{"id":"https://openalex.org/W3177164137","doi":"https://doi.org/10.22270/jddt.v11i3-s.4866","title":"Formulation and Evaluation of Lignocaine Hydrochloride Proniosomes Loaded Orabase for Dental Anaesthesia","display_name":"Formulation and Evaluation of Lignocaine Hydrochloride Proniosomes Loaded Orabase for Dental Anaesthesia","publication_year":2021,"publication_date":"2021-06-15","ids":{"openalex":"https://openalex.org/W3177164137","doi":"https://doi.org/10.22270/jddt.v11i3-s.4866","mag":"3177164137"},"language":"en","primary_location":{"id":"doi:10.22270/jddt.v11i3-s.4866","doi":"https://doi.org/10.22270/jddt.v11i3-s.4866","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v11i3-s.4866","pdf_url":"http://jddtonline.info/index.php/jddt/article/download/4866/3881","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://jddtonline.info/index.php/jddt/article/download/4866/3881","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007213333","display_name":"Gadela Venkata Radha","orcid":"https://orcid.org/0000-0001-6726-2185","observed_orcids":["https://orcid.org/0000-0001-6726-2185"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Radha G. V.","raw_affiliation_strings":["GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017197851","display_name":"Ganesh Sai Myneni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"GANESH SAI MYNENI","raw_affiliation_strings":["GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059325916","display_name":"N Sunayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunayana N","raw_affiliation_strings":["GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027312031","display_name":"G.V.R.L. Soujanya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Soujanya G. V. R. L.","raw_affiliation_strings":["GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009940666","display_name":"Kali Charan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Charan K","raw_affiliation_strings":["GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India - 530045","institution_ids":["https://openalex.org/I885392262"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I885392262"],"apc_list":null,"apc_paid":null,"fwci":0.2025,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.35189229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"11","issue":"3-S","first_page":"27","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.09019999951124191,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12145","display_name":"Dental Anxiety and Anesthesia Techniques","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lignocaine-hydrochloride","display_name":"lignocaine hydrochloride","score":0.9980000257492065},{"id":"https://openalex.org/keywords/proniosomes","display_name":"proniosomes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/orabase","display_name":"Orabase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dental-anesthesia","display_name":"dental anesthesia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mucoadhesive-gel","display_name":"mucoadhesive gel","score":0.6890000104904175},{"id":"https://openalex.org/keywords/span-80","display_name":"Span 80","score":0.7129999995231628},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.843999981880188},{"id":"https://openalex.org/keywords/drug-permeation","display_name":"drug permeation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.8059999942779541},{"id":"https://openalex.org/keywords/surfactant-selection","display_name":"surfactant selection","score":0.6150000095367432},{"id":"https://openalex.org/keywords/drug-excipient-compatibility","display_name":"drug-excipient compatibility","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.7616629600524902},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5742945075035095},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40428003668785095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40067288279533386},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34355831146240234},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.21548983454704285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15827521681785583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22270/jddt.v11i3-s.4866","doi":"https://doi.org/10.22270/jddt.v11i3-s.4866","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v11i3-s.4866","pdf_url":"http://jddtonline.info/index.php/jddt/article/download/4866/3881","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22270/jddt.v11i3-s.4866","doi":"https://doi.org/10.22270/jddt.v11i3-s.4866","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v11i3-s.4866","pdf_url":"http://jddtonline.info/index.php/jddt/article/download/4866/3881","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317448","display_name":"Gandhi Institute of Technology and Management","ror":"https://ror.org/0440p1d37"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3177164137.pdf","grobid_xml":"https://content.openalex.org/works/W3177164137.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2010690108","https://openalex.org/W2037406186","https://openalex.org/W2061324711","https://openalex.org/W2065946738","https://openalex.org/W2152815646","https://openalex.org/W2157430128","https://openalex.org/W2614357744"],"related_works":["https://openalex.org/W2901013542","https://openalex.org/W2092222009","https://openalex.org/W1999408043","https://openalex.org/W3214221262","https://openalex.org/W4380148818","https://openalex.org/W2465632777","https://openalex.org/W7135034574","https://openalex.org/W2800441279","https://openalex.org/W2516577345","https://openalex.org/W2961739903"],"abstract_inverted_index":{"The":[0,33,110],"aim":[1],"of":[2,147,187],"this":[3],"research":[4],"is":[5],"to":[6,67,75,165],"prepare":[7],"and":[8,17,44,52,70,86,104,122,189],"evaluate":[9],"lignocaine":[10,24,197],"HCl":[11],"Proniosomal":[12,201],"orabase":[13,114,143],"for":[14,37,72,96,106,141,168,178,193],"enhanced":[15,181],"permeation":[16,50,94,123],"prolonged":[18,92,117,191,206],"dental":[19],"anaesthesia":[20],"effect.":[21],"Objective:":[22],"Various":[23],"proniosomal":[25,142,169],"gels":[26],"were":[27,35,57],"formulated":[28],"employing":[29],"various":[30],"surfactants.":[31],"Methods:":[32],"formulations":[34],"scrutinized":[36],"entrapment":[38,80],"efficiency,":[39,205],"optical":[40],"microscopy,":[41],"in-vitro":[42],"diffusion":[43],"release":[45,118,192],"studies,":[46],"mucoadhesive":[47,137],"strength,":[48],"ex-vivo":[49],"studies":[51],"drug":[53,93],"\u2013":[54,128],"excipient":[55],"interactions":[56],"determined":[58],"by":[59],"FTIR":[60,153],"spectroscopy.":[61],"Results:":[62],"span":[63,83],"80":[64,84],"was":[65,102,139],"found":[66],"be":[68,174],"superior":[69],"significant":[71,116],"loading":[73,107],"in":[74,132],"orabase.":[76,109,170],"Considering":[77],"the":[78,99,158,185],"best":[79],"efficiency":[81],"with":[82,91,134,180],"(91.60%)":[85],"optimum":[87],"vesicle":[88],"shape,":[89],"along":[90],"(33.6%":[95],"24":[97],"h)":[98],"formulation":[100,111,150],"F4":[101,112],"selected":[103],"optimized":[105],"into":[108],"loaded":[113],"exhibited":[115,125],"over":[119],"10":[120],"h,":[121],"profiles":[124],"nearly":[126],"two":[127],"fold":[129],"increased":[130],"flux":[131],"comparison":[133],"control.":[135],"Good":[136],"strength":[138],"observed":[140],"6273dynes/cm2,":[144],"No":[145],"evidence":[146],"incompatibility":[148],"amongst":[149],"components":[151],"from":[152,162],"studies.":[154],"SEM":[155],"images":[156],"revealed":[157],"particle":[159],"size":[160],"range":[161],"50":[163],"\u03bcmt":[164,167],"100":[166],"Conclusion:":[171],"Orabase":[172],"can":[173],"an":[175],"effective":[176],"carrier":[177],"proniosomes":[179],"retention":[182],"time":[183],"at":[184],"site":[186],"application":[188],"provide":[190],"oro-dental":[194],"conditions.":[195],"Keywords:":[196],"Hcl,":[198],"Oro-dental":[199],"anaesthesia,":[200],"gel,":[202],"Orabase,":[203],"Entrapment":[204],"release.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2021-07-05T00:00:00"}