{"id":"https://openalex.org/W3177581045","doi":"https://doi.org/10.1158/1538-7445.am2021-2637","title":"Abstract 2637: The use of 3D-printed Polylactic acid scaffolds (PLA) as a substrate for growth of MCF7 human breast cancer cells","display_name":"Abstract 2637: The use of 3D-printed Polylactic acid scaffolds (PLA) as a substrate for growth of MCF7 human breast cancer cells","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3177581045","doi":"https://doi.org/10.1158/1538-7445.am2021-2637","mag":"3177581045"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2021-2637","doi":"https://doi.org/10.1158/1538-7445.am2021-2637","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2021-2637","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053152914","display_name":"Brenna McAllister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126350171","display_name":"Fairfield University","ror":"https://ror.org/04z49n283","country_code":"US","type":"education","lineage":["https://openalex.org/I126350171"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenna McAllister","raw_affiliation_strings":["Fairfield University, Fairfield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairfield University, Fairfield, CT","institution_ids":["https://openalex.org/I126350171"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammed Mustafa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126350171","display_name":"Fairfield University","ror":"https://ror.org/04z49n283","country_code":"US","type":"education","lineage":["https://openalex.org/I126350171"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Mustafa","raw_affiliation_strings":["Fairfield University, Fairfield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairfield University, Fairfield, CT","institution_ids":["https://openalex.org/I126350171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086480556","display_name":"Sriharsha Srinivas Sundarram","orcid":"https://orcid.org/0000-0002-4306-8844","observed_orcids":["https://orcid.org/0000-0002-4306-8844"]},"institutions":[{"id":"https://openalex.org/I126350171","display_name":"Fairfield University","ror":"https://ror.org/04z49n283","country_code":"US","type":"education","lineage":["https://openalex.org/I126350171"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriharsha Sundarram","raw_affiliation_strings":["Fairfield University, Fairfield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairfield University, Fairfield, CT","institution_ids":["https://openalex.org/I126350171"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005530860","display_name":"Shelley Ann Phelan","orcid":"https://orcid.org/0000-0002-4707-1872","observed_orcids":["https://orcid.org/0000-0002-4707-1872"]},"institutions":[{"id":"https://openalex.org/I126350171","display_name":"Fairfield University","ror":"https://ror.org/04z49n283","country_code":"US","type":"education","lineage":["https://openalex.org/I126350171"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley A. Phelan","raw_affiliation_strings":["Fairfield University, Fairfield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairfield University, Fairfield, CT","institution_ids":["https://openalex.org/I126350171"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126350171"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"13_Supplement","first_page":"2637","last_page":"2637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polylactic-acid-scaffolds","display_name":"polylactic acid scaffolds","score":0.9520000219345093},{"id":"https://openalex.org/keywords/3d-printed-scaffolds","display_name":"3D-printed scaffolds","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cell-attachment","display_name":"cell attachment","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7519999742507935},{"id":"https://openalex.org/keywords/oleuropein","display_name":"oleuropein","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/scaffold-porosity","display_name":"scaffold porosity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.5860000252723694},{"id":"https://openalex.org/keywords/cell-culture-substrates","display_name":"cell culture substrates","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C38240268","wikidata":"https://www.wikidata.org/wiki/Q17125118","display_name":"Trypsinization","level":4,"score":0.9673565626144409},{"id":"https://openalex.org/C2781162966","wikidata":"https://www.wikidata.org/wiki/Q413769","display_name":"Polylactic acid","level":3,"score":0.6827974915504456},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5713777542114258},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5389275550842285},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5299150943756104},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.49887728691101074},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4920939803123474},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4692057967185974},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4557797610759735},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4454529881477356},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44416165351867676},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4310922622680664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4151822626590729},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36253249645233154},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32009923458099365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23578274250030518},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.1845826804637909},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16266000270843506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12220644950866699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1097838282585144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1091998815536499},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09159514307975769},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.05864003300666809},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2021-2637","doi":"https://doi.org/10.1158/1538-7445.am2021-2637","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2021-2637","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3005856001","https://openalex.org/W4213203387","https://openalex.org/W4289859357","https://openalex.org/W2895990667","https://openalex.org/W2940324129","https://openalex.org/W2700891747","https://openalex.org/W2774098571","https://openalex.org/W3005705636","https://openalex.org/W2485697282","https://openalex.org/W7074604000"],"abstract_inverted_index":{"Abstract":[0],"This":[1,234,417],"study":[2],"focuses":[3],"on":[4,231,258,286,411],"fabrication":[5],"of":[6,36,65,77,86,95,154,170,196,228,253,268,273,282,294,311,354,377,391,423,447,458,467],"large-scale":[7],"tissue":[8,431],"scaffolds":[9,24,44,56,88,113,160,185,400,425,451],"from":[10,158,212],"Polylactic":[11,449],"acid":[12,450],"(PLA)":[13,452],"and":[14,31,48,52,75,93,119,130,148,200,216,262,327,330,406,430,480],"their":[15],"feasibility":[16],"as":[17,103,105,453],"a":[18,69,166,187,237,266,335,454],"substrate":[19,455],"for":[20,71,132,141,240,385,420,426,456,471],"cell":[21,73,101,146,155,245,248,287,404,412,429],"growth.":[22],"The":[23,34,54,445],"were":[25,114,125,138],"fabricated":[26],"via":[27],"combined":[28],"additive":[29],"manufacturing":[30],"microwave":[32],"foaming.":[33],"benefit":[35],"this":[37,218],"approach":[38],"is":[39,180],"the":[40,84,96,111,159,162,177,184,213,226,232,251,256,259,283,291,298,307,313,342,352,367,375,389,421,468],"ability":[41],"to":[42,82,89,134,176,223],"generate":[43],"with":[45,61,247,265,297,362,379,408],"specific":[46],"architectures":[47],"controllable":[49],"pore":[50,59],"size":[51,267],"porosity.":[53],"resulting":[55],"have":[57],"dual":[58],"networks":[60],"porosity":[62],"in":[63,116,250,306,318,351,370,374,383,388],"excess":[64],"80%":[66],"which":[67,179],"provide":[68],"pathway":[70],"both":[72],"growth":[74,92,249,457],"circulation":[76],"culture":[78,432],"media.":[79],"We":[80],"sought":[81],"determine":[83,225,290],"capability":[85],"these":[87,109],"support":[90,402,419],"attachment,":[91,246],"viability":[94,149,274,413],"MCF7":[97,123,303,371,403,459],"human":[98,460],"breast":[99,461],"cancer":[100,462],"line,":[102],"well":[104,129,164],"drug":[106,292],"sensitivity.":[107],"For":[108],"experiments":[110],"PLA":[112,214,284,299,343,392,399,424],"sterilized":[115],"24-well":[117],"plates":[118],"1":[120],"x":[121],"105":[122],"cells":[124,171,198,211,229,295,304,372,386,463],"seeded":[126],"into":[127],"each":[128],"cultured":[131],"up":[133],"7":[135,328],"days.":[136],"Scaffolds":[137],"then":[139],"used":[140,222],"SEM":[142,242],"imaging,":[143],"hoescht-staining,":[144],"or":[145,309,414],"counting":[147],"measurements":[150],"after":[151],"trypsinization.":[152],"Comparisons":[153],"numbers":[156],"detached":[157],"vs.":[161],"remaining":[163],"suggest":[165,203,397],"proportionally":[167],"small":[168],"percentage":[169],"(less":[172],"than":[173],"5%)":[174],"attached":[175],"PLA,":[178,378],"not":[181,208,347],"surprising":[182],"since":[183],"lack":[186],"solid":[188],"bottom.":[189],"However,":[190],"our":[191,395],"imaging":[192,243],"data":[193,339],"using":[194,275],"hoescht-staining":[195],"PLA-attached":[197],"pre-":[199],"post-":[201],"trypsinization":[202,206],"that":[204,341,360,398],"traditional":[205],"does":[207],"effectively":[209],"detach":[210],"material,":[215,300],"therefore":[217],"method":[219],"cannot":[220],"be":[221],"accurately":[224],"proportion":[227],"growing":[230],"scaffolds.":[233,393],"also":[235,358],"reveals":[236],"potential":[238],"limitation":[239],"application.":[241],"confirmed":[244,359],"form":[252],"sheets":[254],"along":[255],"struts":[257],"bottom":[260],"layer,":[261],"clusters":[263],"elsewhere":[264],"around":[269],"50":[270],"micron.":[271],"Analysis":[272],"trypan":[276],"blue":[277],"exclusion":[278],"shows":[279],"no":[280,380,409],"effect":[281,410],"material":[285,344],"viability.":[288],"To":[289],"sensitivity":[293],"grown":[296,305,373,387],"we":[301],"treated":[302],"presence":[308,390],"absence":[310,353,376],"oleuropein,":[312],"main":[314],"phenolic":[315],"compound":[316],"found":[317],"olive":[319],"leaves.":[320],"Media":[321],"was":[322],"collected":[323],"at":[324],"48":[325],"hours":[326],"days":[329],"released":[331],"LDH":[332],"measured":[333],"by":[334],"cytotoxicity":[336,369],"assay.":[337],"Our":[338],"showed":[340],"itself":[345],"did":[346],"increase":[348],"cellular":[349],"toxicity":[350],"oleuropein":[355,365],"treatment.":[356],"It":[357],"treatment":[361],"200":[363],"ug/ml":[364],"induces":[366],"expected":[368],"significant":[381],"difference":[382],"oleuropein-susceptibility":[384],"Together,":[394],"results":[396],"can":[401],"attachment":[405],"growth,":[407],"drug-induced":[415],"cytotoxicity.":[416],"provides":[418],"promise":[422],"physiologically":[427],"relevant":[428],"work.":[433],"Citation":[434],"Format:":[435],"Brenna":[436],"McAllister,":[437],"Mohammed":[438],"Mustafa,":[439],"Sriharsha":[440],"Sundarram,":[441],"Shelley":[442],"A.":[443],"Phelan.":[444],"use":[446],"3D-printed":[448],"[abstract].":[464],"In:":[465],"Proceedings":[466],"American":[469],"Association":[470],"Cancer":[472,486],"Research":[473],"Annual":[474],"Meeting":[475],"2021;":[476],"2021":[477],"Apr":[478],"10-15":[479],"May":[481],"17-21.":[482],"Philadelphia":[483],"(PA):":[484],"AACR;":[485],"Res":[487],"2021;81(13_Suppl):Abstract":[488],"nr":[489],"2637.":[490]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2021-07-19T00:00:00"}
