CTCs)","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3180210461","doi":"https://doi.org/10.1158/1538-7445.am2021-463","mag":"3180210461"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2021-463","doi":"https://doi.org/10.1158/1538-7445.am2021-463","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2021-463","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072850546","display_name":"Howard I. Scher","orcid":"https://orcid.org/0000-0002-6791-9324","observed_orcids":["https://orcid.org/0000-0002-6791-9324"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard I. Scher","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066167344","display_name":"Adam Jendrisak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Jendrisak","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013124422","display_name":"Cole Gilbertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cole Gilbertson","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106628367","display_name":"Audrey Gill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Gill","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112533343","display_name":"Ethan S. Barnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Barnett","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010079764","display_name":"Anuradha Gopalan","orcid":"https://orcid.org/0009-0007-6017-0991","observed_orcids":["https://orcid.org/0009-0007-6017-0991"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuradha Gopalan","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032373949","display_name":"Niamh M. Keegan","orcid":"https://orcid.org/0000-0002-5145-4892","observed_orcids":["https://orcid.org/0000-0002-5145-4892"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niamh Keegan","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085090650","display_name":"Samir Zaidi","orcid":"https://orcid.org/0000-0003-1592-2932","observed_orcids":["https://orcid.org/0000-0003-1592-2932"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir Zaidi","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018580062","display_name":"Hannah Benoliel","orcid":"https://orcid.org/0009-0009-8639-6440","observed_orcids":["https://orcid.org/0009-0009-8639-6440"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Benoliel","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000401096","display_name":"Carbone Emily","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carbone Emily","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032257682","display_name":"Eva Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Wang","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011610617","display_name":"James Jian-Qiang Lu","orcid":"https://orcid.org/0000-0002-9687-5607","observed_orcids":["https://orcid.org/0000-0002-9687-5607"]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lu","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084178911","display_name":"Alisa Tubbs","orcid":"https://orcid.org/0000-0003-1392-2736","observed_orcids":["https://orcid.org/0000-0003-1392-2736"]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alisa Tubbs","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045985687","display_name":"Amanda K. L. Anderson","orcid":"https://orcid.org/0000-0001-7686-7477","observed_orcids":["https://orcid.org/0000-0001-7686-7477"]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Anderson","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077241291","display_name":"Joshua Timothy Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Jones","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061253538","display_name":"Joseph D. Schonhoft","orcid":"https://orcid.org/0000-0002-5860-5040","observed_orcids":["https://orcid.org/0000-0002-5860-5040"]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Schonhoft","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086848806","display_name":"Rick Wenstrup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159579","display_name":"Epic Sciences (United States)","ror":"https://ror.org/0527cde49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick Wenstrup","raw_affiliation_strings":["2Epic Sciences, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Epic Sciences, San Diego, CA","institution_ids":["https://openalex.org/I4210159579"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"13_Supplement","first_page":"463","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/androgen-receptor-pathway-inhibitors","display_name":"androgen receptor pathway inhibitors","score":0.7160000205039978},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/lineage-plasticity","display_name":"lineage plasticity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.6589999794960022},{"id":"https://openalex.org/keywords/dll3","display_name":"DLL3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ctc-quantification","display_name":"CTC quantification","score":0.42500001192092896},{"id":"https://openalex.org/keywords/clinical-trial-eligibility-criteria","display_name":"inclusion and exclusion criteria","score":0.5},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.6614689826965332},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.6119996905326843},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5861971378326416},{"id":"https://openalex.org/C2780341458","wikidata":"https://www.wikidata.org/wiki/Q18391873","display_name":"Neuroendocrine differentiation","level":4,"score":0.5336970090866089},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4782675504684448},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.47356927394866943},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4571019411087036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4450402855873108},{"id":"https://openalex.org/C2909444961","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small Cell Lung Carcinoma","level":4,"score":0.4401454031467438},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4230515658855438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41300636529922485},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4128879904747009},{"id":"https://openalex.org/C2778911148","wikidata":"https://www.wikidata.org/wiki/Q15979047","display_name":"Large cell","level":4,"score":0.412309467792511},{"id":"https://openalex.org/C2779292878","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small-cell carcinoma","level":3,"score":0.3636261820793152},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3599817752838135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3267233669757843},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.2687903642654419},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.21435153484344482},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.11238187551498413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10075080394744873},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.09938770532608032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2021-463","doi":"https://doi.org/10.1158/1538-7445.am2021-463","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2021-463","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152819527","https://openalex.org/W2222802229","https://openalex.org/W4282959509","https://openalex.org/W3136107259","https://openalex.org/W108674637","https://openalex.org/W2968732601","https://openalex.org/W7160608286","https://openalex.org/W2766285479","https://openalex.org/W2119436512","https://openalex.org/W3201116764"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2],"increasing":[3],"availability":[4],"and":[5,69,105,165,177,210,233,247,335,358],"earlier":[6],"use":[7],"of":[8,27,56,107,127,161,189,205,345],"life":[9],"prolonging":[10],"drugs":[11],"targeting":[12],"the":[13,25,49,70,80,103,112,198,203,217,346],"androgen":[14],"receptor":[15],"signaling":[16],"axis":[17],"(ARSI)":[18],"has":[19,270],"resulted":[20],"in":[21,24,75,118,202,236,238,261,337],"an":[22,90,124],"increase":[23],"frequency":[26],"late":[28,211],"state":[29,212],"tumors":[30,44],"with":[31,134,148,181,207,224,244,324],"\u201csmall":[32],"cell/neuroendocrine":[33],"like":[34,139,255,328],"(SC/NE-L)":[35,256,329],"phenotypes\u201d":[36],"similar":[37],"to":[38,62,82,152,253,266],"small-cell":[39,50,64,116,208,225,245,252,326],"lung":[40,209,246],"cancer":[41],"(SCLC).":[42],"These":[43],"are":[45,67],"typically":[46],"heterogenous":[47],"wherein":[48],"component":[51],"represents":[52],"only":[53],"a":[54,95,132,144,149,239,267,325],"portion":[55],"CTC's":[57],"present.":[58],"Definitive":[59],"pathologic":[60],"criteria":[61,72,129],"diagnose":[63],"neuroendocrine":[65,138,227,254,327],"transformation":[66,228,265,330],"lacking,":[68],"eligibility":[71],"across":[73],"trials":[74],"this":[76],"space":[77],"inconsistent,":[78],"limiting":[79],"ability":[81],"relate":[83],"outcomes":[84],"between":[85],"studies.":[86],"We":[87],"hypothesize":[88],"that":[89,142,263],"analytically":[91],"validated":[92],"assay":[93],"for":[94,115,130,349],"rigorously":[96],"defined":[97,123],"\u201csmall-cell":[98],"CTC\u201d":[99],"phenotype":[100,269],"would":[101],"clarify":[102],"identification":[104],"diagnosis":[106,117],"SC/NE-L":[108,268],"tumors.":[109],"Methods:":[110],"Using":[111,216],"WHO":[113],"guidelines":[114],"tissue":[119,276],"as":[120],"reference,":[121],"we":[122],"equivalent":[125],"set":[126],"single-cell":[128],"defining":[131],"CTC":[133,257],"small":[135,156],"cell":[136,147],"or":[137,169,226,282],"(SC/NE)":[140],"histology":[141],"include:":[143],"circulating":[145,338],"CD45-":[146],"high":[150,158],"nuclear":[151],"cytoplasm":[153],"area":[154],"ratio,":[155],"size,":[157],"circularity,":[159],"lack":[160],"detectable":[162],"nucleoli,":[163],"salt":[164],"pepper":[166],"chromatin,":[167],"SC/NE":[168],"tumor-related":[170],"protein":[171],"expression":[172],"(DLL3,":[173],"CD56,":[174],"CK":[175,185],"etc.),":[176],"other":[178],"features":[179,222],"associated":[180,223],"lineage":[182,264],"plasticity":[183],"(i.e.,":[184],"speckling).":[186],"Clinical":[187],"feasibility":[188],"feature":[190],"extraction":[191],"was":[192],"explored":[193],"on":[194],"CTCs":[195,237],"detected":[196,334],"using":[197],"Epic":[199,218],"Sciences":[200,219],"platform":[201],"blood":[204],"patients":[206,243],"prostate":[213,248],"cancers.":[214,249],"Results:":[215],"platform,":[220],"morphologic":[221],"can":[229,331],"be":[230,280,332],"readily":[231,333],"identified":[232],"quantified":[234,336],"automatically":[235],"liquid":[240],"biopsy":[241],"from":[242],"Conclusions:":[250],"Identifying":[251],"subtypes":[258],"may":[259,278],"aid":[260],"establishing":[262],"occurred":[271],"where":[272],"invasive":[273],"single":[274],"site":[275],"biopsies":[277],"not":[279],"informative":[281],"feasible.":[283],"Citation":[284],"Format:":[285],"Howard":[286],"I.":[287],"Scher,":[288],"Adam":[289],"Jendrisak,":[290],"Cole":[291],"Gilbertson,":[292],"Audrey":[293],"Gill,":[294],"Ethan":[295],"Barnett,":[296],"Anuradha":[297],"Gopalan,":[298],"Niamh":[299],"Keegan,":[300],"Samir":[301],"Zaidi,":[302],"Hannah":[303],"Benoliel,":[304],"Carbone":[305],"Emily,":[306],"Eva":[307],"Wang,":[308],"James":[309],"Lu,":[310],"Alisa":[311],"Tubbs,":[312],"Amanda":[313],"Anderson,":[314],"Joshua":[315],"Jones,":[316],"Joseph":[317],"D.":[318],"Schonhoft,":[319],"Rick":[320],"Wenstrup.":[321],"Features":[322],"consistent":[323],"tumor":[339],"cells":[340],"(CTCs)":[341],"[abstract].":[342],"In:":[343],"Proceedings":[344],"American":[347],"Association":[348],"Cancer":[350,364],"Research":[351],"Annual":[352],"Meeting":[353],"2021;":[354],"2021":[355],"Apr":[356],"10-15":[357],"May":[359],"17-21.":[360],"Philadelphia":[361],"(PA):":[362],"AACR;":[363],"Res":[365],"2021;81(13_Suppl):Abstract":[366],"nr":[367],"463.":[368]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-07-19T00:00:00"}
