{"id":"https://openalex.org/W3177901966","doi":"https://doi.org/10.1016/j.cub.2021.06.021","title":"Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization","display_name":"Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization","publication_year":2021,"publication_date":"2021-07-08","ids":{"openalex":"https://openalex.org/W3177901966","doi":"https://doi.org/10.1016/j.cub.2021.06.021","mag":"3177901966","pmid":"https://pubmed.ncbi.nlm.nih.gov/34242576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8478408"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2021.06.021","doi":"https://doi.org/10.1016/j.cub.2021.06.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2021.06.021","pdf_url":"http://www.cell.com/article/S0960982221008162/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S0960982221008162/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078262254","display_name":"Ariana D. Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariana D. Sanchez","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087810007","display_name":"Tess Caroline Branon","orcid":"https://orcid.org/0000-0002-6520-6419","observed_orcids":["https://orcid.org/0000-0002-6520-6419"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tess C. Branon","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA","Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA","Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031692965","display_name":"Lauren E. Cote","orcid":"https://orcid.org/0000-0002-1772-7447","observed_orcids":["https://orcid.org/0000-0002-1772-7447"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E. Cote","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-1772-7447","affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054250949","display_name":"Alexandros Papagiannakis","orcid":"https://orcid.org/0000-0002-6363-804X","observed_orcids":["https://orcid.org/0000-0002-6363-804X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandros Papagiannakis","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035697957","display_name":"Xing Liang","orcid":"https://orcid.org/0000-0002-8298-1214","observed_orcids":["https://orcid.org/0000-0002-8298-1214","https://orcid.org/0000-0002-8580-8847"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Liang","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072175310","display_name":"Melissa A. Pickett","orcid":"https://orcid.org/0000-0001-8364-4757","observed_orcids":["https://orcid.org/0000-0001-8364-4757"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A. Pickett","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA"],"raw_orcid":"https://orcid.org/0000-0001-8364-4757","affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067304730","display_name":"Kang Shen","orcid":"https://orcid.org/0000-0003-4059-8249","observed_orcids":["https://orcid.org/0000-0003-4059-8249"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kang Shen","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111718369","display_name":"Christine Jacobs","orcid":"https://orcid.org/0000-0003-0980-5334","observed_orcids":["https://orcid.org/0000-0003-0980-5334"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Jacobs-Wagner","raw_affiliation_strings":["Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA; Department of Biology and ChEM-H Institute, Stanford University, Stanford, CA, USA","Department of Biology and ChEM-H Institute, Stanford University, Stanford, CA, USA","Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA; Department of Biology and ChEM-H Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology and ChEM-H Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048170851","display_name":"Alice Y. Ting","orcid":"https://orcid.org/0000-0002-8277-5226","observed_orcids":["https://orcid.org/0000-0002-8277-5226"]},"institutions":[{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Y. Ting","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA","Chan Zuckerberg Biohub, San Francisco, CA, USA","Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA","Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8277-5226","affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210100286","https://openalex.org/I63966007","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Chan Zuckerberg Biohub, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Departments of Genetics and Chemistry, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010411927","display_name":"Jessica L. Feldman","orcid":"https://orcid.org/0000-0002-5210-5045","observed_orcids":["https://orcid.org/0000-0002-5210-5045"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jessica L. Feldman","raw_affiliation_strings":["Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA. Electronic address: feldmanj@stanford.edu","Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA. Electronic address: feldmanj@stanford.edu","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010411927"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":6700,"currency":"USD","value_usd":6700},"apc_paid":{"value":6700,"currency":"USD","value_usd":6700},"fwci":5.4857,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.97477755,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"31","issue":"16","first_page":"3586","last_page":"3600.e11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-growth","display_name":"microtubule growth","score":0.906000018119812},{"id":"https://openalex.org/keywords/turboid-proximity-labeling","display_name":"TurboID proximity labeling","score":0.7300000190734863},{"id":"https://openalex.org/keywords/wdr62","display_name":"WDR62","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gamma-tubulin-ring-complex","display_name":"\u03b3-tubulin ring complex","score":0.8679999709129333},{"id":"https://openalex.org/keywords/microtubule-minus-ends","display_name":"microtubule minus ends","score":0.7160000205039978},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.8200532793998718},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8184385299682617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7962942123413086},{"id":"https://openalex.org/C104672736","wikidata":"https://www.wikidata.org/wiki/Q903644","display_name":"Microtubule organizing center","level":5,"score":0.7959350347518921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7681325674057007},{"id":"https://openalex.org/C94921385","wikidata":"https://www.wikidata.org/wiki/Q12134483","display_name":"Microtubule nucleation","level":5,"score":0.7400954961776733},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.6015962958335876},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.5490700006484985},{"id":"https://openalex.org/C9565192","wikidata":"https://www.wikidata.org/wiki/Q2868390","display_name":"Astral microtubules","level":5,"score":0.4973748028278351},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.43968743085861206},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.42481905221939087},{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.41245898604393005},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.3734566569328308},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24432605504989624},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.203343003988266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13766998052597046}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022101","descriptor_name":"Microtubule-Organizing Center","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cub.2021.06.021","doi":"https://doi.org/10.1016/j.cub.2021.06.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2021.06.021","pdf_url":"http://www.cell.com/article/S0960982221008162/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:34242576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34242576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8478408","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8478408","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.cub.2021.06.021","doi":"https://doi.org/10.1016/j.cub.2021.06.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2021.06.021","pdf_url":"http://www.cell.com/article/S0960982221008162/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8","score":0.5099999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1172905597","display_name":"Mapping protein communication between organs in homeostasis and disease","funder_award_id":"R01DK121409","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1340484205","display_name":null,"funder_award_id":"R01GM133950","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G135256158","display_name":null,"funder_award_id":"019.182EN.018","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G1742625790","display_name":"Mechanisms controlling microtubule organization during cell differentiation","funder_award_id":"1dp2gm119136-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2822375070","display_name":null,"funder_award_id":"DP2GM119136-01","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G4227984967","display_name":"Cellular and Molecular Biology Training Program","funder_award_id":"T32GM007276","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4759498286","display_name":null,"funder_award_id":"P40 OD010440","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5035028041","display_name":null,"funder_award_id":"DP2 GM119136","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6584045426","display_name":null,"funder_award_id":"R01 DK121409","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6773952900","display_name":null,"funder_award_id":"NS082208","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8437636521","display_name":null,"funder_award_id":"019.182EN.018","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8532445268","display_name":"Investigating the establishment, structure, and function of microtubule organizing centers in differentiated cells in vivo","funder_award_id":"R01GM133950","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8965797727","display_name":null,"funder_award_id":"2T32GM007276","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000899032","display_name":"Patterning dendritic branches with environmental and neuronal surface molecules","funder_award_id":"R01NS082208","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320308507","display_name":"Stanford University","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3177901966.pdf"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W1514480564","https://openalex.org/W1597886318","https://openalex.org/W1763836146","https://openalex.org/W1935003487","https://openalex.org/W1944127002","https://openalex.org/W1970035510","https://openalex.org/W1988308292","https://openalex.org/W1989952069","https://openalex.org/W1990157435","https://openalex.org/W1996446743","https://openalex.org/W2000766568","https://openalex.org/W2008917555","https://openalex.org/W2012083512","https://openalex.org/W2020343730","https://openalex.org/W2040667056","https://openalex.org/W2045088110","https://openalex.org/W2045419701","https://openalex.org/W2047077861","https://openalex.org/W2052489620","https://openalex.org/W2058428747","https://openalex.org/W2068474659","https://openalex.org/W2070576225","https://openalex.org/W2074525543","https://openalex.org/W2075802731","https://openalex.org/W2079665723","https://openalex.org/W2089605842","https://openalex.org/W2091546915","https://openalex.org/W2094074562","https://openalex.org/W2102905759","https://openalex.org/W2105707485","https://openalex.org/W2109791816","https://openalex.org/W2111211467","https://openalex.org/W2113279580","https://openalex.org/W2113799806","https://openalex.org/W2120772351","https://openalex.org/W2125394700","https://openalex.org/W2127322768","https://openalex.org/W2129018625","https://openalex.org/W2132654115","https://openalex.org/W2137117135","https://openalex.org/W2145300176","https://openalex.org/W2147905813","https://openalex.org/W2148200511","https://openalex.org/W2150080396","https://openalex.org/W2152401699","https://openalex.org/W2159957100","https://openalex.org/W2166574880","https://openalex.org/W2167844024","https://openalex.org/W2168451433","https://openalex.org/W2168614708","https://openalex.org/W2168997921","https://openalex.org/W2257475384","https://openalex.org/W2291986393","https://openalex.org/W2314133794","https://openalex.org/W2342249984","https://openalex.org/W2402433838","https://openalex.org/W2406343444","https://openalex.org/W2410106639","https://openalex.org/W2414947116","https://openalex.org/W2470019017","https://openalex.org/W2513049201","https://openalex.org/W2522470354","https://openalex.org/W2525884380","https://openalex.org/W2543622711","https://openalex.org/W2593500419","https://openalex.org/W2610994034","https://openalex.org/W2625678278","https://openalex.org/W2759849034","https://openalex.org/W2810798322","https://openalex.org/W2887360529","https://openalex.org/W2888618670","https://openalex.org/W2900569176","https://openalex.org/W2948331893","https://openalex.org/W2949295459","https://openalex.org/W2971421521","https://openalex.org/W2985168002","https://openalex.org/W2994978818","https://openalex.org/W3003257820","https://openalex.org/W3005654419","https://openalex.org/W3011361513","https://openalex.org/W3028549436","https://openalex.org/W3032932333","https://openalex.org/W3033181093","https://openalex.org/W3035965352","https://openalex.org/W3099878876","https://openalex.org/W3103145119","https://openalex.org/W3128261063","https://openalex.org/W3169565946","https://openalex.org/W3175207148","https://openalex.org/W4253248585","https://openalex.org/W6676766870","https://openalex.org/W7073703679"],"related_works":["https://openalex.org/W3081535358","https://openalex.org/W7024097403","https://openalex.org/W2810798322","https://openalex.org/W2888216822","https://openalex.org/W2887164111","https://openalex.org/W2271490646","https://openalex.org/W2011038386","https://openalex.org/W2794562345","https://openalex.org/W6927058040","https://openalex.org/W4309231200"],"abstract_inverted_index":{"Microtubules":[0],"are":[1,72,247],"polarized":[2],"intracellular":[3,26],"polymers":[4],"that":[5],"play":[6],"key":[7],"roles":[8,213,224],"in":[9,13,92,164,201],"the":[10,54,84,100,107,144,153,184,208,220],"cell,":[11],"including":[12],"transport,":[14],"polarity,":[15],"and":[16,122,138,146,152,167,189,200,236,245],"cell":[17,21,75,198,222],"division.":[18],"Across":[19],"eukaryotic":[20],"types,":[22],"microtubules":[23,67,151,188],"adopt":[24],"diverse":[25,69],"organization":[27],"to":[28,64,74,99,130],"accommodate":[29],"these":[30],"distinct":[31],"functions":[32],"coordinated":[33],"by":[34],"specific":[35],"cellular":[36],"sites":[37],"called":[38],"microtubule-organizing":[39],"centers":[40],"(MTOCs).":[41],"Over":[42],"50":[43],"years":[44],"of":[45,110,156,161,170,181,186,197,214,225,240],"research":[46],"on":[47,53,115],"MTOC":[48],"biology":[49],"has":[50],"focused":[51],"mainly":[52],"centrosome;":[55],"however,":[56],"most":[57],"differentiated":[58],"cells":[59],"employ":[60],"non-centrosomal":[61,150,212],"MTOCs":[62],"(ncMTOCs)":[63],"organize":[65],"their":[66],"into":[68],"arrays,":[70],"which":[71],"critical":[73],"function.":[76],"To":[77],"identify":[78,127,232],"essential":[79,233],"ncMTOC":[80,109,234],"components,":[81],"we":[82,126,218],"developed":[83],"biotin":[85],"ligase-based,":[86],"proximity-labeling":[87],"approach":[88],"TurboID":[89],"for":[90,211],"use":[91],"C.":[93],"elegans.":[94],"We":[95],"identified":[96],"proteins":[97],"proximal":[98],"microtubule":[101,157,165,172,243],"minus":[102],"end":[103],"protein":[104,120,125,135],"PTRN-1/Patronin":[105],"at":[106],"apical":[108,154],"intestinal":[111],"epithelial":[112],"cells,":[113],"focusing":[114],"two":[116],"conserved":[117],"proteins:":[118],"spectraplakin":[119],"VAB-10B/MACF1":[121],"WDR-62,":[123],"a":[124,171,238],"as":[128],"homologous":[129],"vertebrate":[131],"primary":[132],"microcephaly":[133],"disease":[134,228],"WDR62.":[136],"VAB-10B":[137,162],"WDR-62":[139,182],"do":[140],"not":[141],"associate":[142],"with":[143,203],"centrosome":[145],"instead":[147],"specifically":[148],"regulate":[149],"targeting":[155],"minus-end":[158],"proteins.":[159],"Depletion":[160],"resulted":[163],"mislocalization":[166],"delayed":[168],"localization":[169,246],"nucleation":[173],"complex":[174,177],"\u0263-tubulin":[175],"ring":[176],"(\u03b3-TuRC),":[178],"while":[179],"loss":[180],"decreased":[183],"number":[185],"dynamic":[187],"abolished":[190],"\u03b3-TuRC":[191],"localization.":[192],"This":[193],"regulation":[194],"occurs":[195],"downstream":[196],"polarity":[199],"conjunction":[202],"actin.":[204],"As":[205],"this":[206,226],"is":[207],"first":[209],"report":[210],"WDR62":[215],"family":[216],"proteins,":[217],"expand":[219],"basic":[221],"biological":[223],"important":[227],"protein.":[229],"Our":[230],"studies":[231],"components":[235],"suggest":[237],"division":[239],"labor":[241],"where":[242],"growth":[244],"distinctly":[248],"regulated.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-07-19T00:00:00"}