{"id":"https://openalex.org/W3177635763","doi":"https://doi.org/10.52340/jecmj.2021.381","title":"THE ROLE OF INFLAMMATION IN AGE-RELATED DISEASES","display_name":"THE ROLE OF INFLAMMATION IN AGE-RELATED DISEASES","publication_year":2021,"publication_date":"2021-07-07","ids":{"openalex":"https://openalex.org/W3177635763","doi":"https://doi.org/10.52340/jecmj.2021.381","mag":"3177635763"},"language":"en","primary_location":{"id":"doi:10.52340/jecmj.2021.381","doi":"https://doi.org/10.52340/jecmj.2021.381","is_oa":true,"landing_page_url":"https://doi.org/10.52340/jecmj.2021.381","pdf_url":"https://journals.4science.ge/index.php/jecm/article/download/381/374","source":{"id":"https://openalex.org/S4394735711","display_name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","issn_l":"1512-0392","issn":["1512-0392","2667-9736"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.4science.ge/index.php/jecm/article/download/381/374","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060894643","display_name":"Medea Jgarkava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"MEDEA JGARKAVA","raw_affiliation_strings":["AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035311506","display_name":"Rusudan Rukhadze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"RUSUDAN RUKHADZE","raw_affiliation_strings":["AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":null,"display_name":"NINO KARANADZE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"NINO KARANADZE","raw_affiliation_strings":["AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012950343","display_name":"Ia Pantsulaia","orcid":"https://orcid.org/0000-0002-7439-6867","observed_orcids":["https://orcid.org/0000-0002-7439-6867"]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"IA PANTSULAIA","raw_affiliation_strings":["AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGE-RELATED DISEASES Tbilisi State Medical University , Tbilisi , Georgia","institution_ids":["https://openalex.org/I7848551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7848551"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.49729999899864197,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.49729999899864197,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.06719999760389328,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.05119999870657921,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9150000214576721},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.9089999794960022},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.5509999990463257},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7690844535827637},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7599958181381226},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6616359949111938},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47199419140815735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.448814332485199},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44324761629104614},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4195062816143036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21249938011169434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07283422350883484}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52340/jecmj.2021.381","doi":"https://doi.org/10.52340/jecmj.2021.381","is_oa":true,"landing_page_url":"https://doi.org/10.52340/jecmj.2021.381","pdf_url":"https://journals.4science.ge/index.php/jecm/article/download/381/374","source":{"id":"https://openalex.org/S4394735711","display_name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","issn_l":"1512-0392","issn":["1512-0392","2667-9736"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52340/jecmj.2021.381","doi":"https://doi.org/10.52340/jecmj.2021.381","is_oa":true,"landing_page_url":"https://doi.org/10.52340/jecmj.2021.381","pdf_url":"https://journals.4science.ge/index.php/jecm/article/download/381/374","source":{"id":"https://openalex.org/S4394735711","display_name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","issn_l":"1512-0392","issn":["1512-0392","2667-9736"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3177635763.pdf","grobid_xml":"https://content.openalex.org/works/W3177635763.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1603763228","https://openalex.org/W1987631879","https://openalex.org/W1990826584","https://openalex.org/W1991958139","https://openalex.org/W1995891832","https://openalex.org/W2006998501","https://openalex.org/W2034521172","https://openalex.org/W2038970022","https://openalex.org/W2069436393","https://openalex.org/W2082402714","https://openalex.org/W2084013192","https://openalex.org/W2085804112","https://openalex.org/W2106233765","https://openalex.org/W2117738774","https://openalex.org/W2120304599","https://openalex.org/W2122641903","https://openalex.org/W2130227007","https://openalex.org/W2160412430","https://openalex.org/W2162456111","https://openalex.org/W2164022766","https://openalex.org/W2169742866","https://openalex.org/W2324841714","https://openalex.org/W2494134352","https://openalex.org/W2532576306","https://openalex.org/W2585197640","https://openalex.org/W2586714736","https://openalex.org/W2596316189","https://openalex.org/W2735453195","https://openalex.org/W2888722873","https://openalex.org/W2892668330","https://openalex.org/W2920869614","https://openalex.org/W2993908729","https://openalex.org/W3001118548","https://openalex.org/W4242171500"],"related_works":["https://openalex.org/W2104355396","https://openalex.org/W6959232869","https://openalex.org/W2462347288","https://openalex.org/W2894690940","https://openalex.org/W2129155846","https://openalex.org/W2005822229","https://openalex.org/W3163948118","https://openalex.org/W1976213964","https://openalex.org/W2353216548","https://openalex.org/W2372682932"],"abstract_inverted_index":{"The":[0,71],"risk":[1,132],"of":[2,4,40,59,62,91,94,102,111,125,133,143,146,152,202],"developing":[3],"the":[5,38,46,55,60,78,88,92,96,100,109,139,150,167,182,203],"diseases":[6,26,42],"such":[7],"as":[8,31],"Alzheimer's":[9],"disease,":[10],"atherosclerosis,":[11],"osteoporosis,":[12],"arthritis,":[13],"type":[14],"2":[15],"diabetes":[16],"and":[17,85,108,130,166,173,199],"cancer":[18],"increases":[19],"with":[20,99],"age.":[21],"This":[22],"is":[23,35,64,122],"why":[24],"these":[25],"are":[27,162,169],"also":[28],"referred":[29],"to":[30,45,188],"age-related":[32,41,52,127,153],"diseases.":[33,154],"There":[34],"evidence":[36],"that":[37,141,180,195],"development":[39,93,101,129],"significantly":[43],"contributes":[44],"so-called.":[47],"Immune":[48],"aging,":[49],"in":[50,54,164,176,181,192],"particular,":[51],"changes":[53],"immune":[56],"system,":[57],"one":[58],"manifestations":[61],"which":[63],"a":[65,123,193,197],"low":[66],"level":[67],"systemic":[68],"chronic":[69,83,105],"inflammation.":[70],"term":[72],"\"inflammatory":[73],"aging\"":[74],"(Inflamm-aging)":[75],"well":[76],"describes":[77],"close":[79],"relationship":[80],"between":[81],"low-grade":[82],"inflammation":[84,147],"aging.":[86],"At":[87],"present":[89],"stage":[90],"medicine,":[95],"mechanisms":[97],"associated":[98],"age-related,":[103],"low-level,":[104],"inflammatory":[106,120,190],"processes":[107,191],"ways":[110],"their":[112],"evaluation":[113],"require":[114],"further":[115],"in-depth,":[116],"multidisciplinary":[117],"studies.":[118],"Clearly,":[119],"aging":[121,201],"predictor":[124],"many":[126],"disease":[128],"high":[131],"death.":[134],"Clinical":[135],"studies":[136,157,175],"have":[137],"confirmed":[138],"view":[140],"inhibition":[142],"certain":[144],"mediators":[145],"may":[148],"reduce":[149],"incidence":[151],"However,":[155],"similar":[156],"focusing":[158],"on":[159],"anti-inflammatory":[160],"drugs":[161],"few":[163],"number":[165],"results":[168],"ambiguous.":[170],"Further":[171],"fundamental":[172],"translational":[174],"this":[177],"direction":[178],"hope":[179],"future":[183],"we":[184],"will":[185],"be":[186],"able":[187],"regulate":[189],"way":[194],"ensures":[196],"healthy":[198],"long-lasting":[200],"population.":[204]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2021-07-19T00:00:00"}