{"id":"https://openalex.org/W3179320191","doi":null,"title":"Allostasis: The Fundamental Biology and Implications for Social Standing and Longevity","display_name":"Allostasis: The Fundamental Biology and Implications for Social Standing and Longevity","publication_year":2021,"publication_date":"2021-05-28","ids":{"openalex":"https://openalex.org/W3179320191","mag":"3179320191"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt56j9884f","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/56j9884f","pdf_url":"https://escholarship.org/uc/item/56j9884f","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/56j9884f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007663692","display_name":"Barry Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Barry Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007663692"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allostasis","display_name":"allostasis","score":1.0},{"id":"https://openalex.org/keywords/allostatic-load","display_name":"allostatic load","score":0.9869999885559082},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9959999918937683},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":1.0},{"id":"https://openalex.org/keywords/social-class","display_name":"social class","score":0.6140000224113464},{"id":"https://openalex.org/keywords/social-inequality","display_name":"social inequality","score":0.6140000224113464},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8330000042915344},{"id":"https://openalex.org/keywords/biological-stress","display_name":"biological stress","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.8344330787658691},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.830620527267456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3342803716659546},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.2591245472431183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15704426169395447},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08607310056686401}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt56j9884f","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/56j9884f","pdf_url":"https://escholarship.org/uc/item/56j9884f","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"mag:3179320191","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt56j9884f/qt56j9884f.pdf?t=qttlmt","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt56j9884f","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/56j9884f","pdf_url":"https://escholarship.org/uc/item/56j9884f","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3179320191.pdf","grobid_xml":"https://content.openalex.org/works/W3179320191.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1981748148","https://openalex.org/W1987391422","https://openalex.org/W1989523576","https://openalex.org/W1990035761","https://openalex.org/W1993637512","https://openalex.org/W1995322135","https://openalex.org/W2000770184","https://openalex.org/W2000876197","https://openalex.org/W2012719201","https://openalex.org/W2025373842","https://openalex.org/W2039300784","https://openalex.org/W2055823139","https://openalex.org/W2056975096","https://openalex.org/W2071532085","https://openalex.org/W2082347869","https://openalex.org/W2083274461","https://openalex.org/W2098406427","https://openalex.org/W2162038554","https://openalex.org/W2327202751","https://openalex.org/W2360484118","https://openalex.org/W2564321869","https://openalex.org/W2603180890"],"related_works":["https://openalex.org/W1980533762","https://openalex.org/W1979658347","https://openalex.org/W1978762354","https://openalex.org/W4237547583","https://openalex.org/W7603151","https://openalex.org/W2490404993","https://openalex.org/W2000344066","https://openalex.org/W1981748148","https://openalex.org/W1686749590","https://openalex.org/W2014247660"],"abstract_inverted_index":{"In":[0],"the":[1,6,18,25,38,45,54,63,66,69,83,90,93,96,101,106,119,154,197],"face":[2],"of":[3,13,65,92,158,188,199],"external":[4,166],"adversities,":[5],"human":[7],"body":[8,84,107],"utilizes":[9],"a":[10,50,109,156,207],"vast":[11],"array":[12],"physiological":[14,97],"systems":[15,74],"to":[16,23,72,116,122,145,149],"combat":[17],"perceived":[19],"threat":[20],"in":[21,28,53,75,153,161],"order":[22],"keep":[24,73],"internal":[26,78],"conditions":[27,79],"balance.This":[29],"intricate":[30],"and":[31,60,105,176,204],"well-coordinated":[32],"process":[33],"is":[34,163],"known":[35,111],"as":[36,80,82,112],"allostasis.Among":[37],"various":[39],"hormones":[40,70],"that":[41],"are":[42],"secreted":[43],"by":[44],"allostatic":[46,94,113,126,159,189],"networks,":[47],"four":[48],"play":[49],"prominent":[51],"role":[52],"stress":[55,67,88,135],"response:":[56],"glucocorticoids,":[57],"dehydroepiandrosterone,":[58],"cytokines,":[59],"catecholamines.To":[61],"counteract":[62],"effects":[64,198],"stimulus,":[68],"work":[71],"balance,":[76],"shifting":[77],"needed.However,":[81],"continuously":[85],"deals":[86],"with":[87,100,124,138],"through":[89],"activation":[91],"process,":[95],"processes":[98],"associated":[99,137],"response":[102],"slowly":[103],"degrades,":[104],"enters":[108],"state":[110],"overload.In":[114],"addition":[115],"negatively":[117],"affecting":[118],"body's":[120],"capacity":[121],"deal":[123],"stress,":[125],"overload":[127],"entails":[128],"an":[129],"even":[130],"greater":[131],"risk:":[132],"neurological":[133],"degeneration.Increased":[134],"levels":[136],"increased":[139],"hormonal":[140],"secretion":[141],"have":[142],"been":[143],"observed":[144],"be":[146,183,202,211],"closely":[147],"linked":[148],"certain":[150],"degenerative":[151],"changes":[152],"brain.Stress,":[155],"determinant":[157],"load":[160,190],"particular,":[162],"derived":[164],"from":[165],"forces":[167],"or":[168],"experiences.Such":[169],"experiences":[170],"differ":[171],"greatly":[172],"across":[173,191],"social":[174,193],"classes":[175],"therefore,":[177],"confer":[178],"differential":[179,186],"effects.Furthermore,":[180],"inferences":[181],"can":[182,201,210],"made":[184],"on":[185,206],"manifestations":[187],"differing":[192],"standings.In":[194],"doing":[195],"so,":[196],"allostasis":[200],"quantified":[203],"implications":[205],"larger":[208],"scale":[209],"made.":[212]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2021-07-19T00:00:00"}