{"id":"https://openalex.org/W3178700860","doi":"https://doi.org/10.1158/1538-7445.am2021-3027","title":"Abstract 3027: Role of BCOR in retinoblastoma","display_name":"Abstract 3027: Role of BCOR in retinoblastoma","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3178700860","doi":"https://doi.org/10.1158/1538-7445.am2021-3027","mag":"3178700860"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2021-3027","doi":"https://doi.org/10.1158/1538-7445.am2021-3027","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2021-3027","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022849084","display_name":"Michelle Garying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Garying Zhang","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013289840","display_name":"Dawn A. Owens","orcid":"https://orcid.org/0000-0003-4661-2718","observed_orcids":["https://orcid.org/0000-0003-4661-2718"]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Owens","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038984327","display_name":"Stefan Kurtenbach","orcid":"https://orcid.org/0000-0002-7445-596X","observed_orcids":["https://orcid.org/0000-0002-7445-596X"]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Kurtenbach","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112697847","display_name":"Jeffim N. Kuznetsov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffim Kuznetsov","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew Fields","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Fields","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034794862","display_name":"Daniel Pelaez","orcid":"https://orcid.org/0000-0002-4483-5160","observed_orcids":["https://orcid.org/0000-0002-4483-5160"]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Pelaez","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077374286","display_name":"J. William Harbour","orcid":"https://orcid.org/0000-0002-1104-9809","observed_orcids":["https://orcid.org/0000-0002-1104-9809"]},"institutions":[{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W. Harbour","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, and Interdisciplinary Stem Cell Institute, Miami, FL","institution_ids":["https://openalex.org/I4210157065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210157065"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"13_Supplement","first_page":"3027","last_page":"3027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma","display_name":"retinoblastoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bcor","display_name":"BCOR","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rb1-inactivation","display_name":"RB1 inactivation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/therapeutic-escape","display_name":"therapeutic escape","score":0.6589999794960022},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.7009999752044678},{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.6949999928474426},{"id":"https://openalex.org/keywords/epigenetic-dysregulation","display_name":"epigenetic dysregulation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.906000018119812},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.9693536758422852},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48691022396087646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4673213064670563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41627955436706543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3403303921222687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25261157751083374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.194466233253479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2021-3027","doi":"https://doi.org/10.1158/1538-7445.am2021-3027","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2021-3027","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282980246","https://openalex.org/W4415931281","https://openalex.org/W7133361114","https://openalex.org/W4362542717","https://openalex.org/W4309016786","https://openalex.org/W4386385125","https://openalex.org/W4409348303","https://openalex.org/W4398200392","https://openalex.org/W7163811953","https://openalex.org/W2408557296"],"abstract_inverted_index":{"Abstract":[0],"Retinoblastoma,":[1],"which":[2,43],"is":[3,13,23,30,44,58],"usually":[4],"initiated":[5],"by":[6,60],"the":[7,14,69,82,86,98,131,156,199],"biallelic":[8],"mutational":[9],"inactivation":[10],"of":[11,48,64,72,76,91,100,118,143,158,191,198],"RB1,":[12],"most":[15,88],"common":[16,89],"primary":[17,77,122],"eye":[18,51],"cancer":[19],"in":[20,93,102,112,121,130,161,193],"children":[21],"and":[22,53,133,164,211],"fatal":[24],"if":[25],"left":[26],"untreated.":[27],"While":[28],"retinoblastoma":[29,66,78,123,149,162,194],"initially":[31],"sensitive":[32],"to":[33,106],"chemotherapy,":[34],"it":[35],"demonstrates":[36],"a":[37,45,61],"strong":[38],"propensity":[39],"for":[40,169,202],"therapeutic":[41,170],"escape,":[42],"leading":[46],"cause":[47],"ocular":[49],"morbidity,":[50],"loss,":[52],"reduced":[54],"survival.":[55],"This":[56,151],"problem":[57],"exacerbated":[59],"poor":[62],"understanding":[63],"how":[65],"progresses":[67],"after":[68],"initial":[70],"loss":[71],"RB1.":[73],"Genomic":[74],"analysis":[75],"tumors":[79],"has":[80],"revealed":[81,125,139],"corepressor":[83],"BCOR":[84,101,120,127,144,192],"as":[85],"second":[87],"target":[90],"mutations":[92],"retinoblastoma.":[94,113],"Here,":[95],"we":[96],"explored":[97],"role":[99,111,157],"normal":[103],"retinal":[104],"development":[105],"provide":[107],"insights":[108,155],"into":[109],"its":[110],"Mass":[114],"spectrometry":[115],"following":[116],"immunoprecipitation":[117],"wildtype":[119],"cells":[124],"novel":[126],"interacting":[128],"proteins":[129],"Polycomb":[132],"MiDAC":[134],"epigenetic":[135,159],"complexes.":[136],"Subsequent":[137],"studies":[138],"potential":[140],"functional":[141],"consequences":[142],"mutation":[145],"that":[146],"may":[147],"promote":[148],"progression.":[150],"work":[152],"reveals":[153],"new":[154,167],"deregulation":[160],"progression,":[163],"they":[165],"nominate":[166],"candidates":[168],"intervention.":[171],"Citation":[172],"Format:":[173],"Michelle":[174],"Garying":[175],"Zhang,":[176],"Dawn":[177],"Owens,":[178],"Stefan":[179],"Kurtenbach,":[180],"Jeffim":[181],"Kuznetsov,":[182],"Matthew":[183],"Fields,":[184],"Daniel":[185],"Pelaez,":[186],"James":[187],"W.":[188],"Harbour.":[189],"Role":[190],"[abstract].":[195],"In:":[196],"Proceedings":[197],"American":[200],"Association":[201],"Cancer":[203,217],"Research":[204],"Annual":[205],"Meeting":[206],"2021;":[207],"2021":[208],"Apr":[209],"10-15":[210],"May":[212],"17-21.":[213],"Philadelphia":[214],"(PA):":[215],"AACR;":[216],"Res":[218],"2021;81(13_Suppl):Abstract":[219],"nr":[220],"3027.":[221]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2021-07-19T00:00:00"}